NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: TSI Mason Research PYRIDINE DATE: 10/08/97
EXPERIMENT: 55301 TEST: 06 TIME: 10:17:37
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: C55301B
CONT: N01-ES-95268 CAS: 110-86-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: TSI MASON RESEARCH PYRIDINE DATE: 10/08/97
EXPERIMENT: 55301 TEST: 06 TIME: 10:33:13
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: 55301B
CONT: N01-ES-95268 CAS: 110-86-1
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED WATER STUDY OF PYRIDINE
==================================================================================================================================
0 PPM 100 PPM 200 PPM 400 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 37.6 201.3 37.5 197.9 1.00 19 39.3 198.9 1.05 40 35.9 198.1 0.95 72
2 40.9 254.9 38.9 249.7 0.95 16 39.8 245.9 0.97 32 37.9 239.5 0.93 63
3 38.9 293.7 40.2 289.0 1.03 14 41.3 285.0 1.06 29 41.9 279.5 1.08 60
4 42.1 327.1 42.1 325.7 1.00 13 43.9 320.5 1.04 27 42.7 311.9 1.01 55
5 46.3 357.3 48.6 359.3 1.05 14 48.5 346.8 1.05 28 45.7 344.5 0.99 53
6 39.4 382.3 39.3 379.6 1.00 10 39.9 371.5 1.01 21 38.9 358.3 0.99 43
7 40.8 412.8 44.3 410.8 1.09 11 44.4 402.0 1.09 22 46.0 387.6 1.13 47
8 47.4 426.2 43.5 428.3 0.92 10 47.1 412.3 0.99 23 45.6 399.6 0.96 46
9 53.3 447.5 49.2 445.6 0.92 11 49.5 434.9 0.93 23 48.7 418.6 0.91 47
10 42.7 464.0 41.4 463.2 0.97 9 43.3 451.7 1.01 19 43.2 431.1 1.01 40
11 50.3 479.0 46.3 478.1 0.92 10 47.0 462.7 0.93 20 47.0 442.9 0.93 42
12 48.2 494.2 47.3 492.1 0.98 10 47.3 479.4 0.98 20 43.9 457.2 0.91 38
13 46.8 506.3 46.7 502.9 1.00 9 46.6 490.2 1.00 19 46.3 466.0 0.99 40
17 44.0 545.9 42.3 541.5 0.96 8 41.9 526.9 0.95 16 41.0 501.9 0.93 33
21 46.5 569.3 42.8 574.7 0.92 7 41.5 562.4 0.89 15 44.8 527.7 0.96 34
25 41.9 599.2 39.4 602.2 0.94 7 41.0 583.0 0.98 14 42.9 551.6 1.02 31
29 40.4 627.4 36.7 629.6 0.91 6 40.0 611.5 0.99 13 41.6 575.9 1.03 29
33 43.6 657.7 42.8 656.9 0.98 7 39.9 637.5 0.92 13 44.2 598.7 1.01 30
37 46.8 671.9 46.6 673.0 1.00 7 48.1 650.9 1.03 15 48.6 610.0 1.04 32
41 38.4 690.8 38.8 686.0 1.01 6 39.2 664.3 1.02 12 40.3 627.3 1.05 26
45 43.5 714.8 42.9 710.6 0.99 6 43.0 684.3 0.99 13 44.0 642.3 1.01 27
49 40.5 736.1 40.5 718.6 1.00 6 41.9 694.5 1.03 12 44.5 653.9 1.10 27
53 50.9 754.7 48.3 734.7 0.95 7 52.6 705.2 1.03 15 53.5 662.1 1.05 32
57 45.4 774.1 47.3 747.9 1.04 6 48.8 714.0 1.07 14 50.7 667.6 1.12 30
61 54.7 789.1 53.9 752.8 0.99 7 59.4 718.1 1.09 17 57.4 668.6 1.05 34
65 49.8 795.2 52.5 757.2 1.05 7 55.6 719.6 1.12 15 55.7 660.5 1.12 34
69 54.3 800.3 55.5 739.3 1.02 8 56.7 698.9 1.04 16 58.2 657.8 1.07 35
73 54.6 802.7 60.1 736.4 1.10 8 59.8 705.6 1.10 17 62.6 657.1 1.15 38
77 56.3 796.6 60.5 725.2 1.07 8 63.2 717.4 1.12 18 63.7 644.1 1.13 40
81 58.1 798.6 66.8 698.0 1.15 10 64.3 698.4 1.11 18 62.2 623.6 1.07 40
85 60.1 781.6 65.1 707.3 1.08 9 64.4 698.7 1.07 18 57.4 630.4 0.96 36
89 60.5 775.2 68.4 691.9 1.13 10 67.0 675.8 1.11 20 64.6 613.6 1.07 42
93 69.3 778.8 69.2 677.7 1.00 10 67.7 656.5 0.98 21 57.7 612.1 0.83 38
97 66.1 756.9 71.2 675.4 1.08 11 61.2 618.1 0.93 20 55.7 589.6 0.84 38
==================================================================================================================================
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED WATER STUDY OF PYRIDINE
==================================================================================================================================
0 PPM 100 PPM 200 PPM 400 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
101 59.6 724.9 59.0 675.2 0.99 9 54.5 578.4 0.91 19 57.5 604.1 0.96 38
1 TO 13 WEEKS
----------------
MEAN 44.2 388.2 43.5 386.3 0.99 12 44.5 377.1 1.01 25 43.4 364.2 0.98 50
SD(D) 4.8 3.9 0.05 3 3.5 0.05 6 3.8 0.06 10
CV(E) 10.9 9.0 5.2 24.7 7.9 4.7 24.5 8.9 6.4 20.8
14 TO 52 WEEKS
----------------
MEAN 42.8 645.9 41.4 643.7 0.97 6 41.8 623.9 0.98 14 43.5 587.7 1.02 30
SD(D) 2.8 2.9 0.04 1 2.7 0.05 1 2.5 0.05 3
CV(E) 6.5 7.0 3.8 12.1 6.3 5.1 10.6 5.7 4.7 9.3
> 52 WEEKS
----------------
MEAN 56.9 779.1 59.8 716.9 1.05 8 59.6 685.0 1.05 17 58.2 637.8 1.03 37
SD(D) 6.5 8.0 0.06 1 5.7 0.07 2 4.1 0.10 3
CV(E) 11.4 13.3 5.7 17.0 9.6 6.7 11.9 7.0 10.0 9.0
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED WATER STUDY OF PYRIDINE
=========================================================================================================
0 PPM 100 PPM 200 PPM 400 PPM
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 201.3 50 197.9 50 198.9 50 198.1 50
1 37.6 6830 201.3 50 37.5 6752 197.9 50 39.3 6509 198.9 50 35.9 6927 198.1 50
2 40.9 4733 254.9 50 38.9 4495 249.7 50 39.8 4517 245.9 50 37.9 4555 239.5 50
3 38.9 4528 293.7 50 40.2 4217 289.0 50 41.3 4466 285.0 50 41.9 4664 279.5 50
4 42.1 4377 327.1 50 42.1 4750 325.7 50 43.9 4630 320.5 50 42.7 4424 311.9 50
5 46.3 4180 357.3 50 48.6 4217 359.3 50 48.5 4465 346.8 50 45.7 4584 344.5 50
6 39.4 4232 382.3 50 39.3 4723 379.6 50 39.9 4716 371.5 50 38.9 4876 358.3 50
7 40.8 4051 412.8 50 44.3 4766 410.8 50 44.4 4181 402.0 50 46.0 4462 387.6 50
8 47.4 3819 426.2 50 43.5 3914 428.3 50 47.1 3977 412.3 50 45.6 4186 399.6 50
9 53.3 3757 447.5 50 49.2 3727 445.6 50 49.5 3575 434.9 50 48.7 3825 418.6 50
10 42.7 4473 464.0 50 41.4 4750 463.2 50 43.3 4300 451.7 50 43.2 4251 431.1 50
11 50.3 3888 479.0 50 46.3 3999 478.1 50 47.0 3875 462.7 50 47.0 4271 442.9 50
12 48.2 4078 494.2 50 47.3 4076 492.1 50 47.3 4195 479.4 50 43.9 4504 457.2 50
13 46.8 3299 506.3 50 46.7 4017 502.9 50 46.6 3515 490.2 50 46.3 3849 466.0 50
17 44.0 2231 545.9 50 42.3 3782 541.5 50 41.9 3831 526.9 50 41.0 3290 501.9 49
21 46.5 4429 569.3 50 42.8 4671 574.7 50 41.5 4527 562.4 49 44.8 4135 527.7 49
25 41.9 3880 599.2 50 39.4 3875 602.2 50 41.0 4280 583.0 50 42.9 4342 551.6 49
29 40.4 4726 627.4 50 36.7 4727 629.6 50 40.0 4721 611.5 50 41.6 4634 575.9 49
33 43.6 4210 657.7 50 42.8 4446 656.9 50 39.9 3526 637.5 50 44.2 3629 598.7 49
37 46.8 2677 671.9 50 46.6 3801 673.0 50 48.1 3383 650.9 50 48.6 3132 610.0 49
41 38.4 4361 690.8 50 38.8 4630 686.0 50 39.2 4295 664.3 50 40.3 4185 627.3 49
45 43.5 3778 714.8 49 42.9 4294 710.6 50 43.0 4015 684.3 50 44.0 3775 642.3 49
49 40.5 3789 736.1 49 40.5 4384 718.6 49 41.9 3848 694.5 50 44.5 4235 653.9 49
53 50.9 4692 754.7 49 48.3 4522 734.7 48 52.6 4691 705.2 49 53.5 4693 662.1 49
57 45.4 3510 774.1 49 47.3 4043 747.9 47 48.8 3677 714.0 49 50.7 4229 667.6 49
61 54.7 4539 789.1 49 53.9 4307 752.8 47 59.4 4212 718.1 48 57.4 4598 668.6 49
65 49.8 4262 795.2 49 52.5 4404 757.2 46 55.6 4281 719.6 47 55.7 4553 660.5 48
69 54.3 4373 800.3 48 55.5 4367 739.3 45 56.7 4245 698.9 46 58.2 3849 657.8 42
73 54.6 3258 802.7 48 60.1 3620 736.4 43 59.8 3249 705.6 39 62.6 3214 657.1 37
77 56.3 3765 796.6 48 60.5 3799 725.2 42 63.2 3256 717.4 36 63.7 3073 644.1 34
81 58.1 2714 798.6 45 66.8 2496 698.0 38 64.3 2210 698.4 34 62.2 1820 623.6 27
85 60.1 3426 781.6 41 65.1 3198 707.3 35 64.4 2793 698.7 32 57.4 1923 630.4 21
89 60.5 2907 775.2 37 68.4 2714 691.9 31 67.0 2735 675.8 31 64.6 1662 613.6 18
92 776.9 35 667.3 29 664.7 26 612.9 15
93 69.3 2705 778.8 32 69.2 2418 677.7 27 67.7 2401 656.5 25 57.7 1235 612.1 15
95 753.4 31 671.4 24 630.3 24 580.7 14
97 66.1 2022 756.9 30 71.2 1939 675.4 22 61.2 1866 618.1 22 55.7 1060 589.6 13
99 715.3 27 666.0 20 618.1 17 608.5 8
101 59.6 1932 724.9 25 59.0 1375 675.2 17 54.5 1287 578.4 16 57.5 764 604.1 8
103 709.9 23 646.3 15 590.8 12 597.7 7
MEAN BODY WGT FOR WEEKS
1 TO 13 388.2 386.3 377.1 364.2
14 TO 52 645.9 643.7 623.9 587.7
> 52 769.6 704.1 671.1 628.9
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.