                                                 Toxicology Data Management System                                     Page: 1
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                    Date of
 Species: RATS                                           Vehicle: ACETONE                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510911  11/14/88   729       50(1)      21  (651)    437.2     TRIETHANOLAMINE                            |
|E.G. & G. MASON    050506908  09/12/89   729       50(1)       5  (619)    483.8     1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE       |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510911  11/14/88   729       50(1)      25  (678)    279.5     TRIETHANOLAMINE                            |
|E.G. & G. MASON    050506908  09/12/89   736       50(1)      19  (667)    340.1     1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE       |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                    Date of
 Species: RATS                                           Vehicle: ETHANOL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510205  06/15/87   731       52(1)      15  (654)    496.6     BENZETHONIUM CHLORIDE                      |
|BATTELLE COLUMBUS  055531203  02/01/93   729       50(1)       8  (594)    480.5     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE |
|BATTELLE COLUMBUS  050516209  10/08/90   729       50(1)      14  (651)    467.0     DIETHANOLAMINE                             |
|BATTELLE COLUMBUS  055532303  12/14/92   729       50(1)      12  (657)    471.8     LAURIC ACID DIETHANOLAMINE CONDENSATE      |
|BATTELLE COLUMBUS  059101403  05/19/93   728       50(1)       8  (622)    456.4     OLEIC ACID DIETHANOLAMINE CONDENSATE       |
|BATTELLE COLUMBUS  050518805  11/29/90   735       50(1)       7  (637)    439.3     SODIUM XYLENESULFONATE                     |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050510205  06/15/87   731       51(1)      24  (671)    308.5     BENZETHONIUM CHLORIDE                      |
|BATTELLE COLUMBUS  055531203  02/01/93   728       50(1)      28  (683)    311.9     COCONUT OIL ACID DIETHANOLAMINE CONDENSATE |
|BATTELLE COLUMBUS  050516209  10/08/90   730       50(1)      25  (669)    305.9     DIETHANOLAMINE                             |
|BATTELLE COLUMBUS  055532303  12/14/92   729       50(1)      28  (653)    302.3     LAURIC ACID DIETHANOLAMINE CONDENSATE      |
|BATTELLE COLUMBUS  059101403  05/19/93   728       50(1)      15  (627)    297.1     OLEIC ACID DIETHANOLAMINE CONDENSATE       |
|BATTELLE COLUMBUS  050518805  11/29/90   736       50(1)      22  (647)    289.4     SODIUM XYLENESULFONATE                     |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                    Date of
 Species: RATS                                           Vehicle: NEAT                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|HAZLETON           050510601  02/06/85   734       50(1)       4  (610)    464.5     DIETHYLPHTHALATE                           |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|HAZLETON           050510601  02/06/85   734       51(1)      30  (682)    305.0     DIETHYLPHTHALATE                           |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 4
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                    Date of
 Species: RATS                                           Vehicle: CORN OIL                                Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050508601  10/29/84   729       50(5)      23  (641)    496.9     O-BENZYL-P-CHLOROPHENOL                    |
|BIOASSAY SYS CORP  050509101  10/02/84   729       51(5)      28  (671)    529.1     3,4-DIHYDROCOUMARIN                        |
|BIOASSAY SYS CORP  050509001  09/06/84   729       49(5)      28  (666)    526.9     COUMARIN                                   |
|E.G. & G. MASON    050511101  06/03/85   731       50(5)      34  (688)    488.8     1,2,3-TRICHLOROPROPANE                     |
|E.G. & G. MASON    050510801  03/05/85   730       50(5)      23  (675)    482.3     PROMETHAZINE HYDROCHLORIDE                 |
|E.G. & G. MASON    050521401  12/13/88   731       52(1)      22  (652)    464.8     TRANS-DELTA-9-TETRAHYDROCANNABINOL         |
|SOUTHERN RESEARCH  050509907  12/12/88   729       50(5)      35  (686)    477.3     SALICYLAZOSULFAPYRIDINE                    |
|SOUTHERN RESEARCH  050506709  10/25/90   733       50(5)      23  (676)    491.2     THEOPHYLLINE                               |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050508601  10/29/84   729       50(5)      26  (652)    311.3     O-BENZYL-P-CHLOROPHENOL                    |
|BIOASSAY SYS CORP  050509101  10/02/84   730       50(5)      31  (687)    322.9     3,4-DIHYDROCOUMARIN                        |
|BIOASSAY SYS CORP  050509001  09/06/84   729       50(5)      29  (665)    339.1     COUMARIN                                   |
|E.G. & G. MASON    050511101  06/03/85   738       50(5)      31  (687)    313.7     1,2,3-TRICHLOROPROPANE                     |
|E.G. & G. MASON    050510801  03/05/85   735       50(5)      30  (667)    335.0     PROMETHAZINE HYDROCHLORIDE                 |
|E.G. & G. MASON    050521401  12/13/88   736       51(1)      23  (649)    316.9     TRANS-DELTA-9-TETRAHYDROCANNABINOL         |
|SOUTHERN RESEARCH  050509907  12/12/88   738       50(5)      34  (697)    295.0     SALICYLAZOSULFAPYRIDINE                    |
|SOUTHERN RESEARCH  050506709  10/25/90   734       50(5)      31  (684)    320.7     THEOPHYLLINE                               |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 5
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                    Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                        Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050518709  02/07/94   730       50(3)      20  (678)    466.1     METHYLEUGENOL                              |
|BATTELLE COLUMBUS  058803205  04/21/93   728       51(3)      15  (625)    505.6     OXYMETHOLONE                               |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050518709  02/07/94   730       50(5)      22  (659)    349.5     METHYLEUGENOL                              |
|BATTELLE COLUMBUS  058803205  04/21/93   728       50(5)      25  (664)    322.2     OXYMETHOLONE                               |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 6
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                    Date of
 Species: RATS                                           Vehicle: WATER                                   Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050512105  10/20/88   726       50(5)      20  (659)    485.0     SCOPOLAMINE HYDROBROMIDE TRIHYDRATE        |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050512105  10/20/88   726       50(5)      34  (680)    334.6     SCOPOLAMINE HYDROBROMIDE TRIHYDRATE        |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 7
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                Date of
 Species: RATS                                           Vehicle: AIR                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 050519711  08/23/93   729       50(1)      19  (660)    510.8     2-BUTOXYETHANOL                            |
|BATTELLE NORTHWEST 050513303  03/31/88   733       48(1)      11  (639)    498.2     ACETONITRILE                               |
|BATTELLE NORTHWEST 050513607  09/20/90   733       50(1)      13  (645)    529.2     CHLOROPRENE                                |
|BATTELLE NORTHWEST 050515605  08/30/90   734       50(1)      17  (648)    497.6     COBALT SULFATE HEPTAHYDRATE                |
|BATTELLE NORTHWEST 050520105  11/26/91   735       50(1)       8  (618)    546.6     FURFURYL ALCOHOL                           |
|BATTELLE NORTHWEST 050518405  06/27/94   729       50(1)      12  (631)    503.6     GLUTARALDEHYDE                             |
|BATTELLE NORTHWEST 050511401  12/02/85   733       50(1)      18  (661)    488.4     HEXACHLOROCYCLOPENTADIENE (HCCPD)          |
|BATTELLE NORTHWEST 058807003  03/11/93   733       50(1)       7  (630)    531.3     ISOBUTENE                                  |
|BATTELLE NORTHWEST 056096801  08/16/90   733       50(1)      12  (641)    530.8     ISOBUTYRALDEHYDE                           |
|BATTELLE NORTHWEST 050513507  06/24/93   733       50(1)      18  (643)    513.1     ISOPRENE                                   |
|BATTELLE NORTHWEST 050515803  03/15/90   735       50(1)      17  (645)    518.7     MOLYBDENUM TRIOXIDE                        |
|BATTELLE NORTHWEST 050520005  09/07/89   733       50(1)      13  (642)    533.0     NITROMETHANE                               |
|BATTELLE NORTHWEST 058803403  01/25/90   733       50(1)       8  (620)    525.8     OZONE                                      |
|BATTELLE NORTHWEST 050513205  06/23/88   733       50(1)      17  (665)    485.7     TETRAFLUOROETHYLENE                        |
|BATTELLE NORTHWEST 050518103  12/14/89   733       50(1)      12  (616)    542.0     TETRAHYDROFURAN                            |
|I. I. T. RESEARCH I050521003  03/07/90   734       50(1)      15  (651)    507.1     ETHYLBENZENE                               |
|I. I. T. RESEARCH I050518503  12/08/88   729       46(1)      17  (655)    465.8     ISOBUTYL NITRITE                           |
|LOVELACE RESEARCH  050512305  04/04/88   733       54(1)      14  (648)    500.6     NICKEL OXIDE                               |
|LOVELACE RESEARCH  050510705  10/31/88   733       53(1)      13  (635)    502.6     NICKEL SUBSULFIDE                          |
|LOVELACE RESEARCH  050512205  06/20/88   733       54(1)      16  (641)    497.4     NICKEL SULFATE HEXAHYDRATE                 |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 8
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                Date of
 Species: RATS                                           Vehicle: AIR                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 050519711  08/23/93   730       50(1)      29  (688)    366.8     2-BUTOXYETHANOL                            |
|BATTELLE NORTHWEST 050513303  03/31/88   734       48(1)      23  (649)    342.1     ACETONITRILE                               |
|BATTELLE NORTHWEST 050513607  09/20/90   733       49(1)      29  (685)    365.7     CHLOROPRENE                                |
|BATTELLE NORTHWEST 050515605  08/30/90   735       50(1)      28  (699)    334.1     COBALT SULFATE HEPTAHYDRATE                |
|BATTELLE NORTHWEST 050520105  11/26/91   735       50(1)      26  (667)    382.3     FURFURYL ALCOHOL                           |
|BATTELLE NORTHWEST 050518405  06/27/94   730       50(1)      26  (675)    353.5     GLUTARALDEHYDE                             |
|BATTELLE NORTHWEST 050511401  12/02/85   733       50(1)      28  (689)    340.2     HEXACHLOROCYCLOPENTADIENE (HCCPD)          |
|BATTELLE NORTHWEST 058807003  03/11/93   733       50(1)      23  (667)    360.6     ISOBUTENE                                  |
|BATTELLE NORTHWEST 056096801  08/16/90   734       50(1)      27  (659)    360.1     ISOBUTYRALDEHYDE                           |
|BATTELLE NORTHWEST 050513507  06/24/93   734       50(1)      29  (686)    359.3     ISOPRENE                                   |
|BATTELLE NORTHWEST 050515803  03/15/90   735       50(1)      28  (685)    363.0     MOLYBDENUM TRIOXIDE                        |
|BATTELLE NORTHWEST 050520005  09/07/89   733       50(1)      28  (683)    358.0     NITROMETHANE                               |
|BATTELLE NORTHWEST 058803403  01/25/90   733       50(1)      28  (676)    359.6     OZONE                                      |
|BATTELLE NORTHWEST 050513205  06/23/88   734       50(1)      28  (694)    335.5     TETRAFLUOROETHYLENE                        |
|BATTELLE NORTHWEST 050518103  12/14/89   733       50(1)      25  (657)    373.8     TETRAHYDROFURAN                            |
|I. I. T. RESEARCH I050521003  03/07/90   734       50(1)      31  (661)    347.4     ETHYLBENZENE                               |
|I. I. T. RESEARCH I050518503  12/08/88   733       46(1)      29  (696)    306.2     ISOBUTYL NITRITE                           |
|LOVELACE RESEARCH  050512305  04/04/88   729       53(1)      21  (659)    344.6     NICKEL OXIDE                               |
|LOVELACE RESEARCH  050510705  10/31/88   729       53(1)      25  (658)    335.8     NICKEL SUBSULFIDE                          |
|LOVELACE RESEARCH  050512205  06/20/88   729       53(1)      22  (676)    339.2     NICKEL SULFATE HEXAHYDRATE                 |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 9
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                           Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|I. I. T. RESEARCH I058902905  09/26/94   736      100(5)      57  (692)    498.3     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|I. I. T. RESEARCH I058902905  09/26/94   737      100(5)      59  (692)    338.0     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 10
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                      Date of
 Species: RATS                                           Vehicle: FEED                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050516501  12/22/86   731       50(5)      18  (648)    462.1     4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL)        |
|BATTELLE COLUMBUS  050508501  09/24/84   729       52(5)      25  (655)    510.0     MANGANESE SULFATE                          |
|BATTELLE COLUMBUS  050521205  09/23/91   730       50(5)      17  (662)    509.2     OXAZEPAM                                   |
|BATTELLE COLUMBUS  058900202  11/23/92   736       50(5)      12  (656)    514.7     PENTACHLOROPHENOL                          |
|BATTELLE COLUMBUS  058803505  04/06/92   723       50(5)      13  (639)    522.0     PRIMACLONE                                 |
|BATTELLE COLUMBUS  050508701  09/10/84   729       50(5)      25  (638)    489.9     TRIAMTERENE                                |
|BATTELLE COLUMBUS  050510003  09/18/86   731       51(5)      31  (684)    466.8     TRICRESYL PHOSPHATE                        |
|E.G. & G. MASON    050515001  08/27/86   735       50(5)      28  (678)    430.5     METHYLPHENIDATE HYDROCHLORIDE              |
|E.G. & G. MASON    050508401  07/24/84   732       50(5)      18  (649)    494.1     TURMERIC, OLEORESIN (CURCUMIN)             |
|MICROB. ASSOC.     050513003  05/15/86   733       50(5)      30  (676)    468.9     C. I. DIRECT BLUE 218                      |
|MICROB. ASSOC.     050506809  04/14/89   732       50(5)      29  (664)    478.2     CODEINE                                    |
|SOUTHERN RESEARCH  050510305  03/27/89   736       51(5)      26  (688)    462.5     2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL       |
|SOUTHERN RESEARCH  050512003  09/09/86   729       50(5)      27  (684)    449.3     BENZYL ACETATE                             |
|SOUTHERN RESEARCH  050509402  06/26/89   729       50(5)      28  (658)    451.2     BUTYL BENZYL PHTHALATE                     |
|SOUTHERN RESEARCH  050512806  04/26/90   733       50(5)      19  (679)    476.9     D & C YELLOW NO. 11                        |
|SOUTHERN RESEARCH  050509201  09/11/84   728       50(5)      32  (695)    447.8     O-NITROANISOLE                             |
|SOUTHERN RESEARCH  050515503  05/11/88   729       50(5)      12  (613)    484.4     P-NITROBENZOIC ACID                        |
|TSI MASON RESEARCH 050518203  03/13/91   729       50(5)      21  (640)    470.3     PHENOLPHTHALEIN                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 11
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                      Date of
 Species: RATS                                           Vehicle: FEED                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050516501  12/22/86   731       50(5)      34  (706)    340.6     4,4-THIOBIS-(6-TERT-BUTYL-M-CRESOL)        |
|BATTELLE COLUMBUS  050508501  09/24/84   729       50(5)      37  (708)    339.6     MANGANESE SULFATE                          |
|BATTELLE COLUMBUS  050521205  09/23/91   729       50(5)      32  (676)    348.2     OXAZEPAM                                   |
|BATTELLE COLUMBUS  058900202  11/23/92   738       50(5)      28  (680)    338.6     PENTACHLOROPHENOL                          |
|BATTELLE COLUMBUS  058803505  04/06/92   722       50(5)      24  (673)    363.0     PRIMACLONE                                 |
|BATTELLE COLUMBUS  050508701  09/10/84   729       50(5)      29  (697)    343.8     TRIAMTERENE                                |
|BATTELLE COLUMBUS  050510003  09/18/86   731       51(5)      34  (676)    328.4     TRICRESYL PHOSPHATE                        |
|E.G. & G. MASON    050515001  08/27/86   747       50(5)      30  (699)    325.8     METHYLPHENIDATE HYDROCHLORIDE              |
|E.G. & G. MASON    050508401  07/24/84   734       50(5)      32  (691)    343.2     TURMERIC, OLEORESIN (CURCUMIN)             |
|MICROB. ASSOC.     050513003  05/15/86   734       50(5)      35  (689)    345.6     C. I. DIRECT BLUE 218                      |
|MICROB. ASSOC.     050506809  04/14/89   733       50(5)      28  (662)    348.6     CODEINE                                    |
|SOUTHERN RESEARCH  050510305  03/27/89   739       50(5)      36  (712)    329.5     2,2-BIS(BROMOMETHYL)-1,3-PROPANEDIOL       |
|SOUTHERN RESEARCH  050512003  09/09/86   731       50(5)      30  (693)    320.6     BENZYL ACETATE                             |
|SOUTHERN RESEARCH  050509402  06/26/89   736       50(5)      25  (690)    334.9     BUTYL BENZYL PHTHALATE                     |
|SOUTHERN RESEARCH  050512806  04/26/90   742       50(5)      22  (694)    356.7     D & C YELLOW NO. 11                        |
|SOUTHERN RESEARCH  050509201  09/11/84   728       50(5)      33  (694)    316.8     O-NITROANISOLE                             |
|SOUTHERN RESEARCH  050515503  05/11/88   731       50(5)      27  (699)    341.0     P-NITROBENZOIC ACID                        |
|TSI MASON RESEARCH 050518203  03/13/91   735       50(5)      30  (680)    351.2     PHENOLPHTHALEIN                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 12
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                      Date of
 Species: RATS                                           Vehicle: WATER                                   Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050513101  10/07/85   729       80(5)      42  (668)    487.2     SODIUM FLUORIDE                            |
|E.G. & G. MASON    050512701  09/09/85   733       50(5)      22  (685)    468.0     BARIUM CHLORIDE DIHYDRATE                  |
|SOUTHERN RESEARCH  050508901  01/28/85   729       51(5)      14  (637)    495.7     CHLORAMINE                                 |
|SOUTHERN RESEARCH  050514203  11/12/86   729       50(1)      10  (618)    486.0     TERT-BUTYL ALCOHOL                         |
|TSI MASON RESEARCH 050516005  02/05/91   729       50(5)      20  (659)    516.1     1-CHLORO-2-PROPANOL                        |
|TSI MASON RESEARCH 055530105  04/23/91   722       50(5)      25  (663)    511.0     PYRIDINE                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  050513101  10/07/85   729       80(5)      59  (697)    335.8     SODIUM FLUORIDE                            |
|E.G. & G. MASON    050512701  09/09/85   745       50(5)      30  (688)    335.5     BARIUM CHLORIDE DIHYDRATE                  |
|SOUTHERN RESEARCH  050508901  01/28/85   730       50(5)      31  (694)    352.2     CHLORAMINE                                 |
|SOUTHERN RESEARCH  050514203  11/12/86   729       50(1)      28  (669)    336.8     TERT-BUTYL ALCOHOL                         |
|TSI MASON RESEARCH 050516005  02/05/91   734       50(5)      25  (698)    348.1     1-CHLORO-2-PROPANOL                        |
|TSI MASON RESEARCH 055530105  04/23/91   729       50(5)      32  (694)    344.2     PYRIDINE                                   |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 13
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       44/50 (88%)   48/50 (96%)                       43/50 (86%)   43/50 (86%)                  |
| Overall Incidence               Total 92/100 (92%)    Mean 92%     SD 5.66%     Total 86/100 (86%)     Mean 86%     SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    26/50 (52%)   27/50 (54%)                       16/50 (32%)   30/50 (60%)                  |
| Overall Incidence               Total 53/100 (53%)    Mean 53%     SD 1.41%     Total 46/100 (46%)     Mean 46%     SD 19.8%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         47/50 (94%)   48/50 (96%)                       47/50 (94%)   49/50 (98%)                  |
| Overall Incidence               Total 95/100 (95%)    Mean 95%     SD 1.41%     Total 96/100 (96%)     Mean 96%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   24/50 (48%)   25/50 (50%)                       13/50 (26%)   22/50 (44%)                  |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 49/100 (49%)    Mean 49%     SD 1.41%     Total 35/100 (35%)     Mean 35%     SD 12.73%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     2/50 (4%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
|      NOS                                                                                                                         |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              3/50 (6%)     5/50 (10%)                        0/50 (0%)     4/50 (8%)                   |
| Overall Incidence               Total 8/100 (8%)      Mean 8%      SD 2.83%     Total 4/100 (4%)       Mean 4%      SD 5.66%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            3/50 (6%)     5/50 (10%)                        0/50 (0%)     5/50 (10%)                  |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 8/100 (8%)      Mean 8%      SD 2.83%     Total 5/100 (5%)       Mean 5%      SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma NOS                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant, Mixed              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma NOS                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Benign           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Benign                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma NOS                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)                         2/48 (4%)     4/49 (8%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 6/97 (6.19%)     Mean 6.16%   SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            1/50 (2%)     0/50 (0%)                         2/48 (4%)     1/49 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 3/97 (3.09%)     Mean 3.1%    SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)     1/50 (2%)                         4/48 (8%)     5/49 (10%)                  |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 9/97 (9.28%)     Mean 9.27%   SD 1.32%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma NOS                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma NOS                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma NOS                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibroma                              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/50 (2%)     6/50 (12%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 7/100 (7%)      Mean 7%      SD 7.07%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)     6/50 (12%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 7/100 (7%)      Mean 7%      SD 7.07%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|   Papilloma                                                                                                                      |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Mesenchymal Tumor Benign             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Nephroblastoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Oncocytoma Benign                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               3/50 (6%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          3/50 (6%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            3/50 (6%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)     0/50 (0%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    0/50 (0%)     0/50 (0%)                         0/50 (0%)     2/50 (4%)                   |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoacanthoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/50 (0%)                         0/50 (0%)     3/50 (6%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 3/100 (3%)       Mean 3%      SD 4.24%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)                         0/50 (0%)     4/50 (8%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 4/100 (4%)       Mean 4%      SD 5.66%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         1/50 (2%)     0/50 (0%)                        13/50 (26%)   25/50 (50%)                  |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 38/100 (38%)     Mean 38%     SD 16.97%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     1/50 (2%)     0/50 (0%)                        13/50 (26%)   26/50 (52%)                  |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 39/100 (39%)     Mean 39%     SD 18.38%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    2/50 (4%)     0/50 (0%)                        13/50 (26%)   29/50 (58%)                  |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 42/100 (42%)     Mean 42%     SD 22.63%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/50 (2%)     0/50 (0%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Benign                                                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sex Cord Stromal Tumor, Malignant                                                    0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/49 (0%)     1/48 (2%)                         1/41 (2%)     0/44 (0%)                   |
| Overall Incidence               Total 1/97 (1.03%)    Mean 1.04%   SD 1.47%     Total 1/85 (1.18%)     Mean 1.22%   SD 1.72%     |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Paraganglioma Benign                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      35/50 (70%)   25/49 (51%)                       33/50 (66%)   30/49 (61%)                  |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 60/99 (60.61%)  Mean 60.51%  SD 13.42%    Total 63/99 (63.64%)   Mean 63.61%  SD 3.38%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/49 (0%)                         0/50 (0%)     2/49 (4%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 2/99 (2.02%)     Mean 2.04%   SD 2.89%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      35/50 (70%)   25/49 (51%)                       33/50 (66%)   32/49 (65%)                  |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 60/99 (60.61%)  Mean 60.51%  SD 13.42%    Total 65/99 (65.66%)   Mean 65.65%  SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
|   Craniopharyngioma                                                                                                              |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
|   Ganglioneuroma                                                                                                                 |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Nervosa                                                                                                    |
|   Adenoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            1/50 (2%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         8/50 (16%)    3/50 (6%)                         1/50 (2%)     0/50 (0%)                   |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 11/100 (11%)    Mean 11%     SD 7.07%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      5/50 (10%)    2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 7/100 (7%)      Mean 7%      SD 4.24%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              3/50 (6%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           3/50 (6%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             7/50 (14%)    3/50 (6%)                         1/50 (2%)     0/50 (0%)                   |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 10/100 (10%)    Mean 10%     SD 5.66%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             7/50 (14%)    3/50 (6%)                         1/50 (2%)     0/50 (0%)                   |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 10/100 (10%)    Mean 10%     SD 5.66%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              2/50 (4%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      4/50 (8%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 5/100 (5%)      Mean 5%      SD 4.24%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Benign                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Malignant                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Chordoma                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Glioma Benign                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Benign               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Malignant            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             31/50 (62%)   36/50 (72%)                                                                  |
| Overall Incidence               Total 67/100 (67%)    Mean 67%     SD 7.07%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/46 (0%)     0/45 (0%)                         0/49 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Schwannoma Malignant                 0/46 (0%)     0/45 (0%)                         0/49 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/46 (0%)     0/45 (0%)                         0/49 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/46 (0%)     0/45 (0%)                         0/49 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/46 (0%)     0/45 (0%)                         0/49 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/46 (0%)     0/45 (0%)                         0/49 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/91 (0%)       Mean 0%      SD 0%        Total 0/96 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              6/50 (12%)    0/50 (0%)                         1/50 (2%)     7/49 (14%)                  |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 8.49%     Total 8/99 (8.08%)     Mean 8.14%   SD 8.69%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 6/50 (12%)    0/50 (0%)                         1/50 (2%)     7/49 (14%)                  |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 8.49%     Total 8/99 (8.08%)     Mean 8.14%   SD 8.69%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         2/50 (4%)     1/49 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 3/99 (3.03%)     Mean 3.02%   SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         3/50 (6%)     1/49 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 4/99 (4.04%)     Mean 4.02%   SD 2.8%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Chemodectoma Malignant               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Yolk Sac Carcinoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Malignant               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Urethra:                                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/49 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyoma                            0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma NOS                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibroma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Malignant                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/50 (4%)     4/50 (8%)                   |
| Overall Incidence                                                               Total 6/100 (6%)       Mean 6%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/50 (4%)     4/50 (8%)                   |
| Overall Incidence                                                               Total 6/100 (6%)       Mean 6%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma NOS                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Polyp                                                                                0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ACETONE                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

                                                This page intentionally left blank
                                                 Toxicology Data Management System                                     Page: 43
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       50/52 (96%)   48/50 (96%)   47/50 (94%)         38/51 (75%)   43/50 (86%)   38/50 (76%)    |
|                                       48/50 (96%)   47/50 (94%)   49/50 (98%)         33/50 (66%)   38/50 (76%)   40/50 (80%)    |
| Overall Incidence               Total 289/302 (95.7%) Mean 95.69%  SD 1.51%     Total 230/301 (76.41%) Mean 76.42%  SD 6.59%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    30/52 (58%)   25/50 (50%)   32/50 (64%)         22/51 (43%)   19/50 (38%)   17/50 (34%)    |
|                                       23/50 (46%)   21/50 (42%)   20/50 (40%)         18/50 (36%)   12/50 (24%)   23/50 (46%)    |
| Overall Incidence               Total 151/302 (50%)   Mean 49.95%  SD 9.33%     Total 111/301 (36.88%) Mean 36.86%  SD 7.73%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         52/52 (100%)  49/50 (98%)   50/50 (100%)        43/51 (84%)   48/50 (96%)   46/50 (92%)    |
|                                       50/50 (100%)  49/50 (98%)   50/50 (100%)        40/50 (80%)   40/50 (80%)   45/50 (90%)    |
| Overall Incidence               Total 300/302 (99.34%)Mean 99.33%  SD 1.03%     Total 262/301 (87.04%) Mean 87.05%  SD 6.64%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      2/52 (4%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 0.97%   SD 1.62%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/52 (4%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 0.97%   SD 1.62%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  3/52 (6%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 0.96%   SD 2.36%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.03%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   23/52 (44%)   16/50 (32%)   23/50 (46%)         18/51 (35%)   10/50 (20%)   11/50 (22%)    |
|      Mononuclear, or Undifferentiated  6/50 (12%)   14/50 (28%)   12/50 (24%)         10/50 (20%)    5/50 (10%)   17/50 (34%)    |
| Overall Incidence               Total 94/302 (31.13%) Mean 31.04%  SD 12.81%    Total 71/301 (23.59%)  Mean 23.55%  SD 9.57%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/52 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.03%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/52 (2%)     2/50 (4%)     2/50 (4%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               6/50 (12%)    2/50 (4%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 14/302 (4.64%)  Mean 4.65%   SD 3.73%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              1/52 (2%)     2/50 (4%)     2/50 (4%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        6/50 (12%)    2/50 (4%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 14/302 (4.64%)  Mean 4.65%   SD 3.73%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/52 (2%)     0/50 (0%)     2/50 (4%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 0.99%   SD 1.66%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/52 (2%)     0/50 (0%)     2/50 (4%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 0.99%   SD 1.66%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                               0/0 (0%)     0/50 (0%)     0/50 (0%)            0/0 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 2/250 (0.8%)     Mean 0.8%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                             0/0 (0%)     0/50 (0%)     0/50 (0%)            0/0 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/250 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                        0/0 (0%)     0/50 (0%)     0/50 (0%)            0/0 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign               0/0 (0%)     6/50 (12%)    9/50 (18%)           0/0 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)    12/50 (24%)    8/50 (16%)          0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 37/250 (14.8%)  Mean 14.8%   SD 7.43%     Total 3/249 (1.2%)     Mean 1.2%    SD 1.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex              0/0 (0%)     0/50 (0%)     0/50 (0%)            0/0 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant            0/0 (0%)     0/50 (0%)     1/50 (2%)            0/0 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/250 (1.2%)    Mean 1.2%    SD 1.79%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,             0/0 (0%)     6/50 (12%)   10/50 (20%)           0/0 (0%)     0/50 (0%)     0/49 (0%)     |
|      Complex, Malignant, NOS           4/50 (8%)    12/50 (24%)    8/50 (16%)          0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 40/250 (16%)    Mean 16%     SD 6.32%     Total 3/249 (1.2%)     Mean 1.2%    SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         1/52 (2%)     0/50 (0%)     2/50 (4%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 0.99%   SD 1.66%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              1/52 (2%)     0/50 (0%)     2/50 (4%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 0.99%   SD 1.66%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/52 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.03%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma NOS                      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant, Mixed              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma NOS                           0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Benign           0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Benign                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma NOS                0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/52 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.03%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/52 (0%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Schwannoma Malignant                 0/52 (0%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/52 (0%)     1/50 (2%)     1/50 (2%)           3/50 (6%)     8/49 (16%)    4/50 (8%)     |
|                                        4/50 (8%)     0/50 (0%)     1/50 (2%)           7/49 (14%)   10/49 (20%)    1/49 (2%)     |
| Overall Incidence               Total 7/302 (2.32%)   Mean 2.33%   SD 2.94%     Total 33/296 (11.15%)  Mean 11.18%  SD 6.95%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            2/52 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/49 (4%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           3/49 (6%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 4/302 (1.32%)   Mean 1.31%   SD 2.03%     Total 5/296 (1.69%)    Mean 1.7%    SD 2.71%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 2/52 (4%)     1/50 (2%)     1/50 (2%)           3/50 (6%)     9/49 (18%)    4/50 (8%)     |
|                                        6/50 (12%)    0/50 (0%)     1/50 (2%)          10/49 (20%)   10/49 (20%)    1/49 (2%)     |
| Overall Incidence               Total 11/302 (3.64%)  Mean 3.64%   SD 4.27%     Total 37/296 (12.5%)   Mean 12.54%  SD 8.14%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neurofibrosarcoma                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma Benign                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma NOS                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Papilloma              3/52 (6%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 0.96%   SD 2.36%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma NOS                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Schwannoma Malignant                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibroma                              0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/301 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/301 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/301 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma NOS                       0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/301 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Schwannoma Malignant                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Mast Cell Tumor Benign               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.65%   SD 1.01%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Mast Cell Tumor Benign               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/52 (2%)     3/50 (6%)     3/50 (6%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     5/50 (10%)          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 15/302 (4.97%)  Mean 4.99%   SD 3.05%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     2/50 (4%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 8/302 (2.65%)   Mean 2.67%   SD 3.27%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/52 (2%)     3/50 (6%)     5/50 (10%)          0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        6/50 (12%)    3/50 (6%)     5/50 (10%)          0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 23/302 (7.62%)  Mean 7.65%   SD 3.69%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/52 (0%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/302 (1.99%)   Mean 2%      SD 2.53%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/52 (0%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     4/50 (8%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/302 (2.32%)   Mean 2.33%   SD 3.2%      Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Mesenchymal Tumor Benign             0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Nephroblastoma                       0/52 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Oncocytoma Benign                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|      Hepatocellular Adenoma            0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|      Hepatocellular Adenoma, or        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/301 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 1/301 (0.33%)   Mean 0.33%   SD 0.82%     Total 5/301 (1.66%)    Mean 1.67%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/301 (0.66%)   Mean 0.67%   SD 1.63%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     2/50 (4%)     |
|      Alveolar/Bronchiolar Adenoma      0/50 (0%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 3/301 (1%)      Mean 1%      SD 2.45%     Total 5/301 (1.66%)    Mean 1.67%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/301 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrosarcoma                         0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/301 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Schwannoma Malignant                 0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/301 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/301 (0%)      Mean 0%      SD 0%        Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangiosarcoma                      1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Plasma Cell Tumor Malignant          0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoacanthoma                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              1/52 (2%)     1/50 (2%)     0/50 (0%)           3/51 (6%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.65%   SD 1.01%     Total 5/301 (1.66%)    Mean 1.65%   SD 2.29%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 4/301 (1.33%)    Mean 1.33%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 1/52 (2%)     1/50 (2%)     0/50 (0%)           3/51 (6%)     3/50 (6%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 0.99%   SD 1.08%     Total 9/301 (2.99%)    Mean 2.98%   SD 2.42%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         1/52 (2%)     2/50 (4%)     1/50 (2%)          17/51 (33%)   18/50 (36%)   14/50 (28%)    |
|                                        2/50 (4%)     3/50 (6%)     1/50 (2%)          11/50 (22%)    9/50 (18%)   16/50 (32%)    |
| Overall Incidence               Total 10/302 (3.31%)  Mean 3.32%   SD 1.65%     Total 85/301 (28.24%)  Mean 28.22%  SD 6.99%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              3/52 (6%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 0.96%   SD 2.36%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     5/52 (10%)    3/50 (6%)     1/50 (2%)          19/51 (37%)   18/50 (36%)   14/50 (28%)    |
|                                        2/50 (4%)     3/50 (6%)     1/50 (2%)          11/50 (22%)    9/50 (18%)   16/50 (32%)    |
| Overall Incidence               Total 15/302 (4.97%)  Mean 4.94%   SD 2.91%     Total 87/301 (28.9%)   Mean 28.88%  SD 7.71%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    5/52 (10%)    3/50 (6%)     1/50 (2%)          19/51 (37%)   20/50 (40%)   14/50 (28%)    |
|      or Adenoma                        2/50 (4%)     4/50 (8%)     1/50 (2%)          11/50 (22%)   10/50 (20%)   16/50 (32%)    |
| Overall Incidence               Total 16/302 (5.3%)   Mean 5.27%   SD 3.16%     Total 90/301 (29.9%)   Mean 29.88%  SD 8.06%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Lipoma                               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Benign                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Malignant                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondrosarcoma                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Papilloma              0/52 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/52 (2%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/302 (1.32%)   Mean 1.32%   SD 1.02%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              1/52 (2%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 0.99%   SD 1.08%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             2/52 (4%)     1/50 (2%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 7/302 (2.32%)   Mean 2.31%   SD 0.75%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.03%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/52 (0%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.03%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Benign                                                         0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sex Cord Stromal Tumor, Malignant                                                    0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/52 (0%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 62
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/52 (0%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              1/50 (2%)     0/48 (0%)     1/46 (2%)           0/47 (0%)     1/42 (2%)     0/43 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/46 (0%)           0/47 (0%)     0/42 (0%)     0/48 (0%)     |
| Overall Incidence               Total 2/282 (0.71%)   Mean 0.7%    SD 1.08%     Total 1/269 (0.37%)    Mean 0.4%    SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Paraganglioma Benign                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma Malignant                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma: Benign, Malignant, NOS   0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      31/52 (60%)   37/50 (74%)   32/50 (64%)         28/51 (55%)   27/50 (54%)   27/49 (55%)    |
|   Adenoma                             48/50 (96%)   38/50 (76%)   44/50 (88%)         23/50 (46%)   29/50 (58%)   34/50 (68%)    |
| Overall Incidence               Total 230/302 (76.16%)Mean 76.27%  SD 13.86%    Total 168/300 (56%)    Mean 56%     SD 7.13%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 63
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/52 (0%)     0/50 (0%)     0/50 (0%)           2/51 (4%)     0/50 (0%)     2/49 (4%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 5/300 (1.67%)    Mean 1.67%   SD 1.97%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      31/52 (60%)   37/50 (74%)   32/50 (64%)         30/51 (59%)   27/50 (54%)   29/49 (59%)    |
|   Carcinoma or Adenoma                48/50 (96%)   38/50 (76%)   45/50 (90%)         23/50 (46%)   29/50 (58%)   35/50 (70%)    |
| Overall Incidence               Total 231/302 (76.49%)Mean 76.6%   SD 14.21%    Total 173/300 (57.67%) Mean 57.67%  SD 7.82%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|   Craniopharyngioma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|   Ganglioneuroma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Nervosa                                                                                                    |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/52 (0%)     2/50 (4%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.63%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 64
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/52 (0%)     2/50 (4%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.63%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 65
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Schwannoma Malignant                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/52 (0%)     1/50 (2%)     2/50 (4%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 1%      SD 1.67%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.65%   SD 1.01%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 1/52 (2%)     1/50 (2%)     2/50 (4%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/302 (1.66%)   Mean 1.65%   SD 1.5%      Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Papilloma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.03%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/52 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.03%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 66
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/52 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  2/50 (4%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 3/302 (0.99%)   Mean 1%      SD 1.67%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/52 (0%)     2/50 (4%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.63%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/52 (0%)     2/50 (4%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.67%   SD 1.63%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/52 (0%)     2/50 (4%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       2/50 (4%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 5/302 (1.66%)   Mean 1.67%   SD 1.97%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         2/52 (4%)     6/50 (12%)    2/50 (4%)           1/51 (2%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    7/50 (14%)    1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 18/302 (5.96%)  Mean 5.97%   SD 5.67%     Total 2/301 (0.66%)    Mean 0.66%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/52 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 1/301 (0.33%)    Mean 0.33%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 67
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/52 (2%)     3/50 (6%)     2/50 (4%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 12/302 (3.97%)  Mean 3.99%   SD 3.59%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/52 (0%)     2/50 (4%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 3/302 (0.99%)   Mean 1%      SD 1.67%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/52 (2%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.65%   SD 1.01%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/52 (2%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/302 (0.66%)   Mean 0.65%   SD 1.01%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 68
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/52 (4%)     4/50 (8%)     2/50 (4%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          5/50 (10%)    1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 14/302 (4.64%)  Mean 4.64%   SD 3.73%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/52 (4%)     4/50 (8%)     2/50 (4%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     5/50 (10%)    1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 14/302 (4.64%)  Mean 4.64%   SD 3.73%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/52 (0%)     3/50 (6%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     2/50 (4%)     1/50 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 9/302 (2.98%)   Mean 3%      SD 2.76%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/52 (0%)     3/50 (6%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   4/50 (8%)     2/50 (4%)     1/50 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 10/302 (3.31%)  Mean 3.33%   SD 3.27%     Total 3/301 (1%)       Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|      Myxosarcoma, or Fibrous           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma                         1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 69
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Benign                   0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Malignant                0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Chordoma                             0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Glioma Benign                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 70
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Osteosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Basal Cell Adenoma                   0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 71
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/52 (0%)     3/50 (6%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 1%      SD 2.45%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/52 (0%)     3/50 (6%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/302 (0.99%)   Mean 1%      SD 2.45%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Benign               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Malignant            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             42/52 (81%)   23/50 (46%)   32/50 (64%)                                                    |
|                                       20/50 (40%)   24/50 (48%)   24/50 (48%)                                                    |
| Overall Incidence               Total 165/302 (54.64%)Mean 54.46%  SD 15.15%                                                     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/44 (0%)     0/47 (0%)     0/47 (0%)           0/46 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/45 (0%)     0/46 (0%)           0/44 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/273 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Schwannoma Malignant                 0/44 (0%)     0/47 (0%)     0/47 (0%)           0/46 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/45 (0%)     0/46 (0%)           0/44 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/273 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)     0/47 (0%)     0/47 (0%)           0/46 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/45 (0%)     0/46 (0%)           0/44 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/273 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 72
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/44 (0%)     0/47 (0%)     0/47 (0%)           0/46 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/45 (0%)     0/46 (0%)           0/44 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/273 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/44 (0%)     0/47 (0%)     0/47 (0%)           0/46 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/45 (0%)     0/46 (0%)           0/44 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/273 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)     0/47 (0%)     0/47 (0%)           0/46 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/45 (0%)     0/46 (0%)           0/44 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/273 (0%)      Mean 0%      SD 0%        Total 0/282 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/301 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              7/51 (14%)    3/50 (6%)     6/50 (12%)         11/51 (22%)    4/50 (8%)     8/50 (16%)    |
|                                        2/50 (4%)     2/50 (4%)     9/50 (18%)          1/50 (2%)     4/50 (8%)    10/50 (20%)    |
| Overall Incidence               Total 29/301 (9.63%)  Mean 9.62%   SD 5.81%     Total 38/301 (12.62%)  Mean 12.59%  SD 7.76%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/51 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/301 (1%)      Mean 1%      SD 1.67%     Total 3/301 (1%)       Mean 0.99%   SD 1.09%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 7/51 (14%)    3/50 (6%)     6/50 (12%)         11/51 (22%)    5/50 (10%)    8/50 (16%)    |
|                                        3/50 (6%)     3/50 (6%)     9/50 (18%)          2/50 (4%)     4/50 (8%)    10/50 (20%)    |
| Overall Incidence               Total 31/301 (10.3%)  Mean 10.29%  SD 5.09%     Total 40/301 (13.29%)  Mean 13.26%  SD 7.01%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/51 (2%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/301 (0.66%)   Mean 0.66%   SD 1.02%     Total 4/301 (1.33%)    Mean 1.33%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/51 (0%)     2/50 (4%)     1/50 (2%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/301 (1.33%)   Mean 1.33%   SD 1.63%     Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/51 (2%)     2/50 (4%)     2/50 (4%)           0/51 (0%)     3/50 (6%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 6/301 (1.99%)   Mean 1.99%   SD 1.79%     Total 5/301 (1.66%)    Mean 1.67%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 73
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Chemodectoma Malignant               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibroma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Osteosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 74
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Yolk Sac Carcinoma                   0/52 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Malignant               0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Fibrosarcoma                         0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Squamous Cell Carcinoma              1/52 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/302 (0.33%)   Mean 0.32%   SD 0.79%     Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 75
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Urethra:                                                                                                                         |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/52 (0%)     0/50 (0%)     0/48 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/300 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/52 (0%)     0/50 (0%)     0/48 (0%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 2/300 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyoma                            0/52 (0%)     0/50 (0%)     0/48 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/52 (0%)     0/50 (0%)     0/48 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/52 (0%)     0/50 (0%)     0/48 (0%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 1/300 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma NOS                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 76
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibroma                                                                              0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibrosarcoma                                                                         0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Malignant                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        3/51 (6%)     6/50 (12%)    3/50 (6%)     |
|                                                                                        2/50 (4%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence                                                               Total 17/301 (5.65%)   Mean 5.65%   SD 3.44%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/301 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 77
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     3/51 (6%)     6/50 (12%)    4/50 (8%)     |
|                                                                                        2/50 (4%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence                                                               Total 18/301 (5.98%)   Mean 5.98%   SD 3.58%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma NOS                                                                       0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Fibrosarcoma                                                                         0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Polyp                                                                                0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 78
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: ETHANOL                                  Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            2/52 (4%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/302 (1.32%)   Mean 1.31%   SD 1.58%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 2/52 (4%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/302 (1.32%)   Mean 1.31%   SD 1.58%     Total 2/301 (0.66%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Squamous Cell Papilloma              0/52 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/302 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 79
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       45/50 (90%)                                     47/51 (92%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    17/50 (34%)                                     32/51 (63%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         46/50 (92%)                                     51/51 (100%)                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,    9/50 (18%)                                     17/51 (33%)                                |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)                                       0/51 (0%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 2/50 (4%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     2/50 (4%)                                       0/51 (0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 80
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/49 (0%)                                       4/51 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             14/49 (29%)                                      3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           14/49 (29%)                                      4/50 (8%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrosarcoma                         0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 81
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma NOS                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 82
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant, Mixed              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma NOS                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Benign           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma NOS                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        1/50 (2%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 83
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/34 (0%)                                       5/44 (11%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            1/34 (3%)                                       2/44 (5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 1/34 (3%)                                       7/44 (16%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Carcinoma              0/34 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/34 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma Benign                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma NOS                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 84
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma NOS                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma NOS                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 85
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Schwannoma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 86
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 87
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              6/49 (12%)                                      3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 6/49 (12%)                                      5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/51 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/51 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/51 (0%)                                 |
|   Papilloma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 88
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Mesenchymal Tumor Benign             0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Nephroblastoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Oncocytoma Benign                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 89
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)                                       0/50 (0%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          1/50 (2%)                                       1/50 (2%)                                 |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            1/50 (2%)                                       1/50 (2%)                                 |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    0/50 (0%)                                       2/50 (4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 90
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoacanthoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       5/51 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       6/51 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         0/50 (0%)                                      21/51 (41%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              2/50 (4%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     2/50 (4%)                                      22/51 (43%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    2/50 (4%)                                      25/51 (49%)                                |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 91
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Lipoma                               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Benign                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 92
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 93
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Benign                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sex Cord Stromal Tumor, Malignant                                                    0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 94
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/47 (0%)                                       0/45 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Paraganglioma Benign                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma: Benign, Malignant, NOS   0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      39/44 (89%)                                     38/50 (76%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/44 (0%)                                       2/50 (4%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      39/44 (89%)                                     40/50 (80%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/44 (0%)                                       0/50 (0%)                                 |
|   Craniopharyngioma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 95
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/44 (0%)                                       0/50 (0%)                                 |
|   Ganglioneuroma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/44 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/44 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/44 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Nervosa                                                                                                    |
|   Adenoma                              0/44 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/48 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/48 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/48 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 96
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 97
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/50 (2%)                                       0/51 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)                                       0/51 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/51 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)                                       0/51 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         2/50 (4%)                                       0/51 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 98
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/51 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             1/50 (2%)                                       0/51 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 99
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             1/50 (2%)                                       0/51 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)                                       0/51 (0%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)                                       0/51 (0%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/51 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 100
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/51 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Benign                   0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Malignant                0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Chordoma                             0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Glioma Benign                        0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 101
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           2/50 (4%)                                       0/51 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              2/50 (4%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Benign               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Malignant            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              4/50 (8%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 102
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/35 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Schwannoma Malignant                 0/35 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/35 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/35 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/35 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/35 (0%)                                       0/44 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/48 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              2/48 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/48 (0%)                                       6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 2/48 (4%)                                       6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/48 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/48 (2%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/48 (4%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 103
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Chemodectoma Malignant               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibroma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         1/50 (2%)                                       1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Yolk Sac Carcinoma                   0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 104
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/51 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Malignant               0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Urethra:                                                                                                                         |
|   Carcinoma                            1/50 (2%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/48 (0%)                                       1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyoma                            0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/48 (0%)                                       1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 105
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma NOS                                                                        0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibroma                                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibrosarcoma                                                                         0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Malignant                                                        0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/51 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 106
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/51 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 1/51 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma NOS                                                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Fibrosarcoma                                                                         0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Polyp                                                                                0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 107
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: DERMAL                                     Date of
 Species: RATS                                           Vehicle: NEAT                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 109
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       45/50 (90%)   48/51 (94%)   45/49 (92%)         36/50 (72%)   41/50 (82%)   37/50 (74%)    |
|                                       49/50 (98%)   48/50 (96%)   50/52 (96%)         41/50 (82%)   39/50 (78%)   40/51 (78%)    |
|                                       49/50 (98%)   49/50 (98%)                       41/50 (82%)   37/50 (74%)                  |
| Overall Incidence               Total 383/402 (95.27%)Mean 95.26%  SD 3.04%     Total 312/401 (77.81%) Mean 77.8%   SD 4.07%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    24/50 (48%)   16/51 (31%)   17/49 (35%)         24/50 (48%)   15/50 (30%)   10/50 (20%)    |
|                                       22/50 (44%)   28/50 (56%)   22/52 (42%)         20/50 (40%)   19/50 (38%)   18/51 (35%)    |
|                                       23/50 (46%)   23/50 (46%)                       21/50 (42%)   18/50 (36%)                  |
| Overall Incidence               Total 175/402 (43.53%)Mean 43.55%  SD 7.7%      Total 145/401 (36.16%) Mean 36.16%  SD 8.39%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)   48/51 (94%)   46/49 (94%)         44/50 (88%)   46/50 (92%)   41/50 (82%)    |
|                                       50/50 (100%)  48/50 (96%)   51/52 (98%)         48/50 (96%)   46/50 (92%)   44/51 (86%)    |
|                                       49/50 (98%)   49/50 (98%)                       44/50 (88%)   44/50 (88%)                  |
| Overall Incidence               Total 386/402 (96.02%)Mean 96.01%  SD 3.22%     Total 357/401 (89.03%) Mean 89.03%  SD 4.25%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        0/50 (0%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.5%    SD 1.41%     Total 2/401 (0.5%)     Mean 0.5%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 110
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   10/50 (20%)   10/51 (20%)    8/49 (16%)         14/50 (28%)   10/50 (20%)    6/50 (12%)    |
|      Mononuclear, or Undifferentiated 16/50 (32%)   22/50 (44%)   14/52 (27%)         13/50 (26%)   17/50 (34%)    9/51 (18%)    |
|                                       13/50 (26%)   15/50 (30%)                       14/50 (28%)   10/50 (20%)                  |
| Overall Incidence               Total 108/402 (26.87%)Mean 26.86%  SD 8.79%     Total 93/401 (23.19%)  Mean 23.21%  SD 7.04%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|      Undifferentiated Cell Type        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 4/50 (8%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/402 (1%)      Mean 1%      SD 2.83%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/50 (8%)     0/51 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      NOS                               3/50 (6%)     0/50 (0%)     2/52 (4%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 12/402 (2.99%)  Mean 2.99%   SD 2.82%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     0/50 (0%)     2/52 (4%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 7/402 (1.74%)   Mean 1.73%   SD 2.23%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.5%    SD 0.93%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.5%    SD 0.93%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 111
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           1/49 (2%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 4/400 (1%)       Mean 1.01%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/401 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 1/400 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             13/50 (26%)   17/50 (34%)    9/49 (18%)          0/50 (0%)     1/50 (2%)     3/50 (6%)     |
|                                       10/50 (20%)   14/50 (28%)    9/52 (17%)          5/49 (10%)    4/50 (8%)     2/51 (4%)     |
|                                       15/50 (30%)    7/50 (14%)                        1/50 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 94/401 (23.44%) Mean 23.46%  SD 7.03%     Total 18/400 (4.5%)    Mean 4.52%   SD 3.39%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/52 (0%)           0/49 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/401 (0.5%)    Mean 0.5%    SD 0.93%     Total 1/400 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           1/50 (2%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     1/52 (2%)           2/49 (4%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/401 (2%)      Mean 1.99%   SD 1.85%     Total 3/400 (0.75%)    Mean 0.76%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           14/50 (28%)   18/50 (36%)    9/49 (18%)          0/50 (0%)     2/50 (4%)     3/50 (6%)     |
|      Complex, Malignant, NOS          11/50 (22%)   16/50 (32%)    9/52 (17%)          7/49 (14%)    4/50 (8%)     2/51 (4%)     |
|                                       16/50 (32%)    8/50 (16%)                        1/50 (2%)     3/50 (6%)                   |
| Overall Incidence               Total 101/401 (25.19%)Mean 25.21%  SD 7.75%     Total 22/400 (5.5%)    Mean 5.53%   SD 4.33%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrosarcoma                         0/50 (0%)     0/47 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/399 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 112
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/51 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.26%   SD 0.72%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 113
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   1/50 (2%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/397 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/397 (0.76%)   Mean 0.75%   SD 1.04%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma NOS                      0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant, Mixed              0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 114
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma NOS                           0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Benign           0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Benign                    0/50 (0%)     1/48 (2%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/397 (0.25%)   Mean 0.26%   SD 0.74%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     1/48 (2%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/397 (0.25%)   Mean 0.26%   SD 0.74%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/48 (0%)     0/47 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 115
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma NOS                0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        1/50 (2%)     0/48 (0%)     0/47 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       1/50 (2%)     1/50 (2%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     2/51 (4%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 4/397 (1.01%)   Mean 1%      SD 1.07%     Total 4/401 (1%)       Mean 0.99%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              6/49 (12%)    8/47 (17%)    2/45 (4%)           8/49 (16%)    3/47 (6%)     0/48 (0%)     |
|                                        5/49 (10%)    2/48 (4%)     2/52 (4%)           5/46 (11%)    3/46 (7%)     4/48 (8%)     |
|                                        1/50 (2%)     0/50 (0%)                         2/50 (4%)     4/49 (8%)                   |
| Overall Incidence               Total 26/390 (6.67%)  Mean 6.74%   SD 5.81%     Total 29/383 (7.57%)   Mean 7.57%   SD 4.8%      |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            2/49 (4%)     3/47 (6%)     1/45 (2%)           5/49 (10%)    2/47 (4%)     0/48 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/52 (0%)           0/46 (0%)     0/46 (0%)     0/48 (0%)     |
|                                        2/50 (4%)     3/50 (6%)                         1/50 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 11/390 (2.82%)  Mean 2.84%   SD 2.67%     Total 8/383 (2.09%)    Mean 2.06%   SD 3.63%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 8/49 (16%)   11/47 (23%)    3/45 (7%)          13/49 (27%)    5/47 (11%)    0/48 (0%)     |
|                                        5/49 (10%)    2/48 (4%)     2/52 (4%)           5/46 (11%)    3/46 (7%)     4/48 (8%)     |
|                                        3/50 (6%)     3/50 (6%)                         3/50 (6%)     4/49 (8%)                   |
| Overall Incidence               Total 37/390 (9.49%)  Mean 9.58%   SD 6.9%      Total 37/383 (9.66%)   Mean 9.63%   SD 7.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 116
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Carcinoma              0/49 (0%)     0/47 (0%)     0/45 (0%)           0/49 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/52 (0%)           0/46 (0%)     0/46 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/390 (0%)      Mean 0%      SD 0%        Total 0/383 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/49 (0%)     0/47 (0%)     0/45 (0%)           0/49 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/52 (0%)           0/46 (0%)     0/46 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/390 (0%)      Mean 0%      SD 0%        Total 0/383 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neurofibrosarcoma                    0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma Benign                    0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma NOS                       0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 117
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Papilloma              1/50 (2%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma NOS                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 118
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         3/50 (6%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 3/401 (0.75%)    Mean 0.75%   SD 2.12%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma NOS                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibroma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 119
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 120
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibroma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 121
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Mast Cell Tumor Benign               0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibroma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 122
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Mast Cell Tumor Benign               0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/49 (0%)     4/49 (8%)     4/47 (9%)           0/50 (0%)     2/50 (4%)     1/49 (2%)     |
|                                        9/50 (18%)    4/50 (8%)     5/52 (10%)          2/50 (4%)     2/50 (4%)     1/51 (2%)     |
|                                        2/50 (4%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 28/397 (7.05%)  Mean 7.04%   SD 5.85%     Total 9/400 (2.25%)    Mean 2.25%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            2/49 (4%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/52 (0%)           1/50 (2%)     0/50 (0%)     1/51 (2%)     |
|                                        1/50 (2%)     3/50 (6%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 7/397 (1.76%)   Mean 1.76%   SD 2.26%     Total 2/400 (0.5%)     Mean 0.5%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/49 (4%)     4/49 (8%)     4/47 (9%)           0/50 (0%)     2/50 (4%)     1/49 (2%)     |
|                                       10/50 (20%)    4/50 (8%)     5/52 (10%)          3/50 (6%)     2/50 (4%)     2/51 (4%)     |
|                                        3/50 (6%)     3/50 (6%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 35/397 (8.82%)  Mean 8.8%    SD 4.86%     Total 11/400 (2.75%)   Mean 2.75%   SD 2.11%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 123
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/52 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/400 (0.75%)   Mean 0.75%   SD 1.03%     Total 1/400 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/400 (0.5%)    Mean 0.5%    SD 1.41%     Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/52 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/400 (1.25%)   Mean 1.25%   SD 1.49%     Total 1/400 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Mesenchymal Tumor Benign             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 124
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Nephroblastoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Oncocytoma Benign                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 1/400 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/52 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/400 (0.25%)   Mean 0.24%   SD 0.68%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/400 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)     0/49 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     3/52 (6%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        2/50 (4%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 12/400 (3%)     Mean 2.97%   SD 2.99%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 125
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/49 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/52 (4%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/400 (1%)      Mean 0.99%   SD 1.84%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/49 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     0/50 (0%)     2/52 (4%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/400 (1%)      Mean 0.99%   SD 1.84%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/49 (0%)     2/49 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Hepatocellular Adenoma            1/50 (2%)     4/50 (8%)     5/52 (10%)          0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        2/50 (4%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 16/400 (4%)     Mean 3.96%   SD 3.45%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)     0/49 (0%)     2/49 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Hepatocellular Adenoma, or        1/50 (2%)     4/50 (8%)     5/52 (10%)          0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|      Hepatoblastoma                    2/50 (4%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 16/400 (4%)     Mean 3.96%   SD 3.45%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         0/50 (0%)     2/50 (4%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     1/52 (2%)           2/50 (4%)     1/50 (2%)     0/51 (0%)     |
|                                        2/50 (4%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 11/401 (2.74%)  Mean 2.75%   SD 1.49%     Total 4/401 (1%)       Mean 1%      SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       2/50 (4%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/401 (0.75%)   Mean 0.75%   SD 1.49%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    2/50 (4%)     2/50 (4%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Alveolar/Bronchiolar Adenoma      2/50 (4%)     1/50 (2%)     1/52 (2%)           2/50 (4%)     1/50 (2%)     0/51 (0%)     |
|                                        2/50 (4%)     3/50 (6%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 14/401 (3.49%)  Mean 3.5%    SD 1.42%     Total 4/401 (1%)       Mean 1%      SD 1.51%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 126
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/401 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/401 (0.25%)   Mean 0.26%   SD 0.72%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/52 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/401 (0.25%)   Mean 0.24%   SD 0.68%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 127
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoacanthoma                       0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     1/51 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/52 (0%)           1/50 (2%)     3/50 (6%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.5%    SD 0.92%     Total 5/401 (1.25%)    Mean 1.25%   SD 2.12%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/52 (2%)           1/50 (2%)     0/50 (0%)     1/51 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.49%   SD 0.91%     Total 8/401 (2%)       Mean 2%      SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     1/51 (2%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     1/52 (2%)           2/50 (4%)     3/50 (6%)     1/51 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 4/402 (1%)      Mean 0.99%   SD 1.05%     Total 13/401 (3.24%)   Mean 3.25%   SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         2/50 (4%)     3/51 (6%)     3/49 (6%)          13/50 (26%)   14/50 (28%)   17/50 (34%)    |
|                                        2/50 (4%)     4/50 (8%)     3/52 (6%)          15/50 (30%)   14/50 (28%)   15/51 (29%)    |
|                                        3/50 (6%)     3/50 (6%)                        22/50 (44%)   22/50 (44%)                  |
| Overall Incidence               Total 23/402 (5.72%)  Mean 5.72%   SD 1.28%     Total 132/401 (32.92%) Mean 32.93%  SD 7.21%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     2/50 (4%)     4/51 (8%)     3/49 (6%)          13/50 (26%)   14/50 (28%)   18/50 (36%)    |
|                                        2/50 (4%)     5/50 (10%)    3/52 (6%)          16/50 (32%)   15/50 (30%)   15/51 (29%)    |
|                                        3/50 (6%)     3/50 (6%)                        22/50 (44%)   22/50 (44%)                  |
| Overall Incidence               Total 25/402 (6.22%)  Mean 6.22%   SD 1.97%     Total 135/401 (33.67%) Mean 33.68%  SD 7.01%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    2/50 (4%)     4/51 (8%)     3/49 (6%)          14/50 (28%)   14/50 (28%)   19/50 (38%)    |
|      or Adenoma                        2/50 (4%)     5/50 (10%)    4/52 (8%)          17/50 (34%)   15/50 (30%)   16/51 (31%)    |
|                                        3/50 (6%)     3/50 (6%)                        24/50 (48%)   23/50 (46%)                  |
| Overall Incidence               Total 26/402 (6.47%)  Mean 6.46%   SD 2.02%     Total 142/401 (35.41%) Mean 35.42%  SD 7.88%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 128
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Lipoma                               0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Sarcoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 129
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Benign                    0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/401 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 130
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/401 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/52 (2%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/401 (0.5%)    Mean 0.49%   SD 0.91%     Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/401 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/51 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     2/50 (4%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 3/402 (0.75%)   Mean 0.76%   SD 1.49%     Total 2/401 (0.5%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 2/401 (0.5%)     Mean 0.5%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/51 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  1/50 (2%)     0/50 (0%)     0/52 (0%)           1/50 (2%)     0/50 (0%)     1/51 (2%)     |
|                                        0/50 (0%)     2/50 (4%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 4/402 (1%)      Mean 1.01%   SD 1.52%     Total 4/401 (1%)       Mean 1%      SD 1.06%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 131
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 2/401 (0.5%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Benign                                                         0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 132
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sex Cord Stromal Tumor, Malignant                                                    0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              1/49 (2%)     2/49 (4%)     1/47 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        5/50 (10%)    2/50 (4%)     8/52 (15%)          0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                       12/50 (24%)   10/50 (20%)                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 41/397 (10.33%) Mean 10.2%   SD 8.63%     Total 1/398 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/397 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/398 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 1/49 (2%)     2/49 (4%)     1/47 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        5/50 (10%)    2/50 (4%)     8/52 (15%)          0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                       13/50 (26%)   10/50 (20%)                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 42/397 (10.58%) Mean 10.45%  SD 9.1%      Total 1/398 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/49 (0%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/397 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/398 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 133
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/49 (0%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/52 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/397 (0.5%)    Mean 0.49%   SD 0.91%     Total 0/398 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/47 (0%)     0/47 (0%)     1/41 (2%)           0/46 (0%)     0/42 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/49 (0%)           0/47 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/46 (0%)     0/49 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/374 (0.27%)   Mean 0.3%    SD 0.86%     Total 0/374 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Paraganglioma Benign                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma: Benign, Malignant, NOS   0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.26%   SD 0.72%     Total 2/401 (0.5%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      16/48 (33%)   24/49 (49%)   19/48 (40%)         19/50 (38%)   31/49 (63%)   30/49 (61%)    |
|   Adenoma                              9/48 (19%)   16/50 (32%)   21/52 (40%)         28/50 (56%)   26/49 (53%)   23/51 (45%)    |
|                                       14/50 (28%)   19/50 (38%)                       26/50 (52%)   22/47 (47%)                  |
| Overall Incidence               Total 138/395 (34.94%)Mean 34.88%  SD 9.1%      Total 205/395 (51.9%)  Mean 51.93%  SD 8.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 134
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       2/48 (4%)     0/49 (0%)     0/48 (0%)           2/50 (4%)     0/49 (0%)     1/49 (2%)     |
|   Carcinoma                            0/48 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 2/395 (0.51%)   Mean 0.52%   SD 1.47%     Total 3/395 (0.76%)    Mean 0.76%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      18/48 (38%)   24/49 (49%)   19/48 (40%)         21/50 (42%)   31/49 (63%)   31/49 (63%)    |
|   Carcinoma or Adenoma                 9/48 (19%)   16/50 (32%)   21/52 (40%)         28/50 (56%)   26/49 (53%)   23/51 (45%)    |
|                                       14/50 (28%)   19/50 (38%)                       26/50 (52%)   22/47 (47%)                  |
| Overall Incidence               Total 140/395 (35.44%)Mean 35.4%   SD 9.11%     Total 208/395 (52.66%) Mean 52.69%  SD 7.94%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/49 (0%)     0/48 (0%)           1/50 (2%)     0/49 (0%)     0/49 (0%)     |
|   Craniopharyngioma                    0/48 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 1/395 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|   Ganglioneuroma                       0/48 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 1/395 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/395 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 0/395 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/48 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 0/395 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 0/395 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Nervosa                                                                                                    |
|   Adenoma                              0/48 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 0/395 (0%)      Mean 0%      SD 0%        Total 0/395 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 135
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/45 (0%)     0/45 (0%)                                                     |
|                                        0/48 (0%)     0/48 (0%)     0/52 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/388 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/45 (0%)     0/45 (0%)                                                     |
|                                        0/48 (0%)     0/48 (0%)     0/52 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/388 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/45 (0%)     0/45 (0%)                                                     |
|                                        0/48 (0%)     0/48 (0%)     0/52 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/388 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/52 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.24%   SD 0.68%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 136
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         1/50 (2%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrous Histiocytoma                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 137
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/51 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/402 (0.75%)   Mean 0.76%   SD 1.49%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     1/51 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/402 (1%)      Mean 1%      SD 1.51%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     1/51 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  1/50 (2%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|      Trichoepithelioma                 2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/402 (1.24%)   Mean 1.25%   SD 1.49%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 138
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              1/50 (2%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|      NOS)                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     1/51 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       1/50 (2%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|      (benign, malignant or NOS), or    2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 6/402 (1.49%)   Mean 1.5%    SD 1.41%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         7/50 (14%)    5/51 (10%)    2/49 (4%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Carcinoma, Basosq. Tumor (M or    3/50 (6%)     3/50 (6%)     4/52 (8%)           1/50 (2%)     0/50 (0%)     1/51 (2%)     |
|      B), Basal Cell Adenoma, Adenoma,  6/50 (12%)    2/50 (4%)                         3/50 (6%)     0/50 (0%)                   |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 32/402 (7.96%)  Mean 7.95%   SD 3.68%     Total 7/401 (1.75%)    Mean 1.75%   SD 1.98%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     1/51 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.69%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         1/50 (2%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      6/50 (12%)    2/51 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     3/52 (6%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        3/50 (6%)     2/50 (4%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 18/402 (4.48%)  Mean 4.46%   SD 3.81%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 139
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/52 (2%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.49%   SD 0.91%     Total 3/401 (0.75%)    Mean 0.75%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       1/50 (2%)     0/51 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     1/50 (2%)     1/52 (2%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 3/402 (0.75%)   Mean 0.74%   SD 1.02%     Total 3/401 (0.75%)    Mean 0.75%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     2/51 (4%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         3/50 (6%)     0/50 (0%)                   |
| Overall Incidence               Total 6/402 (1.49%)   Mean 1.5%    SD 1.76%     Total 3/401 (0.75%)    Mean 0.75%   SD 2.12%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 140
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     2/51 (4%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     2/50 (4%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         3/50 (6%)     0/50 (0%)                   |
| Overall Incidence               Total 6/402 (1.49%)   Mean 1.5%    SD 1.76%     Total 3/401 (0.75%)    Mean 0.75%   SD 2.12%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             6/50 (12%)    4/51 (8%)     1/49 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma, Squamous Cell          2/50 (4%)     3/50 (6%)     4/52 (8%)           1/50 (2%)     0/50 (0%)     0/51 (0%)     |
|      Carcinoma or Keratoacanthoma      4/50 (8%)     2/50 (4%)                         3/50 (6%)     0/50 (0%)                   |
| Overall Incidence               Total 26/402 (6.47%)  Mean 6.45%   SD 3.12%     Total 6/401 (1.5%)     Mean 1.5%    SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             6/50 (12%)    4/51 (8%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     2/50 (4%)     2/50 (4%)     3/52 (6%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        4/50 (8%)     2/50 (4%)                         3/50 (6%)     0/50 (0%)                   |
| Overall Incidence               Total 24/402 (5.97%)  Mean 5.96%   SD 3.19%     Total 3/401 (0.75%)    Mean 0.75%   SD 2.12%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              1/50 (2%)     1/51 (2%)     2/49 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     3/50 (6%)     0/52 (0%)           0/50 (0%)     1/50 (2%)     0/51 (0%)     |
|                                        2/50 (4%)     6/50 (12%)                        0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 17/402 (4.23%)  Mean 4.26%   SD 3.62%     Total 4/401 (1%)       Mean 1%      SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      2/50 (4%)     2/51 (4%)     3/49 (6%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|      Myxoma, Myxosarcoma, or Fibrous   3/50 (6%)     3/50 (6%)     1/52 (2%)           1/50 (2%)     1/50 (2%)     1/51 (2%)     |
|      Histiocytoma                      2/50 (4%)     6/50 (12%)                        0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 22/402 (5.47%)  Mean 5.5%    SD 3%        Total 8/401 (2%)       Mean 2%      SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     1/51 (2%)     1/49 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/402 (0.75%)   Mean 0.75%   SD 1.04%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)     1/51 (2%)     1/49 (2%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           1/50 (2%)     0/50 (0%)     1/52 (2%)           1/50 (2%)     0/50 (0%)     1/51 (2%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/402 (1.24%)   Mean 1.24%   SD 1.03%     Total 4/401 (1%)       Mean 1%      SD 1.06%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 141
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     1/50 (2%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     1/50 (2%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|      or NOS)                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/52 (2%)           1/50 (2%)     0/50 (0%)     1/51 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.49%   SD 0.91%     Total 3/401 (0.75%)    Mean 0.75%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 142
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Benign                   0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Malignant                0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Chordoma                             1/50 (2%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Glioma Benign                        0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibroma                              0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/398 (0.5%)    Mean 0.5%    SD 1.41%     Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/49 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/398 (0.25%)   Mean 0.26%   SD 0.72%     Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/398 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 143
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/398 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Leiomyosarcoma                       0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/398 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Osteosarcoma                         0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/398 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/398 (0%)      Mean 0%      SD 0%        Total 0/400 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.5%    SD 0.93%     Total 2/401 (0.5%)     Mean 0.5%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 144
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.5%    SD 0.93%     Total 2/401 (0.5%)     Mean 0.5%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Benign               0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Malignant            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             38/50 (76%)   43/49 (88%)   38/45 (84%)                                                    |
|                                       47/50 (94%)   47/50 (94%)   46/52 (88%)                                                    |
|                                       45/50 (90%)   46/50 (92%)                                                                  |
| Overall Incidence               Total 350/396 (88.38%)Mean 88.33%  SD 5.95%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/45 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/396 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/45 (0%)     0/46 (0%)     1/47 (2%)           0/48 (0%)     0/44 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/42 (0%)     0/51 (0%)           0/46 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/376 (0.27%)   Mean 0.27%   SD 0.75%     Total 0/375 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Schwannoma Malignant                 0/45 (0%)     0/46 (0%)     0/47 (0%)           0/48 (0%)     0/44 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/42 (0%)     0/51 (0%)           0/46 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/376 (0%)      Mean 0%      SD 0%        Total 0/375 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 145
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/45 (0%)     0/46 (0%)     0/47 (0%)           1/48 (2%)     0/44 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/42 (0%)     0/51 (0%)           0/46 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        1/47 (2%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/376 (0.27%)   Mean 0.27%   SD 0.75%     Total 1/375 (0.27%)    Mean 0.26%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/45 (0%)     0/46 (0%)     0/47 (0%)           0/48 (0%)     0/44 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/42 (0%)     0/51 (0%)           0/46 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/376 (0%)      Mean 0%      SD 0%        Total 0/375 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/45 (0%)     0/46 (0%)     0/47 (0%)           0/48 (0%)     0/44 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/42 (0%)     0/51 (0%)           0/46 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/376 (0%)      Mean 0%      SD 0%        Total 0/375 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/45 (0%)     0/46 (0%)     0/47 (0%)           1/48 (2%)     0/44 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/42 (0%)     0/51 (0%)           0/46 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        1/47 (2%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/376 (0.27%)   Mean 0.27%   SD 0.75%     Total 1/375 (0.27%)    Mean 0.26%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/397 (0%)      Mean 0%      SD 0%        Total 0/398 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              9/49 (18%)    1/50 (2%)     1/47 (2%)           9/50 (18%)    1/49 (2%)     0/49 (0%)     |
|                                        4/50 (8%)     4/49 (8%)     3/52 (6%)           4/50 (8%)     4/49 (8%)     3/51 (6%)     |
|                                        3/50 (6%)     5/50 (10%)                        3/50 (6%)     3/50 (6%)                   |
| Overall Incidence               Total 30/397 (7.56%)  Mean 7.55%   SD 5.2%      Total 27/398 (6.78%)   Mean 6.76%   SD 5.34%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            3/49 (6%)     0/50 (0%)     1/47 (2%)           1/50 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/52 (0%)           0/50 (0%)     0/49 (0%)     1/51 (2%)     |
|                                        2/50 (4%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 7/397 (1.76%)   Mean 1.78%   SD 2.29%     Total 2/398 (0.5%)     Mean 0.5%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                11/49 (22%)    1/50 (2%)     2/47 (4%)          10/50 (20%)    1/49 (2%)     0/49 (0%)     |
|                                        4/50 (8%)     4/49 (8%)     3/52 (6%)           4/50 (8%)     4/49 (8%)     4/51 (8%)     |
|                                        5/50 (10%)    6/50 (12%)                        3/50 (6%)     3/50 (6%)                   |
| Overall Incidence               Total 36/397 (9.07%)  Mean 9.08%   SD 6.26%     Total 29/398 (7.29%)   Mean 7.26%   SD 5.94%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 146
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/49 (4%)     1/50 (2%)     0/47 (0%)           3/50 (6%)     0/49 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     1/49 (2%)     1/52 (2%)           0/50 (0%)     2/49 (4%)     1/51 (2%)     |
|                                        4/50 (8%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 10/397 (2.52%)  Mean 2.51%   SD 2.57%     Total 6/398 (1.51%)    Mean 1.51%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/49 (2%)     1/50 (2%)     1/47 (2%)           0/50 (0%)     0/49 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     1/52 (2%)           0/50 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 5/397 (1.26%)   Mean 1.26%   SD 1.05%     Total 2/398 (0.5%)     Mean 0.51%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 3/49 (6%)     2/50 (4%)     1/47 (2%)           3/50 (6%)     0/49 (0%)     1/49 (2%)     |
|                                        1/50 (2%)     1/49 (2%)     2/52 (4%)           0/50 (0%)     2/49 (4%)     1/51 (2%)     |
|                                        5/50 (10%)    0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 15/397 (3.78%)  Mean 3.77%   SD 3.1%      Total 8/398 (2.01%)    Mean 2.01%   SD 2.15%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.26%   SD 0.72%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Chemodectoma Malignant               0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibroma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.26%   SD 0.72%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 147
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Yolk Sac Carcinoma                   0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 148
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/402 (0.25%)   Mean 0.25%   SD 0.71%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Malignant               0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Urethra:                                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 149
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/45 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/51 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/393 (0%)      Mean 0%      SD 0%        Total 0/396 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               1/50 (2%)     0/49 (0%)     0/45 (0%)           1/50 (2%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/51 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/393 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/396 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyoma                            0/50 (0%)     0/49 (0%)     0/45 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/51 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/393 (0%)      Mean 0%      SD 0%        Total 0/396 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/49 (0%)     0/45 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/51 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/393 (0%)      Mean 0%      SD 0%        Total 0/396 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            1/50 (2%)     0/49 (0%)     0/45 (0%)           1/50 (2%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/51 (0%)           0/49 (0%)     0/49 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/393 (0.25%)   Mean 0.25%   SD 0.71%     Total 1/396 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 150
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma NOS                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibroma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Malignant                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 151
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        5/50 (10%)    9/50 (18%)    7/50 (14%)    |
|                                                                                        9/50 (18%)   10/50 (20%)    8/51 (16%)    |
|                                                                                        6/50 (12%)    9/50 (18%)                  |
| Overall Incidence                                                               Total 63/401 (15.71%)  Mean 15.71%  SD 3.45%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        3/50 (6%)     1/50 (2%)     1/51 (2%)     |
|                                                                                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 8/401 (2%)       Mean 2%      SD 2.14%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     6/50 (12%)    9/50 (18%)    7/50 (14%)    |
|                                                                                       12/50 (24%)   11/50 (22%)    8/51 (16%)    |
|                                                                                        6/50 (12%)   10/50 (20%)                  |
| Overall Incidence                                                               Total 69/401 (17.21%)  Mean 17.21%  SD 4.54%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/51 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/401 (0.25%)    Mean 0.25%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma NOS                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 152
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Polyp                                                                                0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/52 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.49%   SD 0.91%     Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/52 (2%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/402 (0.5%)    Mean 0.49%   SD 0.91%     Total 1/401 (0.25%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/52 (0%)           0/50 (0%)     0/50 (0%)     0/51 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/402 (0%)      Mean 0%      SD 0%        Total 0/401 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 153
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       49/50 (98%)   50/51 (98%)                       43/50 (86%)   44/50 (88%)                  |
| Overall Incidence               Total 99/101 (98.02%) Mean 98.02%  SD 0.03%     Total 87/100 (87%)     Mean 87%     SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    33/50 (66%)   28/51 (55%)                       22/50 (44%)   17/50 (34%)                  |
| Overall Incidence               Total 61/101 (60.4%)  Mean 60.45%  SD 7.85%     Total 39/100 (39%)     Mean 39%     SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         50/50 (100%)  51/51 (100%)                      47/50 (94%)   45/50 (90%)                  |
| Overall Incidence               Total 101/101 (100%)  Mean 100%    SD 0%        Total 92/100 (92%)     Mean 92%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     0/51 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/51 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 0.98%   SD 1.39%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   26/50 (52%)   21/51 (41%)                       17/50 (34%)   12/50 (24%)                  |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 47/101 (46.53%) Mean 46.59%  SD 7.65%     Total 29/100 (29%)     Mean 29%     SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/50 (2%)     2/51 (4%)                         0/50 (0%)     0/50 (0%)                   |
|      NOS                                                                                                                         |
| Overall Incidence               Total 3/101 (2.97%)   Mean 2.96%   SD 1.36%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 154
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              1/50 (2%)     2/51 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/101 (2.97%)   Mean 2.96%   SD 1.36%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             24/50 (48%)   19/51 (37%)                        1/50 (2%)     7/50 (14%)                  |
| Overall Incidence               Total 43/101 (42.57%) Mean 42.63%  SD 7.6%      Total 8/100 (8%)       Mean 8%      SD 8.49%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           25/50 (50%)   19/51 (37%)                        1/50 (2%)     7/50 (14%)                  |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 44/101 (43.56%) Mean 43.63%  SD 9.01%     Total 8/100 (8%)       Mean 8%      SD 8.49%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/98 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 155
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma NOS                      0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 156
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant, Mixed              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma NOS                           0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Benign           0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Benign                    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          1/50 (2%)     0/51 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma NOS                0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        1/50 (2%)     0/51 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 157
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              9/50 (18%)    0/51 (0%)                         5/48 (10%)    4/50 (8%)                   |
| Overall Incidence               Total 9/101 (8.91%)   Mean 9%      SD 12.73%    Total 9/98 (9.18%)     Mean 9.21%   SD 1.71%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            5/50 (10%)    3/51 (6%)                         1/48 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 8/101 (7.92%)   Mean 7.94%   SD 2.91%     Total 2/98 (2.04%)     Mean 2.04%   SD 0.06%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                14/50 (28%)    3/51 (6%)                         6/48 (13%)    5/50 (10%)                  |
| Overall Incidence               Total 17/101 (16.83%) Mean 16.94%  SD 15.64%    Total 11/98 (11.22%)   Mean 11.25%  SD 1.77%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)                         0/48 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 2/98 (2.04%)     Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neurofibrosarcoma                    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma Benign                    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma NOS                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 158
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma NOS                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibroma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma NOS                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 159
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibroma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 160
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibroma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Mast Cell Tumor Benign               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibroma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 161
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Mast Cell Tumor Benign               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/50 (6%)     4/49 (8%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 7/99 (7.07%)    Mean 7.08%   SD 1.53%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         1/50 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/50 (6%)     4/49 (8%)                         1/50 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 7/99 (7.07%)    Mean 7.08%   SD 1.53%     Total 1/99 (1.01%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     1/51 (2%)                         0/50 (0%)     0/50 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 1/101 (0.99%)   Mean 0.98%   SD 1.39%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     1/51 (2%)                         0/50 (0%)     0/50 (0%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 1/101 (0.99%)   Mean 0.98%   SD 1.39%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|   Papilloma                                                                                                                      |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              3/50 (6%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/101 (2.97%)   Mean 3%      SD 4.24%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 162
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 4/50 (8%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/101 (3.96%)   Mean 4%      SD 5.66%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Mesenchymal Tumor Benign             1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Nephroblastoma                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Oncocytoma Benign                    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               5/50 (10%)    1/51 (2%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 6/101 (5.94%)   Mean 5.98%   SD 5.68%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 163
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             2/50 (4%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/101 (1.98%)   Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          2/50 (4%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 2/101 (1.98%)   Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          7/50 (14%)    1/51 (2%)                         1/50 (2%)     1/50 (2%)                   |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 8/101 (7.92%)   Mean 7.98%   SD 8.51%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            7/50 (14%)    1/51 (2%)                         1/50 (2%)     1/50 (2%)                   |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 8/101 (7.92%)   Mean 7.98%   SD 8.51%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         0/50 (0%)     4/51 (8%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/101 (3.96%)   Mean 3.92%   SD 5.55%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)     1/51 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 0.98%   SD 1.39%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    0/50 (0%)     5/51 (10%)                        1/50 (2%)     0/50 (0%)                   |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 5/101 (4.95%)   Mean 4.9%    SD 6.93%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 164
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoacanthoma                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/51 (0%)                         2/50 (4%)     3/50 (6%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 5/100 (5%)       Mean 5%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     0/51 (0%)                         2/50 (4%)     3/50 (6%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 5/100 (5%)       Mean 5%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         5/50 (10%)    4/51 (8%)                        36/50 (72%)   21/50 (42%)                  |
| Overall Incidence               Total 9/101 (8.91%)   Mean 8.92%   SD 1.53%     Total 57/100 (57%)     Mean 57%     SD 21.21%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     5/50 (10%)    4/51 (8%)                        36/50 (72%)   21/50 (42%)                  |
| Overall Incidence               Total 9/101 (8.91%)   Mean 8.92%   SD 1.53%     Total 57/100 (57%)     Mean 57%     SD 21.21%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    5/50 (10%)    4/51 (8%)                        37/50 (74%)   23/50 (46%)                  |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 9/101 (8.91%)   Mean 8.92%   SD 1.53%     Total 60/100 (60%)     Mean 60%     SD 19.8%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 165
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Lipoma                               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Benign                    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 166
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     3/51 (6%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/101 (2.97%)   Mean 2.94%   SD 4.16%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     3/51 (6%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 3/101 (2.97%)   Mean 2.94%   SD 4.16%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     2/51 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/101 (1.98%)   Mean 1.96%   SD 2.77%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 167
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/50 (0%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Benign                                                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sex Cord Stromal Tumor, Malignant                                                    0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 168
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              1/48 (2%)     0/46 (0%)                         0/44 (0%)     0/47 (0%)                   |
| Overall Incidence               Total 1/94 (1.06%)    Mean 1.04%   SD 1.47%     Total 0/91 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Paraganglioma Benign                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma: Benign, Malignant, NOS   0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       7/50 (14%)   30/51 (59%)                       22/50 (44%)   27/50 (54%)                  |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 37/101 (36.63%) Mean 36.41%  SD 31.7%     Total 49/100 (49%)     Mean 49%     SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       7/50 (14%)   30/51 (59%)                       22/50 (44%)   27/50 (54%)                  |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 37/101 (36.63%) Mean 36.41%  SD 31.7%     Total 49/100 (49%)     Mean 49%     SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|   Craniopharyngioma                                                                                                              |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 169
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|   Ganglioneuroma                                                                                                                 |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Nervosa                                                                                                    |
|   Adenoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/51 (0%)                                                                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                                                                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)                                                                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/51 (0%)                                                                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 170
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrous Histiocytoma                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     1/51 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 0.98%   SD 1.39%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     1/51 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 0.98%   SD 1.39%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 171
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         3/50 (6%)     4/51 (8%)                         0/50 (0%)     0/50 (0%)                   |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 7/101 (6.93%)   Mean 6.92%   SD 1.3%      Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 172
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      3/50 (6%)     4/51 (8%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 7/101 (6.93%)   Mean 6.92%   SD 1.3%      Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/51 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             3/50 (6%)     4/51 (8%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 7/101 (6.93%)   Mean 6.92%   SD 1.3%      Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 173
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             3/50 (6%)     4/51 (8%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 7/101 (6.93%)   Mean 6.92%   SD 1.3%      Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              1/50 (2%)     0/51 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/50 (2%)     0/51 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     1/51 (2%)                         0/50 (0%)     0/50 (0%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 1/101 (0.99%)   Mean 0.98%   SD 1.39%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 174
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     1/51 (2%)                         0/50 (0%)     0/50 (0%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 1/101 (0.99%)   Mean 0.98%   SD 1.39%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     1/51 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 0.98%   SD 1.39%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Benign                   0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Malignant                0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Chordoma                             0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Glioma Benign                        0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibroma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 175
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Leiomyosarcoma                       1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Osteosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Benign               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Malignant            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/51 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             46/50 (92%)   33/51 (65%)                                                                  |
| Overall Incidence               Total 79/101 (78.22%) Mean 78.35%  SD 19.3%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                                                                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 176
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/46 (0%)     0/42 (0%)                         0/49 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Schwannoma Malignant                 0/46 (0%)     0/42 (0%)                         0/49 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/46 (0%)     0/42 (0%)                         0/49 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/46 (0%)     0/42 (0%)                         0/49 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/46 (0%)     0/42 (0%)                         0/49 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/46 (0%)     0/42 (0%)                         0/49 (0%)     0/45 (0%)                   |
| Overall Incidence               Total 0/88 (0%)       Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              6/50 (12%)    5/51 (10%)                        2/50 (4%)     5/50 (10%)                  |
| Overall Incidence               Total 11/101 (10.89%) Mean 10.9%   SD 1.55%     Total 7/100 (7%)       Mean 7%      SD 4.24%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 6/50 (12%)    5/51 (10%)                        2/50 (4%)     5/50 (10%)                  |
| Overall Incidence               Total 11/101 (10.89%) Mean 10.9%   SD 1.55%     Total 7/100 (7%)       Mean 7%      SD 4.24%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/50 (4%)     0/51 (0%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 2/101 (1.98%)   Mean 2%      SD 2.83%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     0/51 (0%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 2/101 (1.98%)   Mean 2%      SD 2.83%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 177
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Chemodectoma Malignant               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibroma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Yolk Sac Carcinoma                   0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 178
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     1/51 (2%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 1/101 (0.99%)   Mean 0.98%   SD 1.39%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     1/51 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 0.98%   SD 1.39%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Malignant               0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Squamous Cell Carcinoma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Urethra:                                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/49 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyoma                            0/49 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/49 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 179
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma NOS                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibroma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Malignant                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        4/50 (8%)     4/50 (8%)                   |
| Overall Incidence                                                               Total 8/100 (8%)       Mean 8%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 180
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     4/50 (8%)     5/50 (10%)                  |
| Overall Incidence                                                               Total 9/100 (9%)       Mean 9%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma NOS                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Polyp                                                                                0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/50 (2%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/101 (0.99%)   Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 181
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: METHYL CELLULOSE                         Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Squamous Cell Papilloma              0/50 (0%)     0/51 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/101 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 183
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       48/50 (96%)                                     37/50 (74%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    38/50 (76%)                                     23/50 (46%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         49/50 (98%)                                     48/50 (96%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   33/50 (66%)                                     20/50 (40%)                                |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)                                       0/50 (0%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/50 (2%)                                       0/50 (0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 184
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             11/50 (22%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           11/50 (22%)                                      1/50 (2%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 185
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma NOS                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 186
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant, Mixed              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma NOS                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Benign           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma NOS                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 187
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              3/50 (6%)                                       3/49 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 3/50 (6%)                                       3/49 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma NOS                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 188
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma NOS                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma NOS                       0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 189
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 190
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 191
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Papilloma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 192
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Mesenchymal Tumor Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Nephroblastoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Oncocytoma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 193
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          1/50 (2%)                                       0/50 (0%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          2/50 (4%)                                       1/50 (2%)                                 |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            2/50 (4%)                                       1/50 (2%)                                 |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    1/50 (2%)                                       0/50 (0%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 194
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoacanthoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         3/50 (6%)                                      29/50 (58%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     3/50 (6%)                                      29/50 (58%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    3/50 (6%)                                      29/50 (58%)                                |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 195
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 196
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 197
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Benign                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sex Cord Stromal Tumor, Malignant                                                    0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 198
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/46 (0%)                                       0/41 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Paraganglioma Benign                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      19/49 (39%)                                     20/50 (40%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      19/49 (39%)                                     20/50 (40%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)                                       0/50 (0%)                                 |
|   Craniopharyngioma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 199
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)                                       0/50 (0%)                                 |
|   Ganglioneuroma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Nervosa                                                                                                    |
|   Adenoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 200
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 201
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         4/50 (8%)                                       1/50 (2%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 202
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      4/50 (8%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       1/50 (2%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)                                       1/50 (2%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 203
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)                                       1/50 (2%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              5/50 (10%)                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      6/50 (12%)                                      1/50 (2%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)                                       1/50 (2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 204
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Malignant                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Chordoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Glioma Benign                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 205
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             43/50 (86%)                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 206
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/46 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Schwannoma Malignant                 0/46 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/46 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/46 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/46 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/46 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              1/50 (2%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 2/50 (4%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              3/50 (6%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 4/50 (8%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 207
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Chemodectoma Malignant               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Yolk Sac Carcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 208
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Malignant               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Urethra:                                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 209
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma NOS                                                                        0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibroma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Malignant                                                        0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 210
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma NOS                                                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Polyp                                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 211
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 213
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       49/50 (98%)   45/48 (94%)   50/50 (100%)        42/50 (84%)   38/48 (79%)   44/49 (90%)    |
|                                       48/50 (96%)   47/50 (94%)   48/50 (96%)         45/50 (90%)   48/50 (96%)   42/50 (84%)    |
|                                       46/50 (92%)   48/50 (96%)   47/50 (94%)         44/50 (88%)   42/50 (84%)   44/50 (88%)    |
|                                       49/50 (98%)   50/50 (100%)  50/50 (100%)        43/50 (86%)   45/50 (90%)   44/50 (88%)    |
|                                       48/50 (96%)   49/50 (98%)   47/50 (94%)         41/50 (82%)   46/50 (92%)   42/50 (84%)    |
|                                       48/50 (96%)   42/46 (91%)   52/54 (96%)         37/50 (74%)   32/46 (70%)   39/53 (74%)    |
|                                       49/53 (92%)   49/54 (91%)                       37/53 (70%)   35/53 (66%)                  |
| Overall Incidence               Total 961/1005 (95.62%Mean 95.63%  SD 2.83%     Total 830/1002 (82.83%)Mean 82.9%   SD 8.3%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    41/50 (82%)   36/48 (75%)   40/50 (80%)         26/50 (52%)   29/48 (60%)   26/49 (53%)    |
|                                       38/50 (76%)   35/50 (70%)   28/50 (56%)         25/50 (50%)   31/50 (62%)   27/50 (54%)    |
|                                       36/50 (72%)   31/50 (62%)   40/50 (80%)         29/50 (58%)   30/50 (60%)   21/50 (42%)    |
|                                       34/50 (68%)   40/50 (80%)   40/50 (80%)         28/50 (56%)   28/50 (56%)   28/50 (56%)    |
|                                       33/50 (66%)   39/50 (78%)   37/50 (74%)         26/50 (52%)   21/50 (42%)   27/50 (54%)    |
|                                       33/50 (66%)   30/46 (65%)   37/54 (69%)         20/50 (40%)   21/46 (46%)   32/53 (60%)    |
|                                       33/53 (62%)   37/54 (69%)                       24/53 (45%)   35/53 (66%)                  |
| Overall Incidence               Total 718/1005 (71.44%Mean 71.48%  SD 7.36%     Total 534/1002 (53.29%)Mean 53.24%  SD 7.25%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         50/50 (100%)  48/48 (100%)  50/50 (100%)        47/50 (94%)   47/48 (98%)   47/49 (96%)    |
|                                       50/50 (100%)  50/50 (100%)  49/50 (98%)         48/50 (96%)   49/50 (98%)   49/50 (98%)    |
|                                       50/50 (100%)  50/50 (100%)  50/50 (100%)        47/50 (94%)   50/50 (100%)  48/50 (96%)    |
|                                       50/50 (100%)  50/50 (100%)  50/50 (100%)        49/50 (98%)   48/50 (96%)   49/50 (98%)    |
|                                       49/50 (98%)   49/50 (98%)   48/50 (96%)         48/50 (96%)   49/50 (98%)   46/50 (92%)    |
|                                       49/50 (98%)   46/46 (100%)  53/54 (98%)         42/50 (84%)   40/46 (87%)   52/53 (98%)    |
|                                       52/53 (98%)   53/54 (98%)                       48/53 (91%)   49/53 (92%)                  |
| Overall Incidence               Total 996/1005 (99.1%)Mean 99.12%  SD 1.19%     Total 952/1002 (95.01%)Mean 95%     SD 4.08%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/46 (2%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 3/1005 (0.3%)   Mean 0.31%   SD 0.75%     Total 3/1002 (0.3%)    Mean 0.3%    SD 0.73%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 214
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/46 (2%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 3/1005 (0.3%)   Mean 0.31%   SD 0.75%     Total 4/1002 (0.4%)    Mean 0.4%    SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           2/50 (4%)     0/46 (0%)     0/53 (0%)     |
|                                        1/53 (2%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 5/1005 (0.5%)   Mean 0.49%   SD 0.88%     Total 4/1002 (0.4%)    Mean 0.4%    SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   29/50 (58%)   29/48 (60%)   33/50 (66%)         18/50 (36%)   18/48 (38%)   18/49 (37%)    |
|      Mononuclear, or Undifferentiated 30/50 (60%)   29/50 (58%)   21/50 (42%)         15/50 (30%)   21/50 (42%)   18/50 (36%)    |
|                                       29/50 (58%)   21/50 (42%)   33/50 (66%)         16/50 (32%)   18/50 (36%)   12/50 (24%)    |
|                                       24/50 (48%)   35/50 (70%)   35/50 (70%)         14/50 (28%)   18/50 (36%)   22/50 (44%)    |
|                                       27/50 (54%)   34/50 (68%)   30/50 (60%)         17/50 (34%)   16/50 (32%)   17/50 (34%)    |
|                                       27/50 (54%)   27/46 (59%)   31/54 (57%)         13/50 (26%)   14/46 (30%)   22/53 (42%)    |
|                                       28/53 (53%)   31/54 (57%)                       19/53 (36%)   25/53 (47%)                  |
| Overall Incidence               Total 583/1005 (58.01%Mean 58.04%  SD 7.95%     Total 351/1002 (35.03%)Mean 34.96%  SD 5.85%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           1/50 (2%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 2/1005 (0.2%)   Mean 0.2%    SD 0.62%     Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 215
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     3/50 (6%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 6/1005 (0.6%)   Mean 0.6%    SD 1.6%      Total 1/1002 (0.1%)    Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/50 (2%)     3/48 (6%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|      NOS                               3/50 (6%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    3/50 (6%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     5/50 (10%)    2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        1/53 (2%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 37/1005 (3.68%) Mean 3.71%   SD 3.14%     Total 1/1002 (0.1%)    Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        3/50 (6%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     5/50 (10%)    2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 27/1005 (2.69%) Mean 2.7%    SD 2.99%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/46 (2%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 3/1005 (0.3%)   Mean 0.31%   SD 0.75%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/50 (2%)     1/48 (2%)     1/50 (2%)           1/50 (2%)     0/48 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/46 (0%)     1/54 (2%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        1/53 (2%)     1/54 (2%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 9/1005 (0.9%)   Mean 0.88%   SD 1%        Total 6/1002 (0.6%)    Mean 0.6%    SD 0.94%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 216
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/50 (2%)     1/48 (2%)     1/50 (2%)           1/50 (2%)     0/48 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/46 (2%)     1/54 (2%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        1/53 (2%)     1/54 (2%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 12/1005 (1.19%) Mean 1.19%   SD 1%        Total 6/1002 (0.6%)    Mean 0.6%    SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/50 (4%)     0/48 (0%)     2/50 (4%)           1/50 (2%)     0/48 (0%)     2/49 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/49 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 8/1004 (0.8%)   Mean 0.8%    SD 1.36%     Total 10/998 (1%)      Mean 1.01%   SD 1.53%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/1004 (0.1%)   Mean 0.1%    SD 0.45%     Total 2/998 (0.2%)     Mean 0.19%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/1001 (0%)     Mean 0%      SD 0%        Total 0/989 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             15/50 (30%)    4/48 (8%)    19/50 (38%)          3/50 (6%)     1/48 (2%)     3/49 (6%)     |
|                                       14/50 (28%)   19/50 (38%)    4/50 (8%)           2/48 (4%)     4/50 (8%)     0/50 (0%)     |
|                                       15/50 (30%)   23/50 (46%)   11/49 (22%)          6/47 (13%)    3/50 (6%)     1/49 (2%)     |
|                                       18/50 (36%)   15/50 (30%)   16/50 (32%)          1/50 (2%)     5/49 (10%)    1/49 (2%)     |
|                                       17/50 (34%)   19/50 (38%)   18/48 (38%)          6/50 (12%)    4/50 (8%)     0/50 (0%)     |
|                                       13/50 (26%)    8/45 (18%)   27/54 (50%)          2/50 (4%)     0/45 (0%)     4/51 (8%)     |
|                                       13/53 (25%)   16/54 (30%)                        2/53 (4%)     2/51 (4%)                   |
| Overall Incidence               Total 304/1001 (30.37%Mean 30.21%  SD 10.69%    Total 50/989 (5.06%)   Mean 5.05%   SD 3.84%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 217
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     2/45 (4%)     0/51 (0%)     |
|                                        1/53 (2%)     0/54 (0%)                         0/53 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 3/1001 (0.3%)   Mean 0.29%   SD 0.72%     Total 5/989 (0.51%)    Mean 0.53%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/48 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     3/49 (6%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        3/50 (6%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     1/45 (2%)     0/54 (0%)           0/50 (0%)     0/45 (0%)     0/51 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         1/53 (2%)     0/51 (0%)                   |
| Overall Incidence               Total 18/1001 (1.8%)  Mean 1.82%   SD 2.06%     Total 5/989 (0.51%)    Mean 0.49%   SD 1.09%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           15/50 (30%)    4/48 (8%)    19/50 (38%)          3/50 (6%)     1/48 (2%)     3/49 (6%)     |
|      Complex, Malignant, NOS          15/50 (30%)   19/50 (38%)    6/50 (12%)          2/48 (4%)     5/50 (10%)    0/50 (0%)     |
|                                       16/50 (32%)   23/50 (46%)   14/49 (29%)          6/47 (13%)    4/50 (8%)     1/49 (2%)     |
|                                       20/50 (40%)   15/50 (30%)   17/50 (34%)          2/50 (4%)     6/49 (12%)    2/49 (4%)     |
|                                       17/50 (34%)   20/50 (40%)   18/48 (38%)          6/50 (12%)    4/50 (8%)     2/50 (4%)     |
|                                       13/50 (26%)    8/45 (18%)   27/54 (50%)          2/50 (4%)     2/45 (4%)     4/51 (8%)     |
|                                       14/53 (26%)   16/54 (30%)                        3/53 (6%)     2/51 (4%)                   |
| Overall Incidence               Total 316/1001 (31.57%Mean 31.41%  SD 10.29%    Total 60/989 (6.07%)   Mean 6.07%   SD 3.56%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1003 (0%)     Mean 0%      SD 0%        Total 0/994 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 218
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 219
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 2/1005 (0.2%)   Mean 0.2%    SD 0.62%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         1/50 (2%)     1/48 (2%)     1/50 (2%)           1/50 (2%)     0/48 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        1/53 (2%)     1/54 (2%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 7/1005 (0.7%)   Mean 0.69%   SD 0.97%     Total 5/1002 (0.5%)    Mean 0.5%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              1/50 (2%)     1/48 (2%)     1/50 (2%)           1/50 (2%)     0/48 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        1/53 (2%)     1/54 (2%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 9/1005 (0.9%)   Mean 0.89%   SD 1.01%     Total 5/1002 (0.5%)    Mean 0.5%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 2/1002 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 2/999 (0.2%)     Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 220
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           1/50 (2%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 2/1005 (0.2%)   Mean 0.2%    SD 0.62%     Total 1/999 (0.1%)     Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma NOS                      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/999 (0.1%)     Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     2/50 (4%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     1/46 (2%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 4/1005 (0.4%)   Mean 0.4%    SD 1.05%     Total 1/999 (0.1%)     Mean 0.11%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant, Mixed              0/50 (0%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 221
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma NOS                           0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     1/54 (2%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.09%   SD 0.41%     Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Benign           0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/999 (0.1%)     Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Benign                    0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 222
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma NOS                0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 223
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        2/50 (4%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     1/49 (2%)     |
|      Astrocytoma                       1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           1/50 (2%)     1/46 (2%)     0/53 (0%)     |
|                                        0/53 (0%)     1/54 (2%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 8/1005 (0.8%)   Mean 0.8%    SD 1.36%     Total 5/999 (0.5%)     Mean 0.51%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/999 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              3/46 (7%)     0/47 (0%)     3/50 (6%)           6/46 (13%)    1/46 (2%)     2/46 (4%)     |
|                                        0/50 (0%)     2/49 (4%)     1/50 (2%)           5/50 (10%)    4/44 (9%)     3/49 (6%)     |
|                                        0/50 (0%)     4/50 (8%)     0/50 (0%)           0/49 (0%)     3/50 (6%)     1/48 (2%)     |
|                                        2/50 (4%)     2/50 (4%)     4/50 (8%)           3/47 (6%)     2/44 (5%)     7/47 (15%)    |
|                                        3/49 (6%)     1/50 (2%)     2/49 (4%)           5/43 (12%)    6/49 (12%)    1/48 (2%)     |
|                                        3/49 (6%)     3/44 (7%)     1/54 (2%)           2/47 (4%)     1/44 (2%)     1/53 (2%)     |
|                                        1/53 (2%)     2/54 (4%)                         0/52 (0%)     4/51 (8%)                   |
| Overall Incidence               Total 37/994 (3.72%)  Mean 3.76%   SD 2.71%     Total 57/953 (5.98%)   Mean 6.04%   SD 4.5%      |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            5/46 (11%)    5/47 (11%)    3/50 (6%)           3/46 (7%)     4/46 (9%)     0/46 (0%)     |
|                                        3/50 (6%)     3/49 (6%)     0/50 (0%)           2/50 (4%)     3/44 (7%)     3/49 (6%)     |
|                                        6/50 (12%)    1/50 (2%)     2/50 (4%)           5/49 (10%)    1/50 (2%)     4/48 (8%)     |
|                                        3/50 (6%)     3/50 (6%)     0/50 (0%)           2/47 (4%)     1/44 (2%)     0/47 (0%)     |
|                                        1/49 (2%)     3/50 (6%)     3/49 (6%)           0/43 (0%)     1/49 (2%)     1/48 (2%)     |
|                                        0/49 (0%)     0/44 (0%)     0/54 (0%)           1/47 (2%)     1/44 (2%)     2/53 (4%)     |
|                                        2/53 (4%)     1/54 (2%)                         1/52 (2%)     0/51 (0%)                   |
| Overall Incidence               Total 44/994 (4.43%)  Mean 4.47%   SD 3.79%     Total 35/953 (3.67%)   Mean 3.67%   SD 3.12%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 224
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 8/46 (17%)    5/47 (11%)    6/50 (12%)          9/46 (20%)    5/46 (11%)    2/46 (4%)     |
|                                        3/50 (6%)     4/49 (8%)     1/50 (2%)           7/50 (14%)    7/44 (16%)    6/49 (12%)    |
|                                        6/50 (12%)    5/50 (10%)    2/50 (4%)           5/49 (10%)    4/50 (8%)     5/48 (10%)    |
|                                        5/50 (10%)    5/50 (10%)    4/50 (8%)           5/47 (11%)    3/44 (7%)     7/47 (15%)    |
|                                        4/49 (8%)     4/50 (8%)     5/49 (10%)          5/43 (12%)    7/49 (14%)    2/48 (4%)     |
|                                        3/49 (6%)     3/44 (7%)     1/54 (2%)           3/47 (6%)     2/44 (5%)     3/53 (6%)     |
|                                        3/53 (6%)     3/54 (6%)                         1/52 (2%)     4/51 (8%)                   |
| Overall Incidence               Total 80/994 (8.05%)  Mean 8.13%   SD 3.66%     Total 92/953 (9.65%)   Mean 9.72%   SD 4.61%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Carcinoma              0/46 (0%)     0/47 (0%)     0/50 (0%)           0/46 (0%)     0/46 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/44 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/43 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/44 (0%)     0/54 (0%)           0/47 (0%)     0/44 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/52 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/994 (0%)      Mean 0%      SD 0%        Total 0/953 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/46 (0%)     0/47 (0%)     0/50 (0%)           0/46 (0%)     0/46 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/44 (0%)     0/47 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/43 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/44 (0%)     0/54 (0%)           0/47 (0%)     0/44 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/52 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/994 (0%)      Mean 0%      SD 0%        Total 0/953 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 225
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neurofibrosarcoma                    0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           1/50 (2%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma Benign                    0/50 (0%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.47%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma NOS                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Carcinoma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 226
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Papilloma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Squamous Cell Carcinoma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma NOS                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 227
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibroma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 228
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma NOS                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         1/53 (2%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 2/1002 (0.2%)    Mean 0.19%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibroma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 229
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 2/1002 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 230
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 231
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/46 (2%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 4/1005 (0.4%)   Mean 0.41%   SD 0.84%     Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibroma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibrosarcoma                         0/50 (0%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.47%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 232
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Mast Cell Tumor Benign               0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/46 (2%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 5/1005 (0.5%)   Mean 0.51%   SD 0.9%      Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 233
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/46 (2%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 5/1005 (0.5%)   Mean 0.51%   SD 0.9%      Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibroma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibrosarcoma                         0/50 (0%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.47%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 234
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Mast Cell Tumor Benign               0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              5/50 (10%)    1/48 (2%)     3/50 (6%)           1/50 (2%)     0/48 (0%)     2/49 (4%)     |
|                                        2/50 (4%)     3/50 (6%)     1/50 (2%)           4/49 (8%)     1/49 (2%)     0/49 (0%)     |
|                                        7/50 (14%)    4/50 (8%)     1/50 (2%)           2/50 (4%)     1/50 (2%)     2/50 (4%)     |
|                                        1/50 (2%)     3/50 (6%)     8/50 (16%)          1/49 (2%)     1/49 (2%)     1/50 (2%)     |
|                                        4/50 (8%)     3/50 (6%)     4/50 (8%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|                                        3/50 (6%)     3/45 (7%)     2/54 (4%)           1/50 (2%)     5/46 (11%)    1/52 (2%)     |
|                                        2/53 (4%)     2/52 (4%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 62/1002 (6.19%) Mean 6.2%    SD 3.8%      Total 24/993 (2.42%)   Mean 2.46%   SD 2.8%      |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            4/50 (8%)     1/48 (2%)     3/50 (6%)           0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|                                        3/50 (6%)     1/50 (2%)     4/50 (8%)           2/49 (4%)     0/49 (0%)     0/49 (0%)     |
|                                        4/50 (8%)     4/50 (8%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/48 (2%)     |
|                                        2/50 (4%)     1/45 (2%)     1/54 (2%)           0/50 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/52 (0%)                         1/53 (2%)     0/52 (0%)                   |
| Overall Incidence               Total 39/1002 (3.89%) Mean 3.91%   SD 2.71%     Total 6/993 (0.6%)     Mean 0.6%    SD 1.16%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 9/50 (18%)    2/48 (4%)     6/50 (12%)          1/50 (2%)     0/48 (0%)     3/49 (6%)     |
|                                        5/50 (10%)    4/50 (8%)     5/50 (10%)          6/49 (12%)    1/49 (2%)     0/49 (0%)     |
|                                       11/50 (22%)    8/50 (16%)    3/50 (6%)           2/50 (4%)     1/50 (2%)     2/50 (4%)     |
|                                        3/50 (6%)     4/50 (8%)     9/50 (18%)          1/49 (2%)     1/49 (2%)     1/50 (2%)     |
|                                        7/50 (14%)    4/50 (8%)     5/50 (10%)          1/50 (2%)     0/50 (0%)     2/48 (4%)     |
|                                        5/50 (10%)    4/45 (9%)     3/54 (6%)           1/50 (2%)     5/46 (11%)    1/52 (2%)     |
|                                        2/53 (4%)     2/52 (4%)                         1/53 (2%)     0/52 (0%)                   |
| Overall Incidence               Total 101/1002 (10.08%Mean 10.11%  SD 5.15%     Total 30/993 (3.02%)   Mean 3.07%   SD 3.3%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 235
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        0/52 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1003 (0%)     Mean 0%      SD 0%        Total 1/998 (0.1%)     Mean 0.09%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        0/52 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1003 (0%)     Mean 0%      SD 0%        Total 1/998 (0.1%)     Mean 0.09%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1003 (0%)     Mean 0%      SD 0%        Total 0/998 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     1/54 (2%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 11/1003 (1.1%)  Mean 1.1%    SD 1.37%     Total 1/998 (0.1%)     Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/1003 (0.1%)   Mean 0.1%    SD 0.45%     Total 5/998 (0.5%)     Mean 0.5%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 236
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     1/54 (2%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 12/1003 (1.2%)  Mean 1.2%    SD 1.36%     Total 6/998 (0.6%)     Mean 0.6%    SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1003 (0%)     Mean 0%      SD 0%        Total 0/998 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 2/1003 (0.2%)   Mean 0.2%    SD 0.62%     Total 2/998 (0.2%)     Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1003 (0%)     Mean 0%      SD 0%        Total 0/998 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Mesenchymal Tumor Benign             0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1003 (0%)     Mean 0%      SD 0%        Total 0/998 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 237
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Nephroblastoma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     0/54 (0%)                         1/53 (2%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1003 (0%)     Mean 0%      SD 0%        Total 1/998 (0.1%)     Mean 0.09%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Oncocytoma Benign                    0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1003 (0%)     Mean 0%      SD 0%        Total 0/998 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1003 (0%)     Mean 0%      SD 0%        Total 0/998 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/52 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/1003 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/998 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     1/54 (2%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 2/1004 (0.2%)   Mean 0.19%   SD 0.59%     Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 238
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1004 (0%)     Mean 0%      SD 0%        Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1004 (0%)     Mean 0%      SD 0%        Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     3/50 (6%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/45 (2%)     3/54 (6%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        4/53 (8%)     1/54 (2%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 19/1004 (1.89%) Mean 1.86%   SD 2.28%     Total 4/1000 (0.4%)    Mean 0.4%    SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     2/54 (4%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     1/54 (2%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 8/1004 (0.8%)   Mean 0.78%   SD 1.32%     Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     2/54 (4%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     1/54 (2%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 8/1004 (0.8%)   Mean 0.78%   SD 1.32%     Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 239
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          1/50 (2%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|      Hepatocellular Adenoma            1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     4/50 (8%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/45 (2%)     5/54 (9%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        4/53 (8%)     2/54 (4%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 27/1004 (2.69%) Mean 2.64%   SD 2.77%     Total 4/1000 (0.4%)    Mean 0.4%    SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            1/50 (2%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|      Hepatocellular Adenoma, or        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Hepatoblastoma                    1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     4/50 (8%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/45 (2%)     5/54 (9%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        4/53 (8%)     2/54 (4%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 27/1004 (2.69%) Mean 2.64%   SD 2.77%     Total 4/1000 (0.4%)    Mean 0.4%    SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1004 (0%)     Mean 0%      SD 0%        Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         1/50 (2%)     1/48 (2%)     2/50 (4%)           0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        5/50 (10%)    2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     1/49 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/46 (0%)     0/54 (0%)           1/50 (2%)     0/46 (0%)     1/53 (2%)     |
|                                        0/53 (0%)     0/54 (0%)                         2/53 (4%)     0/52 (0%)                   |
| Overall Incidence               Total 17/1004 (1.69%) Mean 1.7%    SD 2.45%     Total 12/1000 (1.2%)   Mean 1.19%   SD 1.34%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/49 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/46 (2%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     1/54 (2%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 6/1004 (0.6%)   Mean 0.61%   SD 0.95%     Total 2/1000 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 240
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    1/50 (2%)     2/48 (4%)     2/50 (4%)           0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|      Alveolar/Bronchiolar Adenoma      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        5/50 (10%)    2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     2/49 (4%)     |
|                                        1/49 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        3/50 (6%)     1/46 (2%)     0/54 (0%)           1/50 (2%)     0/46 (0%)     1/53 (2%)     |
|                                        0/53 (0%)     1/54 (2%)                         2/53 (4%)     0/52 (0%)                   |
| Overall Incidence               Total 23/1004 (2.29%) Mean 2.31%   SD 2.54%     Total 14/1000 (1.4%)   Mean 1.39%   SD 1.45%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1004 (0%)     Mean 0%      SD 0%        Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1004 (0%)     Mean 0%      SD 0%        Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1004 (0%)     Mean 0%      SD 0%        Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     1/54 (2%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     1/54 (2%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 3/1004 (0.3%)   Mean 0.29%   SD 0.7%      Total 1/1000 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 241
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoacanthoma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 242
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           1/50 (2%)     0/46 (0%)     1/53 (2%)     |
|                                        1/53 (2%)     0/54 (0%)                         1/53 (2%)     1/53 (2%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.09%   SD 0.42%     Total 13/1002 (1.3%)   Mean 1.28%   SD 1.33%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           3/50 (6%)     2/48 (4%)     4/49 (8%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           3/50 (6%)     9/50 (18%)    5/50 (10%)    |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           3/50 (6%)     2/50 (4%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           4/50 (8%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           4/50 (8%)     3/50 (6%)     5/50 (10%)    |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           3/50 (6%)     3/46 (7%)     1/53 (2%)     |
|                                        0/53 (0%)     1/54 (2%)                         1/53 (2%)     4/53 (8%)                   |
| Overall Incidence               Total 4/1005 (0.4%)   Mean 0.39%   SD 0.81%     Total 63/1002 (6.29%)  Mean 6.31%   SD 3.75%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/48 (0%)     0/50 (0%)           3/50 (6%)     2/48 (4%)     4/49 (8%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           5/50 (10%)   10/50 (20%)    5/50 (10%)    |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           3/50 (6%)     3/50 (6%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           4/50 (8%)     1/50 (2%)     4/50 (8%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           5/50 (10%)    4/50 (8%)     5/50 (10%)    |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           4/50 (8%)     3/46 (7%)     2/53 (4%)     |
|                                        1/53 (2%)     1/54 (2%)                         2/53 (4%)     5/53 (9%)                   |
| Overall Incidence               Total 5/1005 (0.5%)   Mean 0.49%   SD 0.87%     Total 75/1002 (7.49%)  Mean 7.49%   SD 3.93%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         3/50 (6%)     0/48 (0%)     2/50 (4%)          23/50 (46%)   16/48 (33%)   24/49 (49%)    |
|                                        3/50 (6%)     2/50 (4%)     1/50 (2%)          22/50 (44%)   19/50 (38%)   24/50 (48%)    |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)          12/50 (24%)   22/50 (44%)   27/50 (54%)    |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)          19/50 (38%)   22/50 (44%)   19/50 (38%)    |
|                                        2/50 (4%)     2/50 (4%)     0/50 (0%)          20/50 (40%)   22/50 (44%)   23/50 (46%)    |
|                                        2/50 (4%)     0/46 (0%)     2/54 (4%)          19/50 (38%)   11/46 (24%)   12/53 (23%)    |
|                                        0/53 (0%)     0/54 (0%)                        22/53 (42%)   17/53 (32%)                  |
| Overall Incidence               Total 24/1005 (2.39%) Mean 2.39%   SD 2.1%      Total 395/1002 (39.42%)Mean 39.42%  SD 8.62%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 243
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     3/50 (6%)     0/48 (0%)     2/50 (4%)          23/50 (46%)   16/48 (33%)   24/49 (49%)    |
|                                        3/50 (6%)     2/50 (4%)     1/50 (2%)          23/50 (46%)   20/50 (40%)   24/50 (48%)    |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)          12/50 (24%)   22/50 (44%)   27/50 (54%)    |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)          19/50 (38%)   22/50 (44%)   20/50 (40%)    |
|                                        2/50 (4%)     2/50 (4%)     0/50 (0%)          21/50 (42%)   23/50 (46%)   24/50 (48%)    |
|                                        2/50 (4%)     0/46 (0%)     2/54 (4%)          20/50 (40%)   11/46 (24%)   13/53 (25%)    |
|                                        1/53 (2%)     0/54 (0%)                        23/53 (43%)   18/53 (34%)                  |
| Overall Incidence               Total 25/1005 (2.49%) Mean 2.48%   SD 2.03%     Total 405/1002 (40.42%)Mean 40.41%  SD 8.57%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    3/50 (6%)     0/48 (0%)     2/50 (4%)          25/50 (50%)   17/48 (35%)   28/49 (57%)    |
|      or Adenoma                        3/50 (6%)     3/50 (6%)     2/50 (4%)          25/50 (50%)   25/50 (50%)   26/50 (52%)    |
|                                        0/50 (0%)     2/50 (4%)     1/50 (2%)          14/50 (28%)   23/50 (46%)   27/50 (54%)    |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)          20/50 (40%)   23/50 (46%)   21/50 (42%)    |
|                                        2/50 (4%)     2/50 (4%)     0/50 (0%)          23/50 (46%)   24/50 (48%)   27/50 (54%)    |
|                                        2/50 (4%)     0/46 (0%)     2/54 (4%)          22/50 (44%)   13/46 (28%)   13/53 (25%)    |
|                                        1/53 (2%)     1/54 (2%)                        24/53 (45%)   22/53 (42%)                  |
| Overall Incidence               Total 29/1005 (2.89%) Mean 2.87%   SD 2.1%      Total 442/1002 (44.11%)Mean 44.11%  SD 9.05%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Lipoma                               0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 244
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 2/1002 (0.2%)    Mean 0.2%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 245
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Benign                    0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     1/54 (2%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.09%   SD 0.41%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/994 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/994 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/994 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 246
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondrosarcoma                       0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/994 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Fibroma                              0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/994 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteoma                              0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     1/45 (2%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 1/998 (0.1%)    Mean 0.11%   SD 0.5%      Total 0/994 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteosarcoma                         0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/994 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/994 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 247
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Papilloma              0/48 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/51 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/994 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      4/50 (8%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        3/50 (6%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        1/53 (2%)     2/54 (4%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 13/1005 (1.29%) Mean 1.28%   SD 2.25%     Total 12/1002 (1.2%)   Mean 1.21%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     1/46 (2%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     3/53 (6%)                   |
| Overall Incidence               Total 2/1005 (0.2%)   Mean 0.2%    SD 0.62%     Total 7/1002 (0.7%)    Mean 0.69%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             4/50 (8%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     1/49 (2%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     1/50 (2%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        3/50 (6%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     1/46 (2%)     0/53 (0%)     |
|                                        1/53 (2%)     2/54 (4%)                         0/53 (0%)     3/53 (6%)                   |
| Overall Incidence               Total 15/1005 (1.49%) Mean 1.48%   SD 2.31%     Total 19/1002 (1.9%)   Mean 1.9%    SD 1.61%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 248
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     3/53 (6%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 5/1002 (0.5%)    Mean 0.48%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              3/50 (6%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     2/54 (4%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 8/1005 (0.8%)   Mean 0.79%   SD 1.74%     Total 4/1002 (0.4%)    Mean 0.4%    SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        2/53 (4%)     1/52 (2%)                   |
| Overall Incidence                                                               Total 7/1000 (0.7%)    Mean 0.68%   SD 1.14%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 249
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 2/1000 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        2/53 (4%)     1/52 (2%)                   |
| Overall Incidence                                                               Total 9/1000 (0.9%)    Mean 0.88%   SD 1.34%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Benign                                                         0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                                                                        0/53 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 1/1000 (0.1%)    Mean 0.09%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 2/1000 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 250
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sex Cord Stromal Tumor, Malignant                                                    1/50 (2%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 1/1000 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/52 (0%)                   |
| Overall Incidence                                                               Total 0/1000 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              1/50 (2%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        3/50 (6%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        1/53 (2%)     0/53 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 11/1003 (1.1%)  Mean 1.09%   SD 1.65%     Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/53 (0%)                         0/53 (0%)     1/52 (2%)                   |
| Overall Incidence               Total 1/1003 (0.1%)   Mean 0.1%    SD 0.45%     Total 1/993 (0.1%)     Mean 0.1%    SD 0.43%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 251
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        3/50 (6%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        1/53 (2%)     0/53 (0%)                         0/53 (0%)     1/52 (2%)                   |
| Overall Incidence               Total 12/1003 (1.2%)  Mean 1.19%   SD 1.64%     Total 1/993 (0.1%)     Mean 0.1%    SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/53 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1003 (0%)     Mean 0%      SD 0%        Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/53 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/1003 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/47 (0%)     0/47 (0%)     1/48 (2%)           0/46 (0%)     0/44 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/42 (0%)           0/50 (0%)     0/46 (0%)     0/42 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/48 (0%)           0/42 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/48 (0%)     0/47 (0%)     0/47 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/46 (0%)           0/49 (0%)     1/48 (2%)     0/43 (0%)     |
|                                        0/45 (0%)     0/39 (0%)     1/50 (2%)           0/48 (0%)     0/41 (0%)     0/47 (0%)     |
|                                        1/50 (2%)     0/49 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 3/945 (0.32%)   Mean 0.3%    SD 0.74%     Total 1/933 (0.11%)    Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Paraganglioma Benign                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     1/54 (2%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.09%   SD 0.41%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 252
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma: Benign, Malignant, NOS   0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Carcinoma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      24/49 (49%)   25/48 (52%)   40/50 (80%)         33/50 (66%)   24/48 (50%)   36/48 (75%)    |
|   Adenoma                             43/49 (88%)   36/50 (72%)   32/50 (64%)         40/50 (80%)   38/50 (76%)   37/50 (74%)    |
|                                       23/50 (46%)   43/50 (86%)   41/50 (82%)         31/50 (62%)   39/50 (78%)   34/48 (71%)    |
|                                       39/50 (78%)   37/49 (76%)   38/50 (76%)         33/50 (66%)   43/49 (88%)   33/50 (66%)    |
|                                       41/50 (82%)   39/50 (78%)   33/49 (67%)         34/50 (68%)   43/50 (86%)   33/49 (67%)    |
|                                       25/49 (51%)   25/45 (56%)   24/53 (45%)         30/49 (61%)   25/46 (54%)   20/52 (38%)    |
|                                       20/53 (38%)   13/54 (24%)                       24/52 (46%)   22/52 (42%)                  |
| Overall Incidence               Total 641/998 (64.23%)Mean 64.47%  SD 18.15%    Total 652/993 (65.66%) Mean 65.77%  SD 13.82%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 253
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/53 (0%)           0/49 (0%)     1/46 (2%)     1/52 (2%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/52 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 3/993 (0.3%)     Mean 0.3%    SD 0.75%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      24/49 (49%)   25/48 (52%)   40/50 (80%)         33/50 (66%)   24/48 (50%)   36/48 (75%)    |
|   Carcinoma or Adenoma                43/49 (88%)   36/50 (72%)   32/50 (64%)         40/50 (80%)   38/50 (76%)   37/50 (74%)    |
|                                       23/50 (46%)   43/50 (86%)   41/50 (82%)         31/50 (62%)   39/50 (78%)   34/48 (71%)    |
|                                       39/50 (78%)   37/49 (76%)   38/50 (76%)         34/50 (68%)   43/49 (88%)   33/50 (66%)    |
|                                       41/50 (82%)   39/50 (78%)   33/49 (67%)         34/50 (68%)   43/50 (86%)   33/49 (67%)    |
|                                       25/49 (51%)   25/45 (56%)   24/53 (45%)         30/49 (61%)   26/46 (57%)   21/52 (40%)    |
|                                       20/53 (38%)   13/54 (24%)                       24/52 (46%)   22/52 (42%)                  |
| Overall Incidence               Total 641/998 (64.23%)Mean 64.47%  SD 18.15%    Total 655/993 (65.96%) Mean 66.08%  SD 13.55%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|   Craniopharyngioma                    0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/53 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/52 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|   Ganglioneuroma                       0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/53 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/52 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/49 (0%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/53 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/52 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 2/998 (0.2%)    Mean 0.2%    SD 0.63%     Total 2/993 (0.2%)     Mean 0.2%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 254
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/53 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/52 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/49 (0%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/53 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/52 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 2/998 (0.2%)    Mean 0.2%    SD 0.63%     Total 2/993 (0.2%)     Mean 0.2%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Nervosa                                                                                                    |
|   Adenoma                              0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/45 (0%)     0/53 (0%)           0/49 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/52 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/998 (0%)      Mean 0%      SD 0%        Total 0/993 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              1/49 (2%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/46 (0%)     0/53 (0%)                                                     |
|                                        0/53 (0%)     0/54 (0%)                                                                   |
| Overall Incidence               Total 4/1002 (0.4%)   Mean 0.4%    SD 0.83%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/46 (0%)     0/53 (0%)                                                     |
|                                        0/53 (0%)     0/54 (0%)                                                                   |
| Overall Incidence               Total 1/1002 (0.1%)   Mean 0.1%    SD 0.45%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 255
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 1/49 (2%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/46 (0%)     0/53 (0%)                                                     |
|                                        0/53 (0%)     0/54 (0%)                                                                   |
| Overall Incidence               Total 5/1002 (0.5%)   Mean 0.5%    SD 0.89%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1001 (0%)     Mean 0%      SD 0%        Total 0/998 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1001 (0%)     Mean 0%      SD 0%        Total 0/998 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1001 (0%)     Mean 0%      SD 0%        Total 0/998 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1001 (0%)     Mean 0%      SD 0%        Total 0/998 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 256
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              1/50 (2%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)                                                     |
|                                        0/53 (0%)     0/54 (0%)                                                                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%                                                      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrous Histiocytoma                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 257
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 5/1005 (0.5%)   Mean 0.5%    SD 0.89%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 258
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 2/1005 (0.2%)   Mean 0.2%    SD 0.89%     Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 7/1005 (0.7%)   Mean 0.7%    SD 1.17%     Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   2/50 (4%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     2/54 (4%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 8/1005 (0.8%)   Mean 0.79%   SD 1.48%     Total 1/1002 (0.1%)    Mean 0.09%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                2/50 (4%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|      Basosquamous Tumor Benign         2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     2/54 (4%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 10/1005 (1%)    Mean 0.99%   SD 1.63%     Total 1/1002 (0.1%)    Mean 0.09%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 259
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     2/50 (4%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     1/48 (2%)     0/49 (0%)     |
|      Tumor Benign, or                  2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     2/54 (4%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 12/1005 (1.19%) Mean 1.19%   SD 1.62%     Total 2/1002 (0.2%)    Mean 0.2%    SD 0.61%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 2/50 (4%)     0/48 (0%)     0/50 (0%)           1/50 (2%)     1/48 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 4/1005 (0.4%)   Mean 0.4%    SD 1.23%     Total 3/1002 (0.3%)    Mean 0.3%    SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              2/50 (4%)     0/48 (0%)     0/50 (0%)           1/50 (2%)     1/48 (2%)     0/49 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 4/1005 (0.4%)   Mean 0.4%    SD 1.23%     Total 3/1002 (0.3%)    Mean 0.3%    SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     4/50 (8%)     0/48 (0%)     1/50 (2%)           1/50 (2%)     1/48 (2%)     0/49 (0%)     |
|      Adenoma, Basosquamous Tumor       2/50 (4%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     2/54 (4%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 16/1005 (1.59%) Mean 1.59%   SD 2.19%     Total 4/1002 (0.4%)    Mean 0.4%    SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         8/50 (16%)    0/48 (0%)     3/50 (6%)           3/50 (6%)     2/48 (4%)     0/49 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    4/50 (8%)     7/50 (14%)    1/50 (2%)           1/50 (2%)     1/50 (2%)     3/50 (6%)     |
|      B), Basal Cell Adenoma, Adenoma,  1/50 (2%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|      Papilloma, Sq Papilloma,          3/50 (6%)     2/50 (4%)     7/50 (14%)          2/50 (4%)     2/50 (4%)     1/50 (2%)     |
|      Keratoacanthoma,                  3/50 (6%)     7/50 (14%)    4/50 (8%)           2/50 (4%)     2/50 (4%)     2/50 (4%)     |
|      Trichoepithelioma                 5/50 (10%)    3/46 (7%)     3/54 (6%)           0/50 (0%)     1/46 (2%)     4/53 (8%)     |
|                                        7/53 (13%)    4/54 (7%)                         0/53 (0%)     1/53 (2%)                   |
| Overall Incidence               Total 77/1005 (7.66%) Mean 7.63%   SD 4.55%     Total 29/1002 (2.89%)  Mean 2.89%   SD 2.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 260
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 2/1005 (0.2%)   Mean 0.2%    SD 0.89%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      3/50 (6%)     0/48 (0%)     2/50 (4%)           2/50 (4%)     0/48 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     5/50 (10%)    1/50 (2%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     6/50 (12%)          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     3/50 (6%)     3/50 (6%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|                                        3/50 (6%)     2/46 (4%)     1/54 (2%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        5/53 (9%)     4/54 (7%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 50/1005 (4.98%) Mean 4.95%   SD 3.21%     Total 11/1002 (1.1%)   Mean 1.09%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 261
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/50 (2%)     0/48 (0%)     2/50 (4%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        1/53 (2%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 8/1005 (0.8%)   Mean 0.79%   SD 1.19%     Total 2/1002 (0.2%)    Mean 0.2%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 2/1002 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 262
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/46 (2%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     1/53 (2%)                   |
| Overall Incidence               Total 6/1005 (0.6%)   Mean 0.61%   SD 0.95%     Total 4/1002 (0.4%)    Mean 0.4%    SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       2/50 (4%)     0/48 (0%)     0/50 (0%)           1/50 (2%)     2/48 (4%)     0/49 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma                         1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/46 (2%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     1/53 (2%)                   |
| Overall Incidence               Total 10/1005 (1%)    Mean 1.01%   SD 1.38%     Total 7/1002 (0.7%)    Mean 0.7%    SD 1.19%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     1/46 (2%)     2/53 (4%)     |
|                                        2/53 (4%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 8/1005 (0.8%)   Mean 0.79%   SD 1.33%     Total 10/1002 (1%)     Mean 1%      SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     1/46 (2%)     2/53 (4%)     |
|                                        2/53 (4%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 8/1005 (0.8%)   Mean 0.79%   SD 1.33%     Total 10/1002 (1%)     Mean 1%      SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)     0/48 (0%)     2/50 (4%)           2/50 (4%)     1/48 (2%)     0/49 (0%)     |
|      Papilloma, Squamous Cell          2/50 (4%)     5/50 (10%)    1/50 (2%)           1/50 (2%)     1/50 (2%)     3/50 (6%)     |
|      Carcinoma or Keratoacanthoma      1/50 (2%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     2/50 (4%)     7/50 (14%)          2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        3/50 (6%)     5/50 (10%)    3/50 (6%)           2/50 (4%)     2/50 (4%)     2/50 (4%)     |
|                                        5/50 (10%)    3/46 (7%)     1/54 (2%)           0/50 (0%)     1/46 (2%)     3/53 (6%)     |
|                                        7/53 (13%)    4/54 (7%)                         0/53 (0%)     1/53 (2%)                   |
| Overall Incidence               Total 62/1005 (6.17%) Mean 6.15%   SD 3.8%      Total 25/1002 (2.5%)   Mean 2.49%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 263
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)     0/48 (0%)     2/50 (4%)           2/50 (4%)     0/48 (0%)     0/49 (0%)     |
|      Papilloma, or Keratoacanthoma     2/50 (4%)     5/50 (10%)    1/50 (2%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        1/50 (2%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     6/50 (12%)          2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        3/50 (6%)     4/50 (8%)     3/50 (6%)           1/50 (2%)     2/50 (4%)     2/50 (4%)     |
|                                        5/50 (10%)    2/46 (4%)     1/54 (2%)           0/50 (0%)     1/46 (2%)     3/53 (6%)     |
|                                        7/53 (13%)    4/54 (7%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 57/1005 (5.67%) Mean 5.64%   SD 3.69%     Total 21/1002 (2.1%)   Mean 2.09%   SD 1.74%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 2/1005 (0.2%)   Mean 0.2%    SD 0.62%     Total 1/1002 (0.1%)    Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              2/50 (4%)     3/48 (6%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     4/50 (8%)     4/50 (8%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     3/50 (6%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/46 (0%)     3/54 (6%)           1/50 (2%)     0/46 (0%)     0/53 (0%)     |
|                                        3/53 (6%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 38/1005 (3.78%) Mean 3.77%   SD 2.8%      Total 5/1002 (0.5%)    Mean 0.5%    SD 0.9%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      3/50 (6%)     3/48 (6%)     2/50 (4%)           0/50 (0%)     2/48 (4%)     2/49 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     4/50 (8%)     4/50 (8%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      Histiocytoma                      3/50 (6%)     2/50 (4%)     3/50 (6%)           1/50 (2%)     3/50 (6%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     6/50 (12%)          2/50 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     3/50 (6%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     1/46 (2%)     3/54 (6%)           1/50 (2%)     1/46 (2%)     0/53 (0%)     |
|                                        4/53 (8%)     0/54 (0%)                         1/53 (2%)     1/53 (2%)                   |
| Overall Incidence               Total 48/1005 (4.78%) Mean 4.78%   SD 3.11%     Total 19/1002 (1.9%)   Mean 1.91%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     1/46 (2%)     0/53 (0%)     |
|                                        1/53 (2%)     0/54 (0%)                         1/53 (2%)     0/53 (0%)                   |
| Overall Incidence               Total 7/1005 (0.7%)   Mean 0.69%   SD 1.49%     Total 6/1002 (0.6%)    Mean 0.61%   SD 1.16%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 264
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)     0/48 (0%)     2/50 (4%)           0/50 (0%)     1/48 (2%)     2/49 (4%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      Histiocytoma                      1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     3/50 (6%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/46 (2%)     0/54 (0%)           0/50 (0%)     1/46 (2%)     0/53 (0%)     |
|                                        1/53 (2%)     0/54 (0%)                         1/53 (2%)     1/53 (2%)                   |
| Overall Incidence               Total 10/1005 (1%)    Mean 1%      SD 1.66%     Total 14/1002 (1.4%)   Mean 1.41%   SD 1.61%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 2/1005 (0.2%)   Mean 0.2%    SD 0.62%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     1/54 (2%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.09%   SD 0.41%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 265
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|      (malignant or NOS)                1/50 (2%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     1/54 (2%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 5/1005 (0.5%)   Mean 0.49%   SD 1.09%     Total 2/1002 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|      or Schwannoma (benign, malignant  1/50 (2%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                           0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     1/54 (2%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 7/1005 (0.7%)   Mean 0.69%   SD 1.17%     Total 2/1002 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     1/48 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/46 (2%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     1/53 (2%)                   |
| Overall Incidence               Total 3/1005 (0.3%)   Mean 0.31%   SD 0.75%     Total 7/1002 (0.7%)    Mean 0.7%    SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 4/1005 (0.4%)   Mean 0.4%    SD 1.05%     Total 2/1002 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 266
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Benign                   0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        1/53 (2%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.09%   SD 0.42%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Malignant                0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Chordoma                             0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Glioma Benign                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibroma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 3/1005 (0.3%)   Mean 0.3%    SD 0.73%     Total 0/995 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 267
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/995 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/995 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/46 (2%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 2/1005 (0.2%)   Mean 0.21%   SD 0.64%     Total 2/995 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Leiomyosarcoma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/995 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Osteosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/46 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/995 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 268
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/49 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 2/995 (0.2%)     Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 269
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Benign               0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Malignant            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             41/50 (82%)   33/48 (69%)   34/50 (68%)                                                    |
|                                       35/50 (70%)   35/50 (70%)   36/50 (72%)                                                    |
|                                       38/50 (76%)   23/50 (46%)   30/50 (60%)                                                    |
|                                       33/50 (66%)   39/50 (78%)   38/50 (76%)                                                    |
|                                       27/50 (54%)   39/50 (78%)   23/50 (46%)                                                    |
|                                       36/50 (72%)   31/46 (67%)   40/54 (74%)                                                    |
|                                       39/53 (74%)   45/54 (83%)                                                                  |
| Overall Incidence               Total 695/1005 (69.15%Mean 69.06%  SD 10.46%                                                     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 270
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)                                                     |
|                                        0/53 (0%)     0/54 (0%)                                                                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/45 (0%)     0/48 (0%)     0/42 (0%)           0/48 (0%)     0/48 (0%)     0/43 (0%)     |
|                                        0/45 (0%)     0/43 (0%)     0/50 (0%)           0/42 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/50 (0%)           0/47 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/45 (0%)           0/48 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/44 (0%)     0/49 (0%)     0/50 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/41 (0%)     0/44 (0%)           0/48 (0%)     0/44 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/921 (0%)      Mean 0%      SD 0%        Total 0/944 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Schwannoma Malignant                 0/45 (0%)     0/48 (0%)     0/42 (0%)           0/48 (0%)     0/48 (0%)     0/43 (0%)     |
|                                        0/45 (0%)     0/43 (0%)     0/50 (0%)           0/42 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/50 (0%)           0/47 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/45 (0%)           0/48 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/44 (0%)     0/49 (0%)     0/50 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/41 (0%)     0/44 (0%)           0/48 (0%)     0/44 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/921 (0%)      Mean 0%      SD 0%        Total 0/944 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/45 (0%)     0/48 (0%)     1/42 (2%)           0/48 (0%)     0/48 (0%)     0/43 (0%)     |
|                                        0/45 (0%)     0/43 (0%)     0/50 (0%)           0/42 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/50 (0%)           0/47 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/45 (0%)           0/48 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/44 (0%)     0/49 (0%)     1/50 (2%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/41 (0%)     0/44 (0%)           0/48 (0%)     0/44 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 2/921 (0.22%)   Mean 0.22%   SD 0.68%     Total 0/944 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/45 (0%)     0/48 (0%)     0/42 (0%)           0/48 (0%)     0/48 (0%)     0/43 (0%)     |
|                                        0/45 (0%)     0/43 (0%)     0/50 (0%)           0/42 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/50 (0%)           0/47 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/45 (0%)           0/48 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/44 (0%)     0/49 (0%)     0/50 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/41 (0%)     0/44 (0%)           0/48 (0%)     0/44 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/921 (0%)      Mean 0%      SD 0%        Total 0/944 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 271
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/45 (0%)     0/48 (0%)     0/42 (0%)           0/48 (0%)     0/48 (0%)     0/43 (0%)     |
|                                        0/45 (0%)     0/43 (0%)     0/50 (0%)           0/42 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/50 (0%)           0/47 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/45 (0%)           0/48 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/44 (0%)     0/49 (0%)     0/50 (0%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/41 (0%)     0/44 (0%)           0/48 (0%)     0/44 (0%)     1/48 (2%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/921 (0%)      Mean 0%      SD 0%        Total 1/944 (0.11%)    Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/45 (0%)     0/48 (0%)     1/42 (2%)           0/48 (0%)     0/48 (0%)     0/43 (0%)     |
|                                        0/45 (0%)     0/43 (0%)     0/50 (0%)           0/42 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/50 (0%)           0/47 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/45 (0%)     0/45 (0%)           0/48 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/44 (0%)     0/49 (0%)     1/50 (2%)           0/45 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/46 (0%)     0/41 (0%)     0/44 (0%)           0/48 (0%)     0/44 (0%)     1/48 (2%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 2/921 (0.22%)   Mean 0.22%   SD 0.68%     Total 1/944 (0.11%)    Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     0/54 (0%)           0/48 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/53 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 0/995 (0%)      Mean 0%      SD 0%        Total 0/988 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              7/50 (14%)    6/48 (13%)    3/50 (6%)           6/50 (12%)    3/48 (6%)     7/49 (14%)    |
|                                        4/49 (8%)     5/49 (10%)    1/50 (2%)           6/49 (12%)    7/49 (14%)    2/50 (4%)     |
|                                        5/49 (10%)    5/48 (10%)    1/50 (2%)           6/50 (12%)    7/50 (14%)    1/49 (2%)     |
|                                        3/49 (6%)     3/50 (6%)     8/50 (16%)          6/48 (13%)    3/49 (6%)     8/50 (16%)    |
|                                        1/49 (2%)     7/50 (14%)    4/50 (8%)           5/50 (10%)    5/50 (10%)    2/48 (4%)     |
|                                        3/50 (6%)     1/45 (2%)     6/54 (11%)          2/48 (4%)     1/46 (2%)     1/52 (2%)     |
|                                        4/52 (8%)     8/53 (15%)                        3/51 (6%)     1/52 (2%)                   |
| Overall Incidence               Total 85/995 (8.54%)  Mean 8.49%   SD 4.49%     Total 82/988 (8.3%)    Mean 8.3%    SD 4.9%      |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/50 (2%)     3/48 (6%)     2/50 (4%)           0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|                                        3/49 (6%)     0/49 (0%)     0/50 (0%)           3/49 (6%)     1/49 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     3/50 (6%)           0/50 (0%)     2/50 (4%)     1/49 (2%)     |
|                                        1/49 (2%)     4/50 (8%)     0/50 (0%)           2/48 (4%)     3/49 (6%)     2/50 (4%)     |
|                                        1/49 (2%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     2/50 (4%)     2/48 (4%)     |
|                                        2/50 (4%)     1/45 (2%)     1/54 (2%)           0/48 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        2/52 (4%)     0/53 (0%)                         0/51 (0%)     1/52 (2%)                   |
| Overall Incidence               Total 28/995 (2.81%)  Mean 2.82%   SD 2.48%     Total 20/988 (2.02%)   Mean 2.03%   SD 2.19%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 272
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 7/50 (14%)    9/48 (19%)    5/50 (10%)          6/50 (12%)    3/48 (6%)     8/49 (16%)    |
|                                        7/49 (14%)    5/49 (10%)    1/50 (2%)           9/49 (18%)    8/49 (16%)    2/50 (4%)     |
|                                        5/49 (10%)    5/48 (10%)    4/50 (8%)           6/50 (12%)    9/50 (18%)    2/49 (4%)     |
|                                        4/49 (8%)     7/50 (14%)    8/50 (16%)          8/48 (17%)    6/49 (12%)   10/50 (20%)    |
|                                        2/49 (4%)     8/50 (16%)    6/50 (12%)          5/50 (10%)    7/50 (14%)    4/48 (8%)     |
|                                        5/50 (10%)    2/45 (4%)     7/54 (13%)          2/48 (4%)     1/46 (2%)     1/52 (2%)     |
|                                        6/52 (12%)    8/53 (15%)                        3/51 (6%)     2/52 (4%)                   |
| Overall Incidence               Total 111/995 (11.16%)Mean 11.11%  SD 4.31%     Total 102/988 (10.32%) Mean 10.33%  SD 6.02%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     0/48 (0%)     0/50 (0%)           1/50 (2%)     0/48 (0%)     1/49 (2%)     |
|                                        0/49 (0%)     0/49 (0%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     0/50 (0%)           0/48 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/45 (0%)     1/54 (2%)           0/48 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/53 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 8/995 (0.8%)    Mean 0.79%   SD 1.19%     Total 4/988 (0.4%)     Mean 0.4%    SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/48 (0%)     0/50 (0%)           1/50 (2%)     1/48 (2%)     0/49 (0%)     |
|                                        1/49 (2%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        1/49 (2%)     0/50 (0%)     1/50 (2%)           0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        1/50 (2%)     1/45 (2%)     1/54 (2%)           0/48 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/53 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 10/995 (1.01%)  Mean 1.01%   SD 1.04%     Total 5/988 (0.51%)    Mean 0.51%   SD 0.9%      |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     0/48 (0%)     0/50 (0%)           2/50 (4%)     1/48 (2%)     1/49 (2%)     |
|                                        1/49 (2%)     0/49 (0%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/48 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/49 (2%)     |
|                                        2/49 (4%)     1/50 (2%)     1/50 (2%)           0/48 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     3/50 (6%)           1/50 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        1/50 (2%)     1/45 (2%)     2/54 (4%)           0/48 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/52 (0%)     0/53 (0%)                         0/51 (0%)     0/52 (0%)                   |
| Overall Incidence               Total 18/995 (1.81%)  Mean 1.81%   SD 1.69%     Total 9/988 (0.91%)    Mean 0.91%   SD 1.22%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 273
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Chemodectoma Malignant               0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibroma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        1/53 (2%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.09%   SD 0.42%     Total 1/1002 (0.1%)    Mean 0.09%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     1/54 (2%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.09%   SD 0.41%     Total 1/1002 (0.1%)    Mean 0.09%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 274
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     1/54 (2%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.09%   SD 0.41%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1005 (0.1%)   Mean 0.1%    SD 0.45%     Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Squamous Cell Carcinoma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     3/53 (6%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 3/1002 (0.3%)    Mean 0.28%   SD 1.27%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Yolk Sac Carcinoma                   0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 275
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     1/46 (2%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.11%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     1/46 (2%)     0/53 (0%)     |
|                                        1/53 (2%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 5/1005 (0.5%)   Mean 0.49%   SD 0.88%     Total 8/1002 (0.8%)    Mean 0.81%   SD 1.21%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              1/50 (2%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        1/53 (2%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 5/1005 (0.5%)   Mean 0.49%   SD 0.88%     Total 7/1002 (0.7%)    Mean 0.7%    SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 276
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Malignant               0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.09%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Squamous Cell Carcinoma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Urethra:                                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 277
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     1/46 (2%)     0/54 (0%)           0/48 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 1/1002 (0.1%)   Mean 0.11%   SD 0.49%     Total 0/992 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               2/49 (4%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     1/46 (2%)     0/54 (0%)           0/48 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 3/1002 (0.3%)   Mean 0.31%   SD 1.01%     Total 1/992 (0.1%)     Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyoma                            0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/54 (0%)           0/48 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1002 (0%)     Mean 0%      SD 0%        Total 0/992 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/54 (0%)           0/48 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1002 (0%)     Mean 0%      SD 0%        Total 0/992 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            2/49 (4%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     1/48 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/54 (0%)           0/48 (0%)     0/46 (0%)     0/52 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 2/1002 (0.2%)   Mean 0.2%    SD 0.91%     Total 1/992 (0.1%)     Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 278
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 2/1002 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     1/50 (2%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma NOS                                                                        1/50 (2%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibroma                                                                              0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 279
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Malignant                                                        0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 1/1002 (0.1%)    Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 280
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 2/1002 (0.2%)    Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        6/50 (12%)    7/48 (15%)    6/49 (12%)    |
|                                                                                        8/50 (16%)    6/50 (12%)    8/50 (16%)    |
|                                                                                        4/50 (8%)     8/50 (16%)    2/50 (4%)     |
|                                                                                        8/50 (16%)    6/50 (12%)    6/50 (12%)    |
|                                                                                       10/50 (20%)    6/50 (12%)    5/50 (10%)    |
|                                                                                        2/50 (4%)     2/46 (4%)     9/53 (17%)    |
|                                                                                        2/53 (4%)     4/53 (8%)                   |
| Overall Incidence                                                               Total 115/1002 (11.48%)Mean 11.47%  SD 4.86%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     1/46 (2%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 6/1002 (0.6%)    Mean 0.61%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     6/50 (12%)    7/48 (15%)    6/49 (12%)    |
|                                                                                        9/50 (18%)    6/50 (12%)    8/50 (16%)    |
|                                                                                        5/50 (10%)    8/50 (16%)    2/50 (4%)     |
|                                                                                        8/50 (16%)    6/50 (12%)    6/50 (12%)    |
|                                                                                       11/50 (22%)    6/50 (12%)    6/50 (12%)    |
|                                                                                        2/50 (4%)     3/46 (7%)     9/53 (17%)    |
|                                                                                        2/53 (4%)     4/53 (8%)                   |
| Overall Incidence                                                               Total 120/1002 (11.98%)Mean 11.98%  SD 4.95%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 281
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/48 (0%)     1/49 (2%)     |
|                                                                                        0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 3/1002 (0.3%)    Mean 0.3%    SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma NOS                                                                       0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 282
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Polyp                                                                                0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     1/53 (2%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 3/1002 (0.3%)    Mean 0.29%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)                   |
| Overall Incidence                                                               Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           1/50 (2%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 1/1002 (0.1%)    Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/50 (2%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     2/48 (4%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/46 (0%)     1/54 (2%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     1/54 (2%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 14/1005 (1.39%) Mean 1.39%   SD 1.31%     Total 5/1002 (0.5%)    Mean 0.51%   SD 1.13%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 283
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/50 (2%)     0/48 (0%)     1/50 (2%)           0/50 (0%)     2/48 (4%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/46 (0%)     1/54 (2%)           1/50 (2%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     1/54 (2%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 14/1005 (1.39%) Mean 1.39%   SD 1.31%     Total 6/1002 (0.6%)    Mean 0.61%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Squamous Cell Papilloma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/54 (0%)           0/50 (0%)     0/46 (0%)     0/53 (0%)     |
|                                        0/53 (0%)     0/54 (0%)                         0/53 (0%)     0/53 (0%)                   |
| Overall Incidence               Total 0/1005 (0%)     Mean 0%      SD 0%        Total 0/1002 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 285
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       99/100(99%)                                     92/100(92%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    66/100(66%)                                     40/100(40%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         10/100(10%)                                     98/100(98%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   50/100(50%)                                     20/100(20%)                                |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/100(0%)                                       0/100(0%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/100(4%)                                       0/100(0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 286
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/100(4%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/99 (0%)                                       6/100(6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/99 (0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/98 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             24/98 (24%)                                      7/96 (7%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/98 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/98 (2%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           26/98 (27%)                                      7/96 (7%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 287
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma NOS                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 288
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant, Mixed              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma NOS                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Benign           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma NOS                0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        2/100(2%)                                       2/100(2%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 289
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                             13/100(13%)                                     11/90 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                13/100(13%)                                     11/90 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neurofibrosarcoma                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma NOS                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 290
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma NOS                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma NOS                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 291
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 292
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Mast Cell Tumor Benign               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 293
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Mast Cell Tumor Benign               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/99 (3%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            1/99 (1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 4/99 (4%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Papilloma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 294
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Mesenchymal Tumor Benign             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Nephroblastoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Oncocytoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 295
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/100(0%)                                       0/100(0%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          1/100(1%)                                       0/100(0%)                                 |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            1/100(1%)                                       0/100(0%)                                 |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         3/100(3%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    3/100(3%)                                       4/100(4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 296
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Plasma Cell Tumor Malignant          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoacanthoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         6/100(6%)                                      56/100(56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     6/100(6%)                                      56/100(56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    6/100(6%)                                      58/100(58%)                                |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 297
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondrosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 298
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 299
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/100(0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Benign                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sex Cord Stromal Tumor, Malignant                                                    0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              3/98 (3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 3/98 (3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 300
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/85 (0%)                                       1/88 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Paraganglioma Benign                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma: Benign, Malignant, NOS   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      34/98 (35%)                                     61/99 (62%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/98 (0%)                                       3/99 (3%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      34/98 (35%)                                     64/99 (65%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/98 (0%)                                       0/99 (0%)                                 |
|   Craniopharyngioma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 301
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/98 (0%)                                       0/99 (0%)                                 |
|   Ganglioneuroma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Nervosa                                                                                                    |
|   Adenoma                              0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 302
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   3/100(3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 303
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                3/100(3%)                                       0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     3/100(3%)                                       0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)                                       0/100(0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     3/100(3%)                                       0/100(0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,        14/100(14%)                                      1/100(1%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 304
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                     10/100(10%)                                      1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)                                       0/100(0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/100(1%)                                       0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/100(11%)                                      1/100(1%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 305
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/100(11%)                                      1/100(1%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                             12/100(12%)                                      4/100(4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,     13/100(13%)                                      6/100(6%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/100(1%)                                       2/100(2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/100(0%)                                       0/100(0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 306
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/100(0%)                                       0/100(0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Benign                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Malignant                0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Chordoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Glioma Benign                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 307
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Basal Cell Adenoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/100(1%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Benign               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Malignant            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             93/100(93%)                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            1/100(1%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 308
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/97 (0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Schwannoma Malignant                 0/97 (0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       2/97 (2%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/97 (0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/97 (0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      2/97 (2%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                             15/99 (15%)                                     15/100(15%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/99 (1%)                                       5/100(5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                16/99 (16%)                                     19/100(19%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/99 (1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/99 (1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 309
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Chemodectoma Malignant               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Yolk Sac Carcinoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 310
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Malignant               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Urethra:                                                                                                                         |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               1/99 (1%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyoma                            0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            1/99 (1%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 311
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma NOS                                                                        0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibroma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Malignant                                                        0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       13/100(13%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 312
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    13/100(13%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma NOS                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Fibrosarcoma                                                                         0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Polyp                                                                                0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 313
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 315
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       49/50 (98%)   49/52 (94%)   47/50 (94%)         42/50 (84%)   40/50 (80%)   43/50 (86%)    |
|                                       48/50 (96%)   49/50 (98%)   44/50 (88%)         37/50 (74%)   39/50 (78%)   40/50 (80%)    |
|                                       49/51 (96%)   47/50 (94%)   47/50 (94%)         45/51 (88%)   40/50 (80%)   41/50 (82%)    |
|                                       47/50 (94%)   49/50 (98%)   50/51 (98%)         37/50 (74%)   38/50 (76%)   40/50 (80%)    |
|                                       50/50 (100%)  46/50 (92%)   49/50 (98%)         43/50 (86%)   40/50 (80%)   42/50 (84%)    |
|                                       50/50 (100%)  47/50 (94%)   47/50 (94%)         40/50 (80%)   40/50 (80%)   43/50 (86%)    |
| Overall Incidence               Total 864/904 (95.58%)Mean 95.57%  SD 3.03%     Total 730/901 (81.02%) Mean 81.01%  SD 4.1%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    37/50 (74%)   38/52 (73%)   38/50 (76%)         22/50 (44%)   24/50 (48%)   21/50 (42%)    |
|                                       32/50 (64%)   41/50 (82%)   26/50 (52%)         20/50 (40%)   21/50 (42%)   16/50 (32%)    |
|                                       28/51 (55%)   32/50 (64%)   34/50 (68%)         13/51 (25%)   19/50 (38%)   25/50 (50%)    |
|                                       27/50 (54%)   36/50 (72%)   32/51 (63%)         17/50 (34%)   27/50 (54%)   21/50 (42%)    |
|                                       20/50 (40%)   37/50 (74%)   42/50 (84%)         14/50 (28%)   30/50 (60%)   30/50 (60%)    |
|                                       35/50 (70%)   39/50 (78%)   35/50 (70%)         21/50 (42%)   21/50 (42%)   30/50 (60%)    |
| Overall Incidence               Total 609/904 (67.37%)Mean 67.37%  SD 11.37%    Total 392/901 (43.51%) Mean 43.53%  SD 10.38%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         49/50 (98%)   51/52 (98%)   50/50 (100%)        47/50 (94%)   45/50 (90%)   49/50 (98%)    |
|                                       50/50 (100%)  50/50 (100%)  45/50 (90%)         45/50 (90%)   47/50 (94%)   46/50 (92%)    |
|                                       50/51 (98%)   48/50 (96%)   49/50 (98%)         47/51 (92%)   47/50 (94%)   48/50 (96%)    |
|                                       49/50 (98%)   50/50 (100%)  51/51 (100%)        45/50 (90%)   46/50 (92%)   45/50 (90%)    |
|                                       50/50 (100%)  50/50 (100%)  50/50 (100%)        48/50 (96%)   49/50 (98%)   48/50 (96%)    |
|                                       50/50 (100%)  48/50 (96%)   49/50 (98%)         46/50 (92%)   44/50 (88%)   49/50 (98%)    |
| Overall Incidence               Total 889/904 (98.34%)Mean 98.34%  SD 2.5%      Total 841/901 (93.34%) Mean 93.34%  SD 3.14%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.33%   SD 0.76%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     2/50 (4%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/904 (0.66%)   Mean 0.67%   SD 1.19%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 316
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     2/50 (4%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 9/904 (1%)      Mean 1%      SD 1.41%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.33%   SD 0.76%     Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   30/50 (60%)   32/52 (62%)   27/50 (54%)         18/50 (36%)   19/50 (38%)   14/50 (28%)    |
|      Mononuclear, or Undifferentiated 25/50 (50%)   35/50 (70%)   22/50 (44%)         15/50 (30%)   13/50 (26%)    8/50 (16%)    |
|                                       20/51 (39%)   29/50 (58%)   27/50 (54%)          8/51 (16%)   13/50 (26%)   15/50 (30%)    |
|                                       18/50 (36%)   32/50 (64%)   27/51 (53%)         11/50 (22%)   14/50 (28%)   15/50 (30%)    |
|                                       16/50 (32%)   31/50 (62%)   37/50 (74%)          9/50 (18%)   21/50 (42%)   16/50 (32%)    |
|                                       26/50 (52%)   29/50 (58%)   31/50 (62%)         14/50 (28%)   17/50 (34%)   21/50 (42%)    |
| Overall Incidence               Total 494/904 (54.65%)Mean 54.65%  SD 11.24%    Total 261/901 (28.97%) Mean 28.98%  SD 7.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.65%     Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 317
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     2/50 (4%)     2/52 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               1/50 (2%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/51 (2%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 20/904 (2.21%)  Mean 2.21%   SD 1.51%     Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              2/50 (4%)     2/52 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/51 (2%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 19/904 (2.1%)   Mean 2.1%    SD 1.59%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.33%   SD 0.76%     Total 4/901 (0.44%)    Mean 0.44%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 318
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.33%   SD 0.76%     Total 4/901 (0.44%)    Mean 0.44%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     1/52 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           1/51 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
|                                        2/48 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/49 (0%)     2/50 (4%)     |
| Overall Incidence               Total 9/900 (1%)      Mean 1%      SD 1.26%     Total 13/900 (1.44%)   Mean 1.44%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/900 (0%)      Mean 0%      SD 0%        Total 1/900 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/47 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/51 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/896 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/896 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             14/50 (28%)   14/52 (27%)   14/50 (28%)          1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                       14/50 (28%)   23/50 (46%)    9/50 (18%)          0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        5/50 (10%)   17/49 (35%)   14/47 (30%)          1/51 (2%)     3/50 (6%)     3/50 (6%)     |
|                                       15/49 (31%)   16/49 (33%)    6/51 (12%)          1/49 (2%)     2/50 (4%)     1/50 (2%)     |
|                                       17/50 (34%)    9/50 (18%)    7/50 (14%)          1/50 (2%)     1/49 (2%)     2/48 (4%)     |
|                                        7/49 (14%)   10/50 (20%)   17/50 (34%)          1/50 (2%)     2/49 (4%)     3/50 (6%)     |
| Overall Incidence               Total 228/896 (25.45%)Mean 25.48%  SD 9.69%     Total 26/896 (2.9%)    Mean 2.91%   SD 1.85%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 319
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/47 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/49 (2%)     0/51 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/48 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/896 (0.45%)   Mean 0.45%   SD 0.86%     Total 4/896 (0.45%)    Mean 0.45%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/49 (2%)     0/47 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/49 (4%)     1/49 (2%)     3/51 (6%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     4/50 (8%)           1/50 (2%)     0/49 (0%)     0/48 (0%)     |
|                                        6/49 (12%)    2/50 (4%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 28/896 (3.13%)  Mean 3.12%   SD 3.05%     Total 4/896 (0.45%)    Mean 0.44%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           14/50 (28%)   14/52 (27%)   14/50 (28%)          1/50 (2%)     2/50 (4%)     3/50 (6%)     |
|      Complex, Malignant, NOS          16/50 (32%)   23/50 (46%)   10/50 (20%)          0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|                                        7/50 (14%)   18/49 (37%)   14/47 (30%)          1/51 (2%)     3/50 (6%)     3/50 (6%)     |
|                                       17/49 (35%)   16/49 (33%)    9/51 (18%)          1/49 (2%)     3/50 (6%)     2/50 (4%)     |
|                                       19/50 (38%)   10/50 (20%)   10/50 (20%)          2/50 (4%)     1/49 (2%)     3/48 (6%)     |
|                                       12/49 (24%)   11/50 (22%)   18/50 (36%)          1/50 (2%)     2/49 (4%)     3/50 (6%)     |
| Overall Incidence               Total 252/896 (28.13%)Mean 28.16%  SD 8.38%     Total 34/896 (3.79%)   Mean 3.8%    SD 1.94%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrosarcoma                         0/50 (0%)     1/52 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/900 (0.11%)   Mean 0.11%   SD 0.45%     Total 0/898 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 320
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.65%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.45%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 321
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.33%   SD 0.76%     Total 4/901 (0.44%)    Mean 0.44%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.33%   SD 0.76%     Total 4/901 (0.44%)    Mean 0.44%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.46%     Total 1/900 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 322
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     2/52 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.32%   SD 1%        Total 1/900 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma NOS                      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/900 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 1/900 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant, Mixed              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 323
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma NOS                           0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Benign           0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.64%     Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/900 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Benign                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 324
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          1/50 (2%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.33%   SD 0.77%     Total 1/900 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma NOS                0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/900 (0.11%)    Mean 0.11%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 325
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        1/50 (2%)     2/52 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 9/904 (1%)      Mean 0.99%   SD 1.21%     Total 5/900 (0.56%)    Mean 0.56%   SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              1/50 (2%)     3/52 (6%)     7/48 (15%)          4/49 (8%)     5/49 (10%)    7/49 (14%)    |
|                                        4/50 (8%)     2/50 (4%)     1/50 (2%)           4/50 (8%)     4/49 (8%)     3/42 (7%)     |
|                                        4/50 (8%)     2/50 (4%)     3/48 (6%)           1/51 (2%)     1/45 (2%)     5/50 (10%)    |
|                                        2/50 (4%)     3/50 (6%)     3/51 (6%)           2/47 (4%)     5/47 (11%)    4/48 (8%)     |
|                                        2/50 (4%)     4/50 (8%)     5/49 (10%)          0/50 (0%)     3/50 (6%)    11/49 (22%)    |
|                                        4/50 (8%)     3/50 (6%)     5/50 (10%)          3/45 (7%)     4/50 (8%)    10/50 (20%)    |
| Overall Incidence               Total 58/898 (6.46%)  Mean 6.48%   SD 3.14%     Total 76/870 (8.74%)   Mean 8.69%   SD 5.71%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            2/50 (4%)     2/52 (4%)     1/48 (2%)           1/49 (2%)     0/49 (0%)     1/49 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     1/49 (2%)     1/42 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     2/48 (4%)           1/51 (2%)     0/45 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     2/51 (4%)           0/47 (0%)     1/47 (2%)     1/48 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     5/49 (10%)          1/50 (2%)     4/50 (8%)     6/49 (12%)    |
|                                        7/50 (14%)    1/50 (2%)     0/50 (0%)           4/45 (9%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 25/898 (2.78%)  Mean 2.79%   SD 3.79%     Total 26/870 (2.99%)   Mean 2.99%   SD 3.35%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 326
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 3/50 (6%)     5/52 (10%)    8/48 (17%)          5/49 (10%)    5/49 (10%)    8/49 (16%)    |
|                                        5/50 (10%)    3/50 (6%)     1/50 (2%)           6/50 (12%)    5/49 (10%)    4/42 (10%)    |
|                                        4/50 (8%)     2/50 (4%)     5/48 (10%)          2/51 (4%)     1/45 (2%)     6/50 (12%)    |
|                                        2/50 (4%)     3/50 (6%)     5/51 (10%)          2/47 (4%)     6/47 (13%)    5/48 (10%)    |
|                                        2/50 (4%)     5/50 (10%)   10/49 (20%)          1/50 (2%)     7/50 (14%)   17/49 (35%)    |
|                                       11/50 (22%)    4/50 (8%)     5/50 (10%)          7/45 (16%)    4/50 (8%)    10/50 (20%)    |
| Overall Incidence               Total 83/898 (9.24%)  Mean 9.27%   SD 5.51%     Total 101/870 (11.61%) Mean 11.57%  SD 7.54%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/52 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/42 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/51 (0%)     0/45 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/45 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/898 (0.22%)   Mean 0.22%   SD 0.94%     Total 0/870 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)     0/52 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/42 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/51 (0%)     0/45 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/51 (2%)           0/47 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/45 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/898 (0.11%)   Mean 0.11%   SD 0.46%     Total 0/870 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 327
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neurofibrosarcoma                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma Benign                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma NOS                       0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Carcinoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 328
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Papilloma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.94%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Squamous Cell Carcinoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma NOS                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.46%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 329
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibroma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.65%     Total 1/899 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 330
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma NOS                       0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.46%     Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibroma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 331
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Schwannoma Malignant                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 332
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 333
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/904 (0.66%)   Mean 0.67%   SD 1.37%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibroma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibrosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 334
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/50 (0%)     0/52 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Mast Cell Tumor Benign               0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.46%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/904 (0.66%)   Mean 0.67%   SD 1.37%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 335
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/52 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/904 (0.66%)   Mean 0.67%   SD 1.37%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibroma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibrosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/50 (0%)     0/52 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.65%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 336
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Mast Cell Tumor Benign               0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.46%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)     0/52 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     3/50 (6%)     |
|                                        2/51 (4%)     1/49 (2%)     2/47 (4%)           0/51 (0%)     0/50 (0%)     2/49 (4%)     |
|                                        4/50 (8%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     5/50 (10%)    4/50 (8%)           3/50 (6%)     1/50 (2%)     1/50 (2%)     |
|                                        1/49 (2%)     2/49 (4%)     3/50 (6%)           2/50 (4%)     1/50 (2%)     2/49 (4%)     |
| Overall Incidence               Total 33/898 (3.67%)  Mean 3.68%   SD 2.85%     Total 17/899 (1.89%)   Mean 1.9%    SD 2.12%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/47 (0%)           0/51 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/49 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     3/49 (6%)     |
| Overall Incidence               Total 6/898 (0.67%)   Mean 0.67%   SD 1.19%     Total 7/899 (0.78%)    Mean 0.79%   SD 1.58%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)     0/52 (0%)     3/50 (6%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     3/50 (6%)     |
|                                        2/51 (4%)     1/49 (2%)     2/47 (4%)           0/51 (0%)     0/50 (0%)     3/49 (6%)     |
|                                        4/50 (8%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     5/50 (10%)    5/50 (10%)          3/50 (6%)     1/50 (2%)     1/50 (2%)     |
|                                        1/49 (2%)     3/49 (6%)     4/50 (8%)           2/50 (4%)     1/50 (2%)     5/49 (10%)    |
| Overall Incidence               Total 39/898 (4.34%)  Mean 4.35%   SD 3.16%     Total 24/899 (2.67%)   Mean 2.68%   SD 2.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 337
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/902 (0.11%)   Mean 0.11%   SD 0.47%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/902 (0.11%)   Mean 0.11%   SD 0.47%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/902 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     1/52 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/902 (0.78%)   Mean 0.77%   SD 1.21%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 338
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     1/52 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/902 (0.78%)   Mean 0.77%   SD 1.21%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/902 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Mesenchymal Tumor Benign             0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 339
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Nephroblastoma                       0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Oncocytoma Benign                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     1/49 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/902 (0.11%)   Mean 0.11%   SD 0.48%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 340
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               1/50 (2%)     0/52 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        5/50 (10%)    2/50 (4%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    2/50 (4%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/49 (4%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 21/902 (2.33%)  Mean 2.34%   SD 3.16%     Total 4/901 (0.44%)    Mean 0.44%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/52 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/49 (6%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/902 (0.78%)   Mean 0.78%   SD 1.58%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/52 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/49 (6%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/902 (0.78%)   Mean 0.78%   SD 1.58%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 341
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          1/50 (2%)     0/52 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatocellular Adenoma            0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        5/50 (10%)    3/50 (6%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    2/50 (4%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     4/49 (8%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 26/902 (2.88%)  Mean 2.9%    SD 3.46%     Total 4/901 (0.44%)    Mean 0.44%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            1/50 (2%)     0/52 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatocellular Adenoma, or        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        5/50 (10%)    3/50 (6%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    2/50 (4%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     4/49 (8%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 26/902 (2.88%)  Mean 2.9%    SD 3.46%     Total 4/901 (0.44%)    Mean 0.44%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/49 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         0/49 (0%)     0/52 (0%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     2/50 (4%)           2/50 (4%)     0/49 (0%)     1/50 (2%)     |
|                                        0/51 (0%)     1/50 (2%)     2/49 (4%)           1/51 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     7/50 (14%)          0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
| Overall Incidence               Total 22/902 (2.44%)  Mean 2.45%   SD 3.26%     Total 13/900 (1.44%)   Mean 1.44%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/49 (2%)     2/52 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     1/49 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 7/902 (0.78%)   Mean 0.77%   SD 1.19%     Total 4/900 (0.44%)    Mean 0.44%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 342
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    1/49 (2%)     2/52 (4%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|      Alveolar/Bronchiolar Adenoma      0/50 (0%)     1/50 (2%)     2/50 (4%)           3/50 (6%)     0/49 (0%)     1/50 (2%)     |
|                                        1/51 (2%)     1/50 (2%)     3/49 (6%)           1/51 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     1/51 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     8/50 (16%)          1/50 (2%)     2/50 (4%)     1/50 (2%)     |
|                                        3/50 (6%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     3/50 (6%)     |
| Overall Incidence               Total 29/902 (3.22%)  Mean 3.22%   SD 3.64%     Total 17/900 (1.89%)   Mean 1.89%   SD 1.88%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/49 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrosarcoma                         0/49 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Schwannoma Malignant                 1/49 (2%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/51 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/902 (0.11%)   Mean 0.11%   SD 0.48%     Total 1/900 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/49 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 343
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoacanthoma                       1/50 (2%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 344
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     4/50 (8%)     |
|                                        0/51 (0%)     0/50 (0%)     1/50 (2%)           3/51 (6%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.65%     Total 21/901 (2.33%)   Mean 2.33%   SD 2.39%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           3/50 (6%)     3/50 (6%)     4/50 (8%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     4/50 (8%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     2/50 (4%)     3/50 (6%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.94%     Total 31/901 (3.44%)   Mean 3.44%   SD 2.64%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/52 (0%)     0/50 (0%)           3/50 (6%)     0/50 (0%)     3/50 (6%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     4/50 (8%)     |
|                                        0/51 (0%)     0/50 (0%)     1/50 (2%)           3/51 (6%)     1/50 (2%)     3/50 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           3/50 (6%)     3/50 (6%)     4/50 (8%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     4/50 (8%)     6/50 (12%)    |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           3/50 (6%)     3/50 (6%)     4/50 (8%)     |
| Overall Incidence               Total 4/904 (0.44%)   Mean 0.44%   SD 1.1%      Total 51/901 (5.66%)   Mean 5.66%   SD 3.01%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         3/50 (6%)     1/52 (2%)     4/50 (8%)          29/50 (58%)   19/50 (38%)   25/50 (50%)    |
|                                        5/50 (10%)    3/50 (6%)     0/50 (0%)          25/50 (50%)   22/50 (44%)   19/50 (38%)    |
|                                        0/51 (0%)     1/50 (2%)     0/50 (0%)          15/51 (29%)   15/50 (30%)   13/50 (26%)    |
|                                        2/50 (4%)     1/50 (2%)     0/51 (0%)          19/50 (38%)   27/50 (54%)   25/50 (50%)    |
|                                        4/50 (8%)     2/50 (4%)     3/50 (6%)          12/50 (24%)   28/50 (56%)   21/50 (42%)    |
|                                        3/50 (6%)     2/50 (4%)     6/50 (12%)         17/50 (34%)   22/50 (44%)   30/50 (60%)    |
| Overall Incidence               Total 40/904 (4.42%)  Mean 4.44%   SD 3.6%      Total 383/901 (42.51%) Mean 42.52%  SD 11.14%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 345
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     3/50 (6%)     1/52 (2%)     4/50 (8%)          31/50 (62%)   19/50 (38%)   26/50 (52%)    |
|                                        5/50 (10%)    3/50 (6%)     0/50 (0%)          25/50 (50%)   24/50 (48%)   22/50 (44%)    |
|                                        0/51 (0%)     1/50 (2%)     1/50 (2%)          18/51 (35%)   15/50 (30%)   13/50 (26%)    |
|                                        2/50 (4%)     1/50 (2%)     0/51 (0%)          19/50 (38%)   27/50 (54%)   25/50 (50%)    |
|                                        4/50 (8%)     2/50 (4%)     3/50 (6%)          12/50 (24%)   28/50 (56%)   22/50 (44%)    |
|                                        3/50 (6%)     2/50 (4%)     7/50 (14%)         17/50 (34%)   23/50 (46%)   32/50 (64%)    |
| Overall Incidence               Total 42/904 (4.65%)  Mean 4.66%   SD 3.76%     Total 398/901 (44.17%) Mean 44.18%  SD 11.61%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    3/50 (6%)     1/52 (2%)     4/50 (8%)          32/50 (64%)   19/50 (38%)   27/50 (54%)    |
|      or Adenoma                        5/50 (10%)    5/50 (10%)    0/50 (0%)          25/50 (50%)   25/50 (50%)   22/50 (44%)    |
|                                        0/51 (0%)     1/50 (2%)     1/50 (2%)          18/51 (35%)   16/50 (32%)   14/50 (28%)    |
|                                        2/50 (4%)     1/50 (2%)     0/51 (0%)          22/50 (44%)   30/50 (60%)   27/50 (54%)    |
|                                        4/50 (8%)     2/50 (4%)     3/50 (6%)          12/50 (24%)   29/50 (58%)   25/50 (50%)    |
|                                        3/50 (6%)     2/50 (4%)     7/50 (14%)         18/50 (36%)   25/50 (50%)   32/50 (64%)    |
| Overall Incidence               Total 44/904 (4.87%)  Mean 4.88%   SD 3.96%     Total 418/901 (46.39%) Mean 46.41%  SD 12.05%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibrosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Lipoma                               0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 346
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 347
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Benign                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Malignant                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.46%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/899 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 348
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondrosarcoma                       0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/899 (0.11%)    Mean 0.11%   SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/904 (0.44%)   Mean 0.44%   SD 0.86%     Total 1/899 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 349
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/50 (2%)     2/52 (4%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 9/904 (1%)      Mean 0.99%   SD 1.4%      Total 12/901 (1.33%)   Mean 1.33%   SD 1.68%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 5/901 (0.55%)    Mean 0.55%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)     2/52 (4%)     0/50 (0%)           3/50 (6%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  2/50 (4%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 10/904 (1.11%)  Mean 1.1%    SD 1.39%     Total 17/901 (1.89%)   Mean 1.89%   SD 1.88%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 350
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.65%     Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/51 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/901 (0.11%)    Mean 0.11%   SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/51 (2%)     1/50 (2%)     2/50 (4%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 9/901 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 351
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Malignant, NOS                                                                    0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        1/51 (2%)     1/50 (2%)     2/50 (4%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 10/901 (1.11%)   Mean 1.11%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Benign                                                         0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 352
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sex Cord Stromal Tumor, Malignant                                                    0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/52 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/48 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/49 (10%)    2/49 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 17/899 (1.89%)  Mean 1.9%    SD 2.82%     Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/48 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/899 (0%)      Mean 0%      SD 0%        Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 353
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/52 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/48 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/49 (10%)    2/49 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 17/899 (1.89%)  Mean 1.9%    SD 2.82%     Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/48 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/899 (0%)      Mean 0%      SD 0%        Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/49 (0%)     0/48 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/899 (0%)      Mean 0%      SD 0%        Total 0/899 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              2/47 (4%)     1/51 (2%)     0/39 (0%)           0/48 (0%)     0/46 (0%)     0/42 (0%)     |
|                                        1/47 (2%)     0/45 (0%)     1/46 (2%)           1/46 (2%)     0/38 (0%)     0/46 (0%)     |
|                                        0/44 (0%)     0/48 (0%)     1/47 (2%)           0/46 (0%)     0/47 (0%)     0/46 (0%)     |
|                                        0/43 (0%)     0/38 (0%)     0/50 (0%)           0/45 (0%)     1/45 (2%)     0/47 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/47 (0%)           0/48 (0%)     0/47 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/41 (0%)           0/49 (0%)     0/48 (0%)     0/46 (0%)     |
| Overall Incidence               Total 6/827 (0.73%)   Mean 0.7%    SD 1.26%     Total 2/828 (0.24%)    Mean 0.24%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Paraganglioma Benign                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 354
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma Malignant                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.65%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma: Benign, Malignant, NOS   0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.65%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Carcinoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/50 (0%)     1/52 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.63%     Total 3/901 (0.33%)    Mean 0.33%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      14/50 (28%)   13/52 (25%)   17/49 (35%)         27/49 (55%)   23/50 (46%)   31/50 (62%)    |
|   Adenoma                             18/50 (36%)   17/49 (35%)    8/50 (16%)         22/50 (44%)   16/49 (33%)   21/50 (42%)    |
|                                        8/51 (16%)   11/48 (23%)   23/50 (46%)         30/51 (59%)   26/50 (52%)   26/50 (52%)    |
|                                       15/50 (30%)    9/50 (18%)    7/50 (14%)         28/50 (56%)   16/46 (35%)   16/49 (33%)    |
|                                        8/49 (16%)   10/50 (20%)   20/50 (40%)         36/50 (72%)   20/49 (41%)   24/50 (48%)    |
|                                       14/50 (28%)   19/49 (39%)   13/50 (26%)         28/50 (56%)   18/50 (36%)   35/50 (70%)    |
| Overall Incidence               Total 244/897 (27.2%) Mean 27.23%  SD 9.58%     Total 443/893 (49.61%) Mean 49.49%  SD 11.98%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 355
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/52 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     1/48 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/46 (2%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/49 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 4/897 (0.45%)   Mean 0.45%   SD 1.1%      Total 11/893 (1.23%)   Mean 1.24%   SD 1.57%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      14/50 (28%)   13/52 (25%)   17/49 (35%)         27/49 (55%)   23/50 (46%)   31/50 (62%)    |
|   Carcinoma or Adenoma                18/50 (36%)   17/49 (35%)    8/50 (16%)         22/50 (44%)   16/49 (33%)   21/50 (42%)    |
|                                        8/51 (16%)   12/48 (25%)   23/50 (46%)         30/51 (59%)   26/50 (52%)   28/50 (56%)    |
|                                       17/50 (34%)    9/50 (18%)    7/50 (14%)         30/50 (60%)   17/46 (37%)   16/49 (33%)    |
|                                        8/49 (16%)   10/50 (20%)   20/50 (40%)         37/50 (74%)   22/49 (45%)   24/50 (48%)    |
|                                       15/50 (30%)   19/49 (39%)   13/50 (26%)         29/50 (58%)   19/50 (38%)   36/50 (72%)    |
| Overall Incidence               Total 248/897 (27.65%)Mean 27.68%  SD 9.67%     Total 454/893 (50.84%) Mean 50.73%  SD 12.28%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/52 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|   Craniopharyngioma                    0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/48 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/897 (0%)      Mean 0%      SD 0%        Total 0/893 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/52 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|   Ganglioneuroma                       0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/48 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/897 (0%)      Mean 0%      SD 0%        Total 0/893 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     0/52 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/48 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/897 (0.22%)   Mean 0.22%   SD 0.65%     Total 3/893 (0.34%)    Mean 0.33%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 356
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/52 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/48 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/897 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/893 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/50 (2%)     0/52 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/48 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/897 (0.33%)   Mean 0.33%   SD 0.77%     Total 3/893 (0.34%)    Mean 0.33%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Nervosa                                                                                                    |
|   Adenoma                              0/50 (0%)     0/52 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/48 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/897 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/893 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/49 (0%)     0/52 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)                                                     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/51 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)                                                     |
| Overall Incidence               Total 2/899 (0.22%)   Mean 0.22%   SD 0.94%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/49 (0%)     0/52 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)                                                     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/51 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/899 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 357
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/52 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)                                                     |
|                                        0/51 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/51 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)                                                     |
| Overall Incidence               Total 2/899 (0.22%)   Mean 0.22%   SD 0.94%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/49 (0%)     0/52 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/901 (0%)      Mean 0%      SD 0%        Total 0/897 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/49 (0%)     0/52 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/901 (0%)      Mean 0%      SD 0%        Total 0/897 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/52 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/901 (0%)      Mean 0%      SD 0%        Total 0/897 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/49 (0%)     0/52 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/49 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/901 (0.11%)   Mean 0.11%   SD 0.48%     Total 0/897 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 358
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrous Histiocytoma                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 359
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              1/50 (2%)     0/52 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.33%   SD 0.77%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 360
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 1/50 (2%)     0/52 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/904 (0.44%)   Mean 0.44%   SD 1.1%      Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 9/904 (1%)      Mean 1%      SD 1.41%     Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/50 (2%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/51 (4%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 12/904 (1.33%)  Mean 1.33%   SD 1.53%     Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 361
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Tumor Benign, or                  1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 2/51 (4%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 13/904 (1.44%)  Mean 1.44%   SD 1.65%     Total 4/901 (0.44%)    Mean 0.44%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/904 (0.44%)   Mean 0.44%   SD 0.85%     Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      NOS)                              0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 6/904 (0.66%)   Mean 0.66%   SD 1.18%     Total 3/901 (0.33%)    Mean 0.33%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       1/50 (2%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    2/51 (4%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     2/50 (4%)     0/50 (0%)     |
|      Trichoepithelioma                 2/50 (4%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 19/904 (2.1%)   Mean 2.1%    SD 1.74%     Total 7/901 (0.78%)    Mean 0.78%   SD 1.4%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         4/50 (8%)     3/52 (6%)     5/50 (10%)          1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    3/50 (6%)     3/50 (6%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  4/51 (8%)     2/50 (4%)     5/50 (10%)          1/51 (2%)     2/50 (4%)     1/50 (2%)     |
|      Papilloma, Sq Papilloma,          4/50 (8%)     2/50 (4%)     4/51 (8%)           0/50 (0%)     1/50 (2%)     4/50 (8%)     |
|      Keratoacanthoma,                  5/50 (10%)    4/50 (8%)    12/50 (24%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Trichoepithelioma                 6/50 (12%)    3/50 (6%)     5/50 (10%)          1/50 (2%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 78/904 (8.63%)  Mean 8.64%   SD 4.4%      Total 17/901 (1.89%)   Mean 1.89%   SD 2%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 362
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            1/50 (2%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.33%   SD 0.76%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.94%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/50 (2%)     1/52 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/51 (4%)     1/50 (2%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     3/51 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    2/50 (4%)     7/50 (14%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        3/50 (6%)     3/50 (6%)     4/50 (8%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 40/904 (4.42%)  Mean 4.43%   SD 3.6%      Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 363
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/52 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 364
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     1/50 (2%)           1/51 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.33%   SD 0.75%     Total 1/901 (0.11%)    Mean 0.11%   SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     2/52 (4%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      1/51 (2%)     0/50 (0%)     1/50 (2%)           1/51 (2%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma                         0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 9/904 (1%)      Mean 0.99%   SD 1.39%     Total 4/901 (0.44%)    Mean 0.44%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              2/50 (4%)     0/52 (0%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     1/50 (2%)     4/50 (8%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     1/50 (2%)     3/50 (6%)     |
|                                        0/50 (0%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 19/904 (2.1%)   Mean 2.11%   SD 2.32%     Total 8/901 (0.89%)    Mean 0.89%   SD 1.57%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           2/50 (4%)     0/52 (0%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     1/50 (2%)     4/50 (8%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     1/50 (2%)     3/50 (6%)     |
|                                        0/50 (0%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 19/904 (2.1%)   Mean 2.11%   SD 2.32%     Total 8/901 (0.89%)    Mean 0.89%   SD 1.57%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             3/50 (6%)     2/52 (4%)     5/50 (10%)          1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          2/50 (4%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      3/51 (6%)     2/50 (4%)     5/50 (10%)          1/51 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     4/51 (8%)           0/50 (0%)     1/50 (2%)     3/50 (6%)     |
|                                        5/50 (10%)    3/50 (6%)    10/50 (20%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        4/50 (8%)     3/50 (6%)     4/50 (8%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 62/904 (6.86%)  Mean 6.87%   SD 4.13%     Total 10/901 (1.11%)   Mean 1.11%   SD 1.57%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 365
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             3/50 (6%)     1/52 (2%)     5/50 (10%)          1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     2/50 (4%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/51 (4%)     2/50 (4%)     4/50 (8%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     4/51 (8%)           0/50 (0%)     1/50 (2%)     3/50 (6%)     |
|                                        5/50 (10%)    3/50 (6%)    10/50 (20%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        4/50 (8%)     3/50 (6%)     4/50 (8%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 59/904 (6.53%)  Mean 6.54%   SD 4.22%     Total 9/901 (1%)       Mean 1%      SD 1.57%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              5/50 (10%)    0/52 (0%)     3/50 (6%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     3/50 (6%)     1/50 (2%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        1/51 (2%)     1/50 (2%)     3/50 (6%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     5/50 (10%)    2/51 (4%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|                                        4/50 (8%)     5/50 (10%)    3/50 (6%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     4/50 (8%)     3/50 (6%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 50/904 (5.53%)  Mean 5.55%   SD 3.12%     Total 13/901 (1.44%)   Mean 1.44%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      5/50 (10%)    1/52 (2%)     5/50 (10%)          1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Myxoma, Myxosarcoma, or Fibrous   5/50 (10%)    3/50 (6%)     1/50 (2%)           3/50 (6%)     3/50 (6%)     1/50 (2%)     |
|      Histiocytoma                      3/51 (6%)     2/50 (4%)     5/50 (10%)          0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        4/50 (8%)     5/50 (10%)    2/51 (4%)           0/50 (0%)     3/50 (6%)     2/50 (4%)     |
|                                        5/50 (10%)    5/50 (10%)    3/50 (6%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     6/50 (12%)    3/50 (6%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 64/904 (7.08%)  Mean 7.1%    SD 3.32%     Total 20/901 (2.22%)   Mean 2.22%   SD 2.16%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     1/52 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        1/51 (2%)     1/50 (2%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 9/904 (1%)      Mean 0.99%   SD 1.41%     Total 4/901 (0.44%)    Mean 0.44%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 366
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     1/52 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           3/50 (6%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     1/50 (2%)     |
|      Histiocytoma                      2/51 (4%)     1/50 (2%)     2/50 (4%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 15/904 (1.66%)  Mean 1.66%   SD 2.19%     Total 7/901 (0.78%)    Mean 0.78%   SD 1.22%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/904 (0.22%)   Mean 0.22%   SD 0.64%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/50 (0%)     2/52 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/904 (0.33%)   Mean 0.32%   SD 1%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 367
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     2/52 (4%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 11/904 (1.22%)  Mean 1.21%   SD 1.82%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     2/52 (4%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                           1/51 (2%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 11/904 (1.22%)  Mean 1.21%   SD 1.82%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/904 (0.44%)   Mean 0.44%   SD 0.86%     Total 3/901 (0.33%)    Mean 0.33%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/52 (0%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/904 (0.88%)   Mean 0.89%   SD 1.71%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 368
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Benign                   0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Malignant                1/50 (2%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Chordoma                             0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Glioma Benign                        0/50 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.45%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibroma                              0/50 (0%)     0/52 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/903 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 369
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/903 (0.33%)   Mean 0.33%   SD 1.41%     Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/903 (0.11%)   Mean 0.11%   SD 0.45%     Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/903 (0.33%)   Mean 0.33%   SD 1.03%     Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Leiomyosarcoma                       0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/903 (0.22%)   Mean 0.22%   SD 0.94%     Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Osteosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/903 (0%)      Mean 0%      SD 0%        Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 370
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/51 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/903 (0.11%)   Mean 0.11%   SD 0.46%     Total 0/900 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       1/50 (2%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.46%     Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 371
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.46%     Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Benign               0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Malignant            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             46/50 (92%)   46/52 (88%)   45/50 (90%)                                                    |
|                                       42/50 (84%)   41/50 (82%)   42/50 (84%)                                                    |
|                                       48/51 (94%)   46/50 (92%)   37/50 (74%)                                                    |
|                                       45/50 (90%)   47/50 (94%)   49/51 (96%)                                                    |
|                                       47/50 (94%)   44/50 (88%)   39/49 (80%)                                                    |
|                                       48/50 (96%)   44/50 (88%)   46/50 (92%)                                                    |
| Overall Incidence               Total 802/903 (88.82%)Mean 88.79%  SD 6.03%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 372
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/903 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/42 (0%)           0/48 (0%)     0/49 (0%)     0/44 (0%)     |
|                                        0/51 (0%)     0/41 (0%)     0/41 (0%)           0/48 (0%)     0/48 (0%)     0/41 (0%)     |
|                                        0/48 (0%)     0/46 (0%)     0/49 (0%)           0/48 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/45 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 0/856 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Schwannoma Malignant                 0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/42 (0%)           0/48 (0%)     0/49 (0%)     1/44 (2%)     |
|                                        0/51 (0%)     0/41 (0%)     0/41 (0%)           0/48 (0%)     0/48 (0%)     0/41 (0%)     |
|                                        0/48 (0%)     0/46 (0%)     0/49 (0%)           0/48 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/45 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 1/856 (0.12%)    Mean 0.13%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     2/46 (4%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/42 (0%)           0/48 (0%)     0/49 (0%)     0/44 (0%)     |
|                                        0/51 (0%)     0/41 (0%)     0/41 (0%)           0/48 (0%)     0/48 (0%)     0/41 (0%)     |
|                                        0/48 (0%)     0/46 (0%)     0/49 (0%)           0/48 (0%)     1/44 (2%)     0/49 (0%)     |
|                                        1/48 (2%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/45 (0%)     1/48 (2%)     0/50 (0%)           1/47 (2%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/850 (0.24%)   Mean 0.23%   SD 0.67%     Total 4/856 (0.47%)    Mean 0.49%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/49 (2%)     0/42 (0%)           0/48 (0%)     1/49 (2%)     0/44 (0%)     |
|                                        0/51 (0%)     0/41 (0%)     0/41 (0%)           0/48 (0%)     0/48 (0%)     0/41 (0%)     |
|                                        0/48 (0%)     0/46 (0%)     0/49 (0%)           0/48 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/45 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/850 (0.12%)   Mean 0.11%   SD 0.48%     Total 1/856 (0.12%)    Mean 0.11%   SD 0.48%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 373
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/42 (0%)           0/48 (0%)     0/49 (0%)     0/44 (0%)     |
|                                        0/51 (0%)     0/41 (0%)     0/41 (0%)           0/48 (0%)     0/48 (0%)     0/41 (0%)     |
|                                        0/48 (0%)     0/46 (0%)     0/49 (0%)           0/48 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/45 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/850 (0%)      Mean 0%      SD 0%        Total 0/856 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/48 (0%)     0/49 (0%)     0/49 (0%)           0/47 (0%)     2/46 (4%)     0/50 (0%)     |
|                                        0/49 (0%)     1/49 (2%)     0/42 (0%)           0/48 (0%)     1/49 (2%)     0/44 (0%)     |
|                                        0/51 (0%)     0/41 (0%)     0/41 (0%)           0/48 (0%)     0/48 (0%)     0/41 (0%)     |
|                                        0/48 (0%)     0/46 (0%)     0/49 (0%)           0/48 (0%)     1/44 (2%)     0/49 (0%)     |
|                                        1/48 (2%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/45 (0%)     1/48 (2%)     0/50 (0%)           1/47 (2%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/850 (0.35%)   Mean 0.34%   SD 0.79%     Total 5/856 (0.58%)    Mean 0.6%    SD 1.24%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/902 (0%)      Mean 0%      SD 0%        Total 0/898 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              5/50 (10%)    6/52 (12%)   10/50 (20%)          3/49 (6%)     8/50 (16%)    6/50 (12%)    |
|                                        5/50 (10%)    7/50 (14%)   10/50 (20%)          3/50 (6%)     5/49 (10%)    5/50 (10%)    |
|                                       12/51 (24%)    4/50 (8%)     2/50 (4%)           9/51 (18%)    3/50 (6%)     6/50 (12%)    |
|                                        7/50 (14%)    3/50 (6%)     7/51 (14%)          3/50 (6%)     4/50 (8%)     6/50 (12%)    |
|                                        8/50 (16%)    5/50 (10%)    6/50 (12%)          4/50 (8%)     4/49 (8%)     2/50 (4%)     |
|                                        1/49 (2%)     4/49 (8%)     9/50 (18%)          5/50 (10%)    9/50 (18%)    7/50 (14%)    |
| Overall Incidence               Total 111/902 (12.31%)Mean 12.28%  SD 5.76%     Total 92/898 (10.24%)  Mean 10.23%  SD 4.17%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     1/50 (2%)     2/50 (4%)           0/51 (0%)     1/50 (2%)     2/50 (4%)     |
|                                        1/50 (2%)     2/50 (4%)     1/51 (2%)           1/50 (2%)     2/50 (4%)     2/50 (4%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        1/49 (2%)     0/49 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 10/902 (1.11%)  Mean 1.11%   SD 1.41%     Total 17/898 (1.89%)   Mean 1.89%   SD 1.6%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 374
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 5/50 (10%)    6/52 (12%)   10/50 (20%)          3/49 (6%)     9/50 (18%)    7/50 (14%)    |
|                                        5/50 (10%)    8/50 (16%)   10/50 (20%)          5/50 (10%)    5/49 (10%)    5/50 (10%)    |
|                                       12/51 (24%)    5/50 (10%)    4/50 (8%)           9/51 (18%)    4/50 (8%)     8/50 (16%)    |
|                                        8/50 (16%)    5/50 (10%)    8/51 (16%)          4/50 (8%)     6/50 (12%)    8/50 (16%)    |
|                                        9/50 (18%)    5/50 (10%)    6/50 (12%)          4/50 (8%)     5/49 (10%)    2/50 (4%)     |
|                                        2/49 (4%)     4/49 (8%)     9/50 (18%)          7/50 (14%)   10/50 (20%)    8/50 (16%)    |
| Overall Incidence               Total 121/902 (13.41%)Mean 13.39%  SD 5.19%     Total 109/898 (12.14%) Mean 12.12%  SD 4.53%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/52 (2%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     1/50 (2%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/902 (0.78%)   Mean 0.78%   SD 1%        Total 3/898 (0.33%)    Mean 0.33%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/52 (0%)     3/50 (6%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 11/902 (1.22%)  Mean 1.22%   SD 1.96%     Total 5/898 (0.56%)    Mean 0.56%   SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     1/52 (2%)     4/50 (8%)           0/49 (0%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     2/50 (4%)     1/50 (2%)           2/50 (4%)     1/49 (2%)     0/50 (0%)     |
|                                        0/51 (0%)     1/50 (2%)     1/50 (2%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        2/49 (4%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 18/902 (2%)     Mean 2%      SD 2.28%     Total 8/898 (0.89%)    Mean 0.89%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 375
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Chemodectoma Malignant               0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibroma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 376
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Squamous Cell Carcinoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Yolk Sac Carcinoma                   0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 377
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 2/901 (0.22%)    Mean 0.22%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           1/50 (2%)     1/52 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 5/904 (0.55%)   Mean 0.55%   SD 0.91%     Total 9/901 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              1/50 (2%)     1/52 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/904 (0.55%)   Mean 0.55%   SD 0.91%     Total 7/901 (0.78%)    Mean 0.78%   SD 1.22%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 378
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Malignant               0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Fibrosarcoma                         1/50 (2%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/52 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Squamous Cell Carcinoma              0/50 (0%)     0/52 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           1/51 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 2/901 (0.22%)    Mean 0.22%   SD 0.64%     |
 __________________________________________________________________________________________________________________________________
|#Urethra:                                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/904 (0%)      Mean 0%      SD 0%        Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 379
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/49 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/51 (0%)     0/43 (0%)     0/49 (0%)           0/51 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/891 (0.11%)   Mean 0.11%   SD 0.48%     Total 0/891 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/48 (0%)     |
|                                        1/48 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/51 (0%)     0/43 (0%)     0/49 (0%)           0/51 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 3/891 (0.34%)   Mean 0.34%   SD 0.77%     Total 2/891 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyoma                            0/49 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/51 (0%)     0/43 (0%)     0/49 (0%)           0/51 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/891 (0%)      Mean 0%      SD 0%        Total 0/891 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/49 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/51 (0%)     0/43 (0%)     0/49 (0%)           0/51 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/891 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/891 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/48 (0%)     |
|                                        1/48 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/51 (0%)     0/43 (0%)     0/49 (0%)           0/51 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/891 (0.22%)   Mean 0.22%   SD 0.65%     Total 2/891 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 380
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 3/901 (0.33%)    Mean 0.33%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/51 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 4/901 (0.44%)    Mean 0.44%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma NOS                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibroma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 381
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Malignant                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 382
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        2/50 (4%)    13/50 (26%)    2/50 (4%)     |
|                                                                                        6/50 (12%)    8/50 (16%)    4/50 (8%)     |
|                                                                                        6/51 (12%)    5/50 (10%)    9/50 (18%)    |
|                                                                                        1/50 (2%)     1/50 (2%)     5/50 (10%)    |
|                                                                                       13/50 (26%)    6/50 (12%)   12/50 (24%)    |
|                                                                                        9/50 (18%)    5/50 (10%)    4/50 (8%)     |
| Overall Incidence                                                               Total 111/901 (12.32%) Mean 12.32%  SD 7.65%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     2/50 (4%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 4/901 (0.44%)    Mean 0.44%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     2/50 (4%)    13/50 (26%)    3/50 (6%)     |
|                                                                                        6/50 (12%)    8/50 (16%)    4/50 (8%)     |
|                                                                                        6/51 (12%)    7/50 (14%)    9/50 (18%)    |
|                                                                                        1/50 (2%)     1/50 (2%)     5/50 (10%)    |
|                                                                                       13/50 (26%)    6/50 (12%)   12/50 (24%)    |
|                                                                                        9/50 (18%)    5/50 (10%)    5/50 (10%)    |
| Overall Incidence                                                               Total 115/901 (12.76%) Mean 12.76%  SD 7.46%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 383
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/901 (0.22%)    Mean 0.22%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma NOS                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Fibrosarcoma                                                                         0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 384
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Polyp                                                                                0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/901 (0.11%)    Mean 0.11%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/50 (2%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        1/50 (2%)     0/50 (0%)     2/51 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 9/904 (1%)      Mean 0.99%   SD 1.22%     Total 5/901 (0.55%)    Mean 0.56%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 385
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/50 (2%)     1/52 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/51 (2%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        1/50 (2%)     0/50 (0%)     2/51 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 10/904 (1.11%)  Mean 1.1%    SD 1.4%      Total 5/901 (0.55%)    Mean 0.56%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Squamous Cell Papilloma              0/50 (0%)     0/52 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/51 (0%)     0/50 (0%)     0/50 (0%)           0/51 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/51 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/904 (0.11%)   Mean 0.11%   SD 0.47%     Total 0/901 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 387
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       74/80 (93%)   46/50 (92%)   47/51 (92%)         63/80 (79%)   43/50 (86%)   45/50 (90%)    |
|                                       47/50 (94%)   48/50 (96%)   47/50 (94%)         43/50 (86%)   43/50 (86%)   39/50 (78%)    |
| Overall Incidence               Total 309/331 (93.35%)Mean 93.44%  SD 1.54%     Total 276/330 (83.64%) Mean 84.13%  SD 4.72%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    58/80 (73%)   39/50 (78%)   31/51 (61%)         38/80 (48%)   27/50 (54%)   16/50 (32%)    |
|                                       38/50 (76%)   40/50 (80%)   34/50 (68%)         32/50 (64%)   26/50 (52%)   21/50 (42%)    |
| Overall Incidence               Total 240/331 (72.51%)Mean 72.55%  SD 7.16%     Total 160/330 (48.48%) Mean 48.58%  SD 10.94%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         76/80 (95%)   50/50 (100%)  50/51 (98%)         73/80 (91%)   48/50 (96%)   48/50 (96%)    |
|                                       49/50 (98%)   48/50 (96%)   49/50 (98%)         48/50 (96%)   48/50 (96%)   45/50 (90%)    |
| Overall Incidence               Total 322/331 (97.28%)Mean 97.51%  SD 1.76%     Total 310/330 (93.94%) Mean 94.21%  SD 2.8%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.82%     Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Granulocytic               0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   54/80 (68%)   35/50 (70%)   25/51 (49%)         26/80 (33%)   15/50 (30%)    8/50 (16%)    |
|      Mononuclear, or Undifferentiated 30/50 (60%)   32/50 (64%)   29/50 (58%)         22/50 (44%)   19/50 (38%)   12/50 (24%)    |
| Overall Incidence               Total 205/331 (61.93%)Mean 61.42%  SD 7.55%     Total 102/330 (30.91%) Mean 30.75%  SD 9.95%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 2/330 (0.61%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 388
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 1/80 (1%)     1/50 (2%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/331 (0.91%)   Mean 0.88%   SD 1%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/80 (1%)     1/50 (2%)     1/51 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)     3/50 (6%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/331 (2.42%)   Mean 2.54%   SD 2.14%     Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/331 (1.51%)   Mean 1.66%   SD 2.34%     Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/331 (0.91%)   Mean 0.99%   SD 1.09%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/331 (0.91%)   Mean 0.99%   SD 1.09%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/80 (1%)     1/49 (2%)     0/51 (0%)           1/80 (1%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/330 (0.91%)   Mean 0.88%   SD 1.01%     Total 3/329 (0.91%)    Mean 0.88%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/80 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/330 (0%)      Mean 0%      SD 0%        Total 1/329 (0.3%)     Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/79 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/329 (0%)      Mean 0%      SD 0%        Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             24/79 (30%)   11/49 (22%)   23/51 (45%)          6/80 (8%)     2/50 (4%)     7/50 (14%)    |
|                                        9/50 (18%)   13/50 (26%)   17/50 (34%)          3/50 (6%)     2/49 (4%)     3/50 (6%)     |
| Overall Incidence               Total 97/329 (29.48%) Mean 29.32%  SD 9.57%     Total 23/329 (6.99%)   Mean 6.93%   SD 3.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 389
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             1/79 (1%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/329 (0.3%)    Mean 0.21%   SD 0.52%     Total 1/329 (0.3%)     Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/79 (3%)     2/49 (4%)     2/51 (4%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 11/329 (3.34%)  Mean 3.42%   SD 2.69%     Total 1/329 (0.3%)     Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           25/79 (32%)   13/49 (27%)   25/51 (49%)          6/80 (8%)     2/50 (4%)     7/50 (14%)    |
|      Complex, Malignant, NOS          12/50 (24%)   14/50 (28%)   17/50 (34%)          3/50 (6%)     4/49 (8%)     3/50 (6%)     |
| Overall Incidence               Total 106/329 (32.22%)Mean 32.2%   SD 8.98%     Total 25/329 (7.6%)    Mean 7.61%   SD 3.45%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Fibrosarcoma                         0/79 (0%)     0/45 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/322 (0%)      Mean 0%      SD 0%        Total 0/327 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.82%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibroma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Hemangiosarcoma                      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 390
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.66%   SD 1.02%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.66%   SD 1.02%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Benign                   0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/80 (0%)     0/50 (0%)     0/51 (0%)           1/80 (1%)     1/50 (2%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 4/328 (1.22%)    Mean 1.21%   SD 1.6%      |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma NOS                      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     1/50 (2%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.8%      Total 1/328 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant, Mixed              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 391
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma NOS                           0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Benign           0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Hemangioma                           0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Benign                    0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma NOS                0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 392
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/80 (0%)     0/50 (0%)     1/51 (2%)           1/80 (1%)     2/50 (4%)     0/48 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.8%      Total 5/328 (1.52%)    Mean 1.54%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Schwannoma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              7/80 (9%)     1/49 (2%)     3/50 (6%)          10/78 (13%)    0/50 (0%)     5/48 (10%)    |
|                                        2/50 (4%)     1/50 (2%)     3/50 (6%)           4/49 (8%)     1/49 (2%)     2/47 (4%)     |
| Overall Incidence               Total 17/329 (5.17%)  Mean 4.8%    SD 2.63%     Total 22/321 (6.85%)   Mean 6.28%   SD 5%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            1/80 (1%)     1/49 (2%)     1/50 (2%)           1/78 (1%)     3/50 (6%)     1/48 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     5/50 (10%)          3/49 (6%)     4/49 (8%)     0/47 (0%)     |
| Overall Incidence               Total 10/329 (3.04%)  Mean 3.22%   SD 3.34%     Total 12/321 (3.74%)   Mean 3.94%   SD 3.25%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 8/80 (10%)    2/49 (4%)     4/50 (8%)          11/78 (14%)    3/50 (6%)     6/48 (13%)    |
|                                        3/50 (6%)     2/50 (4%)     8/50 (16%)          7/49 (14%)    5/49 (10%)    2/47 (4%)     |
| Overall Incidence               Total 27/329 (8.21%)  Mean 8.01%   SD 4.55%     Total 34/321 (10.59%)  Mean 10.22%  SD 4.25%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Carcinoma              0/80 (0%)     0/49 (0%)     0/50 (0%)           0/78 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/329 (0%)      Mean 0%      SD 0%        Total 0/321 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/80 (0%)     0/49 (0%)     0/50 (0%)           0/78 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/329 (0%)      Mean 0%      SD 0%        Total 0/321 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibroma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Fibrosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           2/80 (3%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 2/330 (0.61%)    Mean 0.42%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 393
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neurofibrosarcoma                    1/80 (1%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.21%   SD 0.51%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma Benign                    0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Schwannoma NOS                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Carcinoma              1/80 (1%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.21%   SD 0.51%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Squamous Cell Papilloma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Fibrosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Esophagus:                                                                                                                       |
|   Squamous Cell Carcinoma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.82%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma NOS                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 394
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Schwannoma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Fibroma                              0/80 (0%)     1/50 (2%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.82%     Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    1/80 (1%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.54%   SD 0.87%     Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma NOS                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Hemangiosarcoma                      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            1/80 (1%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.54%   SD 0.86%     Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 1/80 (1%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.54%   SD 0.86%     Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Fibroma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 395
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Schwannoma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Leiomyosarcoma                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Leiomyosarcoma                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 396
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.66%   SD 1.02%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibroma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Fibrosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Mast Cell Tumor Benign               0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.66%   SD 1.02%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 397
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.66%   SD 1.02%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibroma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Fibrosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Mast Cell Tumor Benign               0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/79 (3%)     3/45 (7%)     5/51 (10%)          3/80 (4%)     0/49 (0%)     0/50 (0%)     |
|                                       15/50 (30%)    2/49 (4%)     4/50 (8%)           1/50 (2%)     1/46 (2%)     1/49 (2%)     |
| Overall Incidence               Total 31/324 (9.57%)  Mean 10.18%  SD 10.06%    Total 6/324 (1.85%)    Mean 1.66%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            1/79 (1%)     2/45 (4%)     2/51 (4%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/46 (0%)     0/49 (0%)     |
| Overall Incidence               Total 7/324 (2.16%)   Mean 2.27%   SD 2.09%     Total 1/324 (0.31%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/79 (4%)     5/45 (11%)    7/51 (14%)          3/80 (4%)     0/49 (0%)     0/50 (0%)     |
|                                       17/50 (34%)    2/49 (4%)     4/50 (8%)           2/50 (4%)     1/46 (2%)     1/49 (2%)     |
| Overall Incidence               Total 38/324 (11.73%) Mean 12.45%  SD 11.25%    Total 7/324 (2.16%)    Mean 1.99%   SD 1.74%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 398
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/327 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/327 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/46 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/327 (0%)      Mean 0%      SD 0%        Total 1/324 (0.31%)    Mean 0.36%   SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/327 (0.61%)   Mean 0.67%   SD 1.03%     Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/327 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/327 (0.61%)   Mean 0.67%   SD 1.03%     Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/327 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/327 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/327 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Mesenchymal Tumor Benign             0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/327 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 399
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Nephroblastoma                       0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/327 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Oncocytoma Benign                    0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/327 (0.31%)   Mean 0.33%   SD 0.82%     Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/327 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/79 (0%)     0/47 (0%)     0/51 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/327 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/80 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/330 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangioma                          0/80 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/330 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Fibrosarcoma                         0/80 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/330 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               1/80 (1%)     0/49 (0%)     2/51 (4%)           2/80 (3%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 6/330 (1.82%)   Mean 1.86%   SD 1.28%     Total 5/330 (1.52%)    Mean 1.42%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/80 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/330 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/80 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/330 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 400
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          1/80 (1%)     0/49 (0%)     2/51 (4%)           2/80 (3%)     0/50 (0%)     1/50 (2%)     |
|      Hepatocellular Adenoma            1/50 (2%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 6/330 (1.82%)   Mean 1.86%   SD 1.28%     Total 5/330 (1.52%)    Mean 1.42%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            1/80 (1%)     0/49 (0%)     2/51 (4%)           2/80 (3%)     0/50 (0%)     1/50 (2%)     |
|      Hepatocellular Adenoma, or        1/50 (2%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 6/330 (1.82%)   Mean 1.86%   SD 1.28%     Total 5/330 (1.52%)    Mean 1.42%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         0/80 (0%)     0/50 (0%)     1/51 (2%)           2/80 (3%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/331 (0.91%)   Mean 0.99%   SD 1.09%     Total 5/330 (1.52%)    Mean 1.42%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    0/80 (0%)     0/50 (0%)     1/51 (2%)           2/80 (3%)     1/50 (2%)     1/50 (2%)     |
|      Alveolar/Bronchiolar Adenoma      1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/331 (0.91%)   Mean 0.99%   SD 1.09%     Total 5/330 (1.52%)    Mean 1.42%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Fibrosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Schwannoma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 401
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Hemangiosarcoma                      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Plasma Cell Tumor Malignant          0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoacanthoma                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.8%      Total 6/330 (1.82%)    Mean 2%      SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           6/50 (12%)    1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 11/330 (3.33%)   Mean 3.67%   SD 4.27%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     2/50 (4%)     3/50 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           8/50 (16%)    1/50 (2%)     3/50 (6%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.8%      Total 17/330 (5.15%)   Mean 5.67%   SD 5.57%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         6/80 (8%)     2/50 (4%)     2/51 (4%)          22/80 (28%)   15/50 (30%)   16/50 (32%)    |
|                                        1/50 (2%)     7/50 (14%)    4/50 (8%)          12/50 (24%)   29/50 (58%)   27/50 (54%)    |
| Overall Incidence               Total 22/331 (6.65%)  Mean 6.57%   SD 4.3%      Total 121/330 (36.67%) Mean 37.58%  SD 14.57%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 402
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     6/80 (8%)     2/50 (4%)     3/51 (6%)          22/80 (28%)   16/50 (32%)   17/50 (34%)    |
|                                        1/50 (2%)     7/50 (14%)    4/50 (8%)          14/50 (28%)   29/50 (58%)   27/50 (54%)    |
| Overall Incidence               Total 23/331 (6.95%)  Mean 6.9%    SD 4.13%     Total 125/330 (37.88%) Mean 38.92%  SD 13.51%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    6/80 (8%)     2/50 (4%)     3/51 (6%)          22/80 (28%)   17/50 (34%)   19/50 (38%)    |
|      or Adenoma                        1/50 (2%)     7/50 (14%)    4/50 (8%)          17/50 (34%)   30/50 (60%)   27/50 (54%)    |
| Overall Incidence               Total 23/331 (6.95%)  Mean 6.9%    SD 4.13%     Total 132/330 (40%)    Mean 41.25%  SD 12.8%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibrosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Lipoma                               0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 403
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Benign                    0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.82%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondrosarcoma                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Fibroma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Osteosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.82%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 404
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Papilloma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/80 (0%)     1/50 (2%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 4/331 (1.21%)   Mean 1.33%   SD 1.03%     Total 3/330 (0.91%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/80 (0%)     0/50 (0%)     0/51 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 3/330 (0.91%)    Mean 0.88%   SD 1.61%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/80 (0%)     1/50 (2%)     0/51 (0%)           1/80 (1%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma Squamous, or Papilloma  1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 4/331 (1.21%)   Mean 1.33%   SD 1.03%     Total 6/330 (1.82%)    Mean 1.88%   SD 1.81%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/80 (0%)     0/50 (0%)     0/51 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 3/330 (0.91%)    Mean 0.88%   SD 1.61%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.67%   SD 1.03%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Adenoma                                                                              0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Arrhenoblastoma Benign                                                               0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/329 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 405
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       1/80 (1%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/329 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/80 (1%)     0/49 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/329 (0.61%)    Mean 0.54%   SD 0.87%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Benign                                                         0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/329 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sex Cord Stromal Tumor, Malignant                                                    0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/79 (0%)     3/45 (7%)     4/51 (8%)           1/80 (1%)     1/49 (2%)     0/50 (0%)     |
|                                        3/50 (6%)     1/48 (2%)     2/50 (4%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 13/323 (4.02%)  Mean 4.43%   SD 2.98%     Total 2/325 (0.62%)    Mean 0.55%   SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/79 (0%)     1/45 (2%)     0/51 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/323 (0.31%)   Mean 0.37%   SD 0.91%     Total 0/325 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 406
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/79 (0%)     4/45 (9%)     4/51 (8%)           1/80 (1%)     1/49 (2%)     0/50 (0%)     |
|                                        3/50 (6%)     1/48 (2%)     2/50 (4%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 14/323 (4.33%)  Mean 4.8%    SD 3.42%     Total 2/325 (0.62%)    Mean 0.55%   SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibrous Histiocytoma                 0/79 (0%)     0/45 (0%)     0/51 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/323 (0%)      Mean 0%      SD 0%        Total 0/325 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/79 (0%)     0/45 (0%)     0/51 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/323 (0%)      Mean 0%      SD 0%        Total 0/325 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              4/77 (5%)     0/48 (0%)     0/50 (0%)           0/79 (0%)     0/43 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/48 (0%)     |
| Overall Incidence               Total 4/323 (1.24%)   Mean 0.87%   SD 2.12%     Total 0/316 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Paraganglioma Benign                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Schwannoma: Benign, Malignant, NOS   0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Carcinoma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Pharynx:                                                                                                                         |
|   Squamous Cell Papilloma              0/80 (0%)     1/50 (2%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.82%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      15/80 (19%)   21/48 (44%)   20/50 (40%)         32/80 (40%)   29/48 (60%)   33/50 (66%)    |
|   Adenoma                             33/49 (67%)   15/48 (31%)   16/50 (32%)         30/50 (60%)   29/49 (59%)   18/49 (37%)    |
| Overall Incidence               Total 120/325 (36.92%)Mean 38.85%  SD 16.41%    Total 171/326 (52.45%) Mean 53.72%  SD 12.18%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 407
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/80 (0%)     1/48 (2%)     0/50 (0%)           0/80 (0%)     4/48 (8%)     0/50 (0%)     |
|   Carcinoma                            1/49 (2%)     0/48 (0%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     0/49 (0%)     |
| Overall Incidence               Total 2/325 (0.62%)   Mean 0.69%   SD 1.06%     Total 6/326 (1.84%)    Mean 2.06%   SD 3.23%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      15/80 (19%)   22/48 (46%)   20/50 (40%)         32/80 (40%)   33/48 (69%)   33/50 (66%)    |
|   Carcinoma or Adenoma                33/49 (67%)   15/48 (31%)   16/50 (32%)         31/50 (62%)   30/49 (61%)   18/49 (37%)    |
| Overall Incidence               Total 121/325 (37.23%)Mean 39.2%   SD 16.55%    Total 177/326 (54.29%) Mean 55.78%  SD 13.8%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/80 (0%)     0/48 (0%)     0/50 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|   Craniopharyngioma                    0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/325 (0%)      Mean 0%      SD 0%        Total 0/326 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/80 (0%)     0/48 (0%)     0/50 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|   Ganglioneuroma                       0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/325 (0%)      Mean 0%      SD 0%        Total 0/326 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/80 (0%)     0/48 (0%)     0/50 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     1/50 (2%)           1/50 (2%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/325 (0.31%)   Mean 0.33%   SD 0.82%     Total 1/326 (0.31%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/80 (0%)     0/48 (0%)     0/50 (0%)           1/80 (1%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/325 (0%)      Mean 0%      SD 0%        Total 1/326 (0.31%)    Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/80 (0%)     0/48 (0%)     0/50 (0%)           1/80 (1%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     1/50 (2%)           1/50 (2%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/325 (0.31%)   Mean 0.33%   SD 0.82%     Total 2/326 (0.61%)    Mean 0.54%   SD 0.87%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Nervosa                                                                                                    |
|   Adenoma                              0/80 (0%)     0/48 (0%)     0/50 (0%)           0/80 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/325 (0%)      Mean 0%      SD 0%        Total 0/326 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/79 (0%)     0/48 (0%)     0/51 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/328 (0.3%)    Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma                            0/79 (0%)     0/48 (0%)     0/51 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/328 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 408
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/79 (0%)     0/48 (0%)     0/51 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/328 (0.3%)    Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/328 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrous Histiocytoma                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 2/330 (0.61%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 409
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Schwannoma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Squamous Cell Papilloma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   1/80 (1%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.21%   SD 0.51%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/80 (1%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.21%   SD 0.51%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 410
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/80 (1%)     1/50 (2%)     0/51 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.54%   SD 0.87%     Total 1/330 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/80 (0%)     1/50 (2%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.67%   SD 1.03%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/80 (0%)     1/50 (2%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 2/331 (0.6%)    Mean 0.67%   SD 1.03%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/80 (1%)     2/50 (4%)     0/51 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 4/331 (1.21%)   Mean 1.21%   SD 1.6%      Total 1/330 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,        11/80 (14%)    3/50 (6%)     5/51 (10%)          1/80 (1%)     2/50 (4%)     1/50 (2%)     |
|      Carcinoma, Basosq. Tumor (M or    3/50 (6%)     3/50 (6%)     8/50 (16%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 33/331 (9.97%)  Mean 9.59%   SD 4.41%     Total 5/330 (1.52%)    Mean 1.54%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Benign            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basosquamous Tumor Malignant         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 411
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      9/80 (11%)    1/50 (2%)     3/51 (6%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     6/50 (12%)          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 21/331 (6.34%)  Mean 5.86%   SD 4.89%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/80 (1%)     1/50 (2%)     1/51 (2%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/331 (1.21%)   Mean 1.2%    SD 0.97%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Benign                      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/80 (0%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.8%      Total 2/330 (0.61%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/80 (0%)     1/50 (2%)     1/51 (2%)           0/80 (0%)     1/50 (2%)     1/50 (2%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 3/331 (0.91%)   Mean 0.99%   SD 1.09%     Total 2/330 (0.61%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/80 (1%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        3/50 (6%)     0/50 (0%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 9/331 (2.72%)   Mean 2.87%   SD 3.35%     Total 2/330 (0.61%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/80 (1%)     0/50 (0%)     1/51 (2%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma                         3/50 (6%)     0/50 (0%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 9/331 (2.72%)   Mean 2.87%   SD 3.35%     Total 2/330 (0.61%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 412
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            10/80 (13%)    1/50 (2%)     5/51 (10%)          0/80 (0%)     2/50 (4%)     1/50 (2%)     |
|      Papilloma, Squamous Cell          3/50 (6%)     2/50 (4%)     8/50 (16%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 29/331 (8.76%)  Mean 8.38%   SD 5.34%     Total 4/330 (1.21%)    Mean 1.33%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            10/80 (13%)    1/50 (2%)     4/51 (8%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     3/50 (6%)     2/50 (4%)     8/50 (16%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 28/331 (8.46%)  Mean 8.06%   SD 5.3%      Total 2/330 (0.61%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/80 (0%)     1/50 (2%)     0/51 (0%)           1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.82%     Total 1/330 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     4/50 (8%)     2/50 (4%)     |
|                                        1/50 (2%)     3/50 (6%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 8/331 (2.42%)   Mean 2.67%   SD 3.5%      Total 7/330 (2.12%)    Mean 2.33%   SD 3.2%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/80 (1%)     1/50 (2%)     1/51 (2%)           0/80 (0%)     6/50 (12%)    3/50 (6%)     |
|      Myxoma, Myxosarcoma, or Fibrous   3/50 (6%)     4/50 (8%)     4/50 (8%)           2/50 (4%)     2/50 (4%)     0/50 (0%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 14/331 (4.23%)  Mean 4.54%   SD 3.16%     Total 13/330 (3.94%)   Mean 4.33%   SD 4.46%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/80 (1%)     1/50 (2%)     1/51 (2%)           0/80 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/331 (1.51%)   Mean 1.54%   SD 1.5%      Total 4/330 (1.21%)    Mean 1.33%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/80 (1%)     1/50 (2%)     1/51 (2%)           0/80 (0%)     2/50 (4%)     1/50 (2%)     |
|      Myxosarcoma, or Fibrous           2/50 (4%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 6/331 (1.81%)   Mean 1.87%   SD 1.3%      Total 6/330 (1.82%)    Mean 2%      SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 413
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma                    0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.82%     Total 2/330 (0.61%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Benign                   0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Astrocytoma Malignant                1/80 (1%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.21%   SD 0.51%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Chordoma                             0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Spinal Cord:                                                                                                                     |
|   Glioma Benign                        0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 414
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibroma                              0/79 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/328 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Fibrosarcoma                         1/79 (1%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/328 (0.3%)    Mean 0.21%   SD 0.52%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/79 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/328 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/79 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/328 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Leiomyosarcoma                       0/79 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/328 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Osteosarcoma                         0/79 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/328 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Sarcoma                              0/79 (0%)     1/49 (2%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/328 (0.3%)    Mean 0.34%   SD 0.83%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Basal Cell Adenoma                   1/80 (1%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.21%   SD 0.51%     Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 415
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Benign               0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoid Tumor Malignant            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             70/80 (88%)   39/49 (80%)   33/51 (65%)                                                    |
|                                       34/50 (68%)   46/50 (92%)   42/49 (86%)                                                    |
| Overall Incidence               Total 264/329 (80.24%)Mean 79.59%  SD 11.04%                                                     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/80 (0%)     0/49 (0%)     0/51 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
| Overall Incidence               Total 0/329 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/69 (0%)     0/44 (0%)     0/46 (0%)           0/70 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/303 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Schwannoma Malignant                 0/69 (0%)     0/44 (0%)     0/46 (0%)           0/70 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/303 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/69 (0%)     0/44 (0%)     0/46 (0%)           1/70 (1%)     0/44 (0%)     0/49 (0%)     |
|                                        1/45 (2%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/303 (0.33%)   Mean 0.37%   SD 0.91%     Total 1/309 (0.32%)    Mean 0.24%   SD 0.58%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 416
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/69 (0%)     0/44 (0%)     0/46 (0%)           0/70 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/303 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma NOS                          0/69 (0%)     0/44 (0%)     0/46 (0%)           0/70 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/303 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/69 (0%)     0/44 (0%)     0/46 (0%)           1/70 (1%)     0/44 (0%)     0/49 (0%)     |
|                                        1/45 (2%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/303 (0.33%)   Mean 0.37%   SD 0.91%     Total 1/309 (0.32%)    Mean 0.24%   SD 0.58%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/80 (0%)     0/49 (0%)     0/51 (0%)           0/80 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/330 (0%)      Mean 0%      SD 0%        Total 0/329 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                             14/80 (18%)    5/49 (10%)    6/51 (12%)         13/80 (16%)    5/49 (10%)    4/50 (8%)     |
|                                        4/50 (8%)     5/50 (10%)    2/50 (4%)           7/50 (14%)    2/50 (4%)     3/50 (6%)     |
| Overall Incidence               Total 36/330 (10.91%) Mean 10.24%  SD 4.45%     Total 34/329 (10.33%)  Mean 9.74%   SD 4.71%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/80 (1%)     0/49 (0%)     1/51 (2%)           1/80 (1%)     1/49 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/330 (0.91%)   Mean 0.87%   SD 0.99%     Total 4/329 (1.22%)    Mean 1.22%   SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                15/80 (19%)    5/49 (10%)    7/51 (14%)         14/80 (18%)    5/49 (10%)    5/50 (10%)    |
|                                        5/50 (10%)    5/50 (10%)    2/50 (4%)           8/50 (16%)    2/50 (4%)     3/50 (6%)     |
| Overall Incidence               Total 39/330 (11.82%) Mean 11.11%  SD 4.88%     Total 37/329 (11.25%)  Mean 10.62%  SD 5.33%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/80 (0%)     1/49 (2%)     0/51 (0%)           0/80 (0%)     1/49 (2%)     3/50 (6%)     |
|                                        2/50 (4%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/330 (1.21%)   Mean 1.34%   SD 1.64%     Total 5/329 (1.52%)    Mean 1.67%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/80 (1%)     0/49 (0%)     0/51 (0%)           2/80 (3%)     0/49 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/330 (0.91%)   Mean 0.88%   SD 1.61%     Total 3/329 (0.91%)    Mean 0.75%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/80 (1%)     1/49 (2%)     0/51 (0%)           2/80 (3%)     1/49 (2%)     3/50 (6%)     |
|                                        4/50 (8%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/330 (2.12%)   Mean 2.22%   SD 2.98%     Total 8/329 (2.43%)    Mean 2.42%   SD 2.33%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 417
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Chemodectoma Malignant               0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibroma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Hemangiosarcoma                      0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Osteosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Squamous Cell Carcinoma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 418
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Yolk Sac Carcinoma                   0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma Squamous                1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.82%     Total 3/330 (0.91%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 1/331 (0.3%)    Mean 0.33%   SD 0.82%     Total 3/330 (0.91%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Benign                  0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Adamantinoma Malignant               0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Fibrosarcoma                         0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Squamous Cell Carcinoma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 419
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Urethra:                                                                                                                         |
|   Carcinoma                            0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/79 (0%)     0/42 (0%)     0/51 (0%)           0/80 (0%)     0/45 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/320 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/79 (0%)     0/42 (0%)     0/51 (0%)           0/80 (0%)     0/45 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/320 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyoma                            0/79 (0%)     1/42 (2%)     0/51 (0%)           0/80 (0%)     0/45 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/320 (0.31%)   Mean 0.4%    SD 0.97%     Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/79 (0%)     0/42 (0%)     0/51 (0%)           0/80 (0%)     0/45 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/320 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/79 (0%)     0/42 (0%)     0/51 (0%)           0/80 (0%)     0/45 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/320 (0%)      Mean 0%      SD 0%        Total 0/324 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma NOS                                                                        0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 420
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibroma                                                                              0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibrosarcoma                                                                         1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/330 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Granular Cell Tumor Malignant                                                        0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       12/80 (15%)   13/50 (26%)   10/50 (20%)    |
|                                                                                       11/50 (22%)    7/50 (14%)    4/50 (8%)     |
| Overall Incidence                                                               Total 57/330 (17.27%)  Mean 17.5%   SD 6.44%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 421
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    12/80 (15%)   13/50 (26%)   10/50 (20%)    |
|                                                                                       11/50 (22%)    7/50 (14%)    5/50 (10%)    |
| Overall Incidence                                                               Total 58/330 (17.58%)  Mean 17.83%  SD 5.88%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma NOS                                                                       0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Fibrosarcoma                                                                         1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/330 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       1/80 (1%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/330 (0.3%)     Mean 0.21%   SD 0.51%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Polyp                                                                                0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 1/330 (0.3%)     Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 422
 Version: 11/10/98                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 09-NOV-1998
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            3/80 (4%)     0/50 (0%)     1/51 (2%)           1/80 (1%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/331 (1.81%)   Mean 1.62%   SD 1.43%     Total 4/330 (1.21%)    Mean 1.21%   SD 1.6%      |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 3/80 (4%)     0/50 (0%)     1/51 (2%)           1/80 (1%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/331 (1.81%)   Mean 1.62%   SD 1.43%     Total 5/330 (1.52%)    Mean 1.54%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Squamous Cell Papilloma              0/80 (0%)     0/50 (0%)     0/51 (0%)           0/80 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/331 (0%)      Mean 0%      SD 0%        Total 0/330 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
