National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/40288

List of Genetically Modified Models by Report Number

 

This list of NTP Peer Reviewed studies in Genetically Modified Models (GMM) is arranged by Report Number and includes links to Levels of Evidence definitions,  report abstracts, and Testing Status of Agents. Carcinogenicity conclusions by sex/strain are included where applicable.  Note that the NTP does not apply the levels of evidence of carcinogenic activity criteria to the Tg.AC* model. See the September 17-18, 2002 NTP Board of Scientific Counselors Meeting minutes at URL: http://ntp.niehs.nih.gov/ntp/About_ntp/BSC/2002/September/20020917BSCSummMins_508.pdf

Key to "Conclusions" Abbreviations
Abbreviation Conclusion
CE = Clear Evidence
SE = Some Evidence
EE = Equivocal Evidence
NE = No Evidence
IS = Inadequate Study
NT = Chemical Not Tested in Species/Sex



 
Report
No.
Peer Review Date/ Target Organs Chemical Name CAS Number GMM Mouse Strain Exposure Duration
Conclusion by sex/strain
Males Females
GMM-01
 
05/22/2003
 
Aspartame
 
22839-47-0
 
p53
 
39 weeks
 
NE
 
NE
 
 
 
 
 
 
 
 
 
Cdkn2a
 
39 weeks
 
NE
 
NE
 
 
 
 
 
 
 
 
 
Tg.AC
 
39 weeks
 
*
 
*
 
GMM-02
 
05/22/2003
 
Acesulfame Potassium
 
55589-62-3
 
p53
 
39 weeks
 
NE
 
NE
 
GMM-03
 
09/06/2002
 
Trimethylolpropane triacrylate
 
15625-89-5
 
Tg.AC
 
28 weeks
 
*
 
*
 
GMM-04
 
09/06/2002
 
Pentaerythritol triacrylate
 
3524-68-3
 
Tg.AC
 
27 weeks
 
*
 
*
 
GMM-05
 
09/27/2005
 
Bromodichloromethane (Water Disinfection Byproducts)
 
75-27-4
 
p53
 
26 weeks (Dosed water)
 
NE
 
NE
 
 
 
 
 
 
 
 
 
p53
 
41 weeks (Dosed water)
 
NE
 
NE
 
 
 
 
 
 
 
 
 
p53
 
26 weeks (Gavage)
 
NE
 
NE
 
 
 
 
 
 
 
 
 
p53
 
41 weeks (Gavage)
 
NE
 
NE
 
 
 
 
 
 
 
 
 
Tg.AC
 
26 weeks (Dermal)
 
*
 
*
 
 
 
 
 
 
 
 
 
Tg.AC
 
39 weeks (Dermal)
 
*
 
*
 
 
 
 
 
 
 
 
 
Tg.AC
 
26 weeks (Drinking Water)
 
*
 
*
 
 
 
 
 
 
 
 
 
Tg.AC
 
42 weeks (Drinking Water)
 
*
 
*
 
 
 
 
 
 
 
 
 
Tg.AC
 
26 weeks (Gavage)
 
*
 
*
 
 
 
 
 
 
 
 
 
Tg.AC
 
41 weeks (Gavage)
 
*
 
*
 
GMM-06
 
09/27/2005
 
Sodium Bromate (Water Disinfection Byproducts)
 
7789-38-0
 
p53
 
27 weeks
 
NE
 
NE
 
 
 
 
 
 
 
 
 
p53
 
43 weeks
 
NE
 
NE
 
 
 
 
 
 
 
 
 
Tg.AC
 
26 weeks (Dermal)
 
*
 
*
 
 
 
 
 
 
 
 
 
Tg.AC
 
39 weeks (Dermal)
 
*
 
*
 
 
 
 
 
 
 
 
 
Tg.AC
 
27 weeks (Drinking Water)
 
*
 
*
 
 
 
 
 
 
 
 
 
Tg.AC
 
43 weeks (Drinking Water)
 
*
 
*
 
GMM-07
 
08/28/2006
 
Allyl Bromide
 
106-35-6
 
p53
 
40 weeks
 
NE
 
NE
 
 
 
 
 
 
 
 
 
Tg.AC
 
40 weeks
 
*
 
*
 
GMM-08
 
08/28/2006
 
Benzene
 
71-43-2
 
p16Ink4a
 
27 weeks
 
CE
 
NE
 
GMM-09
 
08/28/2006
 
Dicyclohexylcarbodiimide
 
538-75-0
 
p53
 
27 weeks
 
NT
 
NE
 
 
 
 
 
 
 
 
 
Tg.AC
 
20 weeks
 
*
 
*
 
GMM-10
 
09/28/2005
 
Diisopropylcarbodiimide
 
693-13-0
 
p53
 
27 weeks
 
NT
 
NE
 
 
 
 
 
 
 
 
 
Tg.AC
 
20 weeks
 
*
 
*
 
GMM-11
 
09/27/2005
 
Dichloroacetic Acid (Water Disinfection Byproducts)
 
79-43-6
 
p53
 
26 weeks
 
NE
 
NE
 
 
 
 
 
 
 
 
 
p53
 
41 weeks
 
NE
 
NE
 
GMM-12
 
08/28/2006
 
Phenolphthalein
 
77-09-8
 
p16Ink4a
 
27 weeks
 
NE
 
NE
 
GMM-13
 
08/28/2006
 
Glycidol
 
556-52-5
 
p16Ink4a
 
40 weeks
 
CE
 
SE
 
GMM-14
 
02/09/2012
 
3'-Azido-3'-Deoxythymidine (AZT)
 
30516-87-1
 
p53+/-
 
30 weeks
 
CE
 
EE
 
GMM-15
 
04/05/2011
 
Senna (powdered)
 
8013-11-4
 
p53
 
40 weeks
 
NE
 
SE
 
GMM-16
 
02/09/2012
 
3'-Azido-3'-Deoxythymidine (AZT)
 
30516-87-1
 
F1 p53+/-
 
45 weeks
 
CE
 
NE
 
GMM-16
 
02/09/2012
 
Lamivudine (3TC)
 
134678-17-4
 
F1 p53+/-
 
45 weeks
 
NE
 
EE
 
GMM-16
 
02/09/2012
 
Nevirapine (NVP)
 
129618-40-2
 
F1 p53+/-
 
45 weeks
 
NE
 
EE
 
GMM-16
 
02/09/2012
 
AZT/3TC
 
--
 
F1 p53+/-
 
45 weeks
 
CE
 
EE
 
GMM-16
 
02/09/2012
 
AZT/3TC/NVP
 
--
 
F1 p53+/-
 
45 weeks
 
CE
 
EE
 
 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.