                                                 Toxicology Data Management System                                     Page: 1
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                    Date of
 Species: MICE                                           Vehicle: ACETONE                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510912  10/31/88   729       50(1)      46  (718)     50.8     TRIETHANOLAMINE                            |
|E.G. & G. MASON    050506907  06/06/89   731       50(1)      39  (700)     53.9     1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE       |
|HAZLETON           050510603  12/23/86   730       50(1)      43  (712)     39.5     DIETHYLPHTHALATE                           |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510912  10/31/88   729       50(1)      39  (669)     51.6     TRIETHANOLAMINE                            |
|E.G. & G. MASON    050506907  06/06/89   741       50(1)      34  (714)     57.0     1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE       |
|HAZLETON           050510603  12/23/86   730       50(1)      41  (709)     37.9     DIETHYLPHTHALATE                           |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                    Date of
 Species: MICE                                           Vehicle: ETHANOL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510206  06/22/87   732       50(1)      43  (720)     51.5     BENZETHONIUM CHLORIDE                      |
|BATTELLE COLUMBUS  055531204  01/20/93   727       50(1)      41  (704)     51.2     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE |
|BATTELLE COLUMBUS  050516210  10/22/90   729       50(1)      40  (701)     52.1     DIETHANOLAMINE                             |
|BATTELLE COLUMBUS  055532304  12/30/92   735       50(1)      40  (699)     52.2     LAURIC ACID DIETHANOLAMINE CONDENSATE      |
|BATTELLE COLUMBUS  059101404  05/10/93   729       49(1)      41  (706)     51.3     OLEIC ACID DIETHANOLAMINE CONDENSATE       |
|BATTELLE COLUMBUS  050518806  12/20/90   733       50(1)      32  (704)     47.2     SODIUM XYLENESULFONATE                     |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510206  06/22/87   732       52(1)      38  (704)     54.1     BENZETHONIUM CHLORIDE                      |
|BATTELLE COLUMBUS  055531204  01/20/93   729       50(1)      35  (699)     58.0     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE |
|BATTELLE COLUMBUS  050516210  10/22/90   731       50(1)      44  (720)     55.4     DIETHANOLAMINE                             |
|BATTELLE COLUMBUS  055532304  12/30/92   736       50(1)      37  (704)     55.0     LAURIC ACID DIETHANOLAMINE CONDENSATE      |
|BATTELLE COLUMBUS  059101404  05/10/93   730       50(1)      34  (684)     55.9     OLEIC ACID DIETHANOLAMINE CONDENSATE       |
|BATTELLE COLUMBUS  050518806  12/20/90   740       50(1)      31  (690)     50.6     SODIUM XYLENESULFONATE                     |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: CORN OIL                                Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050508602  11/28/84   722       50(1)      45  (718)     52.0     O-BENZYL-P-CHLOROPHENOL                    |
|BIOASSAY SYS CORP  050509102  12/18/84   729       50(1)      42  (694)     53.1     3,4-DIHYDROCOUMARIN                        |
|BIOASSAY SYS CORP  050509002  11/08/84   729       50(1)      43  (716)     54.4     COUMARIN                                   |
|E.G. & G. MASON    050511102  06/25/85   729       52(1)      42  (685)     45.9     1,2,3-TRICHLOROPROPANE                     |
|E.G. & G. MASON    050510802  04/29/85   733       50(1)      39  (699)     44.7     PROMETHAZINE HYDROCHLORIDE                 |
|E.G. & G. MASON    050521402  05/11/88   730       62(1)      50  (706)     53.4     TRANS-DELTA-9-TETRAHYDROCANNABINOL         |
|SOUTHERN RESEARCH  050509301  09/25/84   729       50(1)      33  (690)     53.8     P-NITROANILINE                             |
|SOUTHERN RESEARCH  050509908  01/03/89   728       50(1)      40  (687)     54.4     SALICYLAZOSULFAPYRIDINE                    |
|SOUTHERN RESEARCH  050506710  10/15/90   730       50(1)      36  (705)     53.6     THEOPHYLLINE                               |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050508602  11/28/84   722       50(1)      37  (707)     49.8     O-BENZYL-P-CHLOROPHENOL                    |
|BIOASSAY SYS CORP  050509102  12/18/84   729       51(1)      36  (669)     49.5     3,4-DIHYDROCOUMARIN                        |
|BIOASSAY SYS CORP  050509002  11/08/84   729       52(1)      33  (618)     52.9     COUMARIN                                   |
|E.G. & G. MASON    050511102  06/25/85   733       50(1)      41  (701)     44.3     1,2,3-TRICHLOROPROPANE                     |
|E.G. & G. MASON    050510802  04/29/85   743       50(1)      37  (721)     45.8     PROMETHAZINE HYDROCHLORIDE                 |
|E.G. & G. MASON    050521402  05/11/88   737       60(1)      47  (702)     55.9     TRANS-DELTA-9-TETRAHYDROCANNABINOL         |
|SOUTHERN RESEARCH  050509301  09/25/84   729       50(1)      29  (662)     55.1     P-NITROANILINE                             |
|SOUTHERN RESEARCH  050509908  01/03/89   735       50(1)      41  (680)     51.6     SALICYLAZOSULFAPYRIDINE                    |
|SOUTHERN RESEARCH  050506710  10/15/90   731       50(1)      37  (700)     57.6     THEOPHYLLINE                               |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 4
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                        Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050518706  10/25/93   730       49(1)      38  (693)     53.7     METHYLEUGENOL                              |
|SOUTHERN RESEARCH  058900606  07/09/90   729       50(1)      32  (683)     50.2     AZT                                        |
|SOUTHERN RESEARCH  058900602  10/08/90   731       50(1)      36  (694)     47.7     AZT/INTERFERON A/INTERFERON AD             |
|SOUTHERN RESEARCH  058900604  01/14/91   729       50(1)      31  (694)     48.1     AZT/INTERFERON A/INTERFERON AD             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050518706  10/25/93   731       50(5)      31  (696)     63.2     METHYLEUGENOL                              |
|SOUTHERN RESEARCH  058900606  07/09/90   731       50(1)      34  (689)     58.0     AZT                                        |
|SOUTHERN RESEARCH  058900602  10/08/90   729       50(1)      33  (662)     51.1     AZT/INTERFERON A/INTERFERON AD             |
|SOUTHERN RESEARCH  058900604  01/14/91   730       50(1)      37  (703)     53.7     AZT/INTERFERON A/INTERFERON AD             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 5
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                    Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050512107  09/22/88   726       50(1)      40  (703)     52.4     SCOPOLAMINE HYDROBROMIDE TRIHYDRATE        |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050512107  09/22/88   726       51(1)      33  (676)     56.0     SCOPOLAMINE HYDROBROMIDE TRIHYDRATE        |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 6
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                Date of
 Species: MICE                                           Vehicle: AIR                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 050513402  01/23/86   736       50(1)      35  (690)     46.1     1,3-BUTADIENE                              |
|BATTELLE NORTHWEST 050519712  07/26/93   729       50(1)      39  (697)     52.2     2-BUTOXYETHANOL                            |
|BATTELLE NORTHWEST 050513304  04/07/88   733       50(1)      32  (690)     48.5     ACETONITRILE                               |
|BATTELLE NORTHWEST 050513608  09/13/90   733       50(1)      27  (689)     49.4     CHLOROPRENE                                |
|BATTELLE NORTHWEST 050515606  08/23/90   733       50(1)      22  (662)     47.1     COBALT SULFATE HEPTAHYDRATE                |
|BATTELLE NORTHWEST 050520106  11/21/91   733       50(1)      34  (688)     51.6     FURFURYL ALCOHOL                           |
|BATTELLE NORTHWEST 050518406  07/07/94   733       50(1)      31  (686)     52.5     GLUTARALDEHYDE                             |
|BATTELLE NORTHWEST 050511402  11/18/85   733       50(1)      35  (685)     43.9     HEXACHLOROCYCLOPENTADIENE (HCCPD)          |
|BATTELLE NORTHWEST 058807004  03/04/93   733       50(1)      28  (676)     51.0     ISOBUTENE                                  |
|BATTELLE NORTHWEST 056096802  08/09/90   733       50(1)      40  (712)     50.0     ISOBUTYRALDEHYDE                           |
|BATTELLE NORTHWEST 050515804  03/22/90   733       50(1)      36  (689)     50.6     MOLYBDENUM TRIOXIDE                        |
|BATTELLE NORTHWEST 050520006  08/31/89   734       50(1)      31  (681)     52.1     NITROMETHANE                               |
|BATTELLE NORTHWEST 058803404  11/09/89   733       50(1)      30  (670)     50.9     OZONE                                      |
|BATTELLE NORTHWEST 050518104  12/07/89   733       50(1)      32  (689)     51.2     TETRAHYDROFURAN                            |
|BROOKHAVEN         050510101  09/26/84   727       50(1)      40  (699)     48.6     METHYL BROMIDE                             |
|I. I. T. RESEARCH I050521004  03/05/90   729       50(1)      28  (636)     48.1     ETHYLBENZENE                               |
|I. I. T. RESEARCH I050518504  12/05/88   725       50(1)      37  (663)     48.4     ISOBUTYL NITRITE                           |
|LOVELACE RESEARCH  050512306  04/25/88   737       55(1)      19  (604)     42.6     NICKEL OXIDE                               |
|LOVELACE RESEARCH  050510706  09/29/88   737       59(1)      26  (644)     42.6     NICKEL SUBSULFIDE                          |
|LOVELACE RESEARCH  050512206  05/30/88   737       60(1)      26  (647)     43.9     NICKEL SULFATE HEXAHYDRATE                 |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 7
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                Date of
 Species: MICE                                           Vehicle: AIR                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 050513402  01/23/86   737       50(1)      37  (706)     48.1     1,3-BUTADIENE                              |
|BATTELLE NORTHWEST 050519712  07/26/93   731       50(1)      29  (688)     55.1     2-BUTOXYETHANOL                            |
|BATTELLE NORTHWEST 050513304  04/07/88   735       49(1)      28  (692)     49.8     ACETONITRILE                               |
|BATTELLE NORTHWEST 050513608  09/13/90   734       50(1)      35  (686)     56.2     CHLOROPRENE                                |
|BATTELLE NORTHWEST 050515606  08/23/90   734       50(1)      34  (694)     48.9     COBALT SULFATE HEPTAHYDRATE                |
|BATTELLE NORTHWEST 050520106  11/21/91   734       50(1)      34  (690)     59.1     FURFURYL ALCOHOL                           |
|BATTELLE NORTHWEST 050518406  07/07/94   735       50(1)      34  (699)     52.9     GLUTARALDEHYDE                             |
|BATTELLE NORTHWEST 050511402  11/18/85   737       49(1)      31  (685)     46.9     HEXACHLOROCYCLOPENTADIENE (HCCPD)          |
|BATTELLE NORTHWEST 058807004  03/04/93   735       50(1)      32  (681)     58.1     ISOBUTENE                                  |
|BATTELLE NORTHWEST 056096802  08/09/90   735       50(1)      28  (668)     49.9     ISOBUTYRALDEHYDE                           |
|BATTELLE NORTHWEST 050515804  03/22/90   733       50(1)      25  (683)     49.6     MOLYBDENUM TRIOXIDE                        |
|BATTELLE NORTHWEST 050520006  08/31/89   734       50(1)      25  (662)     53.3     NITROMETHANE                               |
|BATTELLE NORTHWEST 058803404  11/09/89   735       50(1)      29  (691)     54.2     OZONE                                      |
|BATTELLE NORTHWEST 050518104  12/07/89   733       50(1)      29  (615)     55.6     TETRAHYDROFURAN                            |
|BROOKHAVEN         050510101  09/26/84   727       50(1)      36  (678)     49.5     METHYL BROMIDE                             |
|I. I. T. RESEARCH I050521004  03/05/90   730       50(1)      35  (689)     47.0     ETHYLBENZENE                               |
|I. I. T. RESEARCH I050518504  12/05/88   729       51(1)      32  (676)     48.5     ISOBUTYL NITRITE                           |
|LOVELACE RESEARCH  050512306  04/25/88   729       60(1)      41  (657)     41.1     NICKEL OXIDE                               |
|LOVELACE RESEARCH  050510706  09/29/88   733       58(1)      36  (677)     41.0     NICKEL SUBSULFIDE                          |
|LOVELACE RESEARCH  050512206  05/30/88   730       60(1)      34  (673)     42.6     NICKEL SULFATE HEXAHYDRATE                 |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 8
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                           Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|I. I. T. RESEARCH I058902906  10/05/94   734      100(1)      76  (711)     53.4     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|I. I. T. RESEARCH I058902906  10/05/94   735      100(5)      70  (702)     59.7     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 9
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: FEED                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050516502  01/19/87   732       50(1)      41  (719)     48.8     4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL)        |
|BATTELLE COLUMBUS  050508502  10/08/84   729       50(5)      46  (722)     48.4     MANGANESE SULFATE                          |
|BATTELLE COLUMBUS  050521203  06/22/89   729       50(1)      45  (709)     49.4     OXAZEPAM                                   |
|BATTELLE COLUMBUS  058803506  04/16/92   726       50(1)      35  (686)     51.2     PRIMACLONE                                 |
|BATTELLE COLUMBUS  050508702  09/17/84   729       50(1)      47  (723)     47.1     TRIAMTERENE                                |
|BATTELLE COLUMBUS  050508703  08/26/85   729       50(1)      43  (716)     47.4     TRIAMTERENE                                |
|BATTELLE COLUMBUS  050510004  10/09/86   739       52(1)      43  (686)     48.0     TRICRESYL PHOSPHATE                        |
|E.G. & G. MASON    050515002  07/31/86   741       50(1)      45  (729)     46.2     METHYLPHENIDATE HYDROCHLORIDE              |
|E.G. & G. MASON    050508402  09/05/84   729       50(1)      43  (705)     48.4     TURMERIC, OLEORESIN (CURCUMIN)             |
|MICROB. ASSOC.     050513002  08/13/85   739       50(1)      44  (708)     47.8     C. I. DIRECT BLUE 218                      |
|MICROB. ASSOC.     050506810  03/29/89   729       50(1)      41  (696)     50.7     CODEINE                                    |
|SOUTHERN RESEARCH  050510304  03/13/89   736       50(1)      42  (710)     49.8     2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL       |
|SOUTHERN RESEARCH  050512004  08/25/86   729       50(1)      39  (705)     46.0     BENZYL ACETATE                             |
|SOUTHERN RESEARCH  050509202  10/23/84   729       50(1)      35  (717)     49.2     O-NITROANISOLE                             |
|SOUTHERN RESEARCH  050515504  05/25/88   730       50(1)      39  (709)     49.5     P-NITROBENZOIC ACID                        |
|SOUTHERN RESEARCH  050521705  11/29/89   727       50(1)      39  (711)     52.7     T-BUTYLHYDROQUINONE                        |
|TSI MASON RESEARCH 050518204  11/27/90   729       50(1)      40  (701)     52.0     PHENOLPHTHALEIN                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 10
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: FEED                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050516502  01/19/87   732       51(1)      40  (695)     53.2     4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL)        |
|BATTELLE COLUMBUS  050508502  10/08/84   729       51(5)      42  (696)     53.8     MANGANESE SULFATE                          |
|BATTELLE COLUMBUS  050521203  06/22/89   735       50(1)      39  (704)     56.0     OXAZEPAM                                   |
|BATTELLE COLUMBUS  058803506  04/16/92   727       50(5)      41  (704)     61.6     PRIMACLONE                                 |
|BATTELLE COLUMBUS  050508702  09/17/84   729       50(1)      38  (672)     51.6     TRIAMTERENE                                |
|BATTELLE COLUMBUS  050508703  08/26/85   730       50(1)      40  (708)     49.9     TRIAMTERENE                                |
|BATTELLE COLUMBUS  050510004  10/09/86   739       50(1)      41  (715)     50.9     TRICRESYL PHOSPHATE                        |
|E.G. & G. MASON    050515002  07/31/86   746       49(1)      37  (706)     45.1     METHYLPHENIDATE HYDROCHLORIDE              |
|E.G. & G. MASON    050508402  09/05/84   731       50(1)      37  (697)     47.4     TURMERIC, OLEORESIN (CURCUMIN)             |
|MICROB. ASSOC.     050513002  08/13/85   744       49(1)      37  (692)     47.2     C. I. DIRECT BLUE 218                      |
|MICROB. ASSOC.     050506810  03/29/89   731       50(1)      36  (678)     53.2     CODEINE                                    |
|SOUTHERN RESEARCH  050510304  03/13/89   743       52(1)      37  (690)     54.5     2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL       |
|SOUTHERN RESEARCH  050512004  08/25/86   729       50(1)      29  (681)     45.1     BENZYL ACETATE                             |
|SOUTHERN RESEARCH  050509202  10/23/84   729       50(1)      38  (694)     51.7     O-NITROANISOLE                             |
|SOUTHERN RESEARCH  050515504  05/25/88   735       50(1)      38  (704)     52.1     P-NITROBENZOIC ACID                        |
|SOUTHERN RESEARCH  050521705  11/29/89   734       51(1)      38  (699)     56.2     T-BUTYLHYDROQUINONE                        |
|TSI MASON RESEARCH 050518204  11/27/90   737       50(1)      39  (696)     56.5     PHENOLPHTHALEIN                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 11
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050513102  10/28/85   729       79(1)      58  (707)     51.3     SODIUM FLUORIDE                            |
|E.G. & G. MASON    050512702  10/08/85   730       51(1)      45  (707)     48.2     BARIUM CHLORIDE DIHYDRATE                  |
|SOUTHERN RESEARCH  050508902  11/29/84   733       50(1)      34  (706)     50.9     CHLORAMINE                                 |
|SOUTHERN RESEARCH  050514204  11/19/86   729       60(1)      27  (676)     53.3     TERT-BUTYL ALCOHOL                         |
|TSI MASON RESEARCH 050516006  01/02/91   729       50(1)      40  (689)     53.1     1-CHLORO-2-PROPANOL                        |
|TSI MASON RESEARCH 055530104  04/03/91   722       50(1)      35  (685)     55.4     PYRIDINE                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050513102  10/28/85   729       80(1)      53  (693)     57.4     SODIUM FLUORIDE                            |
|E.G. & G. MASON    050512702  10/08/85   737       50(1)      38  (704)     50.0     BARIUM CHLORIDE DIHYDRATE                  |
|SOUTHERN RESEARCH  050508902  11/29/84   733       50(1)      33  (683)     56.9     CHLORAMINE                                 |
|SOUTHERN RESEARCH  050514204  11/19/86   730       60(1)      36  (657)     60.5     TERT-BUTYL ALCOHOL                         |
|TSI MASON RESEARCH 050516006  01/02/91   735       50(1)      32  (692)     60.1     1-CHLORO-2-PROPANOL                        |
|TSI MASON RESEARCH 055530104  04/03/91   729       50(1)      32  (671)     63.3     PYRIDINE                                   |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 12
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                              Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  058900608  09/05/90   728       50(1)      27  (679)     51.1     INTERFERON A/INTERFERON AD                 |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  058900608  09/05/90   729       50(1)      25  (684)     63.1     INTERFERON A/INTERFERON AD                 |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 13
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                   Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|A. D. LITTLE LABS  058806601  02/18/92   729      100(1)      51  (673)     61.7     POLYVINYL ALCOHOL                          |
|________________________________________________________________________________________________________________________________|

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 15
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       35/50 (70%)   35/50 (70%)   16/50 (32%)         34/50 (68%)   34/50 (68%)   20/50 (40%)    |
| Overall Incidence               Total 86/150 (57.33%) Mean 57.33%  SD 21.94%    Total 88/150 (58.67%)  Mean 58.67%  SD 16.17%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    19/50 (38%)   22/50 (44%)   19/50 (38%)         11/50 (22%)   31/50 (62%)   17/50 (34%)    |
| Overall Incidence               Total 60/150 (40%)    Mean 40%     SD 3.46%     Total 59/150 (39.33%)  Mean 39.33%  SD 20.53%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         39/50 (78%)   42/50 (84%)   27/50 (54%)         37/50 (74%)   46/50 (92%)   31/50 (62%)    |
| Overall Incidence               Total 108/150 (72%)   Mean 72%     SD 15.87%    Total 114/150 (76%)    Mean 76%     SD 15.1%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/150 (2%)      Mean 2%      SD 2%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      2/50 (4%)     4/50 (8%)    10/50 (20%)          4/50 (8%)     4/50 (8%)     1/50 (2%)     |
| Overall Incidence               Total 16/150 (10.67%) Mean 10.67%  SD 8.33%     Total 9/150 (6%)       Mean 6%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        3/50 (6%)     6/50 (12%)   10/50 (20%)          4/50 (8%)     4/50 (8%)     2/50 (4%)     |
| Overall Incidence               Total 19/150 (12.67%) Mean 12.67%  SD 7.02%     Total 10/150 (6.67%)   Mean 6.67%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     4/50 (8%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 4/150 (2.67%)    Mean 2.67%   SD 4.62%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     4/50 (8%)     3/50 (6%)     3/50 (6%)           6/50 (12%)   10/50 (20%)    6/50 (12%)    |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 10/150 (6.67%)  Mean 6.67%   SD 1.15%     Total 22/150 (14.67%)  Mean 14.67%  SD 4.62%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/49 (0%)     8/50 (16%)          1/50 (2%)     2/48 (4%)     2/50 (4%)     |
| Overall Incidence               Total 9/149 (6.04%)   Mean 6%      SD 8.72%     Total 5/148 (3.38%)    Mean 3.39%   SD 1.21%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/48 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/136 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/50 (2%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     4/50 (8%)     |
| Overall Incidence               Total 2/148 (1.35%)   Mean 1.36%   SD 1.18%     Total 5/148 (3.38%)    Mean 3.36%   SD 4.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/148 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 1/148 (0.68%)    Mean 0.69%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/50 (2%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     2/48 (4%)     4/50 (8%)     |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 2/148 (1.35%)   Mean 1.36%   SD 1.18%     Total 6/148 (4.05%)    Mean 4.06%   SD 4%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     2/49 (4%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/149 (1.34%)   Mean 1.36%   SD 2.36%     Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     1/50 (2%)                                                     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%                                                      |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/50 (0%)     0/46 (0%)     0/44 (0%)           0/50 (0%)     0/43 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/140 (0%)      Mean 0%      SD 0%        Total 0/140 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              4/50 (8%)     3/50 (6%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 7/150 (4.67%)   Mean 4.67%   SD 4.16%     Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 4/50 (8%)     3/50 (6%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 7/150 (4.67%)   Mean 4.67%   SD 4.16%     Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/149 (0.67%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     2/50 (4%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 2/149 (1.34%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     2/50 (4%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 3/149 (2.01%)    Mean 2.01%   SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangioma                                                                                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)     3/50 (6%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 6/150 (4%)      Mean 4%      SD 2%        Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              27/50 (54%)   24/50 (48%)    6/50 (12%)         22/50 (44%)   30/50 (60%)    4/50 (8%)     |
| Overall Incidence               Total 57/150 (38%)    Mean 38%     SD 22.72%    Total 56/150 (37.33%)  Mean 37.33%  SD 26.63%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            15/50 (30%)    8/50 (16%)    4/50 (8%)           1/50 (2%)    13/50 (26%)    4/50 (8%)     |
| Overall Incidence               Total 27/150 (18%)    Mean 18%     SD 11.14%    Total 18/150 (12%)     Mean 12%     SD 12.49%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         15/50 (30%)    8/50 (16%)    4/50 (8%)           1/50 (2%)    13/50 (26%)    4/50 (8%)     |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 27/150 (18%)    Mean 18%     SD 11.14%    Total 18/150 (12%)     Mean 12%     SD 12.49%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         31/50 (62%)   27/50 (54%)    9/50 (18%)         23/50 (46%)   33/50 (66%)    7/50 (14%)    |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 67/150 (44.67%) Mean 44.67%  SD 23.44%    Total 63/150 (42%)     Mean 42%     SD 26.23%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           31/50 (62%)   27/50 (54%)    9/50 (18%)         23/50 (46%)   33/50 (66%)    7/50 (14%)    |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 67/150 (44.67%) Mean 44.67%  SD 23.44%    Total 63/150 (42%)     Mean 42%     SD 26.23%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        15/50 (30%)   12/50 (24%)    5/50 (10%)          2/50 (4%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 32/150 (21.33%) Mean 21.33%  SD 10.26%    Total 5/150 (3.33%)    Mean 3.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       2/50 (4%)     7/50 (14%)    5/50 (10%)          0/50 (0%)     3/50 (6%)     2/50 (4%)     |
| Overall Incidence               Total 14/150 (9.33%)  Mean 9.33%   SD 5.03%     Total 5/150 (3.33%)    Mean 3.33%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   16/50 (32%)   18/50 (36%)    8/50 (16%)          2/50 (4%)     4/50 (8%)     4/50 (8%)     |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 42/150 (28%)    Mean 28%     SD 10.58%    Total 10/150 (6.67%)   Mean 6.67%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/50 (0%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence                                                               Total 1/149 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          5/50 (10%)    1/50 (2%)     3/49 (6%)     |
| Overall Incidence                                                               Total 9/149 (6.04%)    Mean 6.04%   SD 4%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/50 (2%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 1/149 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence                                                               Total 1/149 (0.67%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 2/149 (1.34%)    Mean 1.35%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/50 (2%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 1/149 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              3/50 (6%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 3/149 (2.01%)    Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence                                                               Total 1/149 (0.67%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/47 (0%)     0/37 (0%)     0/49 (0%)           0/43 (0%)     0/40 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/133 (0%)      Mean 0%      SD 0%        Total 0/130 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/45 (0%)     0/48 (0%)           4/44 (9%)     5/44 (11%)    6/49 (12%)    |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/141 (0%)      Mean 0%      SD 0%        Total 15/137 (10.95%)  Mean 10.9%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/45 (0%)     0/48 (0%)           0/44 (0%)     0/44 (0%)     0/49 (0%)     |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/141 (0%)      Mean 0%      SD 0%        Total 0/137 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/45 (0%)     0/48 (0%)           4/44 (9%)     5/44 (11%)    6/49 (12%)    |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/141 (0%)      Mean 0%      SD 0%        Total 15/137 (10.95%)  Mean 10.9%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/45 (0%)     0/48 (0%)           0/44 (0%)     0/44 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/141 (0%)      Mean 0%      SD 0%        Total 0/137 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)     0/45 (0%)     0/48 (0%)           0/44 (0%)     0/44 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/141 (0%)      Mean 0%      SD 0%        Total 0/137 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/45 (0%)     0/48 (0%)           0/44 (0%)     0/44 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/141 (0%)      Mean 0%      SD 0%        Total 0/137 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 2.31%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     1/50 (2%)     |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     2/48 (4%)     6/50 (12%)          3/50 (6%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 9/148 (6.08%)   Mean 6.06%   SD 5.26%     Total 4/150 (2.67%)    Mean 2.67%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 2.31%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 2.31%     Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     1/49 (2%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.68%   SD 1.18%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/44 (0%)     0/39 (0%)     0/29 (0%)           0/46 (0%)     0/45 (0%)     0/41 (0%)     |
| Overall Incidence               Total 0/112 (0%)      Mean 0%      SD 0%        Total 0/132 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/44 (0%)     0/39 (0%)     0/29 (0%)           0/46 (0%)     0/45 (0%)     0/41 (0%)     |
| Overall Incidence               Total 0/112 (0%)      Mean 0%      SD 0%        Total 0/132 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)     0/39 (0%)     0/29 (0%)           0/46 (0%)     0/45 (0%)     0/41 (0%)     |
| Overall Incidence               Total 0/112 (0%)      Mean 0%      SD 0%        Total 0/132 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/44 (0%)     0/39 (0%)     1/29 (3%)           0/46 (0%)     0/45 (0%)     0/41 (0%)     |
| Overall Incidence               Total 1/112 (0.89%)   Mean 1.15%   SD 1.99%     Total 0/132 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/44 (0%)     0/39 (0%)     0/29 (0%)           0/46 (0%)     0/45 (0%)     0/41 (0%)     |
| Overall Incidence               Total 0/112 (0%)      Mean 0%      SD 0%        Total 0/132 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/44 (0%)     0/39 (0%)     0/29 (0%)           0/46 (0%)     0/45 (0%)     0/41 (0%)     |
| Overall Incidence               Total 0/112 (0%)      Mean 0%      SD 0%        Total 0/132 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)     0/39 (0%)     0/29 (0%)           0/46 (0%)     0/45 (0%)     0/41 (0%)     |
| Overall Incidence               Total 0/112 (0%)      Mean 0%      SD 0%        Total 0/132 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/44 (0%)     0/39 (0%)     0/29 (0%)           0/46 (0%)     0/45 (0%)     0/41 (0%)     |
| Overall Incidence               Total 0/112 (0%)      Mean 0%      SD 0%        Total 0/132 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/44 (0%)     1/39 (3%)     0/29 (0%)           0/46 (0%)     0/45 (0%)     0/41 (0%)     |
| Overall Incidence               Total 1/112 (0.89%)   Mean 0.85%   SD 1.48%     Total 0/132 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)     1/39 (3%)     0/29 (0%)           0/46 (0%)     0/45 (0%)     0/41 (0%)     |
| Overall Incidence               Total 1/112 (0.89%)   Mean 0.85%   SD 1.48%     Total 0/132 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/149 (0.67%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/149 (0.67%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/49 (4%)     0/50 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 2/149 (1.34%)    Mean 1.36%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/50 (4%)     0/49 (0%)     2/50 (4%)           4/50 (8%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 4/149 (2.68%)   Mean 2.67%   SD 2.31%     Total 5/149 (3.36%)    Mean 3.33%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.68%   SD 1.18%     Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     1/49 (2%)     2/50 (4%)           4/50 (8%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 5/149 (3.36%)   Mean 3.35%   SD 1.13%     Total 5/149 (3.36%)    Mean 3.33%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.68%   SD 1.18%     Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ACETONE                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)     0/50 (0%)     3/50 (6%)     |
| Overall Incidence                                                               Total 4/150 (2.67%)    Mean 2.67%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)     0/50 (0%)     4/50 (8%)     |
| Overall Incidence                                                               Total 5/150 (3.33%)    Mean 3.33%   SD 4.16%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 43
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       35/50 (70%)   26/50 (52%)   38/50 (76%)         28/52 (54%)   39/50 (78%)   40/50 (80%)    |
|                                       27/50 (54%)   28/49 (57%)   43/50 (86%)         34/50 (68%)   37/50 (74%)   29/50 (58%)    |
| Overall Incidence               Total 197/299 (65.89%)Mean 65.86%  SD 13.67%    Total 207/302 (68.54%) Mean 68.64%  SD 10.75%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    16/50 (32%)   22/50 (44%)   21/50 (42%)         27/52 (52%)   23/50 (46%)   22/50 (44%)    |
|                                       29/50 (58%)   24/49 (49%)   39/50 (78%)         30/50 (60%)   22/50 (44%)   25/50 (50%)    |
| Overall Incidence               Total 151/299 (50.5%) Mean 50.5%   SD 15.95%    Total 149/302 (49.34%) Mean 49.32%  SD 6.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         43/50 (86%)   35/50 (70%)   46/50 (92%)         41/52 (79%)   47/50 (94%)   47/50 (94%)    |
|                                       45/50 (90%)   42/49 (86%)   49/50 (98%)         44/50 (88%)   46/50 (92%)   45/50 (90%)    |
| Overall Incidence               Total 260/299 (86.96%)Mean 86.95%  SD 9.45%     Total 270/302 (89.4%)  Mean 89.47%  SD 5.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/50 (0%)           3/52 (6%)     2/50 (4%)     3/50 (6%)     |
|                                        1/50 (2%)     0/49 (0%)     3/50 (6%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 6/299 (2.01%)   Mean 2%      SD 2.53%     Total 11/302 (3.64%)   Mean 3.63%   SD 2.29%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)     6/50 (12%)    2/50 (4%)           3/52 (6%)     1/50 (2%)     2/50 (4%)     |
|                                        8/50 (16%)    4/49 (8%)     6/50 (12%)          3/50 (6%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 30/299 (10.03%) Mean 10.03%  SD 4.18%     Total 10/302 (3.31%)   Mean 3.29%   SD 2.37%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        6/50 (12%)    6/50 (12%)    2/50 (4%)           6/52 (12%)    3/50 (6%)     5/50 (10%)    |
|                                        9/50 (18%)    4/49 (8%)     9/50 (18%)          3/50 (6%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 36/299 (12.04%) Mean 12.03%  SD 5.49%     Total 21/302 (6.95%)   Mean 6.92%   SD 3.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/50 (0%)           3/52 (6%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     3/50 (6%)     3/50 (6%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 11/302 (3.64%)   Mean 3.63%   SD 2.62%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Mononuclear, or Undifferentiated  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     2/50 (4%)     0/50 (0%)           7/52 (13%)   13/50 (26%)   12/50 (24%)    |
|      Lymphocytic, Mixed, NOS, or       4/50 (8%)     1/49 (2%)     5/50 (10%)          9/50 (18%)    3/50 (6%)     8/50 (16%)    |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 15/299 (5.02%)  Mean 5.01%   SD 3.74%     Total 52/302 (17.22%)  Mean 17.24%  SD 7.28%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/302 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/302 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     5/50 (10%)          0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     2/49 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 9/299 (3.01%)   Mean 3.01%   SD 3.95%     Total 3/302 (0.99%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     2/50 (4%)     2/50 (4%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.33%   SD 0.82%     Total 7/301 (2.33%)    Mean 2.33%   SD 1.97%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/50 (2%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     2/50 (4%)     2/50 (4%)     |
|      Complex, Malignant, NOS           0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 1/298 (0.34%)   Mean 0.33%   SD 0.82%     Total 7/301 (2.33%)    Mean 2.33%   SD 1.97%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.03%     Total 3/302 (0.99%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/49 (0%)     0/48 (0%)     0/45 (0%)           0/52 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/49 (0%)           0/47 (0%)     0/46 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/283 (0%)      Mean 0%      SD 0%        Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              2/50 (4%)     2/50 (4%)     0/50 (0%)           2/52 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     2/49 (4%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     3/50 (6%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.68%   SD 1.65%     Total 10/302 (3.31%)   Mean 3.31%   SD 2.41%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           2/52 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 5/302 (1.66%)    Mean 1.64%   SD 1.46%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)     2/50 (4%)     0/50 (0%)           4/52 (8%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     2/49 (4%)     1/50 (2%)           2/50 (4%)     3/50 (6%)     4/50 (8%)     |
| Overall Incidence               Total 9/299 (3.01%)   Mean 3.01%   SD 2.11%     Total 15/302 (4.97%)   Mean 4.95%   SD 2.69%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.68%   SD 1.67%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.68%   SD 1.67%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.68%   SD 1.67%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/49 (4%)     1/50 (2%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     1/50 (2%)     |
| Overall Incidence               Total 3/298 (1.01%)   Mean 1.01%   SD 1.7%      Total 3/301 (1%)       Mean 1.01%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/298 (0.67%)   Mean 0.67%   SD 1.03%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/49 (4%)     1/50 (2%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     2/50 (4%)     |
| Overall Incidence               Total 5/298 (1.68%)   Mean 1.68%   SD 1.53%     Total 4/301 (1.33%)    Mean 1.34%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.03%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     2/50 (4%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.63%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     3/50 (6%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.33%   SD 2.42%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.34%   SD 0.83%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.63%     Total 3/302 (0.99%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      3/50 (6%)     2/50 (4%)     0/50 (0%)           1/52 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        7/50 (14%)    1/49 (2%)     5/50 (10%)          2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 18/299 (6.02%)  Mean 6.01%   SD 5.21%     Total 4/302 (1.32%)    Mean 1.32%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     1/50 (2%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              24/50 (48%)   22/50 (44%)   31/50 (62%)         20/52 (38%)   32/50 (64%)   32/50 (64%)    |
|                                       19/50 (38%)   22/49 (45%)   37/50 (74%)         23/50 (46%)   26/50 (52%)   18/50 (36%)    |
| Overall Incidence               Total 155/299 (51.84%)Mean 51.82%  SD 13.49%    Total 151/302 (50%)    Mean 50.08%  SD 12.17%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            10/50 (20%)   12/50 (24%)   12/50 (24%)         12/52 (23%)    3/50 (6%)     5/50 (10%)    |
|                                       11/50 (22%)    9/49 (18%)   35/50 (70%)         10/50 (20%)    5/50 (10%)   10/50 (20%)    |
| Overall Incidence               Total 89/299 (29.77%) Mean 29.73%  SD 19.85%    Total 45/302 (14.9%)   Mean 14.85%  SD 7.02%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)   13/50 (26%)   12/50 (24%)         12/52 (23%)    3/50 (6%)     5/50 (10%)    |
|      Hepatoblastoma                   11/50 (22%)    9/49 (18%)   35/50 (70%)         10/50 (20%)    6/50 (12%)   10/50 (20%)    |
| Overall Incidence               Total 90/299 (30.1%)  Mean 30.06%  SD 19.75%    Total 46/302 (15.23%)  Mean 15.18%  SD 6.78%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         29/50 (58%)   28/50 (56%)   39/50 (78%)         27/52 (52%)   33/50 (66%)   33/50 (66%)    |
|      Hepatocellular Adenoma           28/50 (56%)   29/49 (59%)   46/50 (92%)         28/50 (56%)   28/50 (56%)   27/50 (54%)    |
| Overall Incidence               Total 199/299 (66.56%)Mean 66.53%  SD 15.03%    Total 176/302 (58.28%) Mean 58.32%  SD 6.14%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           29/50 (58%)   29/50 (58%)   39/50 (78%)         27/52 (52%)   33/50 (66%)   33/50 (66%)    |
|      Hepatocellular Adenoma, or       28/50 (56%)   29/49 (59%)   46/50 (92%)         28/50 (56%)   28/50 (56%)   27/50 (54%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 200/299 (66.89%)Mean 66.86%  SD 14.76%    Total 176/302 (58.28%) Mean 58.32%  SD 6.14%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        13/50 (26%)   11/50 (22%)   11/50 (22%)          1/52 (2%)     2/50 (4%)     4/50 (8%)     |
|                                        6/50 (12%)    7/49 (14%)   13/50 (26%)          1/50 (2%)     1/50 (2%)     4/50 (8%)     |
| Overall Incidence               Total 61/299 (20.4%)  Mean 20.38%  SD 5.93%     Total 13/302 (4.3%)    Mean 4.32%   SD 2.96%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/50 (2%)     4/50 (8%)     5/50 (10%)          1/52 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        8/50 (16%)    7/49 (14%)    2/50 (4%)           7/50 (14%)    3/50 (6%)     2/50 (4%)     |
| Overall Incidence               Total 27/299 (9.03%)  Mean 9.05%   SD 5.53%     Total 15/302 (4.97%)   Mean 4.99%   SD 4.87%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)   15/50 (30%)   15/50 (30%)          2/52 (4%)     2/50 (4%)     6/50 (12%)    |
|      Alveolar/Bronchiolar Adenoma     14/50 (28%)   12/49 (24%)   15/50 (30%)          8/50 (16%)    4/50 (8%)     5/50 (10%)    |
| Overall Incidence               Total 85/299 (28.43%) Mean 28.41%  SD 2.16%     Total 27/302 (8.94%)   Mean 8.97%   SD 4.72%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/302 (0.66%)    Mean 0.65%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 3/302 (0.99%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 3/302 (0.99%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     1/50 (2%)     |
|      or Adenoma                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 3/302 (0.99%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/52 (6%)     3/50 (6%)     2/49 (4%)     |
|                                                                                        4/50 (8%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence                                                               Total 15/301 (4.98%)   Mean 4.98%   SD 2.74%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/52 (0%)     0/50 (0%)     3/49 (6%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 3/301 (1%)       Mean 1.02%   SD 2.5%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/52 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/52 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 62
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/47 (0%)     0/43 (0%)     0/41 (0%)           0/43 (0%)     0/37 (0%)     0/43 (0%)     |
|                                        0/40 (0%)     0/45 (0%)     0/46 (0%)           0/44 (0%)     0/38 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/262 (0%)      Mean 0%      SD 0%        Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/45 (0%)     0/48 (0%)           6/52 (12%)    5/48 (10%)    7/50 (14%)    |
|   Adenoma                              0/48 (0%)     0/49 (0%)     1/49 (2%)          10/47 (21%)    9/50 (18%)    7/50 (14%)    |
| Overall Incidence               Total 1/287 (0.35%)   Mean 0.34%   SD 0.83%     Total 44/297 (14.81%)  Mean 14.87%  SD 4.08%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/45 (0%)     0/48 (0%)           0/52 (0%)     1/48 (2%)     0/50 (0%)     |
|   Carcinoma                            0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/287 (0%)      Mean 0%      SD 0%        Total 1/297 (0.34%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/45 (0%)     0/48 (0%)           6/52 (12%)    6/48 (13%)    7/50 (14%)    |
|   Carcinoma or Adenoma                 0/48 (0%)     0/49 (0%)     1/49 (2%)          10/47 (21%)    9/50 (18%)    7/50 (14%)    |
| Overall Incidence               Total 1/287 (0.35%)   Mean 0.34%   SD 0.83%     Total 45/297 (15.15%)  Mean 15.22%  SD 3.7%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 63
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     1/45 (2%)     1/48 (2%)           0/52 (0%)     0/48 (0%)     1/50 (2%)     |
|                                        0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/287 (0.7%)    Mean 0.72%   SD 1.11%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)     0/45 (0%)     0/48 (0%)           0/52 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/287 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     1/45 (2%)     1/48 (2%)           0/52 (0%)     0/48 (0%)     1/50 (2%)     |
|                                        0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/287 (0.7%)    Mean 0.72%   SD 1.11%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 64
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 65
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 66
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.03%     Total 2/302 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 67
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 68
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     2/50 (4%)           3/52 (6%)     2/50 (4%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.63%     Total 9/302 (2.98%)    Mean 2.96%   SD 2.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     1/50 (2%)           2/52 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 6/302 (1.99%)    Mean 1.97%   SD 1.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     1/50 (2%)           3/52 (6%)     2/50 (4%)     1/50 (2%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 9/302 (2.98%)    Mean 2.96%   SD 2.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 3/302 (0.99%)    Mean 0.99%   SD 1.08%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 69
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     3/50 (6%)     1/50 (2%)           1/52 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        2/50 (4%)     3/49 (6%)     2/50 (4%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 11/299 (3.68%)  Mean 3.69%   SD 2.36%     Total 5/302 (1.66%)    Mean 1.65%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     1/50 (2%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 70
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     1/50 (2%)           0/52 (0%)     1/50 (2%)     1/50 (2%)     |
|      Papilloma Squamous                0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     4/50 (8%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.03%     Total 6/302 (1.99%)    Mean 2%      SD 3.1%      |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 5/302 (1.66%)    Mean 1.67%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 71
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)     0/50 (0%)     2/50 (4%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 3/299 (1%)      Mean 1%      SD 1.67%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        1/45 (2%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 1/238 (0.42%)   Mean 0.37%   SD 0.91%     Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 72
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/31 (0%)     0/43 (0%)     0/37 (0%)           0/41 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/45 (0%)     0/37 (0%)           0/50 (0%)     0/41 (0%)     0/38 (0%)     |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 0/265 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     4/50 (8%)           3/52 (6%)     2/50 (4%)     4/50 (8%)     |
|                                        1/50 (2%)     2/49 (4%)     2/50 (4%)           4/50 (8%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 9/299 (3.01%)   Mean 3.01%   SD 3.04%     Total 17/302 (5.63%)   Mean 5.63%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           1/52 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 1/302 (0.33%)    Mean 0.32%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     4/50 (8%)           4/52 (8%)     2/50 (4%)     4/50 (8%)     |
|                                        1/50 (2%)     3/49 (6%)     2/50 (4%)           4/50 (8%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 11/299 (3.68%)  Mean 3.69%   SD 2.96%     Total 18/302 (5.96%)   Mean 5.95%   SD 2.14%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 73
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 74
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/300 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.34%   SD 0.83%     Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/52 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 75
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/52 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/52 (2%)     1/50 (2%)     3/50 (6%)     |
|                                                                                        2/50 (4%)     1/50 (2%)     3/50 (6%)     |
| Overall Incidence                                                               Total 11/302 (3.64%)   Mean 3.65%   SD 1.98%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/302 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/52 (2%)     1/50 (2%)     3/50 (6%)     |
|                                                                                        2/50 (4%)     2/50 (4%)     3/50 (6%)     |
| Overall Incidence                                                               Total 12/302 (3.97%)   Mean 3.99%   SD 1.81%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 76
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: MICE                                           Vehicle: ETHANOL                                  Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/52 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/302 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 77
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       30/50 (60%)   35/50 (70%)   38/50 (76%)         28/50 (56%)   17/51 (33%)   20/52 (38%)    |
|                                       19/52 (37%)   25/50 (50%)   36/62 (58%)         17/50 (34%)   24/50 (48%)   30/60 (50%)    |
|                                       27/50 (54%)   26/50 (52%)   29/50 (58%)         23/50 (46%)   22/50 (44%)   33/50 (66%)    |
| Overall Incidence               Total 265/464 (57.11%)Mean 57.18%  SD 11.42%    Total 214/463 (46.22%) Mean 46.2%   SD 10.52%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    17/50 (34%)   17/50 (34%)   15/50 (30%)         18/50 (36%)    9/51 (18%)    8/52 (15%)    |
|                                       15/52 (29%)   15/50 (30%)   25/62 (40%)         23/50 (46%)   16/50 (32%)   23/60 (38%)    |
|                                       23/50 (46%)   25/50 (50%)   32/50 (64%)         21/50 (42%)   19/50 (38%)   26/50 (52%)    |
| Overall Incidence               Total 184/464 (39.66%)Mean 39.69%  SD 11.77%    Total 163/463 (35.21%) Mean 35.26%  SD 12.12%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         38/50 (76%)   42/50 (84%)   42/50 (84%)         39/50 (78%)   24/51 (47%)   25/52 (48%)    |
|                                       29/52 (56%)   31/50 (62%)   45/62 (73%)         36/50 (72%)   32/50 (64%)   46/60 (77%)    |
|                                       33/50 (66%)   40/50 (80%)   44/50 (88%)         35/50 (70%)   34/50 (68%)   46/50 (92%)    |
| Overall Incidence               Total 344/464 (74.14%)Mean 74.26%  SD 11.06%    Total 317/463 (68.47%) Mean 68.42%  SD 14.23%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/51 (0%)     1/52 (2%)     |
|                                        1/52 (2%)     0/50 (0%)     0/62 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 5/464 (1.08%)   Mean 1.1%    SD 1.45%     Total 4/463 (0.86%)    Mean 0.88%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)     3/50 (6%)     0/50 (0%)           1/50 (2%)     0/51 (0%)     0/52 (0%)     |
|                                        4/52 (8%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        4/50 (8%)     3/50 (6%)     3/50 (6%)           1/50 (2%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence               Total 22/464 (4.74%)  Mean 4.81%   SD 3.34%     Total 6/463 (1.3%)     Mean 1.3%    SD 1.99%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        6/50 (12%)    3/50 (6%)     0/50 (0%)           2/50 (4%)     0/51 (0%)     1/52 (2%)     |
|                                        4/52 (8%)     0/50 (0%)     1/62 (2%)           1/50 (2%)     0/50 (0%)     1/60 (2%)     |
|                                        5/50 (10%)    4/50 (8%)     3/50 (6%)           1/50 (2%)     4/50 (8%)     0/50 (0%)     |
| Overall Incidence               Total 26/464 (5.6%)   Mean 5.7%    SD 4.32%     Total 10/463 (2.16%)   Mean 2.18%   SD 2.55%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/51 (2%)     1/52 (2%)     |
|                                        1/52 (2%)     1/50 (2%)     2/62 (3%)           2/50 (4%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 5/464 (1.08%)   Mean 1.02%   SD 1.27%     Total 8/463 (1.73%)    Mean 1.73%   SD 1.56%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 78
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Mononuclear, or Undifferentiated  0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     0/50 (0%)     0/50 (0%)           9/50 (18%)    4/51 (8%)     5/52 (10%)    |
|      Lymphocytic, Mixed, NOS, or       5/52 (10%)    3/50 (6%)     6/62 (10%)         15/50 (30%)    8/50 (16%)   11/60 (18%)    |
|      Undifferentiated Cell Type        4/50 (8%)     5/50 (10%)    5/50 (10%)          9/50 (18%)   13/50 (26%)   11/50 (22%)    |
| Overall Incidence               Total 30/464 (6.47%)  Mean 6.37%   SD 4.14%     Total 85/463 (18.36%)  Mean 18.42%  SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 2/463 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 2/463 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     2/48 (4%)     1/62 (2%)           0/50 (0%)     2/50 (4%)     0/59 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     4/50 (8%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence               Total 9/460 (1.96%)   Mean 1.98%   SD 2.67%     Total 3/456 (0.66%)    Mean 0.67%   SD 1.42%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 79
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           1/50 (2%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|   Adenoma                              0/52 (0%)     0/48 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/461 (0.43%)   Mean 0.44%   SD 0.88%     Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/49 (2%)     0/49 (0%)     1/49 (2%)           0/49 (0%)     0/47 (0%)     2/49 (4%)     |
|                                        0/51 (0%)     0/46 (0%)     1/61 (2%)           0/49 (0%)     0/46 (0%)     1/59 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 4/454 (0.88%)   Mean 0.86%   SD 1.02%     Total 5/449 (1.11%)    Mean 1.09%   SD 1.45%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/51 (0%)     0/46 (0%)     0/61 (0%)           0/49 (0%)     0/46 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/454 (0%)      Mean 0%      SD 0%        Total 0/449 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/51 (0%)     0/46 (0%)     0/61 (0%)           0/49 (0%)     0/46 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/454 (0%)      Mean 0%      SD 0%        Total 1/449 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/49 (2%)     0/49 (0%)     1/49 (2%)           0/49 (0%)     0/47 (0%)     2/49 (4%)     |
|      Complex, Malignant, NOS           0/51 (0%)     0/46 (0%)     1/61 (2%)           0/49 (0%)     0/46 (0%)     1/59 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 4/454 (0.88%)   Mean 0.86%   SD 1.02%     Total 6/449 (1.34%)    Mean 1.31%   SD 1.42%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 80
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/52 (2%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/460 (0.87%)   Mean 0.88%   SD 1.45%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 81
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 2/463 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 2/463 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 82
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|      Astrocytoma                       0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 83
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)     0/49 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/49 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/49 (0%)     0/49 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/49 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.19%   SD 0.56%     |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/48 (0%)     0/45 (0%)     0/40 (0%)           0/47 (0%)     0/45 (0%)     0/41 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/57 (0%)           0/49 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/45 (0%)           0/49 (0%)     0/49 (0%)     0/46 (0%)     |
| Overall Incidence               Total 0/426 (0%)      Mean 0%      SD 0%        Total 0/425 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 84
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              3/50 (6%)     5/50 (10%)    3/50 (6%)           4/50 (8%)     1/51 (2%)     1/52 (2%)     |
|                                        1/52 (2%)     0/50 (0%)     2/62 (3%)           2/50 (4%)     2/50 (4%)     3/60 (5%)     |
|                                        4/50 (8%)     2/50 (4%)     1/50 (2%)           3/50 (6%)     2/50 (4%)     6/50 (12%)    |
| Overall Incidence               Total 21/464 (4.53%)  Mean 4.57%   SD 3.2%      Total 24/463 (5.18%)   Mean 5.21%   SD 3.17%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     1/50 (2%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/464 (0.65%)   Mean 0.67%   SD 1%        Total 2/463 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)     5/50 (10%)    3/50 (6%)           4/50 (8%)     1/51 (2%)     1/52 (2%)     |
|                                        1/52 (2%)     1/50 (2%)     2/62 (3%)           2/50 (4%)     3/50 (6%)     3/60 (5%)     |
|                                        4/50 (8%)     3/50 (6%)     1/50 (2%)           4/50 (8%)     2/50 (4%)     6/50 (12%)    |
| Overall Incidence               Total 23/464 (4.96%)  Mean 5.02%   SD 2.91%     Total 26/463 (5.62%)   Mean 5.65%   SD 3.26%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 85
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.18%   SD 0.54%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 86
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/464 (0.43%)   Mean 0.44%   SD 0.87%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/464 (1.08%)   Mean 1.07%   SD 1.74%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 87
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/464 (0.43%)   Mean 0.44%   SD 0.87%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/464 (1.29%)   Mean 1.29%   SD 2.23%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     4/50 (8%)     2/50 (4%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        1/52 (2%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/464 (1.72%)   Mean 1.73%   SD 2.73%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 88
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/52 (0%)     1/50 (2%)     0/62 (0%)           0/49 (0%)     1/49 (2%)     0/59 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/462 (0.43%)   Mean 0.44%   SD 0.88%     Total 3/456 (0.66%)    Mean 0.68%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/462 (0%)      Mean 0%      SD 0%        Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/52 (0%)     1/50 (2%)     0/62 (0%)           0/49 (0%)     1/49 (2%)     0/59 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/462 (0.43%)   Mean 0.44%   SD 0.88%     Total 3/456 (0.66%)    Mean 0.68%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     1/50 (2%)     1/62 (2%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/463 (0.65%)   Mean 0.63%   SD 0.95%     Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 89
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     1/50 (2%)     1/62 (2%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/463 (0.65%)   Mean 0.63%   SD 0.95%     Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/463 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 90
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/464 (0.43%)   Mean 0.44%   SD 0.88%     Total 1/461 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      3/50 (6%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        3/52 (6%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     2/50 (4%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 13/464 (2.8%)   Mean 2.82%   SD 2.46%     Total 3/461 (0.65%)    Mean 0.67%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     2/62 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/464 (0.43%)   Mean 0.36%   SD 1.08%     Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              21/50 (42%)   29/50 (58%)   26/50 (52%)         11/50 (22%)   10/51 (20%)    8/50 (16%)    |
|                                       11/52 (21%)   16/50 (32%)   25/62 (40%)          6/50 (12%)    3/50 (6%)    17/60 (28%)    |
|                                       19/50 (38%)   13/50 (26%)   21/50 (42%)         13/50 (26%)   12/50 (24%)   20/50 (40%)    |
| Overall Incidence               Total 181/464 (39.01%)Mean 39.05%  SD 11.66%    Total 100/461 (21.69%) Mean 21.55%  SD 9.87%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             7/50 (14%)   11/50 (22%)   11/50 (22%)          2/50 (4%)     3/51 (6%)     0/50 (0%)     |
|                                        4/52 (8%)     8/50 (16%)   10/62 (16%)          1/50 (2%)     1/50 (2%)     6/60 (10%)    |
|                                       10/50 (20%)   13/50 (26%)   19/50 (38%)          7/50 (14%)    2/50 (4%)    11/50 (22%)    |
| Overall Incidence               Total 93/464 (20.04%) Mean 20.2%   SD 8.56%     Total 33/461 (7.16%)   Mean 7.1%    SD 7.08%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          7/50 (14%)   11/50 (22%)   11/50 (22%)          2/50 (4%)     3/51 (6%)     0/50 (0%)     |
|      Hepatoblastoma                    4/52 (8%)     8/50 (16%)   12/62 (19%)          1/50 (2%)     1/50 (2%)     6/60 (10%)    |
|                                       10/50 (20%)   13/50 (26%)   19/50 (38%)          7/50 (14%)    2/50 (4%)    11/50 (22%)    |
| Overall Incidence               Total 95/464 (20.47%) Mean 20.56%  SD 8.43%     Total 33/461 (7.16%)   Mean 7.1%    SD 7.08%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         25/50 (50%)   36/50 (72%)   35/50 (70%)         13/50 (26%)   13/51 (25%)    8/50 (16%)    |
|      Hepatocellular Adenoma           13/52 (25%)   18/50 (36%)   31/62 (50%)          7/50 (14%)    4/50 (8%)    22/60 (37%)    |
|                                       25/50 (50%)   24/50 (48%)   34/50 (68%)         17/50 (34%)   14/50 (28%)   29/50 (58%)    |
| Overall Incidence               Total 241/464 (51.94%)Mean 52.11%  SD 15.78%    Total 127/461 (27.55%) Mean 27.35%  SD 14.82%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           25/50 (50%)   36/50 (72%)   35/50 (70%)         13/50 (26%)   13/51 (25%)    8/50 (16%)    |
|      Hepatocellular Adenoma, or       13/52 (25%)   18/50 (36%)   31/62 (50%)          7/50 (14%)    4/50 (8%)    22/60 (37%)    |
|      Hepatoblastoma                   25/50 (50%)   24/50 (48%)   34/50 (68%)         17/50 (34%)   14/50 (28%)   29/50 (58%)    |
| Overall Incidence               Total 241/464 (51.94%)Mean 52.11%  SD 15.78%    Total 127/461 (27.55%) Mean 27.35%  SD 14.82%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 91
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/461 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/461 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/51 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 92
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        12/50 (24%)    8/50 (16%)   14/50 (28%)          3/49 (6%)     2/51 (4%)     2/51 (4%)     |
|                                        7/52 (13%)    9/50 (18%)   11/62 (18%)          4/50 (8%)     6/50 (12%)    1/59 (2%)     |
|                                        7/50 (14%)   11/50 (22%)    8/50 (16%)          2/50 (4%)     2/50 (4%)     3/50 (6%)     |
| Overall Incidence               Total 87/464 (18.75%) Mean 18.8%   SD 4.88%     Total 25/460 (5.43%)   Mean 5.52%   SD 3.02%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       2/50 (4%)     1/50 (2%)     1/50 (2%)           2/49 (4%)     0/51 (0%)     0/51 (0%)     |
|                                        1/52 (2%)     2/50 (4%)     4/62 (6%)           3/50 (6%)     2/50 (4%)     2/59 (3%)     |
|                                        5/50 (10%)    3/50 (6%)     6/50 (12%)          0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 25/464 (5.39%)  Mean 5.37%   SD 3.63%     Total 11/460 (2.39%)   Mean 2.39%   SD 2.15%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)    9/50 (18%)   14/50 (28%)          5/49 (10%)    2/51 (4%)     2/51 (4%)     |
|      Alveolar/Bronchiolar Adenoma      8/52 (15%)   11/50 (22%)   14/62 (23%)          7/50 (14%)    8/50 (16%)    2/59 (3%)     |
|                                        9/50 (18%)   14/50 (28%)   13/50 (26%)          2/50 (4%)     3/50 (6%)     4/50 (8%)     |
| Overall Incidence               Total 106/464 (22.84%)Mean 22.89%  SD 4.91%     Total 35/460 (7.61%)   Mean 7.72%   SD 4.73%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/51 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/51 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/51 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/51 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/51 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 93
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 94
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/51 (2%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 2/463 (0.43%)    Mean 0.44%   SD 0.87%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.19%   SD 0.56%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 95
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/51 (2%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 3/463 (0.65%)    Mean 0.63%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/51 (2%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 2/463 (0.43%)    Mean 0.44%   SD 0.87%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/51 (2%)     0/52 (0%)     |
|      or Adenoma                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 3/463 (0.65%)    Mean 0.63%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 96
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 2/463 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/47 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/462 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/47 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/462 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 97
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/50 (0%)     0/47 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/462 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     1/49 (2%)     0/62 (0%)           0/50 (0%)     0/47 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/462 (0.22%)   Mean 0.23%   SD 0.68%     Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Papilloma Squamous, or Papilloma  0/52 (0%)     0/50 (0%)     0/62 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        1/47 (2%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/453 (0.22%)    Mean 0.24%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 98
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/49 (0%)     1/50 (2%)     2/51 (4%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     1/59 (2%)     |
|                                                                                        0/47 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 5/453 (1.1%)     Mean 1.07%   SD 1.42%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          2/49 (4%)     1/50 (2%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     1/59 (2%)     |
|                                                                                        0/47 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 5/453 (1.1%)     Mean 1.09%   SD 1.46%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        2/49 (4%)     1/50 (2%)     0/51 (0%)     |
|      Malignant, NOS                                                                    0/49 (0%)     0/49 (0%)     1/59 (2%)     |
|                                                                                        0/47 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 5/453 (1.1%)     Mean 1.09%   SD 1.46%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 99
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/49 (2%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/453 (0.22%)    Mean 0.23%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        1/47 (2%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/453 (0.22%)    Mean 0.24%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        1/49 (2%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/453 (0.22%)    Mean 0.23%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 100
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       1/49 (2%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/453 (0.22%)    Mean 0.23%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/461 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/461 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 101
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/461 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/45 (0%)     0/39 (0%)     0/38 (0%)           0/43 (0%)     0/38 (0%)     0/35 (0%)     |
|                                        0/36 (0%)     0/43 (0%)     0/50 (0%)           0/36 (0%)     0/40 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/48 (0%)           0/47 (0%)     0/42 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/396 (0%)      Mean 0%      SD 0%        Total 0/379 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/47 (0%)     0/42 (0%)           8/47 (17%)    9/47 (19%)    4/45 (9%)     |
|   Adenoma                              0/46 (0%)     0/48 (0%)     1/59 (2%)           3/48 (6%)     5/46 (11%)    9/55 (16%)    |
|                                        0/48 (0%)     1/44 (2%)     0/49 (0%)           4/48 (8%)     7/49 (14%)    9/49 (18%)    |
| Overall Incidence               Total 2/430 (0.47%)   Mean 0.44%   SD 0.89%     Total 58/434 (13.36%)  Mean 13.28%  SD 4.79%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/47 (0%)     0/42 (0%)           0/47 (0%)     0/47 (0%)     0/45 (0%)     |
|   Carcinoma                            0/46 (0%)     0/48 (0%)     0/59 (0%)           0/48 (0%)     0/46 (0%)     0/55 (0%)     |
|                                        0/48 (0%)     0/44 (0%)     0/49 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/430 (0%)      Mean 0%      SD 0%        Total 0/434 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/47 (0%)     0/42 (0%)           8/47 (17%)    9/47 (19%)    4/45 (9%)     |
|   Carcinoma or Adenoma                 0/46 (0%)     0/48 (0%)     1/59 (2%)           3/48 (6%)     5/46 (11%)    9/55 (16%)    |
|                                        0/48 (0%)     1/44 (2%)     0/49 (0%)           4/48 (8%)     7/49 (14%)    9/49 (18%)    |
| Overall Incidence               Total 2/430 (0.47%)   Mean 0.44%   SD 0.89%     Total 58/434 (13.36%)  Mean 13.28%  SD 4.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 102
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/47 (0%)     0/47 (0%)     0/42 (0%)           0/47 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/46 (0%)     0/48 (0%)     0/59 (0%)           0/48 (0%)     0/46 (0%)     0/55 (0%)     |
|                                        0/48 (0%)     0/44 (0%)     0/49 (0%)           1/48 (2%)     1/49 (2%)     0/49 (0%)     |
| Overall Incidence               Total 0/430 (0%)      Mean 0%      SD 0%        Total 2/434 (0.46%)    Mean 0.46%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/47 (0%)     0/47 (0%)     0/42 (0%)           0/47 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/46 (0%)     0/48 (0%)     0/59 (0%)           0/48 (0%)     0/46 (0%)     0/55 (0%)     |
|                                        0/48 (0%)     1/44 (2%)     0/49 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/430 (0.23%)   Mean 0.25%   SD 0.76%     Total 0/434 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/47 (0%)     0/47 (0%)     0/42 (0%)           0/47 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/46 (0%)     0/48 (0%)     0/59 (0%)           0/48 (0%)     0/46 (0%)     0/55 (0%)     |
|                                        0/48 (0%)     1/44 (2%)     0/49 (0%)           1/48 (2%)     1/49 (2%)     0/49 (0%)     |
| Overall Incidence               Total 1/430 (0.23%)   Mean 0.25%   SD 0.76%     Total 2/434 (0.46%)    Mean 0.46%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/51 (0%)     0/45 (0%)     0/62 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/51 (0%)     0/45 (0%)     0/62 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/51 (0%)     0/45 (0%)     0/62 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 103
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/461 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/51 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 104
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 105
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Basosquamous Tumor Benign         0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Tumor Benign, or                  0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Basosquamous Tumor (malignant or  0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      NOS)                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Adenoma, Basosquamous Tumor       0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.21%   SD 0.64%     Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 106
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 2/463 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/464 (0.65%)   Mean 0.66%   SD 0.99%     Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     1/52 (2%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.21%   SD 0.64%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 107
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Cell Carcinoma, Basosquamous      0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.21%   SD 0.64%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Papilloma                         1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.21%   SD 0.64%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Papilloma, Squamous Cell          1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Carcinoma or Keratoacanthoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.21%   SD 0.64%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Papilloma, or Keratoacanthoma     1/52 (2%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.21%   SD 0.64%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 108
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     1/52 (2%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.21%   SD 0.64%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     0/51 (0%)     2/52 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/52 (0%)     0/50 (0%)     0/62 (0%)           2/50 (4%)     2/50 (4%)     2/60 (3%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 15/463 (3.24%)   Mean 3.24%   SD 1.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     0/51 (0%)     1/52 (2%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 9/463 (1.94%)    Mean 1.95%   SD 1.74%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     0/51 (0%)     1/52 (2%)     |
|      Myxosarcoma, or Fibrous           0/52 (0%)     0/50 (0%)     0/62 (0%)           2/50 (4%)     2/50 (4%)     2/60 (3%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 14/463 (3.02%)   Mean 3.03%   SD 1.74%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/51 (2%)     0/52 (0%)     |
|      (malignant or NOS)                0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 2/463 (0.43%)    Mean 0.44%   SD 0.87%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 109
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/51 (2%)     0/52 (0%)     |
|      or Schwannoma (benign, malignant  0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      or NOS)                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 2/463 (0.43%)    Mean 0.44%   SD 0.87%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           2/50 (4%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 5/463 (1.08%)    Mean 1.07%   SD 1.43%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/51 (2%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        1/52 (2%)     0/49 (0%)     0/62 (0%)           1/49 (2%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/461 (0.22%)   Mean 0.21%   SD 0.64%     Total 1/458 (0.22%)    Mean 0.23%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 110
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     1/49 (2%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        2/52 (4%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        4/50 (8%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 11/461 (2.39%)  Mean 2.43%   SD 2.59%     Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/464 (0.65%)   Mean 0.67%   SD 1%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           2/50 (4%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     2/51 (4%)     1/52 (2%)     |
|      Papilloma Squamous                3/52 (6%)     1/50 (2%)     3/62 (5%)           0/50 (0%)     1/50 (2%)     3/60 (5%)     |
|                                        4/50 (8%)     3/50 (6%)     1/50 (2%)           3/50 (6%)     5/50 (10%)    4/50 (8%)     |
| Overall Incidence               Total 22/464 (4.74%)  Mean 4.73%   SD 1.97%     Total 19/463 (4.1%)    Mean 4.09%   SD 3.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 111
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     2/51 (4%)     1/52 (2%)     |
|                                        3/52 (6%)     1/50 (2%)     3/62 (5%)           0/50 (0%)     1/50 (2%)     3/60 (5%)     |
|                                        3/50 (6%)     3/50 (6%)     1/50 (2%)           3/50 (6%)     5/50 (10%)    4/50 (8%)     |
| Overall Incidence               Total 19/464 (4.09%)  Mean 4.07%   SD 1.72%     Total 19/463 (4.1%)    Mean 4.09%   SD 3.49%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.18%   SD 0.54%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     1/62 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.18%   SD 0.54%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     1/49 (2%)     3/49 (6%)                                                     |
|                                        0/52 (0%)     1/50 (2%)     0/62 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 5/462 (1.08%)   Mean 1.13%   SD 2.07%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/49 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/462 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 112
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/42 (0%)     0/41 (0%)     0/47 (0%)           0/45 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
|                                        0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/407 (0%)      Mean 0%      SD 0%        Total 0/426 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/42 (0%)     0/41 (0%)     0/47 (0%)           0/45 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
|                                        0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/407 (0%)      Mean 0%      SD 0%        Total 0/426 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/42 (0%)     0/41 (0%)     0/47 (0%)           0/45 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
|                                        0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/407 (0%)      Mean 0%      SD 0%        Total 0/426 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/42 (0%)     0/41 (0%)     0/47 (0%)           0/45 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
|                                        0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/407 (0%)      Mean 0%      SD 0%        Total 0/426 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/42 (0%)     0/41 (0%)     0/47 (0%)           0/45 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
|                                        0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/407 (0%)      Mean 0%      SD 0%        Total 0/426 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/42 (0%)     0/41 (0%)     0/47 (0%)           0/45 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     1/59 (2%)     |
|                                        0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/407 (0%)      Mean 0%      SD 0%        Total 1/426 (0.23%)    Mean 0.19%   SD 0.56%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/42 (0%)     0/41 (0%)     0/47 (0%)           0/45 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
|                                        0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/407 (0%)      Mean 0%      SD 0%        Total 0/426 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/42 (0%)     0/41 (0%)     0/47 (0%)           1/45 (2%)     0/45 (0%)     0/43 (0%)     |
|                                        0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
|                                        0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/407 (0%)      Mean 0%      SD 0%        Total 1/426 (0.23%)    Mean 0.25%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 113
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/42 (0%)     0/41 (0%)     0/47 (0%)           0/45 (0%)     0/45 (0%)     0/43 (0%)     |
|                                        0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
|                                        0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/407 (0%)      Mean 0%      SD 0%        Total 0/426 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/42 (0%)     0/41 (0%)     0/47 (0%)           1/45 (2%)     0/45 (0%)     0/43 (0%)     |
|                                        0/47 (0%)     0/38 (0%)     0/58 (0%)           0/46 (0%)     0/42 (0%)     0/59 (0%)     |
|                                        0/46 (0%)     0/45 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/407 (0%)      Mean 0%      SD 0%        Total 1/426 (0.23%)    Mean 0.25%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/453 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     0/49 (0%)     0/49 (0%)           1/49 (2%)     0/48 (0%)     0/47 (0%)     |
|                                        1/50 (2%)     0/48 (0%)     0/62 (0%)           0/49 (0%)     4/50 (8%)     4/60 (7%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     4/50 (8%)     |
| Overall Incidence               Total 4/458 (0.87%)   Mean 0.89%   SD 1.05%     Total 14/453 (3.09%)   Mean 2.97%   SD 3.56%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/48 (0%)     1/47 (2%)     |
|                                        0/50 (0%)     0/48 (0%)     1/62 (2%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/458 (0.22%)   Mean 0.18%   SD 0.54%     Total 1/453 (0.22%)    Mean 0.24%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 114
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     0/49 (0%)     0/49 (0%)           1/49 (2%)     0/48 (0%)     1/47 (2%)     |
|                                        1/50 (2%)     0/48 (0%)     1/62 (2%)           0/49 (0%)     4/50 (8%)     4/60 (7%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     4/50 (8%)     |
| Overall Incidence               Total 5/458 (1.09%)   Mean 1.07%   SD 1.02%     Total 15/453 (3.31%)   Mean 3.2%    SD 3.4%      |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 115
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|      Papilloma Squamous                0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/464 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/45 (0%)     0/45 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/462 (0%)      Mean 0%      SD 0%        Total 0/447 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/45 (0%)     0/45 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/462 (0%)      Mean 0%      SD 0%        Total 0/447 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 116
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/45 (0%)     0/45 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/462 (0%)      Mean 0%      SD 0%        Total 0/447 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/45 (0%)     0/45 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/462 (0%)      Mean 0%      SD 0%        Total 0/447 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/45 (0%)     0/45 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/62 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/462 (0%)      Mean 0%      SD 0%        Total 0/447 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/51 (0%)     1/52 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/463 (0.22%)    Mean 0.21%   SD 0.64%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 117
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      1/50 (2%)     0/51 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/463 (0.43%)    Mean 0.41%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            1/50 (2%)     0/51 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/51 (0%)     1/52 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/463 (0.22%)    Mean 0.21%   SD 0.64%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)     0/51 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 3/463 (0.65%)    Mean 0.67%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/463 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     1/51 (2%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 4/463 (0.86%)    Mean 0.85%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/50 (2%)     1/51 (2%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence                                                               Total 7/463 (1.51%)    Mean 1.51%   SD 1.32%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 118
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: CORN OIL                                 Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/51 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/62 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/464 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 119
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       33/49 (67%)   33/50 (66%)   26/50 (52%)         29/50 (58%)   30/50 (60%)   23/50 (46%)    |
|                                       28/50 (56%)                                     36/50 (72%)                                |
| Overall Incidence               Total 120/199 (60.3%) Mean 60.34%  SD 7.52%     Total 118/200 (59%)    Mean 59%     SD 10.65%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/49 (47%)   28/50 (56%)   30/50 (60%)         27/50 (54%)   26/50 (52%)   23/50 (46%)    |
|                                       28/50 (56%)                                     32/50 (64%)                                |
| Overall Incidence               Total 109/199 (54.77%)Mean 54.73%  SD 5.53%     Total 108/200 (54%)    Mean 54%     SD 7.48%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         41/49 (84%)   43/50 (86%)   40/50 (80%)         41/50 (82%)   41/50 (82%)   35/50 (70%)    |
|                                       41/50 (82%)                                     44/50 (88%)                                |
| Overall Incidence               Total 165/199 (82.91%)Mean 82.92%  SD 2.54%     Total 161/200 (80.5%)  Mean 80.5%   SD 7.55%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/49 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1%      SD 2%        Total 3/200 (1.5%)     Mean 1.5%    SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/49 (8%)     7/50 (14%)    3/50 (6%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        5/50 (10%)                                      5/50 (10%)                                |
| Overall Incidence               Total 19/199 (9.55%)  Mean 9.54%   SD 3.39%     Total 6/200 (3%)       Mean 3%      SD 4.76%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        4/49 (8%)     9/50 (18%)    3/50 (6%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        5/50 (10%)                                      7/50 (14%)                                |
| Overall Incidence               Total 21/199 (10.55%) Mean 10.54%  SD 5.23%     Total 9/200 (4.5%)     Mean 4.5%    SD 6.4%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/49 (0%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     2/50 (4%)     3/50 (6%)     |
|                                        1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 3/199 (1.51%)   Mean 1.5%    SD 1.91%     Total 8/200 (4%)       Mean 4%      SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Mononuclear, or Undifferentiated  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 120
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/49 (6%)     1/50 (2%)     7/50 (14%)         15/50 (30%)    5/50 (10%)   13/50 (26%)    |
|      Lymphocytic, Mixed, NOS, or       2/50 (4%)                                       8/50 (16%)                                |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 13/199 (6.53%)  Mean 6.53%   SD 5.26%     Total 41/200 (20.5%)   Mean 20.5%   SD 9.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/49 (0%)     5/50 (10%)    0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        2/49 (4%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 7/198 (3.54%)   Mean 3.52%   SD 4.73%     Total 1/199 (0.5%)     Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/48 (2%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 1/197 (0.51%)   Mean 0.52%   SD 1.04%     Total 2/199 (1.01%)    Mean 1%      SD 2%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 121
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/197 (0.51%)   Mean 0.5%    SD 1%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Complex, Malignant, NOS           1/48 (2%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 2/197 (1.02%)   Mean 1.02%   SD 1.18%     Total 3/199 (1.51%)    Mean 1.5%    SD 3%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1%      SD 1.15%     Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 122
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 123
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 124
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/48 (0%)     0/41 (0%)     0/50 (0%)           0/38 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/44 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/183 (0%)      Mean 0%      SD 0%        Total 0/181 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              4/49 (8%)     3/50 (6%)     3/50 (6%)           0/50 (0%)     4/50 (8%)     0/50 (0%)     |
|                                        3/50 (6%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 13/199 (6.53%)  Mean 6.54%   SD 1.08%     Total 7/200 (3.5%)     Mean 3.5%    SD 4.12%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           5/50 (10%)    1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 7/200 (3.5%)     Mean 3.5%    SD 4.43%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 4/49 (8%)     3/50 (6%)     3/50 (6%)           5/50 (10%)    5/50 (10%)    0/50 (0%)     |
|                                        3/50 (6%)                                       4/50 (8%)                                 |
| Overall Incidence               Total 13/199 (6.53%)  Mean 6.54%   SD 1.08%     Total 14/200 (7%)      Mean 7%      SD 4.76%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 125
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            1/49 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.51%   SD 1.02%     Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 1/49 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.51%   SD 1.02%     Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 126
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/49 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 127
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/49 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/49 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/48 (0%)                                       1/48 (2%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 2/196 (1.02%)    Mean 1.02%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/196 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 128
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/48 (0%)                                       1/48 (2%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 2/196 (1.02%)    Mean 1.02%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 129
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/49 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1%      SD 2%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/49 (0%)     6/50 (12%)    3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 11/199 (5.53%)  Mean 5.5%    SD 5%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/49 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/199 (1.51%)   Mean 1.5%    SD 1%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              26/49 (53%)   25/50 (50%)   16/50 (32%)         20/50 (40%)   20/50 (40%)   11/50 (22%)    |
|                                       19/50 (38%)                                     19/50 (38%)                                |
| Overall Incidence               Total 86/199 (43.22%) Mean 43.27%  SD 9.93%     Total 70/200 (35%)     Mean 35%     SD 8.72%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            10/49 (20%)   21/50 (42%)   13/50 (26%)          7/50 (14%)   12/50 (24%)   13/50 (26%)    |
|                                       19/50 (38%)                                     14/50 (28%)                                |
| Overall Incidence               Total 63/199 (31.66%) Mean 31.6%   SD 10.1%     Total 46/200 (23%)     Mean 23%     SD 6.22%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/49 (20%)   21/50 (42%)   13/50 (26%)          7/50 (14%)   13/50 (26%)   13/50 (26%)    |
|      Hepatoblastoma                   20/50 (40%)                                     14/50 (28%)                                |
| Overall Incidence               Total 64/199 (32.16%) Mean 32.1%   SD 10.56%    Total 47/200 (23.5%)   Mean 23.5%   SD 6.4%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 130
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         31/49 (63%)   36/50 (72%)   24/50 (48%)         25/50 (50%)   27/50 (54%)   20/50 (40%)    |
|      Hepatocellular Adenoma           35/50 (70%)                                     24/50 (48%)                                |
| Overall Incidence               Total 126/199 (63.32%)Mean 63.32%  SD 10.87%    Total 96/200 (48%)     Mean 48%     SD 5.89%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           31/49 (63%)   36/50 (72%)   24/50 (48%)         25/50 (50%)   27/50 (54%)   20/50 (40%)    |
|      Hepatocellular Adenoma, or       36/50 (72%)                                     24/50 (48%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 127/199 (63.82%)Mean 63.82%  SD 11.32%    Total 96/200 (48%)     Mean 48%     SD 5.89%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 131
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        11/49 (22%)   12/50 (24%)   10/49 (20%)          6/50 (12%)    3/49 (6%)     1/50 (2%)     |
|                                        6/50 (12%)                                      4/50 (8%)                                 |
| Overall Incidence               Total 39/198 (19.7%)  Mean 19.71%  SD 5.35%     Total 14/199 (7.04%)   Mean 7.03%   SD 4.15%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       5/49 (10%)    4/50 (8%)     6/49 (12%)          1/50 (2%)     3/49 (6%)     0/50 (0%)     |
|                                        2/50 (4%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 17/198 (8.59%)  Mean 8.61%   SD 3.53%     Total 6/199 (3.02%)    Mean 3.03%   SD 2.63%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   15/49 (31%)   14/50 (28%)   16/49 (33%)          7/50 (14%)    6/49 (12%)    1/50 (2%)     |
|      Alveolar/Bronchiolar Adenoma      8/50 (16%)                                      6/50 (12%)                                |
| Overall Incidence               Total 53/198 (26.77%) Mean 26.82%  SD 7.46%     Total 20/199 (10.05%)  Mean 10.06%  SD 5.45%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 132
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      1/49 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.51%   SD 1.02%     Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/49 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 133
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 2/200 (1%)       Mean 1%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/49 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 2/200 (1%)       Mean 1%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 134
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 2/200 (1%)       Mean 1%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 135
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 136
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/50 (6%)     2/50 (4%)     0/49 (0%)     |
|                                                                                        3/50 (6%)                                 |
| Overall Incidence                                                               Total 8/199 (4.02%)    Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Malignant, NOS                                                                    0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 137
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/197 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 1/197 (0.51%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 1/197 (0.51%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 138
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/197 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/197 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/197 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/197 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/197 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/43 (0%)     0/46 (0%)     0/48 (0%)           0/36 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/50 (0%)                                       0/43 (0%)                                 |
| Overall Incidence               Total 0/187 (0%)      Mean 0%      SD 0%        Total 0/171 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)     0/40 (0%)     0/48 (0%)           5/48 (10%)    2/46 (4%)     7/50 (14%)    |
|   Adenoma                              0/47 (0%)                                       8/49 (16%)                                |
| Overall Incidence               Total 0/180 (0%)      Mean 0%      SD 0%        Total 22/193 (11.4%)   Mean 11.27%  SD 5.22%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)     0/40 (0%)     0/48 (0%)           0/48 (0%)     0/46 (0%)     1/50 (2%)     |
|   Carcinoma                            0/47 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/180 (0%)      Mean 0%      SD 0%        Total 1/193 (0.52%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)     0/40 (0%)     0/48 (0%)           5/48 (10%)    2/46 (4%)     8/50 (16%)    |
|   Carcinoma or Adenoma                 0/47 (0%)                                       8/49 (16%)                                |
| Overall Incidence               Total 0/180 (0%)      Mean 0%      SD 0%        Total 23/193 (11.92%)  Mean 11.77%  SD 5.64%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 139
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/45 (0%)     0/40 (0%)     1/48 (2%)           0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/47 (0%)                                       2/49 (4%)                                 |
| Overall Incidence               Total 1/180 (0.56%)   Mean 0.52%   SD 1.04%     Total 2/193 (1.04%)    Mean 1.02%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/45 (0%)     0/40 (0%)     0/48 (0%)           0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/47 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/180 (0%)      Mean 0%      SD 0%        Total 0/193 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/45 (0%)     0/40 (0%)     1/48 (2%)           0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/47 (0%)                                       2/49 (4%)                                 |
| Overall Incidence               Total 1/180 (0.56%)   Mean 0.52%   SD 1.04%     Total 2/193 (1.04%)    Mean 1.02%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            1/49 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 1/198 (0.51%)   Mean 0.51%   SD 1.02%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 1/49 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 1/198 (0.51%)   Mean 0.51%   SD 1.02%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 140
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      1/49 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.51%   SD 1.02%     Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 141
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)                                       0/50 (0%)                                 |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)                                       0/50 (0%)                                 |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)                                       0/50 (0%)                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 142
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)                                       0/50 (0%)                                 |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/49 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1%      SD 1.15%     Total 3/200 (1.5%)     Mean 1.5%    SD 3%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 143
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 144
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/49 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)                                       2/50 (4%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 3/199 (1.51%)   Mean 1.5%    SD 1.91%     Total 3/200 (1.5%)     Mean 1.5%    SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/49 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 2/200 (1%)       Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/49 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)                                       2/50 (4%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 3/199 (1.51%)   Mean 1.5%    SD 1.91%     Total 3/200 (1.5%)     Mean 1.5%    SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)                                       0/50 (0%)                                 |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/49 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1%      SD 1.15%     Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 145
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/49 (4%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        1/48 (2%)                                       3/49 (6%)                                 |
| Overall Incidence               Total 5/197 (2.54%)   Mean 2.54%   SD 1.93%     Total 4/198 (2.02%)    Mean 2.04%   SD 2.89%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 1/198 (0.51%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 1/198 (0.51%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 146
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/49 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     1/50 (2%)     |
|      Papilloma Squamous                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 5/200 (2.5%)     Mean 2.5%    SD 2.52%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/49 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     3/50 (6%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 4/200 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 147
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/49 (2%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.01%   SD 1.17%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/37 (0%)     0/41 (0%)     1/45 (2%)           0/45 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/42 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 1/165 (0.61%)   Mean 0.56%   SD 1.11%     Total 0/187 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/37 (0%)     0/41 (0%)     0/45 (0%)           0/45 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/42 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/165 (0%)      Mean 0%      SD 0%        Total 0/187 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/37 (0%)     0/41 (0%)     0/45 (0%)           0/45 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/42 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/165 (0%)      Mean 0%      SD 0%        Total 0/187 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/37 (0%)     0/41 (0%)     0/45 (0%)           0/45 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/42 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/165 (0%)      Mean 0%      SD 0%        Total 0/187 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/37 (0%)     0/41 (0%)     0/45 (0%)           0/45 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/42 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/165 (0%)      Mean 0%      SD 0%        Total 0/187 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/37 (0%)     0/41 (0%)     0/45 (0%)           0/45 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/42 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/165 (0%)      Mean 0%      SD 0%        Total 0/187 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/37 (0%)     0/41 (0%)     0/45 (0%)           0/45 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/42 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/165 (0%)      Mean 0%      SD 0%        Total 0/187 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/37 (0%)     0/41 (0%)     0/45 (0%)           0/45 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/42 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/165 (0%)      Mean 0%      SD 0%        Total 0/187 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 148
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/37 (0%)     0/41 (0%)     0/45 (0%)           0/45 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/42 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/165 (0%)      Mean 0%      SD 0%        Total 0/187 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/37 (0%)     0/41 (0%)     0/45 (0%)           0/45 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/42 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/165 (0%)      Mean 0%      SD 0%        Total 0/187 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/49 (2%)     2/50 (4%)     4/50 (8%)           2/50 (4%)     3/49 (6%)     1/50 (2%)     |
|                                        6/50 (12%)                                      2/49 (4%)                                 |
| Overall Incidence               Total 13/199 (6.53%)  Mean 6.51%   SD 4.42%     Total 8/198 (4.04%)    Mean 4.05%   SD 1.68%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/49 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.51%   SD 1.02%     Total 1/198 (0.51%)    Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/49 (4%)     2/50 (4%)     4/50 (8%)           2/50 (4%)     4/49 (8%)     1/50 (2%)     |
|                                        6/50 (12%)                                      2/49 (4%)                                 |
| Overall Incidence               Total 14/199 (7.04%)  Mean 7.02%   SD 3.81%     Total 9/198 (4.55%)    Mean 4.56%   SD 2.59%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 149
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 150
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             1/49 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.51%   SD 1.02%     Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 151
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     1/50 (2%)     4/50 (8%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 5/200 (2.5%)     Mean 2.5%    SD 3.79%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     1/50 (2%)     4/50 (8%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 5/200 (2.5%)     Mean 2.5%    SD 3.79%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 152
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: METHYL CELLULOSE                         Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 1/200 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 153
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       36/50 (72%)                                     24/51 (47%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    17/50 (34%)                                     26/51 (51%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         43/50 (86%)                                     40/51 (78%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)                                       4/51 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/50 (4%)                                       4/51 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  3/50 (6%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    1/50 (2%)                                       0/51 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     4/50 (8%)                                       9/51 (18%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 154
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)                                       0/51 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)                                       1/51 (2%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 155
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 156
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/51 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 157
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/49 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              3/50 (6%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       2/51 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)                                       3/51 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 158
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 159
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/50 (6%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 160
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/50 (6%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/51 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/51 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/51 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/51 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            2/50 (4%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 2/50 (4%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 161
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              26/50 (52%)                                     15/51 (29%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             6/50 (12%)                                      8/51 (16%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          6/50 (12%)                                      8/51 (16%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         30/50 (60%)                                     22/51 (43%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           30/50 (60%)                                     22/51 (43%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 162
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        12/50 (24%)                                      3/51 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       3/50 (6%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   15/50 (30%)                                      4/51 (8%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 163
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 164
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       0/51 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 165
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 166
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/51 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/51 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 167
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 168
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/46 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       4/50 (8%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)                                       4/50 (8%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/48 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 169
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/48 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 170
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/51 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/51 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 171
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/51 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/51 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/51 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 172
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/51 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 173
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       1/51 (2%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       1/51 (2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/51 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/51 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 174
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 175
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 176
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/42 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)                                       3/51 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       3/51 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 177
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 178
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 179
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/51 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 181
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       36/50 (72%)   30/50 (60%)   24/50 (48%)         28/50 (56%)   31/50 (62%)   29/49 (59%)    |
|                                       31/50 (62%)   30/50 (60%)   31/50 (62%)         22/50 (44%)   25/50 (50%)   23/50 (46%)    |
|                                       27/50 (54%)   29/50 (58%)   30/50 (60%)         32/50 (64%)   23/49 (47%)   29/50 (58%)    |
|                                       22/50 (44%)   28/50 (56%)   31/50 (62%)         26/50 (52%)   25/50 (50%)   31/50 (62%)    |
|                                       27/50 (54%)   36/50 (72%)   29/50 (58%)         33/50 (66%)   21/50 (42%)   16/50 (32%)    |
|                                       20/50 (40%)   24/50 (48%)   18/55 (33%)         20/50 (40%)   27/51 (53%)   20/60 (33%)    |
|                                       27/59 (46%)   21/60 (35%)                       27/58 (47%)   27/60 (45%)                  |
| Overall Incidence               Total 551/1024 (53.81%Mean 54.17%  SD 10.84%    Total 515/1027 (50.15%)Mean 50.4%   SD 9.73%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    19/50 (38%)   19/50 (38%)   18/50 (36%)         15/50 (30%)   27/50 (54%)   23/49 (47%)    |
|                                       34/50 (68%)   33/50 (66%)   23/50 (46%)         20/50 (40%)   27/50 (54%)   20/50 (40%)    |
|                                       33/50 (66%)   11/50 (22%)   21/50 (42%)         24/50 (48%)   21/49 (43%)   29/50 (58%)    |
|                                       28/50 (56%)   20/50 (40%)   22/50 (44%)         25/50 (50%)   28/50 (56%)   26/50 (52%)    |
|                                       25/50 (50%)   24/50 (48%)   16/50 (32%)         31/50 (62%)   21/50 (42%)   16/50 (32%)    |
|                                       21/50 (42%)   16/50 (32%)   14/55 (25%)         13/50 (26%)   17/51 (33%)   30/60 (50%)    |
|                                       20/59 (34%)   20/60 (33%)                       26/58 (45%)   26/60 (43%)                  |
| Overall Incidence               Total 437/1024 (42.68%Mean 42.93%  SD 13%       Total 465/1027 (45.28%)Mean 45.26%  SD 9.76%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         44/50 (88%)   42/50 (84%)   32/50 (64%)         35/50 (70%)   43/50 (86%)   35/49 (71%)    |
|                                       48/50 (96%)   49/50 (98%)   43/50 (86%)         34/50 (68%)   42/50 (84%)   36/50 (72%)    |
|                                       44/50 (88%)   35/50 (70%)   41/50 (82%)         41/50 (82%)   34/49 (69%)   43/50 (86%)    |
|                                       40/50 (80%)   40/50 (80%)   40/50 (80%)         38/50 (76%)   40/50 (80%)   38/50 (76%)    |
|                                       40/50 (80%)   47/50 (94%)   37/50 (74%)         47/50 (94%)   34/50 (68%)   27/50 (54%)    |
|                                       35/50 (70%)   33/50 (66%)   28/55 (51%)         29/50 (58%)   37/51 (73%)   36/60 (60%)    |
|                                       39/59 (66%)   37/60 (62%)                       42/58 (72%)   41/60 (68%)                  |
| Overall Incidence               Total 794/1024 (77.54%Mean 77.93%  SD 12.44%    Total 752/1027 (73.22%)Mean 73.41%  SD 9.99%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     3/50 (6%)     2/49 (4%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/55 (0%)           0/50 (0%)     2/51 (4%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         1/58 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 8/1024 (0.78%)  Mean 0.78%   SD 1.18%     Total 15/1027 (1.46%)  Mean 1.49%   SD 2.14%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     2/50 (4%)           3/50 (6%)     2/50 (4%)     3/49 (6%)     |
|                                        3/50 (6%)     3/50 (6%)     1/50 (2%)           4/50 (8%)     1/50 (2%)     2/50 (4%)     |
|                                        3/50 (6%)     0/50 (0%)     1/50 (2%)           3/50 (6%)     0/49 (0%)     3/50 (6%)     |
|                                        2/50 (4%)     1/50 (2%)     1/50 (2%)           2/50 (4%)     0/50 (0%)     4/50 (8%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     2/55 (4%)           0/50 (0%)     1/51 (2%)     3/60 (5%)     |
|                                        1/59 (2%)     2/60 (3%)                         3/58 (5%)     1/60 (2%)                   |
| Overall Incidence               Total 27/1024 (2.64%) Mean 2.63%   SD 1.95%     Total 38/1027 (3.7%)   Mean 3.7%    SD 2.62%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 182
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/50 (4%)     1/50 (2%)     3/50 (6%)           5/50 (10%)    5/50 (10%)    5/49 (10%)    |
|                                        3/50 (6%)     5/50 (10%)    1/50 (2%)           4/50 (8%)     1/50 (2%)     2/50 (4%)     |
|                                        3/50 (6%)     0/50 (0%)     1/50 (2%)           3/50 (6%)     1/49 (2%)     3/50 (6%)     |
|                                        2/50 (4%)     1/50 (2%)     1/50 (2%)           2/50 (4%)     0/50 (0%)     7/50 (14%)    |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           2/50 (4%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     2/55 (4%)           0/50 (0%)     3/51 (6%)     3/60 (5%)     |
|                                        2/59 (3%)     2/60 (3%)                         4/58 (7%)     1/60 (2%)                   |
| Overall Incidence               Total 35/1024 (3.42%) Mean 3.42%   SD 2.49%     Total 53/1027 (5.16%)  Mean 5.18%   SD 3.84%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     2/49 (4%)     |
|                                        3/50 (6%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     2/50 (4%)     |
|                                        3/50 (6%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     4/49 (8%)     2/50 (4%)     |
|                                        0/50 (0%)     2/50 (4%)     3/50 (6%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     3/50 (6%)     5/50 (10%)    |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     2/51 (4%)     2/60 (3%)     |
|                                        0/59 (0%)     1/60 (2%)                         2/58 (3%)     1/60 (2%)                   |
| Overall Incidence               Total 16/1024 (1.56%) Mean 1.58%   SD 2.21%     Total 38/1027 (3.7%)   Mean 3.73%   SD 2.53%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           1/50 (2%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Mononuclear, or Undifferentiated  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 183
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     4/50 (8%)     1/50 (2%)     3/50 (6%)           6/50 (12%)    7/50 (14%)   11/49 (22%)    |
|      Lymphocytic, Mixed, NOS, or       2/50 (4%)     1/50 (2%)     3/50 (6%)           7/50 (14%)    4/50 (8%)     6/50 (12%)    |
|      Undifferentiated Cell Type        4/50 (8%)     2/50 (4%)     4/50 (8%)          12/50 (24%)   13/49 (27%)   16/50 (32%)    |
|                                        1/50 (2%)     2/50 (4%)     3/50 (6%)          12/50 (24%)    3/50 (6%)     9/50 (18%)    |
|                                        4/50 (8%)     2/50 (4%)     2/50 (4%)           7/50 (14%)    7/50 (14%)    4/50 (8%)     |
|                                        2/50 (4%)     1/50 (2%)     2/55 (4%)           3/50 (6%)     7/51 (14%)   13/60 (22%)    |
|                                        1/59 (2%)     2/60 (3%)                         5/58 (9%)     7/60 (12%)                  |
| Overall Incidence               Total 46/1024 (4.49%) Mean 4.53%   SD 2.2%      Total 159/1027 (15.48%)Mean 15.53%  SD 7.34%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 5/1027 (0.49%)   Mean 0.5%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 5/1027 (0.49%)   Mean 0.5%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/50 (4%)     2/50 (4%)     2/48 (4%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     6/50 (12%)          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/47 (4%)     0/49 (0%)     2/49 (4%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     5/49 (10%)          0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     3/48 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/47 (2%)     0/49 (0%)     4/55 (7%)           0/47 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        2/59 (3%)     1/60 (2%)                         1/58 (2%)     1/59 (2%)                   |
| Overall Incidence               Total 37/1008 (3.67%) Mean 3.67%   SD 3.26%     Total 5/1021 (0.49%)   Mean 0.47%   SD 0.84%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 184
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     1/49 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/55 (0%)           0/47 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1008 (0%)     Mean 0%      SD 0%        Total 1/1021 (0.1%)    Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/55 (0%)           0/47 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1008 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/55 (0%)           0/47 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1008 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/55 (0%)           0/47 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1008 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/49 (0%)     1/49 (2%)           0/50 (0%)     3/50 (6%)     2/48 (4%)     |
|                                        0/50 (0%)     1/48 (2%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     1/48 (2%)     |
|                                        0/47 (0%)     0/49 (0%)     0/49 (0%)           4/50 (8%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/48 (2%)     0/49 (0%)           2/50 (4%)     0/49 (0%)     1/50 (2%)     |
|                                        0/47 (0%)     0/49 (0%)     0/55 (0%)           0/47 (0%)     0/47 (0%)     1/60 (2%)     |
|                                        0/58 (0%)     0/60 (0%)                         1/58 (2%)     1/59 (2%)                   |
| Overall Incidence               Total 3/1006 (0.3%)   Mean 0.31%   SD 0.76%     Total 19/1012 (1.88%)  Mean 1.87%   SD 2.21%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 185
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/55 (0%)           0/47 (0%)     0/47 (0%)     0/60 (0%)     |
|                                        1/58 (2%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/1006 (0.1%)   Mean 0.09%   SD 0.39%     Total 0/1012 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|                                        1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/55 (0%)           0/47 (0%)     0/47 (0%)     2/60 (3%)     |
|                                        0/58 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/1006 (0.1%)   Mean 0.1%    SD 0.45%     Total 3/1012 (0.3%)    Mean 0.27%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/49 (0%)     1/49 (2%)           0/50 (0%)     3/50 (6%)     3/48 (6%)     |
|      Complex, Malignant, NOS           1/50 (2%)     1/48 (2%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     1/48 (2%)     |
|                                        0/47 (0%)     0/49 (0%)     0/49 (0%)           4/50 (8%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/48 (2%)     0/49 (0%)           2/50 (4%)     0/49 (0%)     1/50 (2%)     |
|                                        0/47 (0%)     0/49 (0%)     0/55 (0%)           0/47 (0%)     0/47 (0%)     3/60 (5%)     |
|                                        1/58 (2%)     0/60 (0%)                         1/58 (2%)     1/59 (2%)                   |
| Overall Incidence               Total 5/1006 (0.5%)   Mean 0.5%    SD 0.89%     Total 22/1012 (2.17%)  Mean 2.14%   SD 2.46%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/54 (0%)           0/48 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/57 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1016 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/54 (0%)           0/48 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/57 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1016 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 186
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        1/48 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     1/48 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/54 (0%)           0/48 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/57 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 3/1016 (0.3%)   Mean 0.31%   SD 0.75%     Total 9/1021 (0.88%)   Mean 0.91%   SD 1.22%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/54 (0%)           0/48 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/57 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1016 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/54 (0%)           0/48 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/57 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1016 (0%)     Mean 0%      SD 0%        Total 1/1021 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/54 (0%)           0/48 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/57 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1016 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/54 (0%)           0/48 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/57 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1016 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 187
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     1/60 (2%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 3/1024 (0.29%)  Mean 0.28%   SD 0.69%     Total 2/1027 (0.19%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 4/1027 (0.39%)   Mean 0.4%    SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 4/1027 (0.39%)   Mean 0.4%    SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 188
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1023 (0%)     Mean 0%      SD 0%        Total 1/1025 (0.1%)    Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1023 (0%)     Mean 0%      SD 0%        Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1023 (0%)     Mean 0%      SD 0%        Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1023 (0%)     Mean 0%      SD 0%        Total 1/1025 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 189
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1023 (0%)     Mean 0%      SD 0%        Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1023 (0%)     Mean 0%      SD 0%        Total 2/1025 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1023 (0%)     Mean 0%      SD 0%        Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     1/60 (2%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.08%   SD 0.37%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 190
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     1/60 (2%)     |
|                                        0/59 (0%)     1/60 (2%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.08%   SD 0.37%     Total 1/1027 (0.1%)    Mean 0.08%   SD 0.37%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/54 (0%)                                                     |
|                                        1/59 (2%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 1/1018 (0.1%)   Mean 0.08%   SD 0.38%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 191
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/54 (0%)                                                     |
|                                        0/59 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/1018 (0%)     Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)                                                     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/54 (0%)                                                     |
|                                        0/59 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 1/1018 (0.1%)   Mean 0.1%    SD 0.45%                                                      |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     1/54 (2%)                                                     |
|                                        0/59 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 1/1018 (0.1%)   Mean 0.09%   SD 0.41%                                                      |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 192
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/44 (0%)     0/42 (0%)     0/45 (0%)           0/46 (0%)     0/43 (0%)     0/42 (0%)     |
|                                        0/41 (0%)     0/37 (0%)     0/45 (0%)           0/45 (0%)     0/43 (0%)     0/43 (0%)     |
|                                        0/42 (0%)     0/48 (0%)     0/46 (0%)           0/45 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     0/43 (0%)     0/43 (0%)           0/46 (0%)     0/40 (0%)     0/40 (0%)     |
|                                        0/46 (0%)     0/42 (0%)     0/44 (0%)           0/50 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/33 (0%)     0/41 (0%)     0/45 (0%)           0/44 (0%)     0/46 (0%)     0/57 (0%)     |
|                                        0/56 (0%)     0/55 (0%)                         0/53 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/885 (0%)      Mean 0%      SD 0%        Total 0/927 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              6/50 (12%)    3/50 (6%)     5/50 (10%)          8/50 (16%)    4/50 (8%)     3/49 (6%)     |
|                                        2/50 (4%)     4/50 (8%)     3/50 (6%)           1/50 (2%)     2/50 (4%)     2/50 (4%)     |
|                                        3/50 (6%)     7/50 (14%)    3/50 (6%)           1/50 (2%)     4/49 (8%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     9/50 (18%)          1/50 (2%)     2/50 (4%)     5/50 (10%)    |
|                                        1/50 (2%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     2/50 (4%)     1/50 (2%)     |
|                                        1/50 (2%)     4/50 (8%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         1/58 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 57/1024 (5.57%) Mean 5.68%   SD 4.84%     Total 39/1027 (3.8%)   Mean 3.9%    SD 4.04%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     1/49 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     3/50 (6%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           1/50 (2%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 11/1024 (1.07%) Mean 1.1%    SD 1.77%     Total 12/1027 (1.17%)  Mean 1.2%    SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)    3/50 (6%)     5/50 (10%)          8/50 (16%)    5/50 (10%)    3/49 (6%)     |
|                                        2/50 (4%)     4/50 (8%)     4/50 (8%)           2/50 (4%)     2/50 (4%)     2/50 (4%)     |
|                                        4/50 (8%)     7/50 (14%)    4/50 (8%)           3/50 (6%)     5/49 (10%)    2/50 (4%)     |
|                                        3/50 (6%)     3/50 (6%)    10/50 (20%)          2/50 (4%)     3/50 (6%)     6/50 (12%)    |
|                                        1/50 (2%)     4/50 (8%)     2/50 (4%)           3/50 (6%)     2/50 (4%)     1/50 (2%)     |
|                                        1/50 (2%)     4/50 (8%)     0/55 (0%)           1/50 (2%)     0/51 (0%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         1/58 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 68/1024 (6.64%) Mean 6.78%   SD 4.89%     Total 51/1027 (4.97%)  Mean 5.1%    SD 4.2%      |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1022 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 193
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1022 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1022 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1022 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 194
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 2/1024 (0.2%)   Mean 0.2%    SD 0.62%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 195
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 2/1024 (0.2%)   Mean 0.18%   SD 0.57%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         1/58 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 4/1027 (0.39%)   Mean 0.39%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 196
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 4/1024 (0.39%)  Mean 0.4%    SD 0.82%     Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 197
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 2/1024 (0.2%)   Mean 0.18%   SD 0.57%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 4/1024 (0.39%)  Mean 0.4%    SD 0.82%     Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 6/1024 (0.59%)  Mean 0.58%   SD 1.12%     Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 198
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         1/58 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 4/1027 (0.39%)   Mean 0.39%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     2/50 (4%)     0/47 (0%)           0/49 (0%)     2/50 (4%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/47 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/47 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     1/49 (2%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     2/50 (4%)     0/52 (0%)           0/50 (0%)     0/51 (0%)     0/59 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         0/58 (0%)     2/59 (3%)                   |
| Overall Incidence               Total 9/1007 (0.89%)  Mean 0.89%   SD 1.51%     Total 9/1016 (0.89%)   Mean 0.88%   SD 1.31%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/47 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/51 (0%)     0/59 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         1/58 (2%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1007 (0%)     Mean 0%      SD 0%        Total 1/1016 (0.1%)    Mean 0.09%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 199
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     2/50 (4%)     0/47 (0%)           0/49 (0%)     2/50 (4%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/47 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/47 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     1/49 (2%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     2/50 (4%)     0/52 (0%)           0/50 (0%)     0/51 (0%)     0/59 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         1/58 (2%)     2/59 (3%)                   |
| Overall Incidence               Total 9/1007 (0.89%)  Mean 0.89%   SD 1.51%     Total 10/1016 (0.98%)  Mean 0.96%   SD 1.31%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1018 (0%)     Mean 0%      SD 0%        Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1018 (0%)     Mean 0%      SD 0%        Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     1/49 (2%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1018 (0.1%)   Mean 0.1%    SD 0.46%     Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1018 (0.1%)   Mean 0.08%   SD 0.38%     Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 200
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 3/1018 (0.29%)  Mean 0.3%    SD 0.74%     Total 1/1025 (0.1%)    Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1018 (0.1%)   Mean 0.1%    SD 0.45%     Total 2/1025 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 4/1018 (0.39%)  Mean 0.4%    SD 1.05%     Total 2/1025 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1018 (0%)     Mean 0%      SD 0%        Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1018 (0%)     Mean 0%      SD 0%        Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 201
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1018 (0%)     Mean 0%      SD 0%        Total 1/1025 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1022 (0%)     Mean 0%      SD 0%        Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1022 (0.1%)   Mean 0.1%    SD 0.46%     Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1022 (0.1%)   Mean 0.08%   SD 0.38%     Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1022 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 202
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        2/49 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/55 (2%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     1/60 (2%)                         2/58 (3%)     0/60 (0%)                   |
| Overall Incidence               Total 15/1022 (1.47%) Mean 1.48%   SD 1.57%     Total 8/1022 (0.78%)   Mean 0.78%   SD 1.3%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     4/50 (8%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 6/1022 (0.59%)  Mean 0.6%    SD 1.85%     Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              13/50 (26%)   22/50 (44%)   13/50 (26%)         11/49 (22%)   16/50 (32%)    4/49 (8%)     |
|                                       22/50 (44%)   22/50 (44%)   13/50 (26%)         17/50 (34%)    8/50 (16%)    7/50 (14%)    |
|                                       19/49 (39%)   19/50 (38%)   20/50 (40%)         11/50 (22%)    5/49 (10%)   20/47 (43%)    |
|                                       12/49 (24%)   20/50 (40%)   17/50 (34%)          9/49 (18%)    9/50 (18%)   14/50 (28%)    |
|                                       23/50 (46%)   24/50 (48%)   17/50 (34%)         20/50 (40%)   12/50 (24%)    6/50 (12%)    |
|                                       12/50 (24%)   14/50 (28%)    8/55 (15%)          6/50 (12%)    6/51 (12%)    6/60 (10%)    |
|                                       13/59 (22%)   17/60 (28%)                       13/58 (22%)   13/60 (22%)                  |
| Overall Incidence               Total 340/1022 (33.27%Mean 33.51%  SD 9.51%     Total 213/1022 (20.84%)Mean 20.98%  SD 10.05%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            11/50 (22%)   10/50 (20%)    7/50 (14%)          4/49 (8%)    10/50 (20%)    7/49 (14%)    |
|                                       24/50 (48%)   23/50 (46%)   15/50 (30%)          4/50 (8%)    12/50 (24%)    9/50 (18%)    |
|                                       15/49 (31%)    7/50 (14%)   13/50 (26%)          4/50 (8%)     4/49 (8%)     5/47 (11%)    |
|                                       17/49 (35%)   12/50 (24%)   16/50 (32%)          6/49 (12%)   19/50 (38%)   10/50 (20%)    |
|                                       12/50 (24%)   14/50 (28%)   14/50 (28%)         15/50 (30%)    6/50 (12%)    4/50 (8%)     |
|                                       17/50 (34%)   12/50 (24%)    6/55 (11%)          7/50 (14%)    4/51 (8%)     8/60 (13%)    |
|                                       10/59 (17%)   11/60 (18%)                       11/58 (19%)    7/60 (12%)                  |
| Overall Incidence               Total 266/1022 (26.03%Mean 26.27%  SD 9.8%      Total 156/1022 (15.26%)Mean 15.27%  SD 8.11%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         11/50 (22%)   10/50 (20%)    7/50 (14%)          4/49 (8%)    10/50 (20%)    7/49 (14%)    |
|      Hepatoblastoma                   24/50 (48%)   27/50 (54%)   15/50 (30%)          4/50 (8%)    12/50 (24%)    9/50 (18%)    |
|                                       15/49 (31%)    7/50 (14%)   13/50 (26%)          4/50 (8%)     4/49 (8%)     5/47 (11%)    |
|                                       17/49 (35%)   12/50 (24%)   16/50 (32%)          6/49 (12%)   19/50 (38%)   10/50 (20%)    |
|                                       12/50 (24%)   14/50 (28%)   14/50 (28%)         15/50 (30%)    6/50 (12%)    4/50 (8%)     |
|                                       17/50 (34%)   12/50 (24%)    6/55 (11%)          7/50 (14%)    4/51 (8%)     8/60 (13%)    |
|                                       10/59 (17%)   11/60 (18%)                       11/58 (19%)    7/60 (12%)                  |
| Overall Incidence               Total 270/1022 (26.42%Mean 26.67%  SD 10.76%    Total 156/1022 (15.26%)Mean 15.27%  SD 8.11%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 203
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         21/50 (42%)   30/50 (60%)   19/50 (38%)         15/49 (31%)   22/50 (44%)    9/49 (18%)    |
|      Hepatocellular Adenoma           43/50 (86%)   38/50 (76%)   28/50 (56%)         20/50 (40%)   18/50 (36%)   14/50 (28%)    |
|                                       32/49 (65%)   24/50 (48%)   30/50 (60%)         14/50 (28%)    9/49 (18%)   23/47 (49%)    |
|                                       27/49 (55%)   30/50 (60%)   29/50 (58%)         12/49 (24%)   23/50 (46%)   19/50 (38%)    |
|                                       30/50 (60%)   35/50 (70%)   28/50 (56%)         27/50 (54%)   17/50 (34%)   10/50 (20%)    |
|                                       27/50 (54%)   24/50 (48%)   12/55 (22%)         13/50 (26%)   10/51 (20%)   14/60 (23%)    |
|                                       23/59 (39%)   26/60 (43%)                       20/58 (34%)   18/60 (30%)                  |
| Overall Incidence               Total 556/1022 (54.4%)Mean 54.83%  SD 14.32%    Total 327/1022 (32%)   Mean 32.11%  SD 10.54%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           21/50 (42%)   30/50 (60%)   19/50 (38%)         15/49 (31%)   22/50 (44%)    9/49 (18%)    |
|      Hepatocellular Adenoma, or       43/50 (86%)   40/50 (80%)   28/50 (56%)         20/50 (40%)   18/50 (36%)   14/50 (28%)    |
|      Hepatoblastoma                   32/49 (65%)   24/50 (48%)   30/50 (60%)         14/50 (28%)    9/49 (18%)   23/47 (49%)    |
|                                       27/49 (55%)   30/50 (60%)   29/50 (58%)         12/49 (24%)   23/50 (46%)   19/50 (38%)    |
|                                       30/50 (60%)   35/50 (70%)   28/50 (56%)         27/50 (54%)   17/50 (34%)   10/50 (20%)    |
|                                       27/50 (54%)   24/50 (48%)   12/55 (22%)         13/50 (26%)   10/51 (20%)   14/60 (23%)    |
|                                       23/59 (39%)   26/60 (43%)                       20/58 (34%)   18/60 (30%)                  |
| Overall Incidence               Total 558/1022 (54.6%)Mean 55.03%  SD 14.65%    Total 327/1022 (32%)   Mean 32.11%  SD 10.54%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             1/50 (2%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     2/50 (4%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/47 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     1/50 (2%)           2/49 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     3/50 (6%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     1/51 (2%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 9/1022 (0.88%)  Mean 0.88%   SD 1.51%     Total 13/1022 (1.27%)  Mean 1.31%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1022 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1022 (0%)     Mean 0%      SD 0%        Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 204
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1022 (0%)     Mean 0%      SD 0%        Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1022 (0%)     Mean 0%      SD 0%        Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1022 (0%)     Mean 0%      SD 0%        Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1022 (0%)     Mean 0%      SD 0%        Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1021 (0%)     Mean 0%      SD 0%        Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 205
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        18/50 (36%)    9/50 (18%)    6/50 (12%)          4/50 (8%)     7/50 (14%)    7/49 (14%)    |
|                                        8/50 (16%)    9/50 (18%)   16/50 (32%)          2/50 (4%)     3/50 (6%)     2/50 (4%)     |
|                                        8/48 (17%)   11/49 (22%)   12/50 (24%)          2/50 (4%)     4/48 (8%)     2/49 (4%)     |
|                                        5/50 (10%)    9/50 (18%)   11/50 (22%)          0/50 (0%)     1/50 (2%)     3/50 (6%)     |
|                                        6/50 (12%)   18/50 (36%)   12/50 (24%)          4/50 (8%)     1/50 (2%)     3/50 (6%)     |
|                                        5/50 (10%)    7/50 (14%)    7/55 (13%)          4/50 (8%)     4/51 (8%)     2/60 (3%)     |
|                                        6/59 (10%)    5/60 (8%)                         3/58 (5%)     3/60 (5%)                   |
| Overall Incidence               Total 188/1021 (18.41%Mean 18.62%  SD 8.42%     Total 61/1025 (5.95%)  Mean 6%      SD 3.6%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       5/50 (10%)    5/50 (10%)    4/50 (8%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        6/50 (12%)    4/50 (8%)     4/50 (8%)           2/50 (4%)     1/50 (2%)     4/50 (8%)     |
|                                       10/48 (21%)    0/49 (0%)     6/50 (12%)          1/50 (2%)     3/48 (6%)     4/49 (8%)     |
|                                        7/50 (14%)    2/50 (4%)     2/50 (4%)           3/50 (6%)     2/50 (4%)     0/50 (0%)     |
|                                        8/50 (16%)    6/50 (12%)    2/50 (4%)           2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     4/55 (7%)           0/50 (0%)     2/51 (4%)     4/60 (7%)     |
|                                        7/59 (12%)    9/60 (15%)                        7/58 (12%)    4/60 (7%)                   |
| Overall Incidence               Total 94/1021 (9.21%) Mean 9.15%   SD 5.25%     Total 42/1025 (4.1%)   Mean 3.99%   SD 3.29%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   21/50 (42%)   14/50 (28%)   10/50 (20%)          4/50 (8%)     7/50 (14%)    8/49 (16%)    |
|      Alveolar/Bronchiolar Adenoma     13/50 (26%)   11/50 (22%)   20/50 (40%)          4/50 (8%)     4/50 (8%)     6/50 (12%)    |
|                                       18/48 (38%)   11/49 (22%)   17/50 (34%)          3/50 (6%)     7/48 (15%)    6/49 (12%)    |
|                                       12/50 (24%)   11/50 (22%)   13/50 (26%)          3/50 (6%)     3/50 (6%)     3/50 (6%)     |
|                                       14/50 (28%)   21/50 (42%)   14/50 (28%)          6/50 (12%)    2/50 (4%)     4/50 (8%)     |
|                                        7/50 (14%)    8/50 (16%)    9/55 (16%)          4/50 (8%)     6/51 (12%)    6/60 (10%)    |
|                                       13/59 (22%)   13/60 (22%)                        9/58 (16%)    7/60 (12%)                  |
| Overall Incidence               Total 270/1021 (26.44%Mean 26.6%   SD 8.48%     Total 102/1025 (9.95%) Mean 9.91%   SD 3.6%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1021 (0%)     Mean 0%      SD 0%        Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1021 (0%)     Mean 0%      SD 0%        Total 1/1025 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 206
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1021 (0.1%)   Mean 0.1%    SD 0.45%     Total 2/1025 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1021 (0%)     Mean 0%      SD 0%        Total 1/1025 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1021 (0%)     Mean 0%      SD 0%        Total 0/1025 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 207
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.08%   SD 0.38%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 208
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     1/60 (2%)     |
|                                        0/59 (0%)     0/60 (0%)                         1/58 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 2/1027 (0.19%)   Mean 0.17%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 209
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/49 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           1/50 (2%)     0/51 (0%)     2/60 (3%)     |
|                                        0/59 (0%)     0/60 (0%)                         1/58 (2%)     2/60 (3%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 24/1027 (2.34%)  Mean 2.33%   SD 2.08%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/49 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           1/50 (2%)     0/51 (0%)     2/60 (3%)     |
|                                        0/59 (0%)     0/60 (0%)                         1/58 (2%)     2/60 (3%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 24/1027 (2.34%)  Mean 2.33%   SD 2.08%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 210
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     3/49 (6%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/49 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           1/50 (2%)     0/51 (0%)     2/60 (3%)     |
|                                        0/59 (0%)     0/60 (0%)                         1/58 (2%)     2/60 (3%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 24/1027 (2.34%)  Mean 2.33%   SD 2.08%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 211
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     1/60 (2%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 3/1027 (0.29%)   Mean 0.28%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 212
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/55 (2%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.09%   SD 0.41%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 2/1027 (0.19%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/53 (0%)           0/49 (0%)     0/51 (0%)     0/59 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1018 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/53 (0%)           0/49 (0%)     0/51 (0%)     0/59 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1018 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 213
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/53 (0%)           0/49 (0%)     0/51 (0%)     0/59 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1018 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/53 (0%)           0/49 (0%)     0/51 (0%)     0/59 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1018 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 2/1027 (0.19%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 214
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              2/49 (4%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     1/49 (2%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 3/1006 (0.3%)    Mean 0.31%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     1/48 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 1/1006 (0.1%)    Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/49 (0%)     0/50 (0%)     1/48 (2%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 1/1006 (0.1%)    Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/1006 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 215
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/49 (0%)     2/50 (4%)     1/48 (2%)     |
|                                                                                        1/48 (2%)     2/48 (4%)     2/50 (4%)     |
|                                                                                        1/49 (2%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        1/50 (2%)     1/50 (2%)     2/47 (4%)     |
|                                                                                        1/50 (2%)     0/49 (0%)     2/50 (4%)     |
|                                                                                        2/49 (4%)     1/49 (2%)     1/57 (2%)     |
|                                                                                        2/58 (3%)     2/58 (3%)                   |
| Overall Incidence                                                               Total 24/1006 (2.39%)  Mean 2.37%   SD 1.52%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/1006 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     1/48 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     1/49 (2%)     1/48 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     1/58 (2%)                   |
| Overall Incidence                                                               Total 6/1006 (0.6%)    Mean 0.6%    SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/1006 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|      Malignant, NOS                                                                    0/48 (0%)     1/48 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     1/49 (2%)     1/48 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     1/58 (2%)                   |
| Overall Incidence                                                               Total 6/1006 (0.6%)    Mean 0.6%    SD 0.94%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 216
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/1006 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           1/49 (2%)     1/50 (2%)     1/48 (2%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 3/1006 (0.3%)    Mean 0.31%   SD 0.75%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/1006 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/1006 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)     0/50 (0%)     1/48 (2%)     |
|                                                                                        0/48 (0%)     1/48 (2%)     1/50 (2%)     |
|                                                                                        2/49 (4%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 6/1006 (0.6%)    Mean 0.61%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 217
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/1006 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     1/48 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     1/48 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     1/57 (2%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 4/1006 (0.4%)    Mean 0.4%    SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 1/1006 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 0/1006 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     1/57 (2%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 2/1006 (0.2%)    Mean 0.19%   SD 0.59%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 218
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 1/1006 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     1/48 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/57 (0%)     |
|                                                                                        0/58 (0%)     0/58 (0%)                   |
| Overall Incidence                                                               Total 2/1006 (0.2%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1009 (0%)     Mean 0%      SD 0%        Total 0/1017 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     1/50 (2%)           1/49 (2%)     0/48 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/1009 (0.1%)   Mean 0.1%    SD 0.45%     Total 2/1017 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     1/50 (2%)           1/49 (2%)     0/48 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/1009 (0.1%)   Mean 0.1%    SD 0.45%     Total 2/1017 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 219
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/52 (0%)           1/50 (2%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1009 (0%)     Mean 0%      SD 0%        Total 1/1017 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1009 (0%)     Mean 0%      SD 0%        Total 0/1017 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1009 (0%)     Mean 0%      SD 0%        Total 0/1017 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1009 (0%)     Mean 0%      SD 0%        Total 1/1017 (0.1%)    Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1009 (0%)     Mean 0%      SD 0%        Total 0/1017 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 220
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/39 (0%)     0/26 (0%)     0/39 (0%)           0/40 (0%)     0/31 (0%)     0/24 (0%)     |
|                                        0/35 (0%)     0/19 (0%)     0/32 (0%)           0/35 (0%)     0/25 (0%)     0/32 (0%)     |
|                                        0/21 (0%)     0/31 (0%)     0/41 (0%)           0/27 (0%)     0/34 (0%)     0/35 (0%)     |
|                                        0/43 (0%)     0/36 (0%)     0/41 (0%)           0/44 (0%)     0/31 (0%)     1/33 (3%)     |
|                                        0/47 (0%)     0/39 (0%)     0/39 (0%)           0/44 (0%)     0/30 (0%)     0/45 (0%)     |
|                                        0/22 (0%)     0/29 (0%)     0/36 (0%)           0/26 (0%)     0/21 (0%)     0/49 (0%)     |
|                                        0/54 (0%)     0/48 (0%)                         0/52 (0%)     0/40 (0%)                   |
| Overall Incidence               Total 0/717 (0%)      Mean 0%      SD 0%        Total 1/698 (0.14%)    Mean 0.15%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/50 (2%)     0/49 (0%)     0/46 (0%)           7/50 (14%)    5/50 (10%)   14/48 (29%)    |
|   Adenoma                              1/49 (2%)     0/48 (0%)     0/50 (0%)           4/49 (8%)    11/48 (23%)    7/48 (15%)    |
|                                        1/46 (2%)     0/49 (0%)     0/50 (0%)          20/49 (41%)    8/49 (16%)    8/49 (16%)    |
|                                        0/49 (0%)     0/47 (0%)     1/47 (2%)          10/50 (20%)    9/49 (18%)    9/50 (18%)    |
|                                        0/47 (0%)     1/45 (2%)     0/43 (0%)          17/50 (34%)   10/47 (21%)    5/49 (10%)    |
|                                        0/44 (0%)     0/47 (0%)     0/54 (0%)           4/48 (8%)    12/48 (25%)    6/59 (10%)    |
|                                        0/56 (0%)     0/52 (0%)                         8/58 (14%)    8/58 (14%)                  |
| Overall Incidence               Total 5/968 (0.52%)   Mean 0.53%   SD 0.94%     Total 182/1006 (18.09%)Mean 18.26%  SD 8.68%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     1/50 (2%)     0/48 (0%)     |
|   Carcinoma                            0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/46 (0%)     1/49 (2%)     0/50 (0%)           1/49 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/47 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/43 (0%)           0/50 (0%)     0/47 (0%)     1/49 (2%)     |
|                                        0/44 (0%)     0/47 (0%)     0/54 (0%)           0/48 (0%)     0/48 (0%)     1/59 (2%)     |
|                                        0/56 (0%)     0/52 (0%)                         0/58 (0%)     0/58 (0%)                   |
| Overall Incidence               Total 1/968 (0.1%)    Mean 0.1%    SD 0.46%     Total 4/1006 (0.4%)    Mean 0.39%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/50 (2%)     0/49 (0%)     0/46 (0%)           7/50 (14%)    6/50 (12%)   14/48 (29%)    |
|   Carcinoma or Adenoma                 1/49 (2%)     0/48 (0%)     0/50 (0%)           4/49 (8%)    11/48 (23%)    7/48 (15%)    |
|                                        1/46 (2%)     1/49 (2%)     0/50 (0%)          21/49 (43%)    8/49 (16%)    8/49 (16%)    |
|                                        0/49 (0%)     0/47 (0%)     1/47 (2%)          10/50 (20%)    9/49 (18%)    9/50 (18%)    |
|                                        0/47 (0%)     1/45 (2%)     0/43 (0%)          17/50 (34%)   10/47 (21%)    6/49 (12%)    |
|                                        0/44 (0%)     0/47 (0%)     0/54 (0%)           4/48 (8%)    12/48 (25%)    7/59 (12%)    |
|                                        0/56 (0%)     0/52 (0%)                         8/58 (14%)    8/58 (14%)                  |
| Overall Incidence               Total 6/968 (0.62%)   Mean 0.63%   SD 0.99%     Total 186/1006 (18.49%)Mean 18.65%  SD 8.72%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 221
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     0/49 (0%)     1/46 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           1/49 (2%)     0/48 (0%)     1/48 (2%)     |
|                                        1/46 (2%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/47 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/47 (2%)     0/45 (0%)     0/43 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/47 (0%)     0/54 (0%)           0/48 (0%)     2/48 (4%)     0/59 (0%)     |
|                                        0/56 (0%)     0/52 (0%)                         0/58 (0%)     0/58 (0%)                   |
| Overall Incidence               Total 3/968 (0.31%)   Mean 0.32%   SD 0.79%     Total 4/1006 (0.4%)    Mean 0.41%   SD 1.09%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/46 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/47 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/43 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/47 (0%)     0/54 (0%)           0/48 (0%)     0/48 (0%)     0/59 (0%)     |
|                                        0/56 (0%)     0/52 (0%)                         0/58 (0%)     0/58 (0%)                   |
| Overall Incidence               Total 0/968 (0%)      Mean 0%      SD 0%        Total 0/1006 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     1/46 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           1/49 (2%)     0/48 (0%)     1/48 (2%)     |
|                                        1/46 (2%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/47 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/47 (2%)     0/45 (0%)     0/43 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/47 (0%)     0/54 (0%)           0/48 (0%)     2/48 (4%)     0/59 (0%)     |
|                                        0/56 (0%)     0/52 (0%)                         0/58 (0%)     0/58 (0%)                   |
| Overall Incidence               Total 3/968 (0.31%)   Mean 0.32%   SD 0.79%     Total 4/1006 (0.4%)    Mean 0.41%   SD 1.09%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/47 (0%)     0/49 (0%)     0/45 (0%)                                                     |
|                                        0/49 (0%)     0/46 (0%)     0/49 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)                                                     |
|                                        0/49 (0%)     0/48 (0%)     0/49 (0%)                                                     |
|                                        0/49 (0%)     0/48 (0%)     0/45 (0%)                                                     |
|                                        0/46 (0%)     0/50 (0%)     0/51 (0%)                                                     |
|                                        0/59 (0%)     0/59 (0%)                                                                   |
| Overall Incidence               Total 0/985 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/47 (0%)     0/49 (0%)     0/45 (0%)                                                     |
|                                        0/49 (0%)     0/46 (0%)     0/49 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)                                                     |
|                                        0/49 (0%)     0/48 (0%)     0/49 (0%)                                                     |
|                                        0/49 (0%)     0/48 (0%)     0/45 (0%)                                                     |
|                                        0/46 (0%)     0/50 (0%)     0/51 (0%)                                                     |
|                                        0/59 (0%)     0/59 (0%)                                                                   |
| Overall Incidence               Total 0/985 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 222
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/47 (0%)     0/49 (0%)     0/45 (0%)                                                     |
|                                        0/49 (0%)     0/46 (0%)     0/49 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)                                                     |
|                                        0/49 (0%)     0/48 (0%)     0/49 (0%)                                                     |
|                                        0/49 (0%)     0/48 (0%)     0/45 (0%)                                                     |
|                                        0/46 (0%)     0/50 (0%)     0/51 (0%)                                                     |
|                                        0/59 (0%)     0/59 (0%)                                                                   |
| Overall Incidence               Total 0/985 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1017 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1017 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1017 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1017 (0%)     Mean 0%      SD 0%        Total 0/1021 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 223
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)                                                     |
|                                        0/59 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)                                                     |
|                                        0/59 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%                                                      |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)                                                     |
|                                        0/59 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%                                                      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 224
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     1/60 (2%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.08%   SD 0.37%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     1/60 (2%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.08%   SD 0.37%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 225
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 226
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     1/60 (2%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.08%   SD 0.37%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     1/60 (2%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 2/1027 (0.19%)   Mean 0.18%   SD 0.57%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|      Papilloma, Sq Papilloma,          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Keratoacanthoma,                  0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     1/60 (2%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 6/1027 (0.58%)   Mean 0.58%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 227
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     1/60 (2%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.08%   SD 0.37%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     1/51 (2%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 1/1027 (0.1%)    Mean 0.1%    SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     1/60 (2%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 3/1024 (0.29%)  Mean 0.3%    SD 0.73%     Total 6/1027 (0.58%)   Mean 0.58%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 228
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 229
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 2/1027 (0.19%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|      Carcinoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     1/60 (2%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 3/1027 (0.29%)   Mean 0.28%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 230
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 4/1027 (0.39%)   Mean 0.4%    SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 2/1027 (0.19%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     0/49 (0%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     6/50 (12%)    1/50 (2%)     |
|      Histiocytoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/49 (2%)     2/50 (4%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     1/51 (2%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         2/58 (3%)     5/60 (8%)                   |
| Overall Incidence               Total 10/1024 (0.98%) Mean 0.98%   SD 1.2%      Total 28/1027 (2.73%)  Mean 2.69%   SD 3.22%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 231
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         2/58 (3%)     5/60 (8%)                   |
| Overall Incidence               Total 4/1024 (0.39%)  Mean 0.38%   SD 0.79%     Total 10/1027 (0.97%)  Mean 0.89%   SD 2.02%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     0/49 (0%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     6/50 (12%)    1/50 (2%)     |
|      Histiocytoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/49 (2%)     2/50 (4%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     1/51 (2%)     0/60 (0%)     |
|                                        1/59 (2%)     0/60 (0%)                         2/58 (3%)     5/60 (8%)                   |
| Overall Incidence               Total 10/1024 (0.98%) Mean 0.98%   SD 1.2%      Total 28/1027 (2.73%)  Mean 2.69%   SD 3.22%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 232
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     1/51 (2%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     1/51 (2%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     6/50 (12%)    1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/49 (0%)     2/50 (4%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     1/51 (2%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 6/1024 (0.59%)  Mean 0.6%    SD 0.94%     Total 18/1027 (1.75%)  Mean 1.8%    SD 2.97%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     1/51 (2%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 233
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/54 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         1/58 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1013 (0%)     Mean 0%      SD 0%        Total 1/1023 (0.1%)    Mean 0.09%   SD 0.39%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/54 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1013 (0%)     Mean 0%      SD 0%        Total 0/1023 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/54 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1013 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1023 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           2/49 (4%)     1/50 (2%)     2/49 (4%)     |
|                                        0/50 (0%)     1/47 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     3/49 (6%)     |
|                                        1/50 (2%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           1/49 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/54 (2%)           0/50 (0%)     1/51 (2%)     2/60 (3%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     1/60 (2%)                   |
| Overall Incidence               Total 6/1013 (0.59%)  Mean 0.61%   SD 0.95%     Total 16/1023 (1.56%)  Mean 1.57%   SD 1.77%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 234
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/54 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1013 (0%)     Mean 0%      SD 0%        Total 1/1023 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/54 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1013 (0%)     Mean 0%      SD 0%        Total 0/1023 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 235
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     1/60 (2%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 2/1027 (0.19%)   Mean 0.18%   SD 0.57%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|      Papilloma Squamous                1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/55 (2%)           1/50 (2%)     0/51 (0%)     2/60 (3%)     |
|                                        0/59 (0%)     0/60 (0%)                         1/58 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 6/1024 (0.59%)  Mean 0.59%   SD 0.93%     Total 10/1027 (0.97%)  Mean 0.95%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/55 (2%)           1/50 (2%)     0/51 (0%)     1/60 (2%)     |
|                                        0/59 (0%)     0/60 (0%)                         1/58 (2%)     0/60 (0%)                   |
| Overall Incidence               Total 6/1024 (0.59%)  Mean 0.59%   SD 0.93%     Total 8/1027 (0.78%)   Mean 0.77%   SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 236
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 2/1024 (0.2%)   Mean 0.2%    SD 0.62%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        1/49 (2%)     0/50 (0%)     0/55 (0%)                                                     |
|                                        1/59 (2%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 7/1020 (0.69%)  Mean 0.69%   SD 1.16%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/55 (0%)                                                     |
|                                        0/59 (0%)     0/60 (0%)                                                                   |
| Overall Incidence               Total 1/1020 (0.1%)   Mean 0.1%    SD 0.45%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 237
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/39 (0%)     0/47 (0%)     0/41 (0%)           0/45 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/39 (0%)     0/30 (0%)     0/33 (0%)           0/41 (0%)     0/40 (0%)     0/43 (0%)     |
|                                        0/39 (0%)     0/35 (0%)     0/41 (0%)           0/47 (0%)     0/40 (0%)     0/45 (0%)     |
|                                        0/37 (0%)     0/45 (0%)     0/43 (0%)           0/42 (0%)     0/47 (0%)     0/56 (0%)     |
|                                        0/46 (0%)     0/54 (0%)                         0/58 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/800 (0%)      Mean 0%      SD 0%        Total 0/920 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/39 (0%)     0/47 (0%)     0/41 (0%)           0/45 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/39 (0%)     0/30 (0%)     0/33 (0%)           0/41 (0%)     0/40 (0%)     0/43 (0%)     |
|                                        0/39 (0%)     0/35 (0%)     0/41 (0%)           0/47 (0%)     0/40 (0%)     0/45 (0%)     |
|                                        0/37 (0%)     0/45 (0%)     0/43 (0%)           0/42 (0%)     0/47 (0%)     0/56 (0%)     |
|                                        0/46 (0%)     0/54 (0%)                         0/58 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/800 (0%)      Mean 0%      SD 0%        Total 0/920 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/39 (0%)     0/47 (0%)     0/41 (0%)           0/45 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/39 (0%)     0/30 (0%)     0/33 (0%)           0/41 (0%)     0/40 (0%)     0/43 (0%)     |
|                                        0/39 (0%)     0/35 (0%)     0/41 (0%)           0/47 (0%)     0/40 (0%)     0/45 (0%)     |
|                                        0/37 (0%)     0/45 (0%)     0/43 (0%)           0/42 (0%)     0/47 (0%)     0/56 (0%)     |
|                                        0/46 (0%)     0/54 (0%)                         0/58 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/800 (0%)      Mean 0%      SD 0%        Total 0/920 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/47 (0%)     0/43 (0%)     1/44 (2%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/39 (0%)     0/47 (0%)     0/41 (0%)           0/45 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/39 (0%)     0/30 (0%)     0/33 (0%)           0/41 (0%)     0/40 (0%)     0/43 (0%)     |
|                                        0/39 (0%)     0/35 (0%)     0/41 (0%)           0/47 (0%)     0/40 (0%)     0/45 (0%)     |
|                                        0/37 (0%)     0/45 (0%)     0/43 (0%)           0/42 (0%)     0/47 (0%)     0/56 (0%)     |
|                                        0/46 (0%)     0/54 (0%)                         0/58 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 1/800 (0.13%)   Mean 0.11%   SD 0.51%     Total 0/920 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/39 (0%)     0/47 (0%)     0/41 (0%)           0/45 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/39 (0%)     0/30 (0%)     0/33 (0%)           0/41 (0%)     0/40 (0%)     1/43 (2%)     |
|                                        0/39 (0%)     0/35 (0%)     0/41 (0%)           0/47 (0%)     0/40 (0%)     0/45 (0%)     |
|                                        0/37 (0%)     0/45 (0%)     0/43 (0%)           0/42 (0%)     0/47 (0%)     0/56 (0%)     |
|                                        0/46 (0%)     0/54 (0%)                         0/58 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/800 (0%)      Mean 0%      SD 0%        Total 1/920 (0.11%)    Mean 0.12%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 238
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/39 (0%)     0/47 (0%)     0/41 (0%)           0/45 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/39 (0%)     0/30 (0%)     0/33 (0%)           0/41 (0%)     0/40 (0%)     0/43 (0%)     |
|                                        0/39 (0%)     0/35 (0%)     0/41 (0%)           0/47 (0%)     0/40 (0%)     0/45 (0%)     |
|                                        0/37 (0%)     0/45 (0%)     0/43 (0%)           0/42 (0%)     0/47 (0%)     0/56 (0%)     |
|                                        0/46 (0%)     0/54 (0%)                         0/58 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/800 (0%)      Mean 0%      SD 0%        Total 0/920 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/39 (0%)     0/47 (0%)     0/41 (0%)           0/45 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/39 (0%)     0/30 (0%)     0/33 (0%)           0/41 (0%)     0/40 (0%)     1/43 (2%)     |
|                                        0/39 (0%)     0/35 (0%)     0/41 (0%)           0/47 (0%)     0/40 (0%)     0/45 (0%)     |
|                                        0/37 (0%)     0/45 (0%)     0/43 (0%)           0/42 (0%)     0/47 (0%)     0/56 (0%)     |
|                                        0/46 (0%)     0/54 (0%)                         0/58 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/800 (0%)      Mean 0%      SD 0%        Total 1/920 (0.11%)    Mean 0.12%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/39 (0%)     0/47 (0%)     0/41 (0%)           0/45 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/39 (0%)     0/30 (0%)     0/33 (0%)           0/41 (0%)     0/40 (0%)     0/43 (0%)     |
|                                        0/39 (0%)     0/35 (0%)     0/41 (0%)           0/47 (0%)     0/40 (0%)     0/45 (0%)     |
|                                        0/37 (0%)     0/45 (0%)     0/43 (0%)           0/42 (0%)     0/47 (0%)     0/56 (0%)     |
|                                        0/46 (0%)     0/54 (0%)                         0/58 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/800 (0%)      Mean 0%      SD 0%        Total 0/920 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/39 (0%)     0/47 (0%)     0/41 (0%)           0/45 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/39 (0%)     0/30 (0%)     0/33 (0%)           0/41 (0%)     0/40 (0%)     0/43 (0%)     |
|                                        0/39 (0%)     0/35 (0%)     0/41 (0%)           0/47 (0%)     0/40 (0%)     0/45 (0%)     |
|                                        0/37 (0%)     0/45 (0%)     0/43 (0%)           0/42 (0%)     0/47 (0%)     0/56 (0%)     |
|                                        0/46 (0%)     0/54 (0%)                         0/58 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/800 (0%)      Mean 0%      SD 0%        Total 0/920 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/46 (0%)     0/44 (0%)     |
|                                        0/34 (0%)     0/28 (0%)     0/35 (0%)           0/44 (0%)     0/41 (0%)     0/42 (0%)     |
|                                        0/39 (0%)     0/47 (0%)     0/41 (0%)           0/45 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/39 (0%)     0/30 (0%)     0/33 (0%)           0/41 (0%)     0/40 (0%)     1/43 (2%)     |
|                                        0/39 (0%)     0/35 (0%)     0/41 (0%)           0/47 (0%)     0/40 (0%)     0/45 (0%)     |
|                                        0/37 (0%)     0/45 (0%)     0/43 (0%)           0/42 (0%)     0/47 (0%)     0/56 (0%)     |
|                                        0/46 (0%)     0/54 (0%)                         0/58 (0%)     0/57 (0%)                   |
| Overall Incidence               Total 0/800 (0%)      Mean 0%      SD 0%        Total 1/920 (0.11%)    Mean 0.12%   SD 0.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 239
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/53 (0%)           0/50 (0%)     0/51 (0%)     0/59 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1013 (0%)     Mean 0%      SD 0%        Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/53 (0%)           0/50 (0%)     0/51 (0%)     0/59 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/1013 (0.1%)   Mean 0.1%    SD 0.46%     Total 1/1022 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/53 (0%)           0/50 (0%)     0/51 (0%)     0/59 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1013 (0%)     Mean 0%      SD 0%        Total 0/1022 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/53 (0%)           0/50 (0%)     0/51 (0%)     0/59 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/1013 (0.1%)   Mean 0.1%    SD 0.46%     Total 1/1022 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/50 (4%)     2/50 (4%)     2/49 (4%)           1/50 (2%)     1/50 (2%)     2/49 (4%)     |
|                                        1/50 (2%)     0/49 (0%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     3/50 (6%)     |
|                                        1/48 (2%)     1/48 (2%)     0/50 (0%)           4/50 (8%)     1/49 (2%)     1/48 (2%)     |
|                                        3/50 (6%)     1/50 (2%)     1/50 (2%)           3/50 (6%)     2/50 (4%)     4/50 (8%)     |
|                                        0/49 (0%)     4/49 (8%)     1/49 (2%)           2/50 (4%)     2/50 (4%)     2/49 (4%)     |
|                                        3/50 (6%)     1/50 (2%)     2/53 (4%)           5/50 (10%)    4/51 (8%)     2/59 (3%)     |
|                                        4/59 (7%)     0/60 (0%)                         2/58 (3%)     1/59 (2%)                   |
| Overall Incidence               Total 30/1013 (2.96%) Mean 2.95%   SD 2.36%     Total 46/1022 (4.5%)   Mean 4.53%   SD 2.46%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 240
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/48 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           3/50 (6%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/53 (0%)           0/50 (0%)     0/51 (0%)     1/59 (2%)     |
|                                        0/59 (0%)     0/60 (0%)                         1/58 (2%)     0/59 (0%)                   |
| Overall Incidence               Total 3/1013 (0.3%)   Mean 0.3%    SD 0.74%     Total 8/1022 (0.78%)   Mean 0.77%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     2/50 (4%)     2/49 (4%)           1/50 (2%)     1/50 (2%)     2/49 (4%)     |
|                                        1/50 (2%)     0/49 (0%)     1/50 (2%)           1/50 (2%)     4/50 (8%)     3/50 (6%)     |
|                                        2/48 (4%)     1/48 (2%)     0/50 (0%)           4/50 (8%)     1/49 (2%)     1/48 (2%)     |
|                                        4/50 (8%)     2/50 (4%)     1/50 (2%)           3/50 (6%)     2/50 (4%)     4/50 (8%)     |
|                                        0/49 (0%)     4/49 (8%)     1/49 (2%)           5/50 (10%)    3/50 (6%)     3/49 (6%)     |
|                                        3/50 (6%)     1/50 (2%)     2/53 (4%)           5/50 (10%)    4/51 (8%)     3/59 (5%)     |
|                                        4/59 (7%)     0/60 (0%)                         3/58 (5%)     1/59 (2%)                   |
| Overall Incidence               Total 33/1013 (3.26%) Mean 3.25%   SD 2.53%     Total 54/1022 (5.28%)  Mean 5.31%   SD 2.76%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 241
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           1/50 (2%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 242
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 2/1027 (0.19%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 1/1027 (0.1%)    Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 4/1024 (0.39%)  Mean 0.4%    SD 0.82%     Total 2/1027 (0.19%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 243
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/48 (0%)     0/45 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/52 (0%)           0/47 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/59 (0%)                         0/56 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/1004 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/48 (0%)     0/45 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/52 (0%)           0/47 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/59 (0%)                         0/56 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1004 (0%)     Mean 0%      SD 0%        Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/48 (0%)     0/45 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/52 (0%)           0/47 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/59 (0%)                         0/56 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 0/1004 (0%)     Mean 0%      SD 0%        Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/48 (0%)     0/45 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/52 (0%)           0/47 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        1/59 (2%)     0/59 (0%)                         0/56 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/1004 (0.1%)   Mean 0.08%   SD 0.38%     Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/48 (0%)     0/45 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/52 (0%)           0/47 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/59 (0%)                         0/56 (0%)     0/59 (0%)                   |
| Overall Incidence               Total 1/1004 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 244
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/51 (0%)     0/60 (0%)     |
|                                                                                        0/58 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 3/1027 (0.29%)   Mean 0.3%    SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                                                                        0/58 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                                                                        0/58 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                                                                        0/58 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/51 (2%)     0/60 (0%)     |
|                                                                                        1/58 (2%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 7/1027 (0.68%)   Mean 0.69%   SD 1.16%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 245
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     2/49 (4%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                                                                        0/58 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 2/1027 (0.19%)   Mean 0.2%    SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/51 (0%)     1/60 (2%)     |
|                                                                                        0/58 (0%)     1/60 (2%)                   |
| Overall Incidence                                                               Total 5/1027 (0.49%)   Mean 0.47%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/51 (0%)     0/60 (0%)     |
|                                                                                        0/58 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 2/1027 (0.19%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/50 (4%)     1/50 (2%)     2/49 (4%)     |
|                                                                                        2/50 (4%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        3/50 (6%)     0/49 (0%)     3/50 (6%)     |
|                                                                                        2/50 (4%)     4/50 (8%)     4/50 (8%)     |
|                                                                                        1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                                                                        2/50 (4%)     3/51 (6%)     2/60 (3%)     |
|                                                                                        1/58 (2%)     2/60 (3%)                   |
| Overall Incidence                                                               Total 38/1027 (3.7%)   Mean 3.72%   SD 2.25%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                                                                        0/58 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 246
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/51 (2%)     1/60 (2%)     |
|                                                                                        0/58 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 4/1027 (0.39%)   Mean 0.38%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/50 (4%)     1/50 (2%)     2/49 (4%)     |
|                                                                                        2/50 (4%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        3/50 (6%)     0/49 (0%)     3/50 (6%)     |
|                                                                                        2/50 (4%)     4/50 (8%)     4/50 (8%)     |
|                                                                                        3/50 (6%)     1/50 (2%)     1/50 (2%)     |
|                                                                                        2/50 (4%)     4/51 (8%)     3/60 (5%)     |
|                                                                                        1/58 (2%)     2/60 (3%)                   |
| Overall Incidence                                                               Total 42/1027 (4.09%)  Mean 4.1%    SD 2.4%      |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/51 (0%)     0/60 (0%)     |
|                                                                                        0/58 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 1/1027 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                                                                        0/58 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                                                                        0/58 (0%)     0/60 (0%)                   |
| Overall Incidence                                                               Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 247
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: MICE                                           Vehicle: AIR                                      Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 0/1024 (0%)     Mean 0%      SD 0%        Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/55 (0%)           0/50 (0%)     0/51 (0%)     0/60 (0%)     |
|                                        0/59 (0%)     0/60 (0%)                         0/58 (0%)     0/60 (0%)                   |
| Overall Incidence               Total 1/1024 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1027 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 249
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       54/100(54%)                                     52/100(52%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    40/100(40%)                                     55/100(55%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         71/100(71%)                                     78/100(78%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      6/100(6%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        6/100(6%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/100(1%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/100(0%)                                       0/100(0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     8/100(8%)                                      32/100(32%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 250
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/99 (3%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/99 (0%)                                       1/92 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/99 (0%)                                       0/92 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/98 (1%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/98 (0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/98 (2%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            2/98 (2%)                                       0/90 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 251
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               1/99 (1%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 252
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/100(0%)                                       0/99 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 253
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/84 (0%)                                       0/70 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                             12/100(12%)                                     10/100(10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                12/100(12%)                                     12/100(12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 254
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 255
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/99 (1%)                                       2/87 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 256
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            2/99 (2%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/99 (3%)                                       2/87 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/99 (0%)                                       0/92 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/99 (0%)                                       0/92 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/99 (0%)                                       0/92 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/99 (0%)                                       0/92 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/99 (1%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            1/99 (1%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 2/99 (2%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 257
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      4/100(4%)                                       1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       2/100(2%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              30/100(30%)                                     17/98 (17%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            19/100(19%)                                      6/98 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         21/100(21%)                                      6/98 (6%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         46/100(46%)                                     22/98 (22%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           47/100(47%)                                     22/98 (22%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/100(0%)                                       1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 258
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        26/100(26%)                                      9/95 (9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       8/100(8%)                                       2/95 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   30/100(30%)                                     11/95 (12%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 259
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 260
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/100(0%)                                       1/100(1%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 261
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 262
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/79 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          2/79 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        2/79 (3%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 263
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 264
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/66 (0%)                                       0/63 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                      17/83 (20%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                       0/83 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                      17/83 (20%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/83 (0%)                                       1/83 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 265
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/83 (0%)                                       0/83 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/83 (0%)                                       1/83 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/99 (0%)                                       1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/99 (0%)                                       0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/99 (0%)                                       0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 266
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/100(0%)                                       0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/100(0%)                                       0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 267
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)                                       1/100(1%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/100(0%)                                       1/100(1%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/100(0%)                                       1/100(1%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 268
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)                                       1/100(1%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 269
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/100(0%)                                       4/100(4%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/100(0%)                                       4/100(4%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/100(0%)                                       2/100(2%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/100(0%)                                       2/100(2%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       4/100(4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 270
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/99 (2%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/99 (0%)                                       1/91 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 271
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/100(0%)                                       1/100(1%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/99 (1%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 272
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/69 (0%)                                       1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/69 (0%)                                       1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              1/99 (1%)                                       2/92 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 273
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 274
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 275
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: MICE                                           Vehicle: MAGNETIC FIELDS                          Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 277
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       30/50 (60%)   38/50 (76%)   30/50 (60%)         27/51 (53%)   21/51 (41%)   29/50 (58%)    |
|                                       26/50 (52%)   21/50 (42%)   25/50 (50%)         26/50 (52%)   22/50 (44%)   12/50 (24%)    |
|                                       26/52 (50%)   31/50 (62%)   33/50 (66%)         27/50 (54%)   19/49 (39%)   14/50 (28%)    |
|                                       25/50 (50%)   34/50 (68%)   30/50 (60%)         20/49 (41%)   26/50 (52%)   26/52 (50%)    |
|                                       28/50 (56%)   29/50 (58%)   20/50 (40%)         29/50 (58%)   31/50 (62%)   22/50 (44%)    |
|                                       33/50 (66%)   29/50 (58%)                       22/51 (43%)   26/50 (52%)                  |
| Overall Incidence               Total 488/852 (57.28%)Mean 57.29%  SD 9.3%      Total 399/853 (46.78%) Mean 46.76%  SD 10.3%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    17/50 (34%)   20/50 (40%)   17/50 (34%)         23/51 (45%)   23/51 (45%)   18/50 (36%)    |
|                                       22/50 (44%)   17/50 (34%)   25/50 (50%)         20/50 (40%)   20/50 (40%)   23/50 (46%)    |
|                                       22/52 (42%)   19/50 (38%)   17/50 (34%)         22/50 (44%)   22/49 (45%)   21/50 (42%)    |
|                                       14/50 (28%)   20/50 (40%)   17/50 (34%)         14/49 (29%)   15/50 (30%)   16/52 (31%)    |
|                                       24/50 (48%)   16/50 (32%)   18/50 (36%)         17/50 (34%)   20/50 (40%)   23/50 (46%)    |
|                                       21/50 (42%)   19/50 (38%)                       18/51 (35%)   25/50 (50%)                  |
| Overall Incidence               Total 325/852 (38.15%)Mean 38.14%  SD 5.82%     Total 340/853 (39.86%) Mean 39.87%  SD 6.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         38/50 (76%)   46/50 (92%)   37/50 (74%)         38/51 (75%)   37/51 (73%)   37/50 (74%)    |
|                                       40/50 (80%)   32/50 (64%)   37/50 (74%)         34/50 (68%)   34/50 (68%)   29/50 (58%)    |
|                                       37/52 (71%)   41/50 (82%)   38/50 (76%)         40/50 (80%)   34/49 (69%)   31/50 (62%)    |
|                                       31/50 (62%)   41/50 (82%)   37/50 (74%)         29/49 (59%)   34/50 (68%)   35/52 (67%)    |
|                                       42/50 (84%)   38/50 (76%)   33/50 (66%)         35/50 (70%)   39/50 (78%)   36/50 (72%)    |
|                                       39/50 (78%)   40/50 (80%)                       32/51 (63%)   40/50 (80%)                  |
| Overall Incidence               Total 647/852 (75.94%)Mean 75.95%  SD 7.51%     Total 594/853 (69.64%) Mean 69.63%  SD 6.64%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           2/51 (4%)     1/51 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/52 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/49 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     1/52 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     2/50 (4%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)                         0/51 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 6/852 (0.7%)    Mean 0.7%    SD 1.21%     Total 14/853 (1.64%)   Mean 1.64%   SD 1.77%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     1/50 (2%)           2/51 (4%)     2/51 (4%)     1/50 (2%)     |
|                                        3/50 (6%)     1/50 (2%)     4/50 (8%)           2/50 (4%)     2/50 (4%)     3/50 (6%)     |
|                                        5/52 (10%)    4/50 (8%)     2/50 (4%)           4/50 (8%)     3/49 (6%)     1/50 (2%)     |
|                                        1/50 (2%)     2/50 (4%)     2/50 (4%)           1/49 (2%)     1/50 (2%)     0/52 (0%)     |
|                                        2/50 (4%)     3/50 (6%)     6/50 (12%)          0/50 (0%)     1/50 (2%)     4/50 (8%)     |
|                                        7/50 (14%)    3/50 (6%)                         2/51 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 48/852 (5.63%)  Mean 5.62%   SD 3.66%     Total 29/853 (3.4%)    Mean 3.41%   SD 2.53%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 278
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/50 (4%)     1/50 (2%)     1/50 (2%)           4/51 (8%)     3/51 (6%)     1/50 (2%)     |
|                                        4/50 (8%)     1/50 (2%)     4/50 (8%)           3/50 (6%)     2/50 (4%)     3/50 (6%)     |
|                                        6/52 (12%)    4/50 (8%)     2/50 (4%)           4/50 (8%)     4/49 (8%)     1/50 (2%)     |
|                                        1/50 (2%)     2/50 (4%)     2/50 (4%)           2/49 (4%)     1/50 (2%)     1/52 (2%)     |
|                                        2/50 (4%)     4/50 (8%)     6/50 (12%)          2/50 (4%)     3/50 (6%)     4/50 (8%)     |
|                                        9/50 (18%)    3/50 (6%)                         2/51 (4%)     2/50 (4%)                   |
| Overall Incidence               Total 54/852 (6.34%)  Mean 6.33%   SD 4.39%     Total 42/853 (4.92%)   Mean 4.93%   SD 2.25%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     1/50 (2%)           1/51 (2%)     0/51 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/49 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     2/50 (4%)     1/52 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         2/51 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 4/852 (0.47%)   Mean 0.47%   SD 0.87%     Total 13/853 (1.52%)   Mean 1.52%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Mononuclear, or Undifferentiated  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 279
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     5/50 (10%)    2/50 (4%)          13/51 (25%)   15/51 (29%)    3/50 (6%)     |
|      Lymphocytic, Mixed, NOS, or       7/50 (14%)    6/50 (12%)    5/50 (10%)          8/50 (16%)   12/50 (24%)    9/50 (18%)    |
|      Undifferentiated Cell Type        3/52 (6%)     3/50 (6%)     1/50 (2%)           4/50 (8%)    12/49 (24%)    9/50 (18%)    |
|                                        2/50 (4%)     7/50 (14%)    2/50 (4%)           7/49 (14%)    7/50 (14%)    5/52 (10%)    |
|                                        2/50 (4%)     4/50 (8%)     2/50 (4%)           8/50 (16%)    5/50 (10%)    9/50 (18%)    |
|                                        4/50 (8%)     6/50 (12%)                        3/51 (6%)    15/50 (30%)                  |
| Overall Incidence               Total 63/852 (7.39%)  Mean 7.4%    SD 3.93%     Total 144/853 (16.88%) Mean 16.89%  SD 7.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/52 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 3/853 (0.35%)    Mean 0.35%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/52 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 3/853 (0.35%)    Mean 0.35%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                             11/50 (22%)    0/49 (0%)     6/49 (12%)          1/51 (2%)     0/51 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     3/50 (6%)     2/50 (4%)     |
|                                        2/52 (4%)     2/49 (4%)     1/50 (2%)           3/50 (6%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/48 (2%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        4/50 (8%)     7/50 (14%)    0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     1/49 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 37/845 (4.38%)  Mean 4.37%   SD 6.23%     Total 9/851 (1.06%)    Mean 1.06%   SD 2.13%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 280
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/845 (0%)      Mean 0%      SD 0%        Total 1/851 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/49 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/845 (0%)      Mean 0%      SD 0%        Total 0/851 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/845 (0%)      Mean 0%      SD 0%        Total 0/851 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)    10/50 (20%)    0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 11/846 (1.3%)   Mean 1.29%   SD 4.84%     Total 0/851 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     1/51 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        2/52 (4%)     1/48 (2%)     0/50 (0%)           2/50 (4%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/49 (0%)                         1/51 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 4/845 (0.47%)   Mean 0.47%   SD 1.1%      Total 7/844 (0.83%)    Mean 0.82%   SD 1.23%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 281
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/845 (0%)      Mean 0%      SD 0%        Total 0/844 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/845 (0.12%)   Mean 0.12%   SD 0.49%     Total 1/844 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     1/51 (2%)     0/50 (0%)     |
|      Complex, Malignant, NOS           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        2/52 (4%)     1/48 (2%)     0/50 (0%)           2/50 (4%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/49 (0%)                         1/51 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 5/845 (0.59%)   Mean 0.58%   SD 1.15%     Total 8/844 (0.95%)    Mean 0.94%   SD 1.25%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     1/52 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 2/853 (0.23%)    Mean 0.23%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 282
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/851 (0.47%)   Mean 0.47%   SD 1.12%     Total 2/853 (0.23%)    Mean 0.23%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/851 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 283
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 2/853 (0.23%)    Mean 0.24%   SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/52 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 3/853 (0.35%)    Mean 0.35%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/52 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 3/853 (0.35%)    Mean 0.35%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 284
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/851 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/851 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/851 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/851 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 285
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/851 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/851 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/851 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 286
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 287
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/851 (0.12%)   Mean 0.12%   SD 0.49%                                                      |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/851 (0.12%)   Mean 0.12%   SD 0.49%                                                      |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 288
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/50 (0%)     0/42 (0%)     0/47 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/46 (0%)     0/43 (0%)           0/49 (0%)     0/44 (0%)     0/45 (0%)     |
|                                        0/45 (0%)     0/34 (0%)     0/48 (0%)           0/47 (0%)     0/43 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)                         0/50 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 1/791 (0.13%)   Mean 0.12%   SD 0.48%     Total 0/818 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              1/50 (2%)     4/50 (8%)     2/50 (4%)           0/51 (0%)     2/51 (4%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
|                                        0/52 (0%)     4/50 (8%)     4/50 (8%)           5/50 (10%)    1/49 (2%)     0/50 (0%)     |
|                                        3/50 (6%)     3/50 (6%)     3/50 (6%)           3/49 (6%)     1/50 (2%)     2/52 (4%)     |
|                                        4/50 (8%)     9/50 (18%)    1/50 (2%)           3/50 (6%)     0/50 (0%)     3/50 (6%)     |
|                                        3/50 (6%)     3/50 (6%)                         0/51 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 47/852 (5.52%)  Mean 5.53%   SD 4.21%     Total 27/853 (3.17%)   Mean 3.17%   SD 2.92%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)     1/50 (2%)     1/50 (2%)           1/51 (2%)     1/51 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        1/52 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     1/52 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 9/852 (1.06%)   Mean 1.05%   SD 1.25%     Total 9/853 (1.06%)    Mean 1.05%   SD 1.43%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)     5/50 (10%)    3/50 (6%)           1/51 (2%)     3/51 (6%)     2/50 (4%)     |
|                                        2/50 (4%)     1/50 (2%)     1/50 (2%)           5/50 (10%)    1/50 (2%)     0/50 (0%)     |
|                                        1/52 (2%)     5/50 (10%)    4/50 (8%)           5/50 (10%)    1/49 (2%)     0/50 (0%)     |
|                                        3/50 (6%)     3/50 (6%)     4/50 (8%)           3/49 (6%)     1/50 (2%)     3/52 (6%)     |
|                                        4/50 (8%)    10/50 (20%)    1/50 (2%)           3/50 (6%)     1/50 (2%)     3/50 (6%)     |
|                                        3/50 (6%)     3/50 (6%)                         0/51 (0%)     4/50 (8%)                   |
| Overall Incidence               Total 56/852 (6.57%)  Mean 6.58%   SD 4.35%     Total 36/853 (4.22%)   Mean 4.22%   SD 3.3%      |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/852 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 289
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/48 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/852 (0.23%)   Mean 0.24%   SD 0.66%     Total 1/852 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 290
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 291
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 2/853 (0.23%)    Mean 0.24%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     1/50 (2%)     1/50 (2%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/852 (0.23%)   Mean 0.24%   SD 0.66%     Total 2/853 (0.23%)    Mean 0.24%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 292
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 7/852 (0.82%)   Mean 0.82%   SD 1.74%     Total 4/853 (0.47%)    Mean 0.47%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 293
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     3/50 (6%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/852 (0.94%)   Mean 0.94%   SD 1.75%     Total 6/853 (0.7%)     Mean 0.71%   SD 1.57%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     3/50 (6%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/852 (0.94%)   Mean 0.94%   SD 1.75%     Total 6/853 (0.7%)     Mean 0.71%   SD 1.57%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 294
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     1/50 (2%)     1/50 (2%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/852 (0.23%)   Mean 0.24%   SD 0.66%     Total 2/853 (0.23%)    Mean 0.24%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        1/45 (2%)     0/50 (0%)     0/47 (0%)           1/50 (2%)     0/49 (0%)     1/49 (2%)     |
|                                        1/52 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/48 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     2/50 (4%)     1/49 (2%)           0/49 (0%)     1/50 (2%)     1/51 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           3/50 (6%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)                         1/51 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 11/841 (1.31%)  Mean 1.31%   SD 1.41%     Total 11/847 (1.3%)    Mean 1.3%    SD 1.72%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/45 (0%)     0/50 (0%)     1/47 (2%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 2/841 (0.24%)   Mean 0.24%   SD 0.69%     Total 1/847 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 295
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        1/45 (2%)     0/50 (0%)     1/47 (2%)           1/50 (2%)     0/49 (0%)     1/49 (2%)     |
|                                        1/52 (2%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     1/48 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     2/50 (4%)     1/49 (2%)           0/49 (0%)     1/50 (2%)     1/51 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           3/50 (6%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)                         1/51 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 13/841 (1.55%)  Mean 1.55%   SD 1.34%     Total 12/847 (1.42%)   Mean 1.41%   SD 1.7%      |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/851 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/851 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 296
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/851 (0.12%)   Mean 0.12%   SD 0.49%     Total 2/852 (0.23%)    Mean 0.24%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/851 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/851 (0.24%)   Mean 0.24%   SD 0.66%     Total 2/852 (0.23%)    Mean 0.24%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 297
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/850 (0.24%)   Mean 0.24%   SD 0.67%     Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 1/852 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/52 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/49 (2%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/850 (0.24%)   Mean 0.23%   SD 0.65%     Total 2/852 (0.23%)    Mean 0.24%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 298
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     1/49 (2%)           0/51 (0%)     1/51 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/52 (0%)     3/50 (6%)     1/50 (2%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/49 (2%)           1/49 (2%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        3/50 (6%)     1/50 (2%)                         1/51 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 19/850 (2.24%)  Mean 2.24%   SD 1.98%     Total 7/852 (0.82%)    Mean 0.82%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 2/852 (0.23%)    Mean 0.24%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              17/50 (34%)   30/50 (60%)   17/49 (35%)         17/51 (33%)   12/51 (24%)   25/50 (50%)    |
|                                       22/50 (44%)   17/50 (34%)   21/50 (42%)         15/50 (30%)   10/50 (20%)    7/50 (14%)    |
|                                       18/52 (35%)   18/50 (36%)   25/50 (50%)         12/50 (24%)    6/49 (12%)    7/50 (14%)    |
|                                       16/50 (32%)   23/50 (46%)   18/49 (37%)          7/49 (14%)   12/50 (24%)   16/51 (31%)    |
|                                       10/50 (20%)   14/50 (28%)   17/50 (34%)          6/50 (12%)   14/50 (28%)   11/50 (22%)    |
|                                       28/50 (56%)   22/50 (44%)                        9/51 (18%)   17/50 (34%)                  |
| Overall Incidence               Total 333/850 (39.18%)Mean 39.18%  SD 10.05%    Total 203/852 (23.83%) Mean 23.79%  SD 10.02%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            11/50 (22%)    9/50 (18%)    9/49 (18%)          4/51 (8%)     3/51 (6%)     9/50 (18%)    |
|                                       12/50 (24%)    5/50 (10%)    9/50 (18%)          3/50 (6%)     4/50 (8%)     5/50 (10%)    |
|                                       15/52 (29%)   10/50 (20%)   12/50 (24%)         10/50 (20%)    5/49 (10%)    7/50 (14%)    |
|                                        7/50 (14%)   13/50 (26%)   11/49 (22%)          5/49 (10%)    5/50 (10%)    5/51 (10%)    |
|                                       12/50 (24%)    7/50 (14%)    8/50 (16%)         10/50 (20%)    5/50 (10%)    4/50 (8%)     |
|                                        8/50 (16%)    8/50 (16%)                        8/51 (16%)    6/50 (12%)                  |
| Overall Incidence               Total 166/850 (19.53%)Mean 19.51%  SD 4.99%     Total 98/852 (11.5%)   Mean 11.51%  SD 4.5%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         11/50 (22%)    9/50 (18%)    9/49 (18%)          4/51 (8%)     3/51 (6%)     9/50 (18%)    |
|      Hepatoblastoma                   12/50 (24%)    5/50 (10%)    9/50 (18%)          4/50 (8%)     4/50 (8%)     5/50 (10%)    |
|                                       15/52 (29%)   10/50 (20%)   12/50 (24%)         10/50 (20%)    5/49 (10%)    7/50 (14%)    |
|                                        7/50 (14%)   13/50 (26%)   11/49 (22%)          5/49 (10%)    5/50 (10%)    5/51 (10%)    |
|                                       12/50 (24%)    7/50 (14%)    8/50 (16%)         10/50 (20%)    6/50 (12%)    4/50 (8%)     |
|                                        8/50 (16%)    8/50 (16%)                        8/51 (16%)    6/50 (12%)                  |
| Overall Incidence               Total 166/850 (19.53%)Mean 19.51%  SD 4.99%     Total 100/852 (11.74%) Mean 11.74%  SD 4.35%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 299
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         25/50 (50%)   34/50 (68%)   23/49 (47%)         20/51 (39%)   13/51 (25%)   28/50 (56%)    |
|      Hepatocellular Adenoma           31/50 (62%)   20/50 (40%)   25/50 (50%)         16/50 (32%)   13/50 (26%)   10/50 (20%)    |
|                                       28/52 (54%)   24/50 (48%)   30/50 (60%)         21/50 (42%)    9/49 (18%)   13/50 (26%)    |
|                                       21/50 (42%)   29/50 (58%)   27/49 (55%)         10/49 (20%)   16/50 (32%)   20/51 (39%)    |
|                                       22/50 (44%)   21/50 (42%)   22/50 (44%)         14/50 (28%)   17/50 (34%)   15/50 (30%)    |
|                                       31/50 (62%)   27/50 (54%)                       17/51 (33%)   21/50 (42%)                  |
| Overall Incidence               Total 440/850 (51.76%)Mean 51.76%  SD 8.27%     Total 273/852 (32.04%) Mean 32%     SD 9.63%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           25/50 (50%)   34/50 (68%)   23/49 (47%)         20/51 (39%)   13/51 (25%)   28/50 (56%)    |
|      Hepatocellular Adenoma, or       31/50 (62%)   20/50 (40%)   25/50 (50%)         16/50 (32%)   13/50 (26%)   10/50 (20%)    |
|      Hepatoblastoma                   28/52 (54%)   24/50 (48%)   30/50 (60%)         21/50 (42%)    9/49 (18%)   13/50 (26%)    |
|                                       21/50 (42%)   29/50 (58%)   27/49 (55%)         10/49 (20%)   16/50 (32%)   20/51 (39%)    |
|                                       22/50 (44%)   21/50 (42%)   22/50 (44%)         14/50 (28%)   17/50 (34%)   15/50 (30%)    |
|                                       31/50 (62%)   27/50 (54%)                       17/51 (33%)   21/50 (42%)                  |
| Overall Incidence               Total 440/850 (51.76%)Mean 51.76%  SD 8.27%     Total 273/852 (32.04%) Mean 32%     SD 9.63%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 1/852 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/850 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 300
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/850 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 301
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         6/50 (12%)    7/50 (14%)   11/50 (22%)          2/51 (4%)     2/51 (4%)     4/50 (8%)     |
|                                        7/50 (14%)    3/50 (6%)     6/50 (12%)          4/50 (8%)     4/50 (8%)     2/50 (4%)     |
|                                        7/52 (13%)   14/50 (28%)   11/50 (22%)          2/50 (4%)     1/48 (2%)     4/50 (8%)     |
|                                       13/50 (26%)   15/50 (30%)   12/50 (24%)          5/49 (10%)    1/50 (2%)     3/52 (6%)     |
|                                        9/50 (18%)    5/50 (10%)    6/50 (12%)          1/50 (2%)     4/50 (8%)     3/50 (6%)     |
|                                       12/50 (24%)    8/50 (16%)                        3/51 (6%)     3/50 (6%)                   |
| Overall Incidence               Total 152/852 (17.84%)Mean 17.85%  SD 7%        Total 48/852 (5.63%)   Mean 5.63%   SD 2.49%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       3/50 (6%)     5/50 (10%)    2/50 (4%)           0/51 (0%)     4/51 (8%)     1/50 (2%)     |
|                                        4/50 (8%)     6/50 (12%)    7/50 (14%)          4/50 (8%)     0/50 (0%)     1/50 (2%)     |
|                                        1/52 (2%)     4/50 (8%)     4/50 (8%)           4/50 (8%)     0/48 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     3/50 (6%)           0/49 (0%)     1/50 (2%)     2/52 (4%)     |
|                                        5/50 (10%)    1/50 (2%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        3/50 (6%)     3/50 (6%)                         2/51 (4%)     4/50 (8%)                   |
| Overall Incidence               Total 54/852 (6.34%)  Mean 6.35%   SD 3.76%     Total 26/852 (3.05%)   Mean 3.04%   SD 3.15%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    8/50 (16%)   12/50 (24%)   13/50 (26%)          2/51 (4%)     6/51 (12%)    5/50 (10%)    |
|      Alveolar/Bronchiolar Adenoma     11/50 (22%)    9/50 (18%)   13/50 (26%)          7/50 (14%)    4/50 (8%)     3/50 (6%)     |
|                                        8/52 (15%)   16/50 (32%)   14/50 (28%)          5/50 (10%)    1/48 (2%)     5/50 (10%)    |
|                                       14/50 (28%)   15/50 (30%)   15/50 (30%)          5/49 (10%)    2/50 (4%)     5/52 (10%)    |
|                                       14/50 (28%)    6/50 (12%)    7/50 (14%)          1/50 (2%)     6/50 (12%)    3/50 (6%)     |
|                                       15/50 (30%)   11/50 (22%)                        5/51 (10%)    6/50 (12%)                  |
| Overall Incidence               Total 201/852 (23.59%)Mean 23.61%  SD 6.38%     Total 71/852 (8.33%)   Mean 8.32%   SD 3.66%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/852 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 302
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/852 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 303
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 304
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 305
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 2/853 (0.23%)    Mean 0.24%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 3/853 (0.35%)    Mean 0.36%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 306
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 2/853 (0.23%)    Mean 0.24%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 3/853 (0.35%)    Mean 0.36%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 307
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 308
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 309
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/852 (0.23%)   Mean 0.24%   SD 0.66%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 310
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/51 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     2/49 (4%)     2/51 (4%)     |
|                                                                                        0/49 (0%)     1/49 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 6/837 (0.72%)    Mean 0.71%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/837 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/837 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/837 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 311
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     2/51 (4%)     1/50 (2%)     |
|                                                                                        3/49 (6%)     1/48 (2%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     1/46 (2%)     1/50 (2%)     |
|                                                                                        2/47 (4%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     1/49 (2%)     1/50 (2%)     |
|                                                                                        2/50 (4%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 15/837 (1.79%)   Mean 1.8%    SD 1.89%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 1/837 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     1/50 (2%)     |
|                                                                                        0/47 (0%)     1/49 (2%)     0/51 (0%)     |
|                                                                                        1/49 (2%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 4/837 (0.48%)    Mean 0.48%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/51 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        1/48 (2%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/837 (0.24%)    Mean 0.24%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/51 (0%)     1/50 (2%)     |
|      Malignant, NOS                                                                    0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        1/48 (2%)     0/46 (0%)     1/50 (2%)     |
|                                                                                        0/47 (0%)     1/49 (2%)     0/51 (0%)     |
|                                                                                        1/49 (2%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 6/837 (0.72%)    Mean 0.72%   SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 312
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      1/50 (2%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/837 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     2/50 (4%)                   |
| Overall Incidence                                                               Total 2/837 (0.24%)    Mean 0.24%   SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/837 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/837 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/51 (0%)     2/50 (4%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 3/837 (0.36%)    Mean 0.35%   SD 1.06%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 313
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     1/48 (2%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/837 (0.12%)    Mean 0.12%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        1/47 (2%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 2/837 (0.24%)    Mean 0.24%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/50 (0%)     0/51 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/837 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        1/48 (2%)     1/46 (2%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/837 (0.24%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       1/50 (2%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/837 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 314
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/837 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                                                                        0/48 (0%)     0/46 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/49 (0%)     0/51 (0%)     |
|                                                                                        0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/837 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/841 (0%)      Mean 0%      SD 0%        Total 0/848 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/841 (0%)      Mean 0%      SD 0%        Total 1/848 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/841 (0%)      Mean 0%      SD 0%        Total 1/848 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 315
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/841 (0%)      Mean 0%      SD 0%        Total 0/848 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/51 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/841 (0%)      Mean 0%      SD 0%        Total 1/848 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        1/46 (2%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/841 (0.12%)   Mean 0.13%   SD 0.53%     Total 0/848 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/841 (0%)      Mean 0%      SD 0%        Total 0/848 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/841 (0%)      Mean 0%      SD 0%        Total 0/848 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 316
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/49 (0%)     0/46 (0%)     0/48 (0%)           0/46 (0%)     0/47 (0%)     0/46 (0%)     |
|                                        0/31 (0%)     0/47 (0%)     0/44 (0%)           0/45 (0%)     0/41 (0%)     0/47 (0%)     |
|                                        0/52 (0%)     0/39 (0%)     0/38 (0%)           0/46 (0%)     0/39 (0%)     0/33 (0%)     |
|                                        0/41 (0%)     0/36 (0%)     0/47 (0%)           0/33 (0%)     0/36 (0%)     0/44 (0%)     |
|                                        0/42 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/40 (0%)     |
|                                        0/49 (0%)     0/46 (0%)                         0/46 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/755 (0%)      Mean 0%      SD 0%        Total 0/733 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/46 (0%)     1/48 (2%)           6/48 (13%)    2/48 (4%)     2/50 (4%)     |
|   Adenoma                              0/45 (0%)     0/49 (0%)     0/50 (0%)           3/49 (6%)     7/49 (14%)    1/49 (2%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           6/46 (13%)    7/48 (15%)    0/46 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/48 (0%)           2/48 (4%)    11/48 (23%)    4/50 (8%)     |
|                                        3/48 (6%)     0/47 (0%)     0/46 (0%)           9/48 (19%)    7/49 (14%)    7/48 (15%)    |
|                                        1/46 (2%)     0/48 (0%)                         5/49 (10%)    3/49 (6%)                   |
| Overall Incidence               Total 5/811 (0.62%)   Mean 0.62%   SD 1.61%     Total 82/822 (9.98%)   Mean 9.99%   SD 6.32%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/46 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|   Carcinoma                            0/45 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/46 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/47 (0%)     0/46 (0%)           0/48 (0%)     0/49 (0%)     1/48 (2%)     |
|                                        0/46 (0%)     0/48 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/811 (0%)      Mean 0%      SD 0%        Total 1/822 (0.12%)    Mean 0.12%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/46 (0%)     1/48 (2%)           6/48 (13%)    2/48 (4%)     2/50 (4%)     |
|   Carcinoma or Adenoma                 0/45 (0%)     0/49 (0%)     0/50 (0%)           3/49 (6%)     7/49 (14%)    1/49 (2%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           6/46 (13%)    7/48 (15%)    0/46 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/48 (0%)           2/48 (4%)    11/48 (23%)    4/50 (8%)     |
|                                        3/48 (6%)     0/47 (0%)     0/46 (0%)           9/48 (19%)    7/49 (14%)    8/48 (17%)    |
|                                        1/46 (2%)     0/48 (0%)                         5/49 (10%)    3/49 (6%)                   |
| Overall Incidence               Total 5/811 (0.62%)   Mean 0.62%   SD 1.61%     Total 83/822 (10.1%)   Mean 10.11%  SD 6.43%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 317
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/47 (0%)     0/46 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/46 (0%)     1/48 (2%)     0/46 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/48 (0%)           0/48 (0%)     1/48 (2%)     0/50 (0%)     |
|                                        0/48 (0%)     0/47 (0%)     0/46 (0%)           0/48 (0%)     1/49 (2%)     0/48 (0%)     |
|                                        0/46 (0%)     1/48 (2%)                         0/49 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 1/811 (0.12%)   Mean 0.12%   SD 0.51%     Total 4/822 (0.49%)    Mean 0.49%   SD 0.9%      |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/47 (0%)     0/46 (0%)     0/48 (0%)           1/48 (2%)     0/48 (0%)     0/50 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/46 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/49 (0%)     1/46 (2%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/47 (0%)     0/46 (0%)           0/48 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/46 (0%)     0/48 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/811 (0.12%)   Mean 0.13%   SD 0.53%     Total 1/822 (0.12%)    Mean 0.12%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/47 (0%)     0/46 (0%)     0/48 (0%)           1/48 (2%)     0/48 (0%)     0/50 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/46 (0%)     1/48 (2%)     0/46 (0%)     |
|                                        0/49 (0%)     1/46 (2%)     0/48 (0%)           0/48 (0%)     1/48 (2%)     0/50 (0%)     |
|                                        0/48 (0%)     0/47 (0%)     0/46 (0%)           0/48 (0%)     1/49 (2%)     0/48 (0%)     |
|                                        0/46 (0%)     1/48 (2%)                         0/49 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 2/811 (0.25%)   Mean 0.25%   SD 0.71%     Total 5/822 (0.61%)    Mean 0.61%   SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/46 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/844 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/46 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/844 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 318
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/46 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/844 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 0/849 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 0/849 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 0/849 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 0/849 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 319
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%                                                      |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/852 (0.23%)   Mean 0.24%   SD 0.66%     Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 320
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 321
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/52 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/52 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 2/853 (0.23%)    Mean 0.23%   SD 0.64%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 322
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         1/51 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 1/853 (0.12%)    Mean 0.12%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         1/51 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 1/853 (0.12%)    Mean 0.12%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         1/51 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 1/853 (0.12%)    Mean 0.12%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|      Papilloma, Sq Papilloma,          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|      Keratoacanthoma,                  0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 1/50 (2%)     0/50 (0%)                         1/51 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/852 (0.23%)   Mean 0.24%   SD 0.66%     Total 1/853 (0.12%)    Mean 0.12%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 323
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           2/51 (4%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 4/853 (0.47%)    Mean 0.47%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/52 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/52 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/50 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/852 (0.94%)   Mean 0.94%   SD 1.24%     Total 3/853 (0.35%)    Mean 0.35%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 324
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/852 (0.23%)   Mean 0.24%   SD 0.66%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 325
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|      Carcinoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         1/51 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 1/853 (0.12%)    Mean 0.12%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 326
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     0/50 (0%)           2/51 (4%)     2/51 (4%)     2/50 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous   1/50 (2%)     1/50 (2%)     0/50 (0%)           3/50 (6%)     3/50 (6%)     1/50 (2%)     |
|      Histiocytoma                      0/52 (0%)     2/50 (4%)     1/50 (2%)           2/50 (4%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         2/51 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 8/852 (0.94%)   Mean 0.94%   SD 1.43%     Total 19/853 (2.23%)   Mean 2.22%   SD 2.21%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 327
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           2/51 (4%)     2/51 (4%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     3/50 (6%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 14/853 (1.64%)   Mean 1.64%   SD 2.36%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     0/50 (0%)           2/51 (4%)     2/51 (4%)     2/50 (4%)     |
|      Myxosarcoma, or Fibrous           1/50 (2%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     3/50 (6%)     1/50 (2%)     |
|      Histiocytoma                      0/52 (0%)     2/50 (4%)     1/50 (2%)           2/50 (4%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         2/51 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 7/852 (0.82%)   Mean 0.82%   SD 1.42%     Total 19/853 (2.23%)   Mean 2.22%   SD 2.21%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/51 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 2/853 (0.23%)    Mean 0.23%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 328
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/51 (2%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 3/853 (0.35%)    Mean 0.35%   SD 0.78%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/51 (2%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      or NOS)                           0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 3/853 (0.35%)    Mean 0.35%   SD 0.78%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         2/51 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 5/852 (0.59%)   Mean 0.59%   SD 1.37%     Total 4/853 (0.47%)    Mean 0.47%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 329
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     1/51 (2%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/844 (0%)      Mean 0%      SD 0%        Total 1/847 (0.12%)    Mean 0.12%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/844 (0%)      Mean 0%      SD 0%        Total 0/847 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/844 (0.12%)   Mean 0.12%   SD 0.49%     Total 1/847 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/49 (0%)           2/51 (4%)     0/51 (0%)     0/50 (0%)     |
|                                        2/48 (4%)     0/50 (0%)     2/47 (4%)           1/50 (2%)     1/49 (2%)     3/49 (6%)     |
|                                        4/52 (8%)     1/50 (2%)     0/50 (0%)           3/50 (6%)     2/48 (4%)     1/49 (2%)     |
|                                        0/49 (0%)     1/50 (2%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     4/50 (8%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        4/50 (8%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 20/844 (2.37%)  Mean 2.36%   SD 3%        Total 14/847 (1.65%)   Mean 1.66%   SD 2.17%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 330
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     0/50 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/844 (0.24%)   Mean 0.24%   SD 0.68%     Total 0/847 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/844 (0%)      Mean 0%      SD 0%        Total 0/847 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 331
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/52 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/852 (0.23%)   Mean 0.23%   SD 0.65%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     1/50 (2%)     2/50 (4%)           2/51 (4%)     1/51 (2%)     1/50 (2%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/52 (2%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        3/50 (6%)     3/50 (6%)     0/50 (0%)           0/50 (0%)     3/50 (6%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/51 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 14/852 (1.64%)  Mean 1.64%   SD 2.15%     Total 11/853 (1.29%)   Mean 1.29%   SD 1.72%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     1/50 (2%)     1/50 (2%)           2/51 (4%)     1/51 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        3/50 (6%)     3/50 (6%)     0/50 (0%)           0/50 (0%)     3/50 (6%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/51 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 12/852 (1.41%)  Mean 1.41%   SD 2.09%     Total 11/853 (1.29%)   Mean 1.29%   SD 1.72%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 332
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     1/50 (2%)                                                                   |
| Overall Incidence               Total 4/851 (0.47%)   Mean 0.47%   SD 0.88%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/851 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 333
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/47 (0%)     0/39 (0%)     0/43 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/42 (0%)     0/36 (0%)     0/40 (0%)           0/45 (0%)     0/38 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/38 (0%)     0/39 (0%)           0/45 (0%)     0/47 (0%)     0/44 (0%)     |
|                                        0/49 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/38 (0%)     0/46 (0%)     |
|                                        0/42 (0%)     0/47 (0%)     0/45 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/44 (0%)     0/43 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/726 (0%)      Mean 0%      SD 0%        Total 0/776 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/47 (0%)     0/39 (0%)     0/43 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/42 (0%)     0/36 (0%)     0/40 (0%)           0/45 (0%)     0/38 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/38 (0%)     0/39 (0%)           0/45 (0%)     0/47 (0%)     0/44 (0%)     |
|                                        0/49 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/38 (0%)     0/46 (0%)     |
|                                        0/42 (0%)     0/47 (0%)     0/45 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/44 (0%)     0/43 (0%)                         0/45 (0%)     1/48 (2%)                   |
| Overall Incidence               Total 0/726 (0%)      Mean 0%      SD 0%        Total 1/776 (0.13%)    Mean 0.12%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/39 (0%)     0/43 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/42 (0%)     0/36 (0%)     0/40 (0%)           0/45 (0%)     0/38 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/38 (0%)     0/39 (0%)           0/45 (0%)     0/47 (0%)     0/44 (0%)     |
|                                        0/49 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/38 (0%)     0/46 (0%)     |
|                                        0/42 (0%)     0/47 (0%)     0/45 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/44 (0%)     0/43 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/726 (0%)      Mean 0%      SD 0%        Total 0/776 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/47 (0%)     0/39 (0%)     0/43 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/42 (0%)     0/36 (0%)     0/40 (0%)           0/45 (0%)     0/38 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/38 (0%)     0/39 (0%)           0/45 (0%)     0/47 (0%)     0/44 (0%)     |
|                                        0/49 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/38 (0%)     0/46 (0%)     |
|                                        0/42 (0%)     0/47 (0%)     0/45 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/44 (0%)     0/43 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/726 (0%)      Mean 0%      SD 0%        Total 0/776 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/47 (0%)     0/39 (0%)     0/43 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/42 (0%)     0/36 (0%)     0/40 (0%)           0/45 (0%)     0/38 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/38 (0%)     0/39 (0%)           0/45 (0%)     0/47 (0%)     0/44 (0%)     |
|                                        0/49 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/38 (0%)     0/46 (0%)     |
|                                        0/42 (0%)     0/47 (0%)     0/45 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/44 (0%)     0/43 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/726 (0%)      Mean 0%      SD 0%        Total 0/776 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 334
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/47 (0%)     0/39 (0%)     0/43 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/42 (0%)     0/36 (0%)     0/40 (0%)           0/45 (0%)     0/38 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/38 (0%)     0/39 (0%)           0/45 (0%)     0/47 (0%)     0/44 (0%)     |
|                                        0/49 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/38 (0%)     0/46 (0%)     |
|                                        0/42 (0%)     0/47 (0%)     0/45 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/44 (0%)     0/43 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/726 (0%)      Mean 0%      SD 0%        Total 0/776 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/39 (0%)     0/43 (0%)           0/46 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/42 (0%)     0/36 (0%)     0/40 (0%)           0/45 (0%)     0/38 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/38 (0%)     0/39 (0%)           0/45 (0%)     0/47 (0%)     0/44 (0%)     |
|                                        0/49 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/38 (0%)     0/46 (0%)     |
|                                        0/42 (0%)     0/47 (0%)     0/45 (0%)           1/45 (2%)     0/47 (0%)     0/50 (0%)     |
|                                        0/44 (0%)     0/43 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/726 (0%)      Mean 0%      SD 0%        Total 2/776 (0.26%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/47 (0%)     0/39 (0%)     0/43 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/42 (0%)     0/36 (0%)     0/40 (0%)           0/45 (0%)     0/38 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/38 (0%)     0/39 (0%)           0/45 (0%)     0/47 (0%)     0/44 (0%)     |
|                                        0/49 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/38 (0%)     0/46 (0%)     |
|                                        0/42 (0%)     0/47 (0%)     0/45 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/44 (0%)     0/43 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/726 (0%)      Mean 0%      SD 0%        Total 0/776 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/47 (0%)     0/39 (0%)     0/43 (0%)           0/46 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/42 (0%)     0/36 (0%)     0/40 (0%)           0/45 (0%)     0/38 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/38 (0%)     0/39 (0%)           0/45 (0%)     0/47 (0%)     0/44 (0%)     |
|                                        0/49 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/38 (0%)     0/46 (0%)     |
|                                        0/42 (0%)     0/47 (0%)     0/45 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/44 (0%)     0/43 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/726 (0%)      Mean 0%      SD 0%        Total 1/776 (0.13%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/39 (0%)     0/43 (0%)           0/46 (0%)     1/49 (2%)     1/50 (2%)     |
|                                        0/42 (0%)     0/36 (0%)     0/40 (0%)           0/45 (0%)     0/38 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/38 (0%)     0/39 (0%)           0/45 (0%)     0/47 (0%)     0/44 (0%)     |
|                                        0/49 (0%)     0/43 (0%)     0/44 (0%)           0/46 (0%)     0/38 (0%)     0/46 (0%)     |
|                                        0/42 (0%)     0/47 (0%)     0/45 (0%)           1/45 (2%)     0/47 (0%)     0/50 (0%)     |
|                                        0/44 (0%)     0/43 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/726 (0%)      Mean 0%      SD 0%        Total 3/776 (0.39%)    Mean 0.37%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 335
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/48 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/846 (0%)      Mean 0%      SD 0%        Total 0/847 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/48 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/846 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/847 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/48 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/846 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/847 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/48 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/846 (0.24%)   Mean 0.24%   SD 0.66%     Total 0/847 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        0/52 (0%)     1/50 (2%)     1/50 (2%)           1/49 (2%)     0/49 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     1/49 (2%)     0/49 (0%)           0/49 (0%)     0/48 (0%)     3/51 (6%)     |
|                                        2/50 (4%)     2/49 (4%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)                         1/51 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 12/846 (1.42%)  Mean 1.42%   SD 1.55%     Total 13/847 (1.53%)   Mean 1.52%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 336
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/49 (2%)           0/49 (0%)     0/48 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/49 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/846 (0.24%)   Mean 0.24%   SD 0.68%     Total 2/847 (0.24%)    Mean 0.24%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     2/49 (4%)     0/50 (0%)     |
|                                        0/52 (0%)     1/50 (2%)     1/50 (2%)           1/49 (2%)     0/49 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     1/49 (2%)     1/49 (2%)           0/49 (0%)     0/48 (0%)     3/51 (6%)     |
|                                        2/50 (4%)     2/49 (4%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     1/49 (2%)                         1/51 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 14/846 (1.65%)  Mean 1.66%   SD 1.47%     Total 15/847 (1.77%)   Mean 1.76%   SD 1.7%      |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 337
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 338
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/852 (0.23%)   Mean 0.24%   SD 0.66%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/852 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/52 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/852 (0.23%)   Mean 0.23%   SD 0.93%     Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 339
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/845 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/841 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/845 (0%)      Mean 0%      SD 0%        Total 0/841 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/48 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/845 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/841 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/845 (0%)      Mean 0%      SD 0%        Total 0/841 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/48 (0%)     0/49 (0%)           0/50 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/845 (0.12%)   Mean 0.12%   SD 0.49%     Total 0/841 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 340
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/51 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/853 (0.12%)    Mean 0.12%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        1/51 (2%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 4/853 (0.47%)    Mean 0.47%   SD 0.87%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/51 (0%)     1/51 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/853 (0.23%)    Mean 0.24%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 341
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/51 (0%)     1/51 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/51 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 3/853 (0.35%)    Mean 0.35%   SD 0.78%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/51 (0%)     1/51 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 4/853 (0.47%)    Mean 0.47%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/51 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/853 (0.23%)    Mean 0.24%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/51 (4%)     1/51 (2%)     1/50 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/50 (4%)     2/49 (4%)     1/50 (2%)     |
|                                                                                        0/49 (0%)     4/50 (8%)     3/52 (6%)     |
|                                                                                        8/50 (16%)    3/50 (6%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 29/853 (3.4%)    Mean 3.4%    SD 4.04%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 342
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/51 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 4/853 (0.47%)    Mean 0.47%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/51 (4%)     1/51 (2%)     1/50 (2%)     |
|                                                                                        2/50 (4%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        2/50 (4%)     2/49 (4%)     1/50 (2%)     |
|                                                                                        1/49 (2%)     4/50 (8%)     3/52 (6%)     |
|                                                                                        8/50 (16%)    3/50 (6%)     1/50 (2%)     |
|                                                                                        0/51 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 33/853 (3.87%)   Mean 3.87%   SD 3.77%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/51 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/853 (0.12%)    Mean 0.12%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 343
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: FEED                                     Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/51 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/52 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/51 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/852 (0%)      Mean 0%      SD 0%        Total 0/853 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 345
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       57/79 (72%)   36/51 (71%)   39/50 (78%)         65/80 (81%)   25/50 (50%)   26/50 (52%)    |
|                                       47/60 (78%)   41/50 (82%)   35/50 (70%)         38/60 (63%)   42/50 (84%)   40/50 (80%)    |
| Overall Incidence               Total 255/340 (75%)   Mean 75.18%  SD 4.93%     Total 236/340 (69.41%) Mean 68.43%  SD 15.34%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    41/79 (52%)   16/51 (31%)   22/50 (44%)         34/80 (43%)   22/50 (44%)   23/50 (46%)    |
|                                       41/60 (68%)   32/50 (64%)   22/50 (44%)         41/60 (68%)   28/50 (56%)   26/50 (52%)    |
| Overall Incidence               Total 174/340 (51.18%)Mean 50.6%   SD 13.8%     Total 174/340 (51.18%) Mean 51.47%  SD 9.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         71/79 (90%)   45/51 (88%)   42/50 (84%)         72/80 (90%)   35/50 (70%)   35/50 (70%)    |
|                                       56/60 (93%)   48/50 (96%)   43/50 (86%)         54/60 (90%)   46/50 (92%)   47/50 (94%)    |
| Overall Incidence               Total 305/340 (89.71%)Mean 89.57%  SD 4.5%      Total 289/340 (85%)    Mean 84.33%  SD 11.2%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     3/50 (6%)           4/80 (5%)     0/50 (0%)     3/50 (6%)     |
|                                        0/60 (0%)     2/50 (4%)     0/50 (0%)           0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 5/340 (1.47%)   Mean 1.67%   SD 2.66%     Total 8/340 (2.35%)    Mean 2.17%   SD 2.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/79 (4%)     3/51 (6%)     3/50 (6%)           3/80 (4%)     1/50 (2%)     3/50 (6%)     |
|                                        4/60 (7%)     5/50 (10%)    2/50 (4%)           5/60 (8%)     4/50 (8%)     0/50 (0%)     |
| Overall Incidence               Total 20/340 (5.88%)  Mean 6.06%   SD 2.25%     Total 16/340 (4.71%)   Mean 4.68%   SD 3.35%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        3/79 (4%)     3/51 (6%)     6/50 (12%)          7/80 (9%)     1/50 (2%)     5/50 (10%)    |
|                                        4/60 (7%)     7/50 (14%)    2/50 (4%)           5/60 (8%)     5/50 (10%)    0/50 (0%)     |
| Overall Incidence               Total 25/340 (7.35%)  Mean 7.72%   SD 4.28%     Total 23/340 (6.76%)   Mean 6.51%   SD 4.37%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/79 (1%)     0/51 (0%)     0/50 (0%)           5/80 (6%)     0/50 (0%)     0/50 (0%)     |
|                                        2/60 (3%)     2/50 (4%)     1/50 (2%)           3/60 (5%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 6/340 (1.76%)   Mean 1.77%   SD 1.67%     Total 12/340 (3.53%)   Mean 3.21%   SD 2.62%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Mononuclear, or Undifferentiated  0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 346
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     4/79 (5%)     8/51 (16%)    0/50 (0%)          11/80 (14%)   15/50 (30%)    9/50 (18%)    |
|      Lymphocytic, Mixed, NOS, or       7/60 (12%)    1/50 (2%)     3/50 (6%)          17/60 (28%)   10/50 (20%)    6/50 (12%)    |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 23/340 (6.76%)  Mean 6.74%   SD 5.93%     Total 68/340 (20%)     Mean 20.35%  SD 7.43%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.28%   SD 0.68%     Total 1/340 (0.29%)    Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/79 (0%)     0/51 (0%)     0/50 (0%)           1/80 (1%)     1/50 (2%)     1/50 (2%)     |
|                                        0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 3/340 (0.88%)    Mean 0.88%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/79 (0%)     0/51 (0%)     0/50 (0%)           2/80 (3%)     1/50 (2%)     1/50 (2%)     |
|                                        1/60 (2%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/340 (0.59%)   Mean 0.61%   SD 0.95%     Total 4/340 (1.18%)    Mean 1.08%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              9/79 (11%)    0/49 (0%)     5/50 (10%)          0/79 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        4/60 (7%)     0/50 (0%)     3/49 (6%)           0/60 (0%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence               Total 21/337 (6.23%)  Mean 5.7%    SD 4.84%     Total 3/338 (0.89%)    Mean 1.01%   SD 1.68%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/79 (0%)     0/49 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 1/338 (0.3%)     Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/79 (0%)     0/49 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/79 (0%)     0/49 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/79 (0%)     0/49 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/50 (0%)     |
|   Adenoma                              0/60 (0%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/76 (0%)     0/48 (0%)     1/49 (2%)           0/76 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/48 (0%)           0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.34%   SD 0.83%     Total 0/334 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 347
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/76 (0%)     0/48 (0%)     0/49 (0%)           0/76 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/48 (0%)           0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/334 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/76 (0%)     0/48 (0%)     0/49 (0%)           0/76 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/48 (0%)           0/60 (0%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 2/334 (0.6%)     Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/76 (0%)     0/48 (0%)     1/49 (2%)           0/76 (0%)     1/49 (2%)     0/50 (0%)     |
|      Complex, Malignant, NOS           0/60 (0%)     0/50 (0%)     0/48 (0%)           0/60 (0%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.34%   SD 0.83%     Total 2/334 (0.6%)     Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 1/337 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 0/337 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/79 (0%)     0/50 (0%)     1/50 (2%)           1/80 (1%)     0/49 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     1/50 (2%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 3/338 (0.89%)   Mean 0.94%   SD 1.04%     Total 1/337 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 0/337 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 0/337 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 0/337 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 0/337 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 348
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.28%   SD 0.68%     Total 1/340 (0.29%)    Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/79 (0%)     0/51 (0%)     0/50 (0%)           1/80 (1%)     1/50 (2%)     1/50 (2%)     |
|                                        0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 3/340 (0.88%)    Mean 0.88%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/79 (0%)     0/51 (0%)     0/50 (0%)           2/80 (3%)     1/50 (2%)     1/50 (2%)     |
|                                        1/60 (2%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/340 (0.59%)   Mean 0.61%   SD 0.95%     Total 4/340 (1.18%)    Mean 1.08%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/339 (0.29%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/339 (0.29%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 349
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/49 (0%)     |
|      Astrocytoma                       0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 350
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/76 (0%)     0/44 (0%)     0/44 (0%)           0/79 (0%)     0/45 (0%)     0/47 (0%)     |
|                                        0/55 (0%)     0/45 (0%)     0/43 (0%)           0/58 (0%)     0/42 (0%)     0/37 (0%)     |
| Overall Incidence               Total 0/307 (0%)      Mean 0%      SD 0%        Total 0/308 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              7/79 (9%)     5/51 (10%)    3/50 (6%)           4/80 (5%)     0/50 (0%)     1/50 (2%)     |
|                                        8/60 (13%)    1/50 (2%)     3/50 (6%)           1/60 (2%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence               Total 27/340 (7.94%)  Mean 7.67%   SD 3.89%     Total 9/340 (2.65%)    Mean 2.44%   SD 2.53%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/79 (1%)     1/51 (2%)     0/50 (0%)           1/80 (1%)     1/50 (2%)     0/50 (0%)     |
|                                        2/60 (3%)     1/50 (2%)     2/50 (4%)           0/60 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 7/340 (2.06%)   Mean 2.09%   SD 1.43%     Total 5/340 (1.47%)    Mean 1.54%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 8/79 (10%)    6/51 (12%)    3/50 (6%)           5/80 (6%)     1/50 (2%)     1/50 (2%)     |
|                                       10/60 (17%)    1/50 (2%)     5/50 (10%)          1/60 (2%)     5/50 (10%)    1/50 (2%)     |
| Overall Incidence               Total 33/340 (9.71%)  Mean 9.43%   SD 5.01%     Total 14/340 (4.12%)   Mean 3.99%   SD 3.42%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 351
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     1/50 (2%)           0/79 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 352
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     1/50 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/79 (0%)     1/51 (2%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           2/60 (3%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/340 (0.59%)   Mean 0.6%    SD 0.94%     Total 3/340 (0.88%)    Mean 0.89%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 353
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/79 (0%)     1/51 (2%)     1/50 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           2/60 (3%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/340 (0.88%)   Mean 0.94%   SD 1.03%     Total 3/340 (0.88%)    Mean 0.89%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/79 (0%)     1/51 (2%)     1/50 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           2/60 (3%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/340 (0.88%)   Mean 0.94%   SD 1.03%     Total 3/340 (0.88%)    Mean 0.89%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/78 (0%)     3/50 (6%)     0/50 (0%)           1/79 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/59 (2%)     1/50 (2%)     0/49 (0%)           1/59 (2%)     1/50 (2%)     1/49 (2%)     |
| Overall Incidence               Total 5/336 (1.49%)   Mean 1.62%   SD 2.33%     Total 4/337 (1.19%)    Mean 1.17%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/78 (0%)     0/50 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/336 (0%)      Mean 0%      SD 0%        Total 0/337 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 354
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/78 (0%)     3/50 (6%)     0/50 (0%)           1/79 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/59 (2%)     1/50 (2%)     0/49 (0%)           1/59 (2%)     1/50 (2%)     1/49 (2%)     |
| Overall Incidence               Total 5/336 (1.49%)   Mean 1.62%   SD 2.33%     Total 4/337 (1.19%)    Mean 1.17%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangioma                           0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|   Hemangiosarcoma                      0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/338 (0.3%)    Mean 0.28%   SD 0.68%     Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/338 (0.3%)    Mean 0.28%   SD 0.68%     Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 1/338 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/79 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/338 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 355
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/79 (0%)     0/50 (0%)     1/50 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/338 (0.3%)    Mean 0.33%   SD 0.82%     Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/59 (2%)     0/50 (0%)     0/50 (0%)           1/59 (2%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/339 (0.29%)   Mean 0.28%   SD 0.69%     Total 1/338 (0.3%)     Mean 0.28%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 1/338 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     0/50 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 1/338 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/79 (3%)     2/51 (4%)     1/50 (2%)           2/80 (3%)     1/50 (2%)     1/50 (2%)     |
|                                        3/59 (5%)     3/50 (6%)     1/50 (2%)           2/59 (3%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence               Total 12/339 (3.54%)  Mean 3.59%   SD 1.69%     Total 7/338 (2.07%)    Mean 1.98%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/79 (0%)     0/51 (0%)     1/50 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/59 (3%)     6/50 (12%)    2/50 (4%)           0/59 (0%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence               Total 11/339 (3.24%)  Mean 3.56%   SD 4.46%     Total 1/338 (0.3%)     Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              50/79 (63%)   24/51 (47%)   30/50 (60%)         49/80 (61%)   13/50 (26%)   19/50 (38%)    |
|                                       40/59 (68%)   35/50 (70%)   29/50 (58%)         29/59 (49%)   40/50 (80%)   37/49 (76%)    |
| Overall Incidence               Total 208/339 (61.36%)Mean 61.02%  SD 8.21%     Total 187/338 (55.33%) Mean 54.99%  SD 21.21%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            25/79 (32%)    5/51 (10%)   12/50 (24%)         14/80 (18%)    4/50 (8%)     6/50 (12%)    |
|                                       25/59 (42%)   13/50 (26%)   15/50 (30%)         25/59 (42%)    6/50 (12%)   13/49 (27%)    |
| Overall Incidence               Total 95/339 (28.02%) Mean 27.3%   SD 10.7%     Total 68/338 (20.12%)  Mean 19.73%  SD 12.81%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         25/79 (32%)    5/51 (10%)   13/50 (26%)         14/80 (18%)    4/50 (8%)     6/50 (12%)    |
|      Hepatoblastoma                   27/59 (46%)   18/50 (36%)   17/50 (34%)         25/59 (42%)    6/50 (12%)   13/49 (27%)    |
| Overall Incidence               Total 105/339 (30.97%)Mean 30.54%  SD 12.04%    Total 68/338 (20.12%)  Mean 19.73%  SD 12.81%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 356
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         62/79 (78%)   27/51 (53%)   35/50 (70%)         55/80 (69%)   16/50 (32%)   20/50 (40%)    |
|      Hepatocellular Adenoma           47/59 (80%)   39/50 (78%)   37/50 (74%)         41/59 (69%)   41/50 (82%)   41/49 (84%)    |
| Overall Incidence               Total 247/339 (72.86%)Mean 72.18%  SD 10.08%    Total 214/338 (63.31%) Mean 62.65%  SD 21.69%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           62/79 (78%)   27/51 (53%)   35/50 (70%)         55/80 (69%)   16/50 (32%)   20/50 (40%)    |
|      Hepatocellular Adenoma, or       48/59 (81%)   40/50 (80%)   38/50 (76%)         41/59 (69%)   41/50 (82%)   41/49 (84%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 250/339 (73.75%)Mean 73.13%  SD 10.67%    Total 214/338 (63.31%) Mean 62.65%  SD 21.69%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     1/50 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/339 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 357
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        11/79 (14%)   14/51 (27%)   15/50 (30%)          5/80 (6%)     3/50 (6%)     4/50 (8%)     |
|                                       12/60 (20%)   12/50 (24%)   12/49 (24%)          2/59 (3%)     4/50 (8%)     2/50 (4%)     |
| Overall Incidence               Total 76/339 (22.42%) Mean 23.31%  SD 5.71%     Total 20/339 (5.9%)    Mean 5.94%   SD 1.94%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma      12/79 (15%)    1/51 (2%)     8/50 (16%)          3/80 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        4/60 (7%)     4/50 (8%)     1/49 (2%)           3/59 (5%)     5/50 (10%)    2/50 (4%)     |
| Overall Incidence               Total 30/339 (8.85%)  Mean 8.31%   SD 6.15%     Total 14/339 (4.13%)   Mean 4.14%   SD 3.38%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   23/79 (29%)   15/51 (29%)   21/50 (42%)          8/80 (10%)    3/50 (6%)     5/50 (10%)    |
|      Alveolar/Bronchiolar Adenoma     15/60 (25%)   16/50 (32%)   13/49 (27%)          4/59 (7%)     9/50 (18%)    4/50 (8%)     |
| Overall Incidence               Total 103/339 (30.38%)Mean 30.68%  SD 6.06%     Total 33/339 (9.73%)   Mean 9.8%    SD 4.34%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     1/50 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/339 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/339 (0.29%)   Mean 0.28%   SD 0.68%     Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     1/50 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/339 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     0/50 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 358
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     1/50 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 359
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/79 (0%)     0/51 (0%)     0/50 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 360
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.28%   SD 0.68%     Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 361
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/339 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/78 (0%)     0/49 (0%)     2/46 (4%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 2/328 (0.61%)    Mean 0.72%   SD 1.77%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 362
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/78 (4%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        2/58 (3%)     1/50 (2%)     4/47 (9%)     |
| Overall Incidence                                                               Total 10/328 (3.05%)   Mean 2.97%   SD 3.17%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/78 (1%)     1/49 (2%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     1/50 (2%)     1/47 (2%)     |
| Overall Incidence                                                               Total 4/328 (1.22%)    Mean 1.24%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/78 (1%)     1/49 (2%)     0/46 (0%)     |
|      Malignant, NOS                                                                    0/58 (0%)     1/50 (2%)     1/47 (2%)     |
| Overall Incidence                                                               Total 4/328 (1.22%)    Mean 1.24%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/78 (0%)     0/49 (0%)     1/46 (2%)     |
|                                                                                        0/58 (0%)     1/50 (2%)     0/47 (0%)     |
| Overall Incidence                                                               Total 2/328 (0.61%)    Mean 0.7%    SD 1.08%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/78 (1%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        1/58 (2%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 2/328 (0.61%)    Mean 0.5%    SD 0.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 363
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/78 (0%)     0/49 (0%)     1/46 (2%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 1/328 (0.3%)     Mean 0.36%   SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/78 (0%)     0/49 (0%)     0/46 (0%)     |
|                                                                                        0/58 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence                                                               Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/78 (0%)     1/50 (2%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/58 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/335 (0.3%)    Mean 0.33%   SD 0.82%     Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/78 (0%)     0/50 (0%)     0/50 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/58 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/335 (0%)      Mean 0%      SD 0%        Total 1/338 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/78 (0%)     1/50 (2%)     0/50 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/58 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/335 (0.3%)    Mean 0.33%   SD 0.82%     Total 1/338 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 364
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/78 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/58 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/335 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/78 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/58 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/335 (0%)      Mean 0%      SD 0%        Total 1/338 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/78 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/58 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/335 (0%)      Mean 0%      SD 0%        Total 1/338 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/78 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/58 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/335 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/78 (0%)     0/50 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/58 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/335 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/70 (0%)     0/35 (0%)     0/49 (0%)           0/73 (0%)     0/29 (0%)     0/47 (0%)     |
|                                        0/55 (0%)     0/48 (0%)     0/31 (0%)           0/48 (0%)     0/49 (0%)     0/31 (0%)     |
| Overall Incidence               Total 0/288 (0%)      Mean 0%      SD 0%        Total 0/277 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/71 (0%)     1/47 (2%)     0/48 (0%)          25/80 (31%)    9/48 (19%)    5/48 (10%)    |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/46 (0%)          11/56 (20%)    6/49 (12%)    8/47 (17%)    |
| Overall Incidence               Total 1/314 (0.32%)   Mean 0.35%   SD 0.87%     Total 64/328 (19.51%)  Mean 18.22%  SD 7.35%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/71 (0%)     0/47 (0%)     0/48 (0%)           0/80 (0%)     0/48 (0%)     0/48 (0%)     |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/46 (0%)           0/56 (0%)     0/49 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/314 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/71 (0%)     1/47 (2%)     0/48 (0%)          25/80 (31%)    9/48 (19%)    5/48 (10%)    |
|   Carcinoma or Adenoma                 0/52 (0%)     0/50 (0%)     0/46 (0%)          11/56 (20%)    6/49 (12%)    8/47 (17%)    |
| Overall Incidence               Total 1/314 (0.32%)   Mean 0.35%   SD 0.87%     Total 64/328 (19.51%)  Mean 18.22%  SD 7.35%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 365
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/71 (0%)     0/47 (0%)     0/48 (0%)           0/80 (0%)     0/48 (0%)     1/48 (2%)     |
|                                        0/52 (0%)     0/50 (0%)     0/46 (0%)           0/56 (0%)     0/49 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/314 (0%)      Mean 0%      SD 0%        Total 1/328 (0.3%)     Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/71 (0%)     0/47 (0%)     0/48 (0%)           0/80 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/52 (0%)     0/50 (0%)     0/46 (0%)           0/56 (0%)     0/49 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/314 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/71 (0%)     0/47 (0%)     0/48 (0%)           0/80 (0%)     0/48 (0%)     1/48 (2%)     |
|                                        0/52 (0%)     0/50 (0%)     0/46 (0%)           0/56 (0%)     0/49 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/314 (0%)      Mean 0%      SD 0%        Total 1/328 (0.3%)     Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/79 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/79 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/79 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     1/50 (2%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/339 (0.29%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/78 (0%)     0/51 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/48 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/78 (0%)     0/51 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/48 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/78 (0%)     0/51 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/48 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/78 (0%)     0/51 (0%)     1/50 (2%)           0/79 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/48 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/337 (0.3%)    Mean 0.33%   SD 0.82%     Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 366
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/79 (0%)     0/51 (0%)     1/50 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     1/50 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 367
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 368
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/60 (0%)     0/50 (0%)     1/50 (2%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/79 (1%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)     1/50 (2%)           1/60 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/340 (0.88%)   Mean 0.88%   SD 1%        Total 2/340 (0.59%)    Mean 0.61%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 369
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     1/50 (2%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/60 (0%)     0/50 (0%)     1/50 (2%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/60 (0%)     0/50 (0%)     1/50 (2%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 370
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/79 (0%)     1/51 (2%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.8%      Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/79 (0%)     1/51 (2%)     0/50 (0%)           2/80 (3%)     3/50 (6%)     2/50 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous   1/60 (2%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     1/50 (2%)     2/50 (4%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 3/340 (0.88%)   Mean 0.94%   SD 1.03%     Total 10/340 (2.94%)   Mean 3.08%   SD 2.06%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/79 (0%)     0/51 (0%)     0/50 (0%)           2/80 (3%)     3/50 (6%)     1/50 (2%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.28%   SD 0.68%     Total 7/340 (2.06%)    Mean 2.08%   SD 2.2%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/79 (0%)     0/51 (0%)     0/50 (0%)           2/80 (3%)     3/50 (6%)     2/50 (4%)     |
|      Myxosarcoma, or Fibrous           1/60 (2%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     1/50 (2%)     2/50 (4%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 2/340 (0.59%)   Mean 0.61%   SD 0.95%     Total 10/340 (2.94%)   Mean 3.08%   SD 2.06%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 3/340 (0.88%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 371
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/79 (0%)     0/50 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/335 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/79 (0%)     0/50 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 1/335 (0.3%)     Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/79 (0%)     0/50 (0%)     1/50 (2%)           0/79 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/337 (0.3%)    Mean 0.33%   SD 0.82%     Total 0/335 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/79 (0%)     1/50 (2%)     3/50 (6%)           0/79 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/59 (2%)     0/50 (0%)     1/49 (2%)           1/59 (2%)     1/49 (2%)     0/49 (0%)     |
| Overall Incidence               Total 6/337 (1.78%)   Mean 1.96%   SD 2.19%     Total 3/335 (0.9%)     Mean 0.96%   SD 1.06%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/79 (0%)     0/50 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/335 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/79 (0%)     0/50 (0%)     0/50 (0%)           0/79 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/335 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 372
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/340 (0.29%)   Mean 0.28%   SD 0.68%     Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/79 (0%)     0/51 (0%)     1/50 (2%)           3/80 (4%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma Squamous                1/60 (2%)     1/50 (2%)     1/50 (2%)           0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 4/340 (1.18%)   Mean 1.28%   SD 1%        Total 5/340 (1.47%)    Mean 1.29%   SD 1.55%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/79 (0%)     0/51 (0%)     1/50 (2%)           3/80 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)     1/50 (2%)           0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/340 (0.88%)   Mean 1%      SD 1.1%      Total 5/340 (1.47%)    Mean 1.29%   SD 1.55%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 373
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/78 (0%)     0/51 (0%)     1/50 (2%)                                                     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 2/339 (0.59%)   Mean 0.61%   SD 0.95%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/78 (0%)     0/51 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/67 (0%)     0/39 (0%)     0/47 (0%)           0/76 (0%)     0/43 (0%)     0/48 (0%)     |
|                                        0/53 (0%)     0/37 (0%)     0/46 (0%)           0/57 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/317 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/67 (0%)     0/39 (0%)     0/47 (0%)           0/76 (0%)     0/43 (0%)     1/48 (2%)     |
|                                        0/53 (0%)     0/37 (0%)     0/46 (0%)           0/57 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 1/317 (0.32%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/67 (0%)     0/39 (0%)     1/47 (2%)           0/76 (0%)     0/43 (0%)     0/48 (0%)     |
|                                        0/53 (0%)     0/37 (0%)     0/46 (0%)           0/57 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 1/289 (0.35%)   Mean 0.35%   SD 0.87%     Total 0/317 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/67 (0%)     0/39 (0%)     0/47 (0%)           0/76 (0%)     0/43 (0%)     0/48 (0%)     |
|                                        1/53 (2%)     0/37 (0%)     0/46 (0%)           0/57 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 1/289 (0.35%)   Mean 0.31%   SD 0.77%     Total 0/317 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/67 (0%)     0/39 (0%)     0/47 (0%)           0/76 (0%)     0/43 (0%)     0/48 (0%)     |
|                                        0/53 (0%)     0/37 (0%)     0/46 (0%)           0/57 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/317 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/67 (0%)     0/39 (0%)     0/47 (0%)           0/76 (0%)     0/43 (0%)     0/48 (0%)     |
|                                        0/53 (0%)     0/37 (0%)     0/46 (0%)           0/57 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/317 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/67 (0%)     0/39 (0%)     0/47 (0%)           0/76 (0%)     0/43 (0%)     1/48 (2%)     |
|                                        0/53 (0%)     0/37 (0%)     0/46 (0%)           0/57 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 1/317 (0.32%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/67 (0%)     0/39 (0%)     0/47 (0%)           0/76 (0%)     0/43 (0%)     0/48 (0%)     |
|                                        0/53 (0%)     0/37 (0%)     0/46 (0%)           0/57 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/317 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 374
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/67 (0%)     0/39 (0%)     0/47 (0%)           0/76 (0%)     0/43 (0%)     0/48 (0%)     |
|                                        0/53 (0%)     0/37 (0%)     0/46 (0%)           0/57 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/317 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/67 (0%)     0/39 (0%)     0/47 (0%)           0/76 (0%)     0/43 (0%)     1/48 (2%)     |
|                                        0/53 (0%)     0/37 (0%)     0/46 (0%)           0/57 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 1/317 (0.32%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/58 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              1/79 (1%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/58 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/339 (0.29%)   Mean 0.21%   SD 0.52%     Total 1/338 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)     0/49 (0%)           0/58 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/339 (0.29%)   Mean 0.33%   SD 0.82%     Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 1/79 (1%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)     0/49 (0%)           0/58 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/339 (0.59%)   Mean 0.54%   SD 0.87%     Total 1/338 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/79 (1%)     1/51 (2%)     1/50 (2%)           4/80 (5%)     0/50 (0%)     2/50 (4%)     |
|                                        1/60 (2%)     1/50 (2%)     2/49 (4%)           2/58 (3%)     1/50 (2%)     3/50 (6%)     |
| Overall Incidence               Total 7/339 (2.06%)   Mean 2.16%   SD 0.98%     Total 12/338 (3.55%)   Mean 3.41%   SD 2.15%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/58 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/339 (0%)      Mean 0%      SD 0%        Total 0/338 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/79 (1%)     1/51 (2%)     1/50 (2%)           4/80 (5%)     0/50 (0%)     2/50 (4%)     |
|                                        1/60 (2%)     1/50 (2%)     2/49 (4%)           2/58 (3%)     1/50 (2%)     3/50 (6%)     |
| Overall Incidence               Total 7/339 (2.06%)   Mean 2.16%   SD 0.98%     Total 12/338 (3.55%)   Mean 3.41%   SD 2.15%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 375
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 376
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/78 (0%)     0/49 (0%)     0/50 (0%)           0/80 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     1/48 (2%)           0/59 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 1/334 (0.3%)    Mean 0.35%   SD 0.85%     Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/78 (0%)     0/49 (0%)     0/50 (0%)           0/80 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     1/50 (2%)     0/48 (0%)           0/59 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 1/334 (0.3%)    Mean 0.33%   SD 0.82%     Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/78 (0%)     0/49 (0%)     0/50 (0%)           0/80 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/48 (0%)           0/59 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/334 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/78 (0%)     0/49 (0%)     0/50 (0%)           0/80 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/48 (0%)           0/59 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/334 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/78 (0%)     0/49 (0%)     0/50 (0%)           0/80 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     1/48 (2%)           0/59 (0%)     0/48 (0%)     0/45 (0%)     |
| Overall Incidence               Total 1/334 (0.3%)    Mean 0.35%   SD 0.85%     Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 377
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           2/80 (3%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/340 (0.59%)    Mean 0.42%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/60 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/340 (0.59%)    Mean 0.61%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/80 (3%)     3/50 (6%)     0/50 (0%)     |
|                                                                                        1/60 (2%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence                                                               Total 9/340 (2.65%)    Mean 2.69%   SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/340 (0.29%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/80 (3%)     3/50 (6%)     0/50 (0%)     |
|                                                                                        1/60 (2%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence                                                               Total 10/340 (2.94%)   Mean 3.03%   SD 2.1%      |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 378
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/79 (0%)     0/51 (0%)     0/50 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/340 (0%)      Mean 0%      SD 0%        Total 0/340 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 379
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       22/50 (44%)                                     34/50 (68%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    32/50 (64%)                                     35/50 (70%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         42/50 (84%)                                     48/50 (96%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        4/50 (8%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    0/50 (0%)                                       0/50 (0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     4/50 (8%)                                      11/50 (22%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 380
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                           0/50 (0%)                                       0/50 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/49 (2%)                                       1/50 (2%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 381
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 382
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 383
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/45 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              2/50 (4%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 4/50 (8%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 384
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 385
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 386
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/48 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/48 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/48 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/49 (0%)                                       0/48 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 387
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      4/50 (8%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       2/50 (4%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              14/50 (28%)                                     24/49 (49%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            18/50 (36%)                                     16/49 (33%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         20/50 (40%)                                     16/49 (33%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         28/50 (56%)                                     33/49 (67%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           30/50 (60%)                                     33/49 (67%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 388
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant             0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                   0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         9/50 (18%)                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       5/50 (10%)                                      2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   13/50 (26%)                                      2/50 (4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 389
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 390
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       0/50 (0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 391
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 392
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          4/46 (9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/46 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/46 (2%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 393
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      1/46 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/49 (0%)                                       1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 394
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)                                       1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                         0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                            0/49 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                      11/46 (24%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                       0/46 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/45 (0%)                                      11/46 (24%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/45 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 395
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/45 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/45 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 396
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 397
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       1/50 (2%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       1/50 (2%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       2/50 (4%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 398
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       1/50 (2%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 399
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       2/50 (4%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       2/50 (4%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 400
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                 0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/49 (0%)                                       1/47 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 401
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                         0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                 0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                      0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 402
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/38 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 403
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 404
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 405
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: SUBCUTANEOUS                               Date of
 Species: MICE                                           Vehicle: BUFFERED SERUM                           Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 407
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                                                                       72/100(72%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                                                                    42/100(42%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors                                                         82/100(82%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma                                                        0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                                                                  2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Erythrocytic                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,                                                    0/100(0%)                                 |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,                                                    14/100(14%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 408
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                                                                              1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                                                                            0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Plasma Cell Tumor Malignant                                                          0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                                                                              0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Gland: Non-medullary,                                                                                                    |
| Non-cortical                                                                           0/94 (0%)                                 |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign                                                              2/94 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex                                                             0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant                                                           0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,                                                            2/94 (2%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrous Histiocytoma                                                                 0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 409
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangioma                                                                           0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                                                                      0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign                                                               0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant                                                            0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor NOS                                                                  0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Plasma Cell Tumor Malignant                                                          0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                                                                   0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 410
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                                                                 0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS                                                   0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign                                                             0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant                                                          0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or                                                        0/99 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                                                                              0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Basosquamous Tumor Malignant                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 411
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                                                                              0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                                                                              9/100(9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                                                                            2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                                                                11/100(11%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangioma                                                                           0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                                                                              0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 412
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                                                                    1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 413
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                                                                    0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                                                                    1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                                                                              3/94 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                                                                            0/94 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 414
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                                                                 3/94 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                                                                             0/98 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                                                                             0/98 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                                                                             0/98 (0%)                                 |
|   Hemangioma                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                                                                             0/98 (0%)                                 |
|   Hemangiosarcoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                                                                              1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                                                                            0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                                                                 1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibrous Histiocytoma                                                                 0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                                                                      0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                                                                              0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                                                                   0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 415
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                                                                          0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                                                                           0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                                                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma                                                              56/99 (57%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma                                                            18/99 (18%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or                                                         18/99 (18%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or                                                         61/99 (62%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,                                                           61/99 (62%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma                                                             0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Benign                                                                0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 416
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor Malignant                                                             0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Ito Cell Tumor NOS                                                                   0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Mast Cell Tumor Malignant                                                            0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Plasma Cell Tumor Malignant                                                          0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                                                                              0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                                                                              0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma                                                         7/98 (7%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma                                                       3/98 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or                                                   10/98 (10%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrous Histiocytoma                                                                 0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangioma                                                                           0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                                                                      0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Mast Cell Tumor Malignant                                                            0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 417
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                                                                              0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Liposarcoma                                                                          1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Plasma Cell Tumor Malignant                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 418
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node: Mesenteric                                                                                                           |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma                                                     0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,                                                    0/100(0%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Chemodectoma Malignant                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibroma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 419
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                                                                            1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,                                                             0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 420
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma NOS                                                                  0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Carcinoma                                                                            0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          5/97 (5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Fibrous Histiocytoma                                                                 0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          2/97 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        2/97 (2%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 421
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Liposarcoma                                                                          1/97 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma                                                                             0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Malignant                                                                   0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma NOS                                                                         0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Yolk Sac Carcinoma                                                                   0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                                                                              0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                                                                            1/95 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                                                                 1/95 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrosarcoma                                                                         0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 422
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                                                                 0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                                                                           0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangiosarcoma                                                                      0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                                                                              0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Carcinoma                                                                            0/59 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                                                                       9/86 (10%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                                                                       0/86 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                                                                       9/86 (10%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                                                                              0/86 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                                                                            0/86 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                                                                 0/86 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 423
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                                                                            0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                                                                 0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Hemangioma                                                                           0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                                                                              0/97 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Osteosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                                                                     2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 424
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma                                                      2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                                                                   0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                                                                0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous                                                     0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or                                                              0/100(0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 425
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell                                                     0/100(0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,                                                         0/100(0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 426
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Paraganglioma Benign                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal                                                       0/100(0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or                                                           0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,                                                             0/100(0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,                                                             0/100(0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                                                                    0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,                                                      2/100(2%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 427
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                                                                         2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,                                                               2/100(2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                                                                    0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma                                                      0/100(0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,                                                     0/100(0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Schwannoma Malignant                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                                                                         0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 428
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrous Histiocytoma                                                                 0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                                                                           0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant                                                            0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant                                                          0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Mast Cell Tumor Benign                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or                                                           0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 429
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrosarcoma                                                                         0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Fibrous Histiocytoma                                                                 0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                                                                           0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Mast Cell Tumor Malignant                                                            0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                                                                              0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                                                                       0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                                                                    0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 430
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                                                                          0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS                                                      0/93 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                                                                              0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                                                                              1/96 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                                                                            0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                                                                 1/96 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                                                                              9/96 (9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                                                                            1/96 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                                                                10/96 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 431
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Lipoma                                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                                                                     0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or                                                           0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                                                                  0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                                                                             0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma                                                               0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                                                                           0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                                                                      0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                                                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 432
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                                                                            0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Benign                                                           1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 433
 Version: 11/03/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VAGINAL                                    Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 02-NOV-1998
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                                                                            1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                                                                 1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
