                                                 Toxicology Data Management System                                     Page: 1
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                   Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                           Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055634803  06/06/96   726      100(3)      52  (681)    492.7     CITRAL                                     |
|BATTELLE COLUMBUS  058805005  10/30/95   729       50(3)      25  (665)    488.4     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812003  12/18/95   729       50(3)      24  (659)    496.8     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800705  08/14/95   729       50(3)      29  (665)    502.2     SODIUM NITRITE                             |
|BATTELLE NORTHWEST 058812403  01/18/96   733       50( )      27  (667)    501.0     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   733       49( )      24  (681)    507.1     NAPHTHALENE                                |
|BATTELLE NORTHWEST 056142707  01/06/97   729       50( )      20  (668)    518.0     VANADIUM PENTOXIDE                         |
|I. I. T. RESEARCH I058902905  09/26/94   736      100(5)      57  (692)    498.3     MAGNETIC FIELDS (EMF)                      |
|SOUTHERN RESEARCH  050520308  02/08/96   729       60(3)      39  (698)    447.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(3)      31  (697)    443.8     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516105  03/06/96   497       50(3)      49  (496)    519.7     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055634803  06/06/96   732      100(5)      75  (705)    335.2     CITRAL                                     |
|BATTELLE COLUMBUS  058805005  10/30/95   731       50(5)      38  (710)    315.4     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812003  12/18/95   730       50(5)      36  (694)    330.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800705  08/14/95   730       50(5)      33  (695)    350.1     SODIUM NITRITE                             |
|BATTELLE NORTHWEST 058812403  01/18/96   735       50( )      34  (682)    337.2     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   734       49( )      28  (700)    325.2     NAPHTHALENE                                |
|BATTELLE NORTHWEST 056142707  01/06/97   731       50( )      33  (688)    351.1     VANADIUM PENTOXIDE                         |
|I. I. T. RESEARCH I058902905  09/26/94   737      100(5)      59  (692)    338.0     MAGNETIC FIELDS (EMF)                      |
|SOUTHERN RESEARCH  050520308  02/08/96   730       60(5)      47  (713)    299.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(5)      39  (702)    295.2     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516105  03/06/96   729       50(5)      33  (683)    322.1     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 3
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       97/100(97%)   47/50 (94%)   42/50 (84%)         78/100(78%)   35/50 (70%)   37/50 (74%)    |
|                                       47/50 (94%)   47/50 (94%)   46/49 (94%)         42/50 (84%)   44/50 (88%)   38/49 (78%)    |
|                                       48/50 (96%)   99/100(99%)   60/60 (100%)        41/50 (82%)   92/100(92%)   47/60 (78%)    |
|                                       49/50 (98%)   47/50 (94%)                       33/50 (66%)   45/50 (90%)                  |
| Overall Incidence               Total 629/659 (95.45%)Mean 94.9%   SD 4.26%     Total 532/659 (80.73%) Mean 79.99%  SD 8.2%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    76/100(76%)   29/50 (58%)   34/50 (68%)         30/100(30%)   26/50 (52%)   15/50 (30%)    |
|                                       30/50 (60%)   26/50 (52%)   34/49 (69%)         23/50 (46%)   25/50 (50%)   26/49 (53%)    |
|                                       28/50 (56%)   66/100(66%)   37/60 (62%)         28/50 (56%)   40/100(40%)   24/60 (40%)    |
|                                       33/50 (66%)    9/50 (18%)                       22/50 (44%)   20/50 (40%)                  |
| Overall Incidence               Total 402/659 (61%)   Mean 59.19%  SD 15.24%    Total 279/659 (42.34%) Mean 43.73%  SD 8.77%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         99/100(99%)   49/50 (98%)   49/50 (98%)         92/100(92%)   45/50 (90%)   42/50 (84%)    |
|                                       49/50 (98%)   49/50 (98%)   48/49 (98%)         45/50 (90%)   49/50 (98%)   44/49 (90%)    |
|                                       50/50 (100%)  10/100(10%)   60/60 (100%)        47/50 (94%)   98/100(98%)   54/60 (90%)    |
|                                       50/50 (100%)  47/50 (94%)                       43/50 (86%)   47/50 (94%)                  |
| Overall Incidence               Total 560/659 (84.98%)Mean 90.27%  SD 26.67%    Total 606/659 (91.96%) Mean 91.44%  SD 4.4%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/100(1%)     0/50 (0%)     0/50 (0%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        2/50 (4%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 3/659 (0.46%)   Mean 0.45%   SD 1.21%     Total 4/659 (0.61%)    Mean 0.55%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/100(0%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/659 (0.46%)   Mean 0.52%   SD 0.89%     Total 3/659 (0.46%)    Mean 0.55%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/100(1%)     0/50 (0%)     1/50 (2%)           2/100(2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        0/50 (0%)     0/100(0%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        2/50 (4%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 6/659 (0.91%)   Mean 0.97%   SD 1.32%     Total 7/659 (1.06%)    Mean 1.1%    SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     1/60 (2%)           1/50 (2%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.15%   SD 0.5%      Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 4
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   68/100(68%)   20/50 (40%)   27/50 (54%)         24/100(24%)   21/50 (42%)    8/50 (16%)    |
|      Mononuclear, or Undifferentiated 17/50 (34%)   16/50 (32%)   26/49 (53%)         15/50 (30%)   14/50 (28%)   16/49 (33%)    |
|                                       22/50 (44%)   50/100(50%)   30/60 (50%)         21/50 (42%)   20/100(20%)   21/60 (35%)    |
|                                       24/50 (48%)    2/50 (4%)                        13/50 (26%)   12/50 (24%)                  |
| Overall Incidence               Total 302/659 (45.83%)Mean 43.37%  SD 16.44%    Total 185/659 (28.07%) Mean 29.06%  SD 8.36%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Undifferentiated Cell Type        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.36%   SD 1.21%     Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.37%   SD 1.23%     Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/100(4%)     0/50 (0%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               3/50 (6%)     2/50 (4%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     4/100(4%)     2/60 (3%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        5/50 (10%)    4/50 (8%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 29/659 (4.4%)   Mean 4.49%   SD 2.72%     Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/100(4%)     0/50 (0%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     2/50 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     4/100(4%)     2/60 (3%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        5/50 (10%)    4/50 (8%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 27/659 (4.1%)   Mean 4.12%   SD 3.04%     Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/100(0%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/659 (1.21%)   Mean 1.43%   SD 1.8%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/100(0%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/659 (1.21%)   Mean 1.43%   SD 1.8%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 5
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/100(2%)     1/50 (2%)     0/50 (0%)           2/100(2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           1/50 (2%)     1/49 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/99 (0%)     0/60 (0%)           0/49 (0%)     6/100(6%)     2/60 (3%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 5/657 (0.76%)   Mean 0.73%   SD 1.37%     Total 17/657 (2.59%)   Mean 2.31%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/49 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/99 (0%)     0/60 (0%)           0/49 (0%)     1/100(1%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/657 (0%)      Mean 0%      SD 0%        Total 2/657 (0.3%)     Mean 0.28%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             10/100(10%)    3/50 (6%)     4/50 (8%)           3/99 (3%)     1/50 (2%)     2/50 (4%)     |
|                                        6/50 (12%)   10/50 (20%)    4/49 (8%)           4/50 (8%)     2/50 (4%)     3/48 (6%)     |
|                                        4/50 (8%)    24/98 (24%)    2/60 (3%)           2/49 (4%)     7/96 (7%)     2/60 (3%)     |
|                                        3/50 (6%)     2/49 (4%)                         2/49 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 72/656 (10.98%) Mean 10.01%  SD 6.61%     Total 29/651 (4.45%)   Mean 4.37%   SD 1.99%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             1/100(1%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/98 (0%)     0/60 (0%)           0/49 (0%)     0/96 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/656 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/651 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/100(0%)     1/50 (2%)     2/50 (4%)           0/99 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        1/50 (2%)     2/98 (2%)     2/60 (3%)           0/49 (0%)     0/96 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 10/656 (1.52%)  Mean 1.58%   SD 1.41%     Total 1/651 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           11/100(11%)    4/50 (8%)     6/50 (12%)          3/99 (3%)     1/50 (2%)     2/50 (4%)     |
|      Complex, Malignant, NOS           7/50 (14%)   10/50 (20%)    5/49 (10%)          4/50 (8%)     2/50 (4%)     3/48 (6%)     |
|                                        5/50 (10%)   26/98 (27%)    4/60 (7%)           2/49 (4%)     7/96 (7%)     2/60 (3%)     |
|                                        3/50 (6%)     2/49 (4%)                         2/49 (4%)     2/50 (4%)                   |
| Overall Incidence               Total 83/656 (12.65%) Mean 11.68%  SD 6.55%     Total 30/651 (4.61%)   Mean 4.55%   SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/100(0%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/659 (1.21%)   Mean 1.43%   SD 1.8%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/100(0%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/659 (1.21%)   Mean 1.43%   SD 1.8%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     1/100(1%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 3/659 (0.46%)    Mean 0.45%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     1/100(1%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     1/50 (2%)     1/50 (2%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     2/100(2%)     0/60 (0%)           0/50 (0%)     2/100(2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 3/659 (0.46%)   Mean 0.36%   SD 0.81%     Total 6/659 (0.91%)    Mean 0.91%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              7/100(7%)     2/50 (4%)     3/50 (6%)          15/98 (15%)    2/49 (4%)     1/47 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     3/48 (6%)           8/46 (17%)    5/49 (10%)    4/49 (8%)     |
|                                        0/50 (0%)    13/100(13%)    2/60 (3%)           2/50 (4%)    11/90 (12%)   12/59 (20%)    |
|                                        2/50 (4%)     2/50 (4%)                         7/50 (14%)    7/49 (14%)                  |
| Overall Incidence               Total 35/658 (5.32%)  Mean 4.51%   SD 3.64%     Total 74/636 (11.64%)  Mean 11.1%   SD 5.93%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            1/100(1%)     1/50 (2%)     0/50 (0%)           1/98 (1%)     1/49 (2%)     0/47 (0%)     |
|                                        5/50 (10%)    2/50 (4%)     3/48 (6%)           2/46 (4%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     2/60 (3%)           0/50 (0%)     0/90 (0%)     2/59 (3%)     |
|                                        2/50 (4%)     0/50 (0%)                         2/50 (4%)     3/49 (6%)                   |
| Overall Incidence               Total 16/658 (2.43%)  Mean 2.78%   SD 3.2%      Total 11/636 (1.73%)   Mean 1.9%    SD 2.22%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 8/100(8%)     3/50 (6%)     3/50 (6%)          16/98 (16%)    3/49 (6%)     1/47 (2%)     |
|                                        5/50 (10%)    3/50 (6%)     6/48 (13%)         10/46 (22%)    5/49 (10%)    4/49 (8%)     |
|                                        0/50 (0%)    13/100(13%)    4/60 (7%)           2/50 (4%)    11/90 (12%)   14/59 (24%)    |
|                                        4/50 (8%)     2/50 (4%)                         8/50 (16%)   10/49 (20%)                  |
| Overall Incidence               Total 51/658 (7.75%)  Mean 7.29%   SD 3.71%     Total 84/636 (13.21%)  Mean 12.82%  SD 7.38%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     0/50 (0%)           0/98 (0%)     1/49 (2%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/46 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/90 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/658 (0%)      Mean 0%      SD 0%        Total 1/636 (0.16%)    Mean 0.19%   SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/98 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/46 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/90 (0%)     0/59 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/658 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/636 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     2/100(2%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 3/659 (0.46%)   Mean 0.36%   SD 0.81%     Total 2/659 (0.3%)     Mean 0.27%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/100(0%)     1/50 (2%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.33%   SD 0.75%     Total 2/659 (0.3%)     Mean 0.27%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     1/100(1%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/99 (3%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     1/50 (2%)     2/49 (4%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        1/50 (2%)     3/99 (3%)     2/60 (3%)           1/49 (2%)     1/100(1%)     1/60 (2%)     |
|                                        3/50 (6%)     0/49 (0%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 19/656 (2.9%)   Mean 2.86%   SD 2.53%     Total 7/658 (1.06%)    Mean 1.16%   SD 1.32%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/99 (0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/50 (2%)     1/99 (1%)     0/60 (0%)           1/49 (2%)     1/100(1%)     0/60 (0%)     |
|                                        2/50 (4%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 12/656 (1.83%)  Mean 2.11%   SD 2.51%     Total 3/658 (0.46%)    Mean 0.46%   SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/99 (3%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    3/50 (6%)     6/49 (12%)          0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        2/50 (4%)     4/99 (4%)     2/60 (3%)           2/49 (4%)     2/100(2%)     1/60 (2%)     |
|                                        5/50 (10%)    0/49 (0%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 31/656 (4.73%)  Mean 4.97%   SD 4.14%     Total 10/658 (1.52%)   Mean 1.62%   SD 1.77%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.19%   SD 0.62%     Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.19%   SD 0.62%     Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        1/50 (2%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 1/658 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 2/658 (0.3%)     Mean 0.28%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/100(0%)     0/50 (0%)     0/50 (0%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|                                        1/50 (2%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 3/658 (0.46%)    Mean 0.37%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/48 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/658 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/100(1%)     2/60 (3%)           1/50 (2%)     0/100(0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 5/659 (0.76%)   Mean 0.76%   SD 1.18%     Total 4/659 (0.61%)    Mean 0.7%    SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/100(0%)     0/50 (0%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/659 (0.76%)   Mean 0.88%   SD 1.36%     Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/100(0%)     0/50 (0%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/659 (0.76%)   Mean 0.88%   SD 1.36%     Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/100(0%)     1/50 (2%)     2/50 (4%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|      Hepatocellular Adenoma            0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/100(1%)     3/60 (5%)           1/50 (2%)     0/100(0%)     1/60 (2%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 10/659 (1.52%)  Mean 1.64%   SD 1.92%     Total 4/659 (0.61%)    Mean 0.7%    SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/100(0%)     1/50 (2%)     2/50 (4%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|      Hepatocellular Adenoma, or        0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     1/100(1%)     3/60 (5%)           1/50 (2%)     0/100(0%)     1/60 (2%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 10/659 (1.52%)  Mean 1.64%   SD 1.92%     Total 4/659 (0.61%)    Mean 0.7%    SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/49 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         3/100(3%)     0/50 (0%)     2/50 (4%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     6/50 (12%)    2/49 (4%)           3/50 (6%)     0/50 (0%)     1/49 (2%)     |
|                                        4/50 (8%)     3/100(3%)     1/60 (2%)           0/49 (0%)     3/100(3%)     1/60 (2%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 24/659 (3.64%)  Mean 3.8%    SD 3.51%     Total 12/658 (1.82%)   Mean 1.7%    SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     1/60 (2%)           0/49 (0%)     1/100(1%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/659 (0.46%)   Mean 0.52%   SD 0.89%     Total 3/658 (0.46%)    Mean 0.36%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    3/100(3%)     0/50 (0%)     2/50 (4%)           3/100(3%)     0/50 (0%)     0/50 (0%)     |
|      Alveolar/Bronchiolar Adenoma      2/50 (4%)     7/50 (14%)    2/49 (4%)           3/50 (6%)     1/50 (2%)     1/49 (2%)     |
|                                        4/50 (8%)     3/100(3%)     2/60 (3%)           0/49 (0%)     4/100(4%)     1/60 (2%)     |
|                                        1/50 (2%)     1/50 (2%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 27/659 (4.1%)   Mean 4.31%   SD 3.76%     Total 15/658 (2.28%)   Mean 2.06%   SD 2.03%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/49 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           1/50 (2%)     1/100(1%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 7/659 (1.06%)    Mean 1.18%   SD 1.33%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     3/50 (6%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           1/50 (2%)     0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           2/50 (4%)     2/100(2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 3/659 (0.46%)   Mean 0.37%   SD 0.82%     Total 15/659 (2.28%)   Mean 2.56%   SD 2.23%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 3/100(3%)     0/50 (0%)     0/50 (0%)           0/100(0%)     3/50 (6%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           2/50 (4%)     0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           3/50 (6%)     3/100(3%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     3/50 (6%)                   |
| Overall Incidence               Total 4/659 (0.61%)   Mean 0.46%   SD 1.04%     Total 20/659 (3.03%)   Mean 3.37%   SD 2.55%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         8/100(8%)     2/50 (4%)     3/50 (6%)          53/100(53%)   21/50 (42%)   15/50 (30%)    |
|                                        3/50 (6%)     2/50 (4%)     0/49 (0%)          21/50 (42%)   20/50 (40%)   17/49 (35%)    |
|                                        2/50 (4%)     6/100(6%)     0/60 (0%)          16/50 (32%)   56/100(56%)   23/60 (38%)    |
|                                        0/50 (0%)     0/50 (0%)                        14/50 (28%)   28/50 (56%)                  |
| Overall Incidence               Total 26/659 (3.95%)  Mean 3.45%   SD 2.98%     Total 284/659 (43.1%)  Mean 41.09%  SD 10.07%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     9/100(9%)     2/50 (4%)     3/50 (6%)          53/100(53%)   21/50 (42%)   16/50 (32%)    |
|                                        3/50 (6%)     2/50 (4%)     0/49 (0%)          23/50 (46%)   20/50 (40%)   17/49 (35%)    |
|                                        2/50 (4%)     6/100(6%)     0/60 (0%)          17/50 (34%)   56/100(56%)   23/60 (38%)    |
|                                        0/50 (0%)     0/50 (0%)                        14/50 (28%)   28/50 (56%)                  |
| Overall Incidence               Total 27/659 (4.1%)   Mean 3.55%   SD 3.14%     Total 288/659 (43.7%)  Mean 41.82%  SD 9.8%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,   11/100(11%)    2/50 (4%)     3/50 (6%)          53/100(53%)   23/50 (46%)   16/50 (32%)    |
|      or Adenoma                        3/50 (6%)     2/50 (4%)     1/49 (2%)          23/50 (46%)   20/50 (40%)   18/49 (37%)    |
|                                        2/50 (4%)     6/100(6%)     0/60 (0%)          19/50 (38%)   58/100(58%)   23/60 (38%)    |
|                                        0/50 (0%)     0/50 (0%)                        14/50 (28%)   30/50 (60%)                  |
| Overall Incidence               Total 30/659 (4.55%)  Mean 3.91%   SD 3.36%     Total 297/659 (45.07%) Mean 43.28%  SD 10.35%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.37%   SD 0.82%     Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/658 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/100(0%)     0/60 (0%)           1/50 (2%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/658 (0.15%)   Mean 0.18%   SD 0.6%      Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/100(1%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.27%   SD 0.65%     Total 2/659 (0.3%)     Mean 0.27%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 2/659 (0.3%)     Mean 0.36%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             2/100(2%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     1/50 (2%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 3/659 (0.46%)   Mean 0.36%   SD 0.81%     Total 4/659 (0.61%)    Mean 0.64%   SD 1.29%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     2/49 (4%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 3/659 (0.46%)    Mean 0.55%   SD 1.32%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/100(0%)     1/50 (2%)     0/50 (0%)     |
|      Malignant, NOS                                                                    0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 4/659 (0.61%)    Mean 0.73%   SD 1.37%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/659 (0.3%)     Mean 0.37%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     1/100(1%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 2/659 (0.3%)     Mean 0.27%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     3/100(3%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 3/659 (0.46%)    Mean 0.27%   SD 0.9%      |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              2/100(2%)     2/50 (4%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     3/98 (3%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 11/657 (1.67%)  Mean 1.52%   SD 1.37%     Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/98 (0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/657 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 2/100(2%)     2/50 (4%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     3/98 (3%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 12/657 (1.83%)  Mean 1.71%   SD 1.28%     Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/98 (0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/657 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/93 (0%)     0/46 (0%)     0/46 (0%)           2/86 (2%)     1/48 (2%)     0/45 (0%)     |
|                                        0/45 (0%)     1/44 (2%)     0/45 (0%)           0/46 (0%)     0/40 (0%)     0/42 (0%)     |
|                                        0/49 (0%)     0/85 (0%)     0/58 (0%)           0/45 (0%)     1/88 (1%)     0/57 (0%)     |
|                                        0/48 (0%)     0/46 (0%)                         0/46 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 1/605 (0.17%)   Mean 0.21%   SD 0.69%     Total 4/591 (0.68%)    Mean 0.5%    SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      17/100(17%)   17/50 (34%)   11/50 (22%)         29/100(29%)   12/50 (24%)   23/50 (46%)    |
|   Adenoma                             13/50 (26%)   36/49 (73%)   31/49 (63%)         24/50 (48%)   30/50 (60%)   23/49 (47%)    |
|                                       35/50 (70%)   34/98 (35%)   11/59 (19%)         31/49 (63%)   61/99 (62%)   19/59 (32%)    |
|                                       15/48 (31%)   11/50 (22%)                       15/50 (30%)   27/50 (54%)                  |
| Overall Incidence               Total 231/653 (35.38%)Mean 37.48%  SD 21.12%    Total 294/656 (44.82%) Mean 45%     SD 14.2%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     1/49 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/98 (0%)     0/59 (0%)           0/49 (0%)     3/99 (3%)     0/59 (0%)     |
|                                        1/48 (2%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/653 (0.46%)   Mean 0.56%   SD 0.95%     Total 4/656 (0.61%)    Mean 0.46%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      17/100(17%)   17/50 (34%)   11/50 (22%)         29/100(29%)   13/50 (26%)   23/50 (46%)    |
|   Carcinoma or Adenoma                13/50 (26%)   37/49 (76%)   31/49 (63%)         24/50 (48%)   30/50 (60%)   23/49 (47%)    |
|                                       35/50 (70%)   34/98 (35%)   11/59 (19%)         31/49 (63%)   64/99 (65%)   19/59 (32%)    |
|                                       16/48 (33%)   12/50 (24%)                       15/50 (30%)   27/50 (54%)                  |
| Overall Incidence               Total 234/653 (35.83%)Mean 38.04%  SD 21.28%    Total 298/656 (45.43%) Mean 45.46%  SD 14.29%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/100(1%)     0/50 (0%)     0/50 (0%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/98 (0%)     0/59 (0%)           0/49 (0%)     0/99 (0%)     1/59 (2%)     |
|                                        0/48 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/653 (0.15%)   Mean 0.09%   SD 0.3%      Total 3/656 (0.46%)    Mean 0.34%   SD 0.75%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/100(1%)     0/50 (0%)     0/50 (0%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/98 (0%)     0/59 (0%)           0/49 (0%)     0/99 (0%)     1/59 (2%)     |
|                                        0/48 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/653 (0.15%)   Mean 0.09%   SD 0.3%      Total 3/656 (0.46%)    Mean 0.34%   SD 0.75%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/100(0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)     2/60 (3%)                                                     |
|                                        2/50 (4%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 6/659 (0.91%)   Mean 1.03%   SD 1.53%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)     2/60 (3%)                                                     |
|                                        2/50 (4%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 6/659 (0.91%)   Mean 1.03%   SD 1.53%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/99 (0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/657 (0%)      Mean 0%      SD 0%        Total 1/658 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/99 (0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/657 (0%)      Mean 0%      SD 0%        Total 1/658 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/100(0%)     2/50 (4%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/99 (0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/657 (0.76%)   Mean 0.91%   SD 1.64%     Total 0/658 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.15%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.37%   SD 0.82%     Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/659 (0.46%)   Mean 0.46%   SD 0.83%     Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     3/100(3%)     2/60 (3%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/659 (1.21%)   Mean 1.03%   SD 1.32%     Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     3/100(3%)     2/60 (3%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/659 (1.21%)   Mean 1.03%   SD 1.32%     Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     2/100(2%)     0/50 (0%)     2/50 (4%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     3/100(3%)     2/60 (3%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 10/659 (1.52%)  Mean 1.3%    SD 1.59%     Total 2/659 (0.3%)     Mean 0.36%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 2/659 (0.3%)     Mean 0.36%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|      NOS)                              0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 2/659 (0.3%)     Mean 0.36%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     2/100(2%)     0/50 (0%)     2/50 (4%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       1/50 (2%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/49 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     3/100(3%)     2/60 (3%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|      Trichoepithelioma                 1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 11/659 (1.67%)  Mean 1.48%   SD 1.54%     Total 4/659 (0.61%)    Mean 0.73%   SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,        11/100(11%)    2/50 (4%)     6/50 (12%)          1/100(1%)     2/50 (4%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    3/50 (6%)     2/50 (4%)     4/49 (8%)           3/50 (6%)     1/50 (2%)     1/49 (2%)     |
|      B), Basal Cell Adenoma, Adenoma,  5/50 (10%)   14/100(14%)    7/60 (12%)          0/50 (0%)     1/100(1%)     0/60 (0%)     |
|      Papilloma, Sq Papilloma,          4/50 (8%)     3/50 (6%)                         0/50 (0%)     1/50 (2%)                   |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 61/659 (9.26%)  Mean 8.62%   SD 3.38%     Total 10/659 (1.52%)   Mean 1.64%   SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.36%   SD 1.21%     Total 1/659 (0.15%)    Mean 0.19%   SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     1/60 (2%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/659 (0.46%)   Mean 0.52%   SD 0.89%     Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      8/100(8%)     1/50 (2%)     3/50 (6%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        4/50 (8%)    10/100(10%)    5/60 (8%)           0/50 (0%)     1/100(1%)     0/60 (0%)     |
|                                        2/50 (4%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 43/659 (6.53%)  Mean 6.05%   SD 2.57%     Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/100(0%)     1/50 (2%)     1/50 (2%)           2/100(2%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 8/659 (1.21%)   Mean 1.37%   SD 1.29%     Total 5/659 (0.76%)    Mean 0.73%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 2/659 (0.3%)     Mean 0.36%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      1/50 (2%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     1/50 (2%)     0/49 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|      Carcinoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.36%   SD 0.81%     Total 4/659 (0.61%)    Mean 0.73%   SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)     0/50 (0%)     1/50 (2%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/50 (2%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/659 (0.91%)   Mean 0.91%   SD 0.94%     Total 3/659 (0.46%)    Mean 0.46%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/100(1%)     0/50 (0%)     1/50 (2%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/50 (2%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/659 (0.91%)   Mean 0.91%   SD 0.94%     Total 3/659 (0.46%)    Mean 0.46%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             9/100(9%)     2/50 (4%)     4/50 (8%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          2/50 (4%)     2/50 (4%)     4/49 (8%)           1/50 (2%)     1/50 (2%)     1/49 (2%)     |
|      Carcinoma or Keratoacanthoma      5/50 (10%)   11/100(11%)    5/60 (8%)           0/50 (0%)     1/100(1%)     0/60 (0%)     |
|                                        3/50 (6%)     3/50 (6%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 50/659 (7.59%)  Mean 7.14%   SD 2.49%     Total 6/659 (0.91%)    Mean 0.91%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             9/100(9%)     1/50 (2%)     4/50 (8%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     2/50 (4%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        5/50 (10%)   11/100(11%)    5/60 (8%)           0/50 (0%)     1/100(1%)     0/60 (0%)     |
|                                        3/50 (6%)     3/50 (6%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 49/659 (7.44%)  Mean 6.95%   SD 2.79%     Total 4/659 (0.61%)    Mean 0.55%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.27%   SD 0.65%     Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              2/100(2%)     3/50 (6%)     2/50 (4%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     5/49 (10%)          1/50 (2%)     3/50 (6%)     0/49 (0%)     |
|                                        2/50 (4%)    12/100(12%)    5/60 (8%)           1/50 (2%)     4/100(4%)     3/60 (5%)     |
|                                        1/50 (2%)     2/50 (4%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 35/659 (5.31%)  Mean 4.96%   SD 3.78%     Total 14/659 (2.12%)   Mean 2%      SD 2.14%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      8/100(8%)     3/50 (6%)     3/50 (6%)           1/100(1%)     0/50 (0%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   1/50 (2%)     2/50 (4%)     7/49 (14%)          1/50 (2%)     3/50 (6%)     1/49 (2%)     |
|      Histiocytoma                      6/50 (12%)   13/100(13%)    5/60 (8%)           1/50 (2%)     6/100(6%)     3/60 (5%)     |
|                                        2/50 (4%)     2/50 (4%)                         2/50 (4%)     3/50 (6%)                   |
| Overall Incidence               Total 52/659 (7.89%)  Mean 7.42%   SD 4.11%     Total 22/659 (3.34%)   Mean 3.28%   SD 2.19%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     1/100(1%)     0/60 (0%)           0/50 (0%)     1/100(1%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 8/659 (1.21%)   Mean 1.19%   SD 1.35%     Total 4/659 (0.61%)    Mean 0.64%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               5/100(5%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Myxosarcoma, or Fibrous           1/50 (2%)     1/50 (2%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|      Histiocytoma                      4/50 (8%)     1/100(1%)     0/60 (0%)           0/50 (0%)     2/100(2%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         2/50 (4%)     2/50 (4%)                   |
| Overall Incidence               Total 16/659 (2.43%)  Mean 2.37%   SD 2.47%     Total 8/659 (1.21%)    Mean 1.28%   SD 1.62%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 2/100(2%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/659 (0.91%)   Mean 0.91%   SD 1.38%     Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.18%   SD 0.6%      Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      or NOS)                           0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.18%   SD 0.6%      Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/50 (2%)     0/100(0%)     0/60 (0%)           0/50 (0%)     1/100(1%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.27%   SD 0.65%     Total 3/659 (0.46%)    Mean 0.46%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma NOS                          0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.18%   SD 0.6%      Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.19%   SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.27%   SD 0.65%     Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/659 (0.3%)    Mean 0.27%   SD 0.65%     Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.18%   SD 0.6%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             96/100(96%)   40/50 (80%)   41/50 (82%)                                                    |
|                                       47/50 (94%)   40/50 (80%)   38/49 (78%)                                                    |
|                                       36/50 (72%)   93/100(93%)   55/60 (92%)                                                    |
|                                       49/50 (98%)   39/50 (78%)                                                                  |
| Overall Incidence               Total 574/659 (87.1%) Mean 85.66%  SD 8.98%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%                                                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/97 (0%)     0/49 (0%)     0/46 (0%)           0/96 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/47 (0%)           0/49 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/49 (0%)     2/97 (2%)     0/56 (0%)           0/49 (0%)     0/95 (0%)     0/57 (0%)     |
|                                        0/49 (0%)     1/49 (2%)                         0/48 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 3/636 (0.47%)   Mean 0.37%   SD 0.83%     Total 0/627 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/97 (0%)     0/49 (0%)     0/46 (0%)           0/96 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/47 (0%)           0/49 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/49 (0%)     0/97 (0%)     0/56 (0%)           0/49 (0%)     0/95 (0%)     0/57 (0%)     |
|                                        0/49 (0%)     0/49 (0%)                         0/48 (0%)     1/48 (2%)                   |
| Overall Incidence               Total 0/636 (0%)      Mean 0%      SD 0%        Total 1/627 (0.16%)    Mean 0.19%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/97 (0%)     0/49 (0%)     0/46 (0%)           0/96 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     0/47 (0%)     0/47 (0%)           0/49 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/49 (0%)     2/97 (2%)     0/56 (0%)           0/49 (0%)     0/95 (0%)     0/57 (0%)     |
|                                        0/49 (0%)     1/49 (2%)                         0/48 (0%)     1/48 (2%)                   |
| Overall Incidence               Total 3/636 (0.47%)   Mean 0.37%   SD 0.83%     Total 1/627 (0.16%)    Mean 0.19%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                             12/100(12%)    9/50 (18%)    8/50 (16%)         21/100(21%)    3/50 (6%)     5/50 (10%)    |
|                                       12/50 (24%)    5/49 (10%)    9/46 (20%)          7/50 (14%)    6/47 (13%)    4/47 (9%)     |
|                                        1/50 (2%)    15/99 (15%)   10/59 (17%)          2/50 (4%)    15/100(15%)    9/60 (15%)    |
|                                       11/50 (22%)    3/50 (6%)                         6/50 (12%)    2/49 (4%)                   |
| Overall Incidence               Total 95/653 (14.55%) Mean 14.72%  SD 6.68%     Total 80/653 (12.25%)  Mean 11.12%  SD 5.23%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            4/100(4%)     1/50 (2%)     0/50 (0%)           0/100(0%)     2/50 (4%)     2/50 (4%)     |
|                                        2/50 (4%)     1/49 (2%)     1/46 (2%)           2/50 (4%)     3/47 (6%)     3/47 (6%)     |
|                                        0/50 (0%)     1/99 (1%)     0/59 (0%)           1/50 (2%)     5/100(5%)     1/60 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 11/653 (1.68%)  Mean 1.57%   SD 1.51%     Total 20/653 (3.06%)   Mean 3.22%   SD 2.26%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                16/100(16%)   10/50 (20%)    8/50 (16%)         21/100(21%)    5/50 (10%)    7/50 (14%)    |
|                                       14/50 (28%)    6/49 (12%)   10/46 (22%)          9/50 (18%)    8/47 (17%)    7/47 (15%)    |
|                                        1/50 (2%)    16/99 (16%)   10/59 (17%)          3/50 (6%)    19/100(19%)   10/60 (17%)    |
|                                       11/50 (22%)    4/50 (8%)                         6/50 (12%)    3/49 (6%)                   |
| Overall Incidence               Total 106/653 (16.23%)Mean 16.28%  SD 7.09%     Total 98/653 (15.01%)  Mean 14.06%  SD 5.03%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              3/100(3%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/49 (0%)     0/46 (0%)           1/50 (2%)     0/47 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     1/99 (1%)     0/59 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 6/653 (0.92%)   Mean 0.73%   SD 1.1%      Total 2/653 (0.31%)    Mean 0.36%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/46 (0%)           1/50 (2%)     1/47 (2%)     1/47 (2%)     |
|                                        0/50 (0%)     0/99 (0%)     1/59 (2%)           2/50 (4%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 3/653 (0.46%)   Mean 0.43%   SD 0.77%     Total 8/653 (1.23%)    Mean 1.39%   SD 1.3%      |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 4/100(4%)     1/50 (2%)     0/50 (0%)           1/100(1%)     1/50 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     0/49 (0%)     0/46 (0%)           2/50 (4%)     1/47 (2%)     1/47 (2%)     |
|                                        0/50 (0%)     1/99 (1%)     1/59 (2%)           2/50 (4%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 9/653 (1.38%)   Mean 1.16%   SD 1.59%     Total 10/653 (1.53%)   Mean 1.75%   SD 1.43%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 0/659 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           1/100(1%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 2/659 (0.3%)     Mean 0.27%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              1/100(1%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/659 (0.15%)   Mean 0.09%   SD 0.3%      Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/99 (0%)     0/60 (0%)           1/50 (2%)     0/99 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/655 (0%)      Mean 0%      SD 0%        Total 1/656 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/49 (2%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     0/49 (0%)     1/48 (2%)     |
|                                        0/49 (0%)     1/99 (1%)     1/60 (2%)           1/50 (2%)     0/99 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 4/655 (0.61%)   Mean 0.62%   SD 0.9%      Total 4/656 (0.61%)    Mean 0.73%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/49 (2%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     0/49 (0%)     1/48 (2%)     |
|                                        0/49 (0%)     1/99 (1%)     1/60 (2%)           0/50 (0%)     0/99 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 4/655 (0.61%)   Mean 0.62%   SD 0.9%      Total 3/656 (0.46%)    Mean 0.55%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/659 (0.15%)    Mean 0.09%   SD 0.3%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/50 (4%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 3/659 (0.46%)    Mean 0.55%   SD 1.29%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/659 (0.3%)     Mean 0.27%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     2/100(2%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/659 (0.3%)     Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       19/100(19%)    7/50 (14%)   10/50 (20%)    |
|                                                                                        7/50 (14%)   10/50 (20%)   15/49 (31%)    |
|                                                                                        6/50 (12%)   13/100(13%)   11/60 (18%)    |
|                                                                                        6/50 (12%)   11/50 (22%)                  |
| Overall Incidence                                                               Total 115/659 (17.45%) Mean 17.72%  SD 5.59%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma NOS                                                                          0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 12/20/00                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: VARIOUS                                    Date of
 Species: RATS                                           Vehicle: NTP 2000 DIET                            Input File: 20-DEC-2000
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    19/100(19%)    7/50 (14%)   11/50 (22%)    |
|                                                                                        7/50 (14%)   10/50 (20%)   15/49 (31%)    |
|                                                                                        6/50 (12%)   13/100(13%)   11/60 (18%)    |
|                                                                                        6/50 (12%)   11/50 (22%)                  |
| Overall Incidence                                                               Total 116/659 (17.6%)  Mean 17.9%   SD 5.7%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     3/100(3%)     0/60 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 4/659 (0.61%)    Mean 0.45%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     1/60 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/659 (0.15%)    Mean 0.15%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/659 (0.15%)    Mean 0.18%   SD 0.6%      |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/60 (0%)           0/50 (0%)     0/100(0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/659 (0%)      Mean 0%      SD 0%        Total 1/659 (0.15%)    Mean 0.15%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     1/60 (2%)     |
|                                        2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/659 (0.91%)   Mean 0.91%   SD 1.3%      Total 4/659 (0.61%)    Mean 0.7%    SD 1.34%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        0/50 (0%)     1/100(1%)     0/60 (0%)           0/50 (0%)     0/100(0%)     2/60 (3%)     |
|                                        2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/659 (0.91%)   Mean 0.91%   SD 1.3%      Total 5/659 (0.76%)    Mean 0.86%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
