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Tox21 Toolbox

The Tox21 toolbox contains useful tools for data analysis. You can use these tools to access and visualize the Tox21 quantitative high-throughput screening (qHTS) 10K library data, as well as to integrate with other publicly available data.


NIEHS/NTP Tools

  • Tox21 Data Analysis—these tools are intended to facilitate analysis and visualization of Tox21 data.
    • BMDExpress 2: Use this tool to perform genomic dose response analysis with the goal of identifying gene set/pathway-level potency estimates.
  • Tox21 Data Visualization—these tools are focused on providing quick, easy-to-use Tox21 qHTS data access, visualization, and clustering.
    • Tox21 Curve Browser—beta version: Use this tool to visualize the concentration-response curves of one or many compounds of interest with the ability to superimpose assay results per compound for easy comparison.
    • Tox21 Activity Profiler—beta version: Use this tool to prioritize compounds through compound structure and/or Tox21 qHTS data activity clustering visualization. Plots and data are available for download.
  • Tox21 Data Integration—these web applications integrate data from external resources to facilitate interpretation of Tox21 data.
    • Tox21 Enricher—beta version: Use this tool to load a set of compounds and find any enriched toxicological characteristics in the set of uploaded compounds from many biological data sources such as DrugMatrix®, PubChem, Comparative Toxicogenomics Database, and Leadscope.
    • Tox21 IVIVE Dose Equivalent—beta version: Use this tool to provide dose estimates for the likelihood of in vivo human biological interactions using Tox21 data and high-throughput toxicokinetics modeling.
  • DrugMatrix® and ToxFX®—these tools increase the efficiency of the toxicological assessment process.
    • DrugMatrix®: This database contains one of the world's largest toxicogenomic reference resources ever assembled.
    • ToxFX®: This is a companion database to Drug Matrix® and contains a reporting system that generates fully annotated reports in minutes.

External Tools

  • PubChem: Access to large-scale screening data (including, but not limited to, Tox21 qHTS data). Also gives access to the medicinal chemistry and informatics necessary to identify chemical probes to study the functions of genes, cells, and biochemical pathways. PubChem is organized as three linked databases within the NCBI's Entrez information retrieval system. These databases are PubChem Substance, PubChem Compound, and PubChem BioAssay.
  • Tox21 Data Browser—beta version: Access chemical quality control information. This tool was developed by the National Center for Advancing Translational Sciences (NCATS).
  • EPA hosts a collection of flat files for Tox21 and ToxCast programs as well as the EPA iCSS Dashboard. Files include assay and chemical descriptions, HTS data, and other related files.