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Target Organs and Levels of Evidence for GMM-03

Toxicology Studies of Trimethylolpropane Triacrylate (Technical Grade) (CASRN 15625-89-5) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Trimethylolpropane triacrylate
15625-89-5
09/06/2002Used in the production of ultraviolet-curable inks, electron beam irradiation-curable coatings, & polymers & resins; as a component of photopolymer & flexographic printing plates & photoresists; & as an ingredient in acrylic glues & anaerobic sealants. Also used in paper & wood impregnates, wire & cable extrusion, polymer-impregnated concrete, & polymer concrete structural composites.Topical Application
0, 0.75, 1.5, 3, 6, or 12 mg/kg; 15/sex/dose
Battelle Columbus Laboratory

Levels of evidence information for toxicology and genetic toxicology studies of Trimethylolpropane Triacrylate (Technical Grade) in Tg.AC Hemizygous Mice
Male Tg.AC Hemizygous MiceFemale Tg.AC Hemizygous Mice
26 Weeks26 Weeks
Neoplastic Lesions
  • Skin (site of application): squamous cell papilloma (0/15, 0/15, 0/15, 2/15, 12/15, 13/15)
  • Skin (site of application): squamous cell papilloma (0/15, 0/15, 0/15, 1/15, 11/15, 15/15); squamous cell carcinoma (0/15, 0/15, 1/15, 0/15, 1/15, 1/15)
May Have Been Related
  • None
  • Forestomach: squamous cell papilloma (4/15, 5/15, 4/15, 2/15, 5/15, 9/15)
Non-Neoplastic Lesions
  • Skin (site of application): epidermal hyperplasia; hyperkeratosis; chronic active inflammation
  • All organs: myelodysplasia
  • Skin (site of application): epidermal hyperplasia; hyperkeratosis; chronic active inflammation
  • All organs: myelodysplasia