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List of Genetically Modified Models by Report Number

This list of NTP Peer Reviewed studies in Genetically Modified Models (GMM) is arranged by Report Number and includes links to Levels of Evidence definitions,  report abstracts, and Testing Status of Agents. Carcinogenicity conclusions by sex/strain are included where applicable.  Note that the NTP does not apply the levels of evidence of carcinogenic activity criteria to the Tg.AC* model. See the September 17-18, 2002 NTP Board of Scientific Counselors Meeting minutes at URL: http://ntp.niehs.nih.gov/ntp/About_ntp/BSC/2002/September/20020917BSCSummMins_508.pdf


Listing of Technical Reports
  Conclusion by Sex/Strain
Report No. Peer Review Date/ Target Organs Chemical Name CAS Number GMM Mouse Strain Exposure Duration Males Females
GMM-01 05/22/2003 Aspartame 22839-47-0 p53 39 weeks No Evidence No Evidence
GMM-01 05/22/2003 Aspartame 22839-47-0 Cdkn2a 39 weeks No Evidence No Evidence
GMM-01 05/22/2003 Aspartame 22839-47-0 Tg.AC 39 weeks * *
GMM-02 05/22/2003 Acesulfame Potassium 55589-62-3 p53 39 weeks No Evidence No Evidence
GMM-03 09/06/2002 Trimethylolpropane triacrylate 15625-89-5 Tg.AC 28 weeks * *
GMM-04 09/06/2002 Pentaerythritol triacrylate 3524-68-3 Tg.AC 27 weeks * *
GMM-05 09/27/2005 Bromodichloromethane (Water Disinfection Byproducts) 75-27-4 p53 26 weeks (Dosed water) No Evidence No Evidence
GMM-05 09/27/2005 Bromodichloromethane (Water Disinfection Byproducts) 75-27-4 p53 41 weeks (Dosed water) No Evidence No Evidence
GMM-05 09/27/2005 Bromodichloromethane (Water Disinfection Byproducts) 75-27-4 p53 26 weeks (Gavage) No Evidence No Evidence
GMM-05 09/27/2005 Bromodichloromethane (Water Disinfection Byproducts) 75-27-4 p53 41 weeks (Gavage) No Evidence No Evidence
GMM-05 09/27/2005 Bromodichloromethane (Water Disinfection Byproducts) 75-27-4 Tg.AC 26 weeks (Dermal) * *
GMM-05 09/27/2005 Bromodichloromethane (Water Disinfection Byproducts) 75-27-4 Tg.AC 39 weeks (Dermal) * *
GMM-05 09/27/2005 Bromodichloromethane (Water Disinfection Byproducts) 75-27-4 Tg.AC 26 weeks (Drinking Water) * *
GMM-05 09/27/2005 Bromodichloromethane (Water Disinfection Byproducts) 75-27-4 Tg.AC 42 weeks (Drinking Water) * *
GMM-05 09/27/2005 Bromodichloromethane (Water Disinfection Byproducts) 75-27-4 Tg.AC 26 weeks (Gavage) * *
GMM-05 09/27/2005 Bromodichloromethane (Water Disinfection Byproducts) 75-27-4 Tg.AC 41 weeks (Gavage) * *
GMM-06 09/27/2005 Sodium Bromate (Water Disinfection Byproducts) 7789-38-0 p53 27 weeks No Evidence No Evidence
GMM-06 09/27/2005 Sodium Bromate (Water Disinfection Byproducts) 7789-38-0 p53 43 weeks No Evidence No Evidence
GMM-06 09/27/2005 Sodium Bromate (Water Disinfection Byproducts) 7789-38-0 Tg.AC 26 weeks (Dermal) * *
GMM-06 09/27/2005 Sodium Bromate (Water Disinfection Byproducts) 7789-38-0 Tg.AC 39 weeks (Dermal) * *
GMM-06 09/27/2005 Sodium Bromate (Water Disinfection Byproducts) 7789-38-0 Tg.AC 27 weeks (Drinking Water) * *
GMM-06 09/27/2005 Sodium Bromate (Water Disinfection Byproducts) 7789-38-0 Tg.AC 43 weeks (Drinking Water) * *
GMM-07 08/28/2006 Allyl Bromide 106-35-6 p53 40 weeks No Evidence No Evidence
GMM-07 08/28/2006 Allyl Bromide 106-35-6 Tg.AC 40 weeks * *
GMM-08 08/28/2006 Benzene 71-43-2 p16Ink4a 27 weeks Clear Evidence No Evidence
GMM-09 08/28/2006 Dicyclohexylcarbodiimide 538-75-0 p53 27 weeks Chemical Not Tested No Evidence
GMM-09 08/28/2006 Dicyclohexylcarbodiimide 538-75-0 Tg.AC 20 weeks * *
GMM-10 09/28/2005 Diisopropylcarbodiimide 693-13-0 p53 27 weeks Chemical Not Tested No Evidence
GMM-10 09/28/2005 Diisopropylcarbodiimide 693-13-0 Tg.AC 20 weeks * *
GMM-11 09/27/2005 Dichloroacetic Acid (Water Disinfection Byproducts) 79-43-6 p53 26 weeks No Evidence No Evidence
GMM-11 09/27/2005 Dichloroacetic Acid (Water Disinfection Byproducts) 79-43-6 p53 41 weeks No Evidence No Evidence
GMM-12 08/28/2006 Phenolphthalein 77-09-8 p16Ink4a 27 weeks No Evidence No Evidence
GMM-13 08/28/2006 Glycidol 556-52-5 p16Ink4a 40 weeks Clear Evidence Some Evidence
GMM-14 02/09/2012 3'-Azido-3'-Deoxythymidine (AZT) 30516-87-1 p53+/- 30 weeks Clear Evidence Equivocal Evidence
GMM-15 04/05/2011 Senna (powdered) 8013-11-4 p53 40 weeks No Evidence Some Evidence
GMM-16 02/09/2012 3'-Azido-3'-Deoxythymidine (AZT) 30516-87-1 F1 p53+/- 45 weeks Clear Evidence No Evidence
GMM-16 02/09/2012 Lamivudine (3TC) 134678-17-4 F1 p53+/- 45 weeks No Evidence Equivocal Evidence
GMM-16 02/09/2012 Nevirapine (NVP) 129618-40-2 F1 p53+/- 45 weeks No Evidence Equivocal Evidence
GMM-16 02/09/2012 AZT/3TC -- F1 p53+/- 45 weeks Clear Evidence Equivocal Evidenc
GMM-16 02/09/2012 AZT/3TC/NVP -- F1 p53+/- 45 weeks Clear Evidence Equivocal Evidence