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https://ntp.niehs.nih.gov/go/36762

Target Organs and Levels of Evidence for GMM-15

Toxicology Study of Senna (CASRN 8013-11-4) in C57BL/6NTAC Mice and Toxicology and Carcinogenesis Study of Senna in Genetically Modified C3B6.129F1/Tac-Trp53tm1Brd  N12 Haploinsufficient Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Senna (powdered)
8013-11-4
04/05/2011 Herbal product, extract of senna fruit, used in laxative preparations Dosed-Feed
0, 100, 300, 1000, 3000, or 10,000 ppm; 25/sex
Battelle Columbus Laboratory

Levels of evidence information for the 40-Week Carcinogenesis and Genetic Toxicology Studies of Senna
  Male Heterozygous F1 p53+/− Mice Female Heterozygous F1 p53+/− Mice
  40 Weeks 40 Weeks
Levels of Evidence No evidence No evidence
Neoplastic Lesions None None
Non-Neoplastic Lesions
  • Large intestine (cecum): epithelial hyperplasia
  • Large intestine (colon): epithelial hyperplasia
  • Large intestine (cecum): epithelial hyperplasia
  • Large intestine (colon): epithelial hyperplasia