                                                 Toxicology Data Management System                                     Page: 1
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055634803  06/06/96   726      100(3)      52  (681)    492.7     CITRAL                                     |
|BATTELLE COLUMBUS  058803105  03/31/97   729       50(3)      23  (662)    519.6     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812206  06/25/97   727       50(3)      26  (667)    483.6     ELMIRON                                    |
|BATTELLE COLUMBUS  058805005  10/30/95   729       50(3)      25  (665)    488.4     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812003  12/18/95   729       50(3)      24  (659)    496.8     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800705  08/14/95   729       50(3)      29  (665)    502.2     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611103  09/08/97   731      100(3)      60  (689)    492.1     TRANS-CINNAMALDEHYDE                       |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055634803  06/06/96   732      100(5)      75  (705)    335.2     CITRAL                                     |
|BATTELLE COLUMBUS  058803105  03/31/97   729       50(5)      30  (683)    350.8     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812206  06/25/97   728       50(5)      30  (672)    327.2     ELMIRON                                    |
|BATTELLE COLUMBUS  058805005  10/30/95   731       50(5)      38  (710)    315.4     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812003  12/18/95   730       50(5)      36  (694)    330.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800705  08/14/95   730       50(5)      33  (695)    350.1     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611103  09/08/97   735      100(5)      70  (706)    344.4     TRANS-CINNAMALDEHYDE                       |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302607  08/14/97   733       50( )      28  (684)    506.2     DECALIN                                    |
|BATTELLE NORTHWEST 058812403  01/18/96   733       50( )      27  (667)    501.0     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   733       49( )      24  (681)    507.1     NAPHTHALENE                                |
|BATTELLE NORTHWEST 056142707  01/06/97   729       50( )      20  (668)    518.0     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302607  08/14/97   734       50( )      32  (700)    345.9     DECALIN                                    |
|BATTELLE NORTHWEST 058812403  01/18/96   735       50( )      34  (682)    337.2     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   734       49( )      28  (700)    325.2     NAPHTHALENE                                |
|BATTELLE NORTHWEST 056142707  01/06/97   731       50( )      33  (688)    351.1     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902905  09/26/94   736      100(5)      57  (692)    498.3     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902905  09/26/94   737      100(5)      59  (692)    338.0     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 4
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302306  07/11/97   729       50(3)      37  (693)    510.6     2,4-HEXADIENAL (2,4-HX)                    |
|SOUTHERN RESEARCH  050520308  02/08/96   729       60(3)      39  (698)    447.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(3)      31  (697)    443.8     P-NITROTOLUENE                             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302306  07/11/97   732       50(5)      37  (699)    314.6     2,4-HEXADIENAL (2,4-HX)                    |
|SOUTHERN RESEARCH  050520308  02/08/96   730       60(5)      47  (713)    299.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(5)      39  (702)    295.2     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516105  03/06/96   729       50(5)      33  (683)    322.1     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 5
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       97/100(97%)   47/50 (94%)   49/50 (98%)         78/100(78%)   44/50 (88%)   37/50 (74%)    |
|                                       47/50 (94%)   42/50 (84%)   47/50 (94%)         35/50 (70%)   37/50 (74%)   42/50 (84%)    |
|                                       99/100(99%)                                     78/100(78%)                                |
| Overall Incidence               Total 428/450 (95.11%)Mean 94.29%  SD 4.99%     Total 351/450 (78%)    Mean 78%     SD 6.22%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    76/100(76%)   35/50 (70%)   29/50 (58%)         30/100(30%)   25/50 (50%)   12/50 (24%)    |
|                                       29/50 (58%)   34/50 (68%)   30/50 (60%)         26/50 (52%)   16/50 (32%)   23/50 (46%)    |
|                                       57/100(57%)                                     39/100(39%)                                |
| Overall Incidence               Total 290/450 (64.44%)Mean 63.86%  SD 7.45%     Total 171/450 (38%)    Mean 39%     SD 10.75%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         99/100(99%)   49/50 (98%)   49/50 (98%)         92/100(92%)   50/50 (100%)  42/50 (84%)    |
|                                       49/50 (98%)   49/50 (98%)   49/50 (98%)         45/50 (90%)   43/50 (86%)   45/50 (90%)    |
|                                      100/100(100%)                                    92/100(92%)                                |
| Overall Incidence               Total 444/450 (98.67%)Mean 98.43%  SD 0.79%     Total 409/450 (90.89%) Mean 90.57%  SD 5.13%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/100(1%)     0/50 (0%)     0/50 (0%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 2/450 (0.44%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/100(1%)     0/50 (0%)     0/50 (0%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.43%   SD 0.79%     Total 3/450 (0.67%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   68/100(68%)   16/50 (32%)   15/50 (30%)         24/100(24%)   10/50 (20%)    7/50 (14%)    |
|      Mononuclear, or Undifferentiated 20/50 (40%)   27/50 (54%)   17/50 (34%)         21/50 (42%)    8/50 (16%)   15/50 (30%)    |
|                                       40/100(40%)                                     21/100(21%)                                |
| Overall Incidence               Total 203/450 (45.11%)Mean 42.57%  SD 13.75%    Total 106/450 (23.56%) Mean 23.86%  SD 9.56%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/100(0%)     1/50 (2%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 2/450 (0.44%)    Mean 0.29%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/100(4%)     6/50 (12%)    2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)     2/50 (4%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/100(5%)                                       0/100(0%)                                 |
| Overall Incidence               Total 22/450 (4.89%)  Mean 5%      SD 3.61%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/100(4%)     6/50 (12%)    2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/100(5%)                                       0/100(0%)                                 |
| Overall Incidence               Total 22/450 (4.89%)  Mean 5%      SD 3.61%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.57%   SD 0.98%     Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.57%   SD 0.98%     Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/100(2%)     0/47 (0%)     0/50 (0%)           2/100(2%)     1/49 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     1/50 (2%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 3/447 (0.67%)   Mean 0.57%   SD 0.98%     Total 9/449 (2%)       Mean 2.15%   SD 0.9%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/447 (0%)      Mean 0%      SD 0%        Total 0/449 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/100(0%)     1/47 (2%)     0/50 (0%)           0/99 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/447 (0.45%)   Mean 0.45%   SD 0.83%     Total 0/448 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             10/100(10%)    4/47 (9%)     7/50 (14%)          3/99 (3%)     0/49 (0%)     2/50 (4%)     |
|                                        3/50 (6%)     4/50 (8%)     6/50 (12%)          1/50 (2%)     2/50 (4%)     4/50 (8%)     |
|                                        5/100(5%)                                       1/100(1%)                                 |
| Overall Incidence               Total 39/447 (8.72%)  Mean 9.07%   SD 3.19%     Total 13/448 (2.9%)    Mean 3.15%   SD 2.61%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             1/100(1%)     0/47 (0%)     0/50 (0%)           0/99 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 1/447 (0.22%)   Mean 0.14%   SD 0.38%     Total 1/448 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/100(0%)     5/47 (11%)    1/50 (2%)           0/99 (0%)     2/49 (4%)     1/50 (2%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence               Total 10/447 (2.24%)  Mean 2.95%   SD 3.66%     Total 5/448 (1.12%)    Mean 1.15%   SD 1.6%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           11/100(11%)    9/47 (19%)    7/50 (14%)          3/99 (3%)     2/49 (4%)     3/50 (6%)     |
|      Complex, Malignant, NOS           4/50 (8%)     6/50 (12%)    7/50 (14%)          1/50 (2%)     2/50 (4%)     4/50 (8%)     |
|                                        5/100(5%)                                       4/100(4%)                                 |
| Overall Incidence               Total 49/447 (10.96%) Mean 11.88%  SD 4.56%     Total 19/448 (4.24%)   Mean 4.44%   SD 1.98%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.57%   SD 0.98%     Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.57%   SD 0.98%     Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 2/450 (0.44%)    Mean 0.43%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 3/450 (0.67%)    Mean 0.71%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              7/100(7%)     3/50 (6%)     1/50 (2%)          15/98 (15%)    6/48 (13%)    3/50 (6%)     |
|                                        2/50 (4%)     3/50 (6%)     0/50 (0%)           2/49 (4%)     1/47 (2%)     8/46 (17%)    |
|                                        7/100(7%)                                       4/99 (4%)                                 |
| Overall Incidence               Total 23/450 (5.11%)  Mean 4.57%   SD 2.7%      Total 39/437 (8.92%)   Mean 8.78%   SD 6.15%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            1/100(1%)     3/50 (6%)     1/50 (2%)           1/98 (1%)     5/48 (10%)    0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     5/50 (10%)          1/49 (2%)     0/47 (0%)     2/46 (4%)     |
|                                        4/100(4%)                                       9/99 (9%)                                 |
| Overall Incidence               Total 15/450 (3.33%)  Mean 3.57%   SD 3.46%     Total 18/437 (4.12%)   Mean 3.85%   SD 4.32%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 8/100(8%)     6/50 (12%)    2/50 (4%)          16/98 (16%)   10/48 (21%)    3/50 (6%)     |
|                                        3/50 (6%)     3/50 (6%)     5/50 (10%)          3/49 (6%)     1/47 (2%)    10/46 (22%)    |
|                                       11/100(11%)                                     13/99 (13%)                                |
| Overall Incidence               Total 38/450 (8.44%)  Mean 8.14%   SD 2.97%     Total 56/437 (12.81%)  Mean 12.33%  SD 7.75%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     0/50 (0%)           0/98 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/47 (0%)     0/46 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/437 (0.23%)    Mean 0.29%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/100(0%)     1/50 (2%)     0/50 (0%)           0/98 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/47 (0%)     0/46 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/437 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/98 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/47 (0%)     0/46 (0%)     |
|                                        0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/437 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/100(0%)     2/50 (4%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.57%   SD 1.51%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence               Total 3/450 (0.67%)   Mean 0.57%   SD 0.98%     Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/100(0%)     0/50 (0%)     1/50 (2%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.57%   SD 0.98%     Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/99 (3%)     2/44 (5%)     1/50 (2%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     4/50 (8%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence               Total 12/443 (2.71%)  Mean 2.8%    SD 2.8%      Total 0/447 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/99 (0%)     0/44 (0%)     0/50 (0%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence               Total 2/443 (0.45%)   Mean 0.57%   SD 0.98%     Total 2/447 (0.45%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/99 (3%)     2/44 (5%)     1/50 (2%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     5/50 (10%)          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/100(2%)                                       2/100(2%)                                 |
| Overall Incidence               Total 14/443 (3.16%)  Mean 3.37%   SD 3.23%     Total 2/447 (0.45%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/447 (0%)      Mean 0%      SD 0%        Total 0/449 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/447 (0%)      Mean 0%      SD 0%        Total 0/449 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/100(0%)     1/47 (2%)     0/50 (0%)           1/100(1%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/447 (0.22%)   Mean 0.3%    SD 0.8%      Total 1/449 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/100(0%)     0/47 (0%)     0/50 (0%)           1/100(1%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/447 (0%)      Mean 0%      SD 0%        Total 1/449 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/100(0%)     1/47 (2%)     0/50 (0%)           2/100(2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/447 (0.22%)   Mean 0.3%    SD 0.8%      Total 2/449 (0.45%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/447 (0%)      Mean 0%      SD 0%        Total 0/449 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/447 (0%)      Mean 0%      SD 0%        Total 0/449 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/100(0%)     0/47 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/447 (0%)      Mean 0%      SD 0%        Total 0/449 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/100(0%)     1/47 (2%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/447 (0.22%)   Mean 0.3%    SD 0.8%      Total 0/449 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence               Total 3/450 (0.67%)   Mean 0.57%   SD 0.98%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.57%   SD 1.51%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Hepatoblastoma                    0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.57%   SD 1.51%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Hepatocellular Adenoma            1/50 (2%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence               Total 5/450 (1.11%)   Mean 1.14%   SD 1.57%     Total 2/450 (0.44%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Hepatocellular Adenoma, or        1/50 (2%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence               Total 5/450 (1.11%)   Mean 1.14%   SD 1.57%     Total 2/450 (0.44%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         3/100(3%)     2/50 (4%)     0/50 (0%)           2/100(2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        4/100(4%)                                       6/100(6%)                                 |
| Overall Incidence               Total 13/450 (2.89%)  Mean 2.71%   SD 1.89%     Total 11/450 (2.44%)   Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/100(0%)     1/50 (2%)     2/50 (4%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence               Total 4/450 (0.89%)   Mean 1%      SD 1.53%     Total 3/450 (0.67%)    Mean 0.57%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    3/100(3%)     3/50 (6%)     2/50 (4%)           3/100(3%)     1/50 (2%)     0/50 (0%)     |
|      Alveolar/Bronchiolar Adenoma      0/50 (0%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        5/100(5%)                                       7/100(7%)                                 |
| Overall Incidence               Total 17/450 (3.78%)  Mean 3.71%   SD 1.89%     Total 14/450 (3.11%)   Mean 2.57%   SD 2.94%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.43%   SD 0.79%     Total 5/450 (1.11%)    Mean 1.29%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     4/50 (8%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     1/50 (2%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.29%   SD 0.76%     Total 11/450 (2.44%)   Mean 3%      SD 2.89%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 3/100(3%)     0/50 (0%)     1/50 (2%)           0/100(0%)     4/50 (8%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     2/50 (4%)     2/50 (4%)     |
|                                        0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence               Total 4/450 (0.89%)   Mean 0.71%   SD 1.25%     Total 14/450 (3.11%)   Mean 3.71%   SD 2.69%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         8/100(8%)     1/50 (2%)     2/50 (4%)          53/100(53%)   36/50 (72%)   15/50 (30%)    |
|                                        2/50 (4%)     3/50 (6%)     3/50 (6%)          21/50 (42%)   15/50 (30%)   21/50 (42%)    |
|                                        3/100(3%)                                      55/100(55%)                                |
| Overall Incidence               Total 22/450 (4.89%)  Mean 4.71%   SD 2.06%     Total 216/450 (48%)    Mean 46.29%  SD 15%       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     9/100(9%)     1/50 (2%)     4/50 (8%)          53/100(53%)   36/50 (72%)   15/50 (30%)    |
|                                        2/50 (4%)     3/50 (6%)     3/50 (6%)          21/50 (42%)   16/50 (32%)   23/50 (46%)    |
|                                        3/100(3%)                                      55/100(55%)                                |
| Overall Incidence               Total 25/450 (5.56%)  Mean 5.43%   SD 2.57%     Total 219/450 (48.67%) Mean 47.14%  SD 14.52%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,   11/100(11%)    1/50 (2%)     4/50 (8%)          53/100(53%)   37/50 (74%)   16/50 (32%)    |
|      or Adenoma                        2/50 (4%)     3/50 (6%)     3/50 (6%)          23/50 (46%)   16/50 (32%)   23/50 (46%)    |
|                                        3/100(3%)                                      56/100(56%)                                |
| Overall Incidence               Total 27/450 (6%)     Mean 5.71%   SD 3.09%     Total 224/450 (49.78%) Mean 48.43%  SD 14.63%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/100(0%)     0/46 (0%)     0/50 (0%)           1/100(1%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/446 (0%)      Mean 0%      SD 0%        Total 1/448 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/100(0%)     0/46 (0%)     0/50 (0%)           0/100(0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/446 (0%)      Mean 0%      SD 0%        Total 0/448 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/100(1%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.29%   SD 0.49%     Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.29%   SD 0.49%     Total 2/450 (0.44%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             2/100(2%)     0/50 (0%)     0/50 (0%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence               Total 4/450 (0.89%)   Mean 0.57%   SD 0.98%     Total 3/450 (0.67%)    Mean 0.71%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.29%   SD 0.49%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/100(1%)                                 |
| Overall Incidence                                                               Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              2/100(2%)     0/44 (0%)     0/50 (0%)           0/100(0%)     1/47 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 5/444 (1.13%)   Mean 1%      SD 1.53%     Total 2/447 (0.45%)    Mean 0.59%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/100(0%)     1/44 (2%)     0/50 (0%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/444 (0.23%)   Mean 0.32%   SD 0.86%     Total 0/447 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 2/100(2%)     1/44 (2%)     0/50 (0%)           0/100(0%)     1/47 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 6/444 (1.35%)   Mean 1.32%   SD 1.52%     Total 2/447 (0.45%)    Mean 0.59%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              1/100(1%)     0/44 (0%)     0/50 (0%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/444 (0.23%)   Mean 0.14%   SD 0.38%     Total 0/447 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/100(0%)     2/44 (5%)     0/50 (0%)           0/100(0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 3/444 (0.68%)   Mean 0.79%   SD 1.7%      Total 0/447 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/93 (0%)     1/45 (2%)     0/46 (0%)           2/86 (2%)     0/49 (0%)     1/46 (2%)     |
|                                        0/46 (0%)     0/46 (0%)     0/45 (0%)           1/48 (2%)     0/45 (0%)     0/46 (0%)     |
|                                        0/92 (0%)                                       0/90 (0%)                                 |
| Overall Incidence               Total 1/413 (0.24%)   Mean 0.32%   SD 0.84%     Total 4/410 (0.98%)    Mean 0.94%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      17/100(17%)   15/47 (32%)   19/50 (38%)         29/100(29%)   20/48 (42%)   21/50 (42%)    |
|   Adenoma                             17/50 (34%)   11/50 (22%)   13/50 (26%)         12/50 (24%)   23/50 (46%)   24/50 (48%)    |
|                                       21/100(21%)                                     35/100(35%)                                |
| Overall Incidence               Total 113/447 (25.28%)Mean 27.13%  SD 7.7%      Total 164/448 (36.61%) Mean 37.95%  SD 8.94%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/100(0%)     0/47 (0%)     1/50 (2%)           0/100(0%)     1/48 (2%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/447 (0.22%)   Mean 0.29%   SD 0.76%     Total 2/448 (0.45%)    Mean 0.58%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      17/100(17%)   15/47 (32%)   20/50 (40%)         29/100(29%)   21/48 (44%)   21/50 (42%)    |
|   Carcinoma or Adenoma                17/50 (34%)   11/50 (22%)   13/50 (26%)         13/50 (26%)   23/50 (46%)   24/50 (48%)    |
|                                       21/100(21%)                                     35/100(35%)                                |
| Overall Incidence               Total 114/447 (25.5%) Mean 27.42%  SD 8.19%     Total 166/448 (37.05%) Mean 38.54%  SD 8.61%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/100(1%)     0/47 (0%)     1/50 (2%)           2/100(2%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/447 (0.45%)   Mean 0.43%   SD 0.79%     Total 2/448 (0.45%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/100(1%)     0/47 (0%)     1/50 (2%)           2/100(2%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/447 (0.45%)   Mean 0.43%   SD 0.79%     Total 2/448 (0.45%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/100(0%)     1/48 (2%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        4/100(4%)                                                                                 |
| Overall Incidence               Total 6/448 (1.34%)   Mean 1.15%   SD 1.58%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)     1/48 (2%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        4/100(4%)                                                                                 |
| Overall Incidence               Total 6/448 (1.34%)   Mean 1.15%   SD 1.58%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/100(0%)     0/49 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/449 (0%)      Mean 0%      SD 0%        Total 1/448 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/100(0%)     0/49 (0%)     0/50 (0%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/449 (0%)      Mean 0%      SD 0%        Total 1/448 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/100(0%)     0/49 (0%)     1/50 (2%)           0/100(0%)     0/49 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 5/449 (1.11%)   Mean 1.43%   SD 1.9%      Total 0/448 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)     1/50 (2%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.57%   SD 0.98%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/100(0%)     1/50 (2%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.57%   SD 0.98%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 4/450 (0.89%)   Mean 0.86%   SD 0.9%      Total 2/450 (0.44%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/100(1%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 4/450 (0.89%)   Mean 0.86%   SD 0.9%      Total 2/450 (0.44%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     2/100(2%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Tumor Benign, or                  0/50 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Trichoepithelioma                 2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence               Total 7/450 (1.56%)   Mean 1.43%   SD 1.51%     Total 3/450 (0.67%)    Mean 0.86%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.43%   SD 0.79%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      NOS)                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.43%   SD 0.79%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     2/100(2%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|      (benign, malignant or NOS), or    3/100(3%)                                       0/100(0%)                                 |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 9/450 (2%)      Mean 1.86%   SD 1.46%     Total 4/450 (0.89%)    Mean 1.14%   SD 1.57%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,        11/100(11%)    1/50 (2%)     4/50 (8%)           1/100(1%)     0/50 (0%)     1/50 (2%)     |
|      Carcinoma, Basosq. Tumor (M or    2/50 (4%)     6/50 (12%)    3/50 (6%)           2/50 (4%)     0/50 (0%)     3/50 (6%)     |
|      B), Basal Cell Adenoma, Adenoma,  8/100(8%)                                       0/100(0%)                                 |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 35/450 (7.78%)  Mean 7.29%   SD 3.59%     Total 7/450 (1.56%)    Mean 1.86%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      8/100(8%)     1/50 (2%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/100(5%)                                       0/100(0%)                                 |
| Overall Incidence               Total 22/450 (4.89%)  Mean 4.43%   SD 2.15%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/100(0%)     1/50 (2%)     1/50 (2%)           2/100(2%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 5/450 (1.11%)   Mean 1.43%   SD 0.98%     Total 4/450 (0.89%)    Mean 0.86%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      Tumor (malignant or NOS), or      1/100(1%)                                       0/100(0%)                                 |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 3/450 (0.67%)   Mean 0.71%   SD 0.95%     Total 2/450 (0.44%)    Mean 0.57%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)     0/50 (0%)     1/50 (2%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 3/450 (0.67%)   Mean 0.71%   SD 0.95%     Total 2/450 (0.44%)    Mean 0.43%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/100(1%)     0/50 (0%)     1/50 (2%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 3/450 (0.67%)   Mean 0.71%   SD 0.95%     Total 2/450 (0.44%)    Mean 0.43%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             9/100(9%)     1/50 (2%)     3/50 (6%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          2/50 (4%)     4/50 (8%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Carcinoma or Keratoacanthoma      5/100(5%)                                       0/100(0%)                                 |
| Overall Incidence               Total 26/450 (5.78%)  Mean 5.43%   SD 2.44%     Total 3/450 (0.67%)    Mean 0.71%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             9/100(9%)     1/50 (2%)     3/50 (6%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     1/50 (2%)     4/50 (8%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        5/100(5%)                                       0/100(0%)                                 |
| Overall Incidence               Total 25/450 (5.56%)  Mean 5.14%   SD 2.73%     Total 2/450 (0.44%)    Mean 0.43%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 3/450 (0.67%)   Mean 0.57%   SD 0.79%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              2/100(2%)     6/50 (12%)    1/50 (2%)           1/100(1%)     1/50 (2%)     1/50 (2%)     |
|                                        3/50 (6%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        7/100(7%)                                       1/100(1%)                                 |
| Overall Incidence               Total 21/450 (4.67%)  Mean 4.71%   SD 4.03%     Total 5/450 (1.11%)    Mean 1.14%   SD 0.9%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      8/100(8%)     9/50 (18%)    3/50 (6%)           1/100(1%)     1/50 (2%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   3/50 (6%)     4/50 (8%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|      Histiocytoma                     12/100(12%)                                      1/100(1%)                                 |
| Overall Incidence               Total 40/450 (8.89%)  Mean 8.57%   SD 5.13%     Total 6/450 (1.33%)    Mean 1.43%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         2/100(2%)     0/50 (0%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        6/100(6%)                                       0/100(0%)                                 |
| Overall Incidence               Total 11/450 (2.44%)  Mean 2%      SD 2.31%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               5/100(5%)     3/50 (6%)     2/50 (4%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Histiocytoma                      6/100(6%)                                       0/100(0%)                                 |
| Overall Incidence               Total 19/450 (4.22%)  Mean 3.86%   SD 2.19%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 3/450 (0.67%)   Mean 0.57%   SD 0.98%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              1/100(1%)     3/50 (6%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 5/450 (1.11%)   Mean 1.29%   SD 2.21%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 2/100(2%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)     0/43 (0%)     0/50 (0%)           0/100(0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/443 (0%)      Mean 0%      SD 0%        Total 0/448 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       1/100(1%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.14%   SD 0.38%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     2/50 (4%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.43%   SD 0.79%     Total 2/450 (0.44%)    Mean 0.57%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.43%   SD 0.79%     Total 2/450 (0.44%)    Mean 0.57%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/450 (0.22%)   Mean 0.29%   SD 0.76%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/100(0%)     0/50 (0%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.57%   SD 0.98%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             96/100(96%)   45/50 (90%)   44/50 (88%)                                                    |
|                                       40/50 (80%)   41/50 (82%)   47/50 (94%)                                                    |
|                                       91/100(91%)                                                                                |
| Overall Incidence               Total 404/450 (89.78%)Mean 88.71%  SD 5.91%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/100(0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/100(0%)                                                                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/97 (0%)     0/39 (0%)     0/45 (0%)           0/96 (0%)     1/48 (2%)     0/45 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/48 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/87 (1%)                                       0/92 (0%)                                 |
| Overall Incidence               Total 1/413 (0.24%)   Mean 0.16%   SD 0.43%     Total 1/424 (0.24%)    Mean 0.3%    SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/97 (0%)     0/39 (0%)     0/45 (0%)           0/96 (0%)     0/48 (0%)     0/45 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/48 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/87 (0%)                                       1/92 (1%)                                 |
| Overall Incidence               Total 0/413 (0%)      Mean 0%      SD 0%        Total 1/424 (0.24%)    Mean 0.16%   SD 0.41%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/97 (0%)     0/39 (0%)     0/45 (0%)           0/96 (0%)     1/48 (2%)     0/45 (0%)     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)           0/48 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/87 (1%)                                       1/92 (1%)                                 |
| Overall Incidence               Total 1/413 (0.24%)   Mean 0.16%   SD 0.43%     Total 2/424 (0.47%)    Mean 0.45%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                             12/100(12%)    4/42 (10%)    8/50 (16%)         21/100(21%)    6/45 (13%)   11/50 (22%)    |
|                                        9/50 (18%)    8/50 (16%)   12/50 (24%)          3/50 (6%)     5/50 (10%)    7/50 (14%)    |
|                                       12/100(12%)                                     11/100(11%)                                |
| Overall Incidence               Total 65/442 (14.71%) Mean 15.36%  SD 4.81%     Total 64/445 (14.38%)  Mean 13.9%   SD 5.81%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            4/100(4%)     2/42 (5%)     2/50 (4%)           0/100(0%)     1/45 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           2/50 (4%)     2/50 (4%)     2/50 (4%)     |
|                                        3/100(3%)                                       3/100(3%)                                 |
| Overall Incidence               Total 14/442 (3.17%)  Mean 3.11%   SD 1.63%     Total 10/445 (2.25%)   Mean 2.46%   SD 1.81%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                16/100(16%)    6/42 (14%)   10/50 (20%)         21/100(21%)    7/45 (16%)   11/50 (22%)    |
|                                       10/50 (20%)    8/50 (16%)   14/50 (28%)          5/50 (10%)    7/50 (14%)    9/50 (18%)    |
|                                       15/100(15%)                                     14/100(14%)                                |
| Overall Incidence               Total 79/442 (17.87%) Mean 18.47%  SD 4.78%     Total 74/445 (16.63%)  Mean 16.37%  SD 4.25%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              3/100(3%)     1/42 (2%)     0/50 (0%)           0/100(0%)     0/45 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence               Total 7/442 (1.58%)   Mean 1.48%   SD 1.17%     Total 3/445 (0.67%)    Mean 0.71%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/100(1%)     0/42 (0%)     2/50 (4%)           1/100(1%)     1/45 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        3/100(3%)                                       0/100(0%)                                 |
| Overall Incidence               Total 7/442 (1.58%)   Mean 1.43%   SD 1.62%     Total 5/445 (1.12%)    Mean 1.32%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 4/100(4%)     1/42 (2%)     2/50 (4%)           1/100(1%)     1/45 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        4/100(4%)                                       1/100(1%)                                 |
| Overall Incidence               Total 14/442 (3.17%)  Mean 2.91%   SD 1.55%     Total 8/445 (1.8%)     Mean 2.03%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           1/100(1%)     0/50 (0%)     0/50 (0%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.29%   SD 0.49%     Total 2/450 (0.44%)    Mean 0.43%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              1/100(1%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence               Total 2/450 (0.44%)   Mean 0.29%   SD 0.49%     Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/100(0%)     0/46 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 0/445 (0%)      Mean 0%      SD 0%        Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/100(0%)     0/46 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/445 (0.22%)   Mean 0.29%   SD 0.77%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/100(0%)     0/46 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/445 (0.22%)   Mean 0.29%   SD 0.77%     Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/100(0%)     1/46 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 1/445 (0.22%)   Mean 0.31%   SD 0.82%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              1/100(1%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 2/450 (0.44%)    Mean 0.43%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 2/450 (0.44%)    Mean 0.57%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 1/450 (0.22%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       19/100(19%)    8/50 (16%)    7/50 (14%)    |
|                                                                                        7/50 (14%)   10/50 (20%)    7/50 (14%)    |
|                                                                                       14/100(14%)                                |
| Overall Incidence                                                               Total 72/450 (16%)     Mean 15.86%  SD 2.61%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 1/450 (0.22%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 2/450 (0.44%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    19/100(19%)    9/50 (18%)    7/50 (14%)    |
|                                                                                        7/50 (14%)   11/50 (22%)    7/50 (14%)    |
|                                                                                       14/100(14%)                                |
| Overall Incidence                                                               Total 74/450 (16.44%)  Mean 16.43%  SD 3.26%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)                                 |
| Overall Incidence                                                               Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 2/450 (0.44%)    Mean 0.43%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/100(1%)     3/50 (6%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence               Total 6/450 (1.33%)   Mean 1.57%   SD 2.15%     Total 0/450 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/100(1%)     3/50 (6%)     0/50 (0%)           0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence               Total 6/450 (1.33%)   Mean 1.57%   SD 2.15%     Total 2/450 (0.44%)    Mean 0.43%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       47/50 (94%)   47/50 (94%)   46/49 (94%)         46/50 (92%)   44/50 (88%)   38/49 (78%)    |
|                                       48/50 (96%)                                     41/50 (82%)                                |
| Overall Incidence               Total 188/199 (94.47%)Mean 94.47%  SD 1.02%     Total 169/199 (84.92%) Mean 84.89%  SD 6.39%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    27/50 (54%)   26/50 (52%)   34/49 (69%)         25/50 (50%)   25/50 (50%)   26/49 (53%)    |
|                                       28/50 (56%)                                     28/50 (56%)                                |
| Overall Incidence               Total 115/199 (57.79%)Mean 57.85%  SD 7.87%     Total 104/199 (52.26%) Mean 52.27%  SD 2.88%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         49/50 (98%)   49/50 (98%)   48/49 (98%)         49/50 (98%)   49/50 (98%)   44/49 (90%)    |
|                                       50/50 (100%)                                    47/50 (94%)                                |
| Overall Incidence               Total 196/199 (98.49%)Mean 98.49%  SD 1.01%     Total 189/199 (94.97%) Mean 94.95%  SD 3.92%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 2/199 (1.01%)    Mean 1.01%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 3/199 (1.51%)    Mean 1.52%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   19/50 (38%)   16/50 (32%)   26/49 (53%)         11/50 (22%)   14/50 (28%)   16/49 (33%)    |
|      Mononuclear, or Undifferentiated 22/50 (44%)                                     21/50 (42%)                                |
| Overall Incidence               Total 83/199 (41.71%) Mean 41.77%  SD 8.98%     Total 62/199 (31.16%)  Mean 31.16%  SD 8.44%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)                                       0/50 (0%)                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.02%   SD 2.04%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/50 (2%)     2/50 (4%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      NOS                               1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 6/199 (3.02%)   Mean 3.02%   SD 1.18%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              1/50 (2%)     2/50 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/199 (2.01%)   Mean 2%      SD 1.63%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/199 (2.51%)   Mean 2.51%   SD 2.51%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/199 (2.51%)   Mean 2.51%   SD 2.51%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     1/49 (2%)     1/49 (2%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.02%   SD 2.04%     Total 2/197 (1.02%)    Mean 1.02%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/49 (2%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/197 (0.51%)    Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/197 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              7/49 (14%)   10/50 (20%)    4/49 (8%)           1/50 (2%)     2/50 (4%)     3/48 (6%)     |
|                                        4/50 (8%)                                       2/49 (4%)                                 |
| Overall Incidence               Total 25/198 (12.63%) Mean 12.61%  SD 5.73%     Total 8/197 (4.06%)    Mean 4.08%   SD 1.74%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/197 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/49 (4%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        1/50 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 4/198 (2.02%)   Mean 2.03%   SD 1.67%     Total 0/197 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            8/49 (16%)   10/50 (20%)    5/49 (10%)          1/50 (2%)     2/50 (4%)     3/48 (6%)     |
|      Complex, Malignant, NOS           5/50 (10%)                                      2/49 (4%)                                 |
| Overall Incidence               Total 28/198 (14.14%) Mean 14.13%  SD 4.89%     Total 8/197 (4.06%)    Mean 4.08%   SD 1.74%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/199 (2.51%)   Mean 2.51%   SD 2.51%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/199 (2.51%)   Mean 2.51%   SD 2.51%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|      Astrocytoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)     3/48 (6%)           8/48 (17%)    5/49 (10%)    4/49 (8%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 4/198 (2.02%)   Mean 2.06%   SD 2.95%     Total 19/196 (9.69%)   Mean 9.76%   SD 5.28%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     2/50 (4%)     3/48 (6%)           1/48 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/198 (2.53%)   Mean 2.56%   SD 3.1%      Total 1/196 (0.51%)    Mean 0.52%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     3/50 (6%)     6/48 (13%)          9/48 (19%)    5/49 (10%)    4/49 (8%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 9/198 (4.55%)   Mean 4.63%   SD 5.96%     Total 20/196 (10.2%)   Mean 10.28%  SD 6.21%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/196 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/196 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/196 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/50 (6%)     1/50 (2%)     2/49 (4%)           1/50 (2%)     1/50 (2%)     1/49 (2%)     |
|                                        1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 7/199 (3.52%)   Mean 3.52%   SD 1.92%     Total 4/198 (2.02%)    Mean 2.02%   SD 0.02%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            4/50 (8%)     2/50 (4%)     4/49 (8%)           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 11/199 (5.53%)  Mean 5.54%   SD 3.05%     Total 3/198 (1.52%)    Mean 1.52%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 7/50 (14%)    3/50 (6%)     6/49 (12%)          2/50 (4%)     1/50 (2%)     2/49 (4%)     |
|                                        2/50 (4%)                                       2/49 (4%)                                 |
| Overall Incidence               Total 18/199 (9.05%)  Mean 9.06%   SD 4.81%     Total 7/198 (3.54%)    Mean 3.54%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/50 (2%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.01%   SD 1.17%     Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/50 (2%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.01%   SD 1.17%     Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1%      SD 1.15%     Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/198 (0.51%)    Mean 0.52%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1%      SD 1.15%     Total 1/198 (0.51%)    Mean 0.52%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/48 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/198 (0.51%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.51%   SD 1.02%     Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.51%   SD 1.02%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Hepatoblastoma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.51%   SD 1.02%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Hepatocellular Adenoma            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.02%   SD 2.04%     Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Hepatocellular Adenoma, or        0/50 (0%)                                       1/50 (2%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.02%   SD 2.04%     Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         1/50 (2%)     6/50 (12%)    2/49 (4%)           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        4/50 (8%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 13/199 (6.53%)  Mean 6.52%   SD 4.42%     Total 2/198 (1.01%)    Mean 1.01%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/50 (2%)     1/50 (2%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1%      SD 1.15%     Total 2/198 (1.01%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    2/50 (4%)     7/50 (14%)    2/49 (4%)           2/50 (4%)     1/50 (2%)     1/49 (2%)     |
|      Alveolar/Bronchiolar Adenoma      4/50 (8%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 15/199 (7.54%)  Mean 7.52%   SD 4.71%     Total 4/198 (2.02%)    Mean 2.01%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     1/49 (2%)           5/50 (10%)    0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.01%   SD 1.17%     Total 10/199 (5.03%)   Mean 5.03%   SD 4.17%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     1/49 (2%)           5/50 (10%)    0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 3/199 (1.51%)   Mean 1.51%   SD 1.92%     Total 11/199 (5.53%)   Mean 5.53%   SD 4.13%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         2/50 (4%)     2/50 (4%)     0/49 (0%)          25/50 (50%)   20/50 (40%)   17/49 (35%)    |
|                                        2/50 (4%)                                      16/50 (32%)                                |
| Overall Incidence               Total 6/199 (3.02%)   Mean 3%      SD 2%        Total 78/199 (39.2%)   Mean 39.17%  SD 7.95%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     3/50 (6%)     2/50 (4%)     0/49 (0%)          25/50 (50%)   20/50 (40%)   17/49 (35%)    |
|                                        2/50 (4%)                                      17/50 (34%)                                |
| Overall Incidence               Total 7/199 (3.52%)   Mean 3.5%    SD 2.52%     Total 79/199 (39.7%)   Mean 39.67%  SD 7.39%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    4/50 (8%)     2/50 (4%)     1/49 (2%)          29/50 (58%)   20/50 (40%)   18/49 (37%)    |
|      or Adenoma                        2/50 (4%)                                      19/50 (38%)                                |
| Overall Incidence               Total 9/199 (4.52%)   Mean 4.51%   SD 2.5%      Total 86/199 (43.22%)  Mean 43.18%  SD 9.97%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.51%   SD 1.02%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/49 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/197 (0.51%)   Mean 0.5%    SD 1%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     1/50 (2%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 2/199 (1.01%)    Mean 1%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     1/50 (2%)     0/49 (0%)           3/50 (6%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 3/199 (1.51%)    Mean 1.5%    SD 3%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)     2/49 (4%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/199 (1.01%)    Mean 1.02%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|      Malignant, NOS                                                                    0/50 (0%)                                 |
| Overall Incidence                                                               Total 3/199 (1.51%)    Mean 1.52%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/199 (1.01%)    Mean 1.01%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.01%   SD 1.17%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.01%   SD 1.17%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/49 (0%)     1/44 (2%)     0/45 (0%)           0/49 (0%)     0/40 (0%)     0/42 (0%)     |
|                                        0/49 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 1/187 (0.53%)   Mean 0.57%   SD 1.14%     Total 0/176 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      27/50 (54%)   36/49 (73%)   31/49 (63%)         34/50 (68%)   30/50 (60%)   23/49 (47%)    |
|   Adenoma                             35/50 (70%)                                     31/49 (63%)                                |
| Overall Incidence               Total 129/198 (65.15%)Mean 65.18%  SD 8.58%     Total 118/198 (59.6%)  Mean 59.55%  SD 9.03%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     1/49 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma                            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/198 (0.51%)   Mean 0.51%   SD 1.02%     Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      27/50 (54%)   37/49 (76%)   31/49 (63%)         34/50 (68%)   30/50 (60%)   23/49 (47%)    |
|   Carcinoma or Adenoma                35/50 (70%)                                     31/49 (63%)                                |
| Overall Incidence               Total 130/198 (65.66%)Mean 65.69%  SD 9.27%     Total 118/198 (59.6%)  Mean 59.55%  SD 9.03%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/198 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/198 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.01%   SD 1.17%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1.01%   SD 1.17%     Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Tumor Benign, or                  0/50 (0%)                                       0/50 (0%)                                 |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)                                       0/50 (0%)                                 |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)                                       0/50 (0%)                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         3/50 (6%)     2/50 (4%)     4/49 (8%)           1/50 (2%)     1/50 (2%)     1/49 (2%)     |
|      Carcinoma, Basosq. Tumor (M or    5/50 (10%)                                      0/50 (0%)                                 |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 14/199 (7.04%)  Mean 7.04%   SD 2.6%      Total 3/199 (1.51%)    Mean 1.51%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/50 (2%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        4/50 (8%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 11/199 (5.53%)  Mean 5.54%   SD 3.05%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/199 (2.01%)   Mean 2.01%   SD 1.63%     Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     0/49 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 2/199 (1.01%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1%      SD 1.15%     Total 1/199 (0.5%)     Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|      Papilloma                         1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1%      SD 1.15%     Total 1/199 (0.5%)     Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|      Papilloma, Squamous Cell          5/50 (10%)                                      0/50 (0%)                                 |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 13/199 (6.53%)  Mean 6.54%   SD 3.03%     Total 2/199 (1.01%)    Mean 1.01%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|      Papilloma, or Keratoacanthoma     5/50 (10%)                                      0/50 (0%)                                 |
| Overall Incidence               Total 13/199 (6.53%)  Mean 6.54%   SD 3.03%     Total 1/199 (0.5%)     Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              2/50 (4%)     1/50 (2%)     5/49 (10%)          0/50 (0%)     3/50 (6%)     0/49 (0%)     |
|                                        2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 10/199 (5.03%)  Mean 5.05%   SD 3.56%     Total 4/199 (2.01%)    Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      4/50 (8%)     2/50 (4%)     7/49 (14%)          2/50 (4%)     3/50 (6%)     1/49 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   6/50 (12%)                                      1/50 (2%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 19/199 (9.55%)  Mean 9.57%   SD 4.53%     Total 7/199 (3.52%)    Mean 3.51%   SD 1.9%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         2/50 (4%)     1/50 (2%)     2/49 (4%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 6/199 (3.02%)   Mean 3.02%   SD 1.18%     Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               2/50 (4%)     1/50 (2%)     2/49 (4%)           2/50 (4%)     0/50 (0%)     1/49 (2%)     |
|      Myxosarcoma, or Fibrous           4/50 (8%)                                       0/50 (0%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 9/199 (4.52%)   Mean 4.52%   SD 2.51%     Total 3/199 (1.51%)    Mean 1.51%   SD 1.92%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/199 (1.01%)   Mean 1%      SD 2%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      (malignant or NOS)                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)                                       0/50 (0%)                                 |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 2/199 (1.01%)    Mean 1.01%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/199 (0.5%)    Mean 0.5%    SD 1%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.51%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma Squamous                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             40/50 (80%)   40/50 (80%)   38/49 (78%)                                                    |
|                                       36/50 (72%)                                                                                |
| Overall Incidence               Total 154/199 (77.39%)Mean 77.39%  SD 3.77%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/50 (0%)     0/47 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/193 (0%)      Mean 0%      SD 0%        Total 0/188 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/50 (0%)     0/47 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/193 (0%)      Mean 0%      SD 0%        Total 0/188 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/50 (0%)     0/47 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/193 (0%)      Mean 0%      SD 0%        Total 0/188 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              7/50 (14%)    5/49 (10%)    9/46 (20%)          5/50 (10%)    6/47 (13%)    4/47 (9%)     |
|                                        1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 22/195 (11.28%) Mean 11.44%  SD 7.38%     Total 17/194 (8.76%)   Mean 8.82%   SD 3.66%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     1/49 (2%)     1/46 (2%)           3/50 (6%)     3/47 (6%)     3/47 (6%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 2/195 (1.03%)   Mean 1.05%   SD 1.22%     Total 10/194 (5.15%)   Mean 5.19%   SD 2.14%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 7/50 (14%)    6/49 (12%)   10/46 (22%)          8/50 (16%)    8/47 (17%)    7/47 (15%)    |
|                                        1/50 (2%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 24/195 (12.31%) Mean 12.5%   SD 8.12%     Total 26/194 (13.4%)   Mean 13.48%  SD 5.06%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     0/47 (0%)     0/47 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/195 (0%)      Mean 0%      SD 0%        Total 0/194 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     1/47 (2%)     1/47 (2%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 0/195 (0%)      Mean 0%      SD 0%        Total 4/194 (2.06%)    Mean 2.06%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     1/47 (2%)     1/47 (2%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 0/195 (0%)      Mean 0%      SD 0%        Total 4/194 (2.06%)    Mean 2.06%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma Squamous                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 2/199 (1.01%)    Mean 1%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 1/197 (0.51%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     0/49 (0%)     1/48 (2%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/197 (0.51%)   Mean 0.52%   SD 1.04%     Total 2/197 (1.02%)    Mean 1.02%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     0/49 (0%)     1/48 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/197 (0.51%)   Mean 0.52%   SD 1.04%     Total 1/197 (0.51%)    Mean 0.52%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/197 (0%)      Mean 0%      SD 0%        Total 0/197 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        7/50 (14%)   10/50 (20%)   15/49 (31%)    |
|                                                                                        6/50 (12%)                                |
| Overall Incidence                                                               Total 38/199 (19.1%)   Mean 19.15%  SD 8.36%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     7/50 (14%)   10/50 (20%)   15/49 (31%)    |
|                                                                                        6/50 (12%)                                |
| Overall Incidence                                                               Total 38/199 (19.1%)   Mean 19.15%  SD 8.36%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/199 (0.5%)     Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 0/199 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 3/199 (1.51%)    Mean 1.52%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/199 (0%)      Mean 0%      SD 0%        Total 3/199 (1.51%)    Mean 1.52%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 53
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       99/100(99%)                                     92/100(92%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    66/100(66%)                                     40/100(40%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors        100/100(100%)                                    98/100(98%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   50/100(50%)                                     20/100(20%)                                |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/100(0%)                                       0/100(0%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/100(4%)                                       0/100(0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/100(4%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/99 (0%)                                       6/100(6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/99 (0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/98 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             24/98 (24%)                                      7/96 (7%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/98 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/98 (2%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           26/98 (27%)                                      7/96 (7%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        2/100(2%)                                       2/100(2%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                             13/100(13%)                                     11/90 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                13/100(13%)                                     11/90 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/99 (3%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            1/99 (1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 4/99 (4%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/100(0%)                                       0/100(0%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          1/100(1%)                                       0/100(0%)                                 |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            1/100(1%)                                       0/100(0%)                                 |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         3/100(3%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    3/100(3%)                                       4/100(4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         6/100(6%)                                      56/100(56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     6/100(6%)                                      56/100(56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    6/100(6%)                                      58/100(58%)                                |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/100(0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              3/98 (3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 3/98 (3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 62
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/85 (0%)                                       1/88 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      34/98 (35%)                                     61/99 (62%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/98 (0%)                                       3/99 (3%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      34/98 (35%)                                     64/99 (65%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 63
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   3/100(3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                3/100(3%)                                       0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     3/100(3%)                                       0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)                                       0/100(0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 64
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     3/100(3%)                                       0/100(0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,        14/100(14%)                                      1/100(1%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                     10/100(10%)                                      1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 65
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)                                       0/100(0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/100(1%)                                       0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/100(11%)                                      1/100(1%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/100(11%)                                      1/100(1%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                             12/100(12%)                                      4/100(4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,     13/100(13%)                                      6/100(6%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/100(1%)                                       2/100(2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 66
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/100(0%)                                       0/100(0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/100(0%)                                       0/100(0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/100(1%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 67
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             93/100(93%)                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            1/100(1%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       2/97 (2%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/97 (0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      2/97 (2%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                             15/99 (15%)                                     15/100(15%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/99 (1%)                                       5/100(5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                16/99 (16%)                                     19/100(19%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/99 (1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 68
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/99 (1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               1/99 (1%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            1/99 (1%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 69
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       13/100(13%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    13/100(13%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 70
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 71
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       48/50 (96%)   60/60 (100%)  49/50 (98%)         45/50 (90%)   47/60 (78%)   33/50 (66%)    |
|                                                                                       45/50 (90%)                                |
| Overall Incidence               Total 157/160 (98.13%)Mean 98%     SD 2%        Total 170/210 (80.95%) Mean 81.08%  SD 11.46%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    21/50 (42%)   37/60 (62%)   33/50 (66%)         18/50 (36%)   24/60 (40%)   22/50 (44%)    |
|                                                                                       20/50 (40%)                                |
| Overall Incidence               Total 91/160 (56.88%) Mean 56.56%  SD 12.79%    Total 84/210 (40%)     Mean 40%     SD 3.27%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         50/50 (100%)  60/60 (100%)  50/50 (100%)        47/50 (94%)   54/60 (90%)   43/50 (86%)    |
|                                                                                       47/50 (94%)                                |
| Overall Incidence               Total 160/160 (100%)  Mean 100%    SD 0%        Total 191/210 (90.95%) Mean 91%     SD 3.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.33%   SD 2.31%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.56%   SD 0.96%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     1/60 (2%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/160 (1.88%)   Mean 1.89%   SD 2.01%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.22%   SD 1.07%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   11/50 (22%)   30/60 (50%)   24/50 (48%)         10/50 (20%)   21/60 (35%)   13/50 (26%)    |
|      Mononuclear, or Undifferentiated                                                 12/50 (24%)                                |
| Overall Incidence               Total 65/160 (40.63%) Mean 40%     SD 15.62%    Total 56/210 (26.67%)  Mean 26.25%  SD 6.34%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or                                                       0/50 (0%)                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.33%   SD 2.31%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 72
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/50 (8%)     2/60 (3%)     5/50 (10%)          1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|      NOS                                                                               0/50 (0%)                                 |
| Overall Incidence               Total 11/160 (6.88%)  Mean 7.11%   SD 3.42%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/50 (8%)     2/60 (3%)     5/50 (10%)          1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 11/160 (6.88%)  Mean 7.11%   SD 3.42%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.56%   SD 0.96%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.56%   SD 0.96%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     2/60 (3%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 4/210 (1.9%)     Mean 1.83%   SD 1.37%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              7/50 (14%)    2/60 (3%)     3/50 (6%)           1/50 (2%)     2/60 (3%)     2/49 (4%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 12/160 (7.5%)   Mean 7.78%   SD 5.55%     Total 6/209 (2.87%)    Mean 2.85%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     2/60 (3%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.11%   SD 1.92%     Total 2/209 (0.96%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 73
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            7/50 (14%)    4/60 (7%)     3/50 (6%)           2/50 (4%)     2/60 (3%)     2/49 (4%)     |
|      Complex, Malignant, NOS                                                           2/50 (4%)                                 |
| Overall Incidence               Total 14/160 (8.75%)  Mean 8.89%   SD 4.44%     Total 8/209 (3.83%)    Mean 3.85%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.56%   SD 0.96%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.56%   SD 0.96%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/60 (0%)     0/50 (0%)           2/50 (4%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 3/210 (1.43%)    Mean 1.5%    SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 74
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/60 (0%)     0/50 (0%)           2/50 (4%)     0/60 (0%)     1/50 (2%)     |
|      Astrocytoma                                                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 3/210 (1.43%)    Mean 1.5%    SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              1/49 (2%)     2/60 (3%)     2/50 (4%)           5/50 (10%)   12/59 (20%)    7/50 (14%)    |
|                                                                                        7/49 (14%)                                |
| Overall Incidence               Total 5/159 (3.14%)   Mean 3.12%   SD 1%        Total 31/208 (14.9%)   Mean 14.66%  SD 4.26%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            3/49 (6%)     2/60 (3%)     2/50 (4%)           2/50 (4%)     2/59 (3%)     2/50 (4%)     |
|                                                                                        3/49 (6%)                                 |
| Overall Incidence               Total 7/159 (4.4%)    Mean 4.49%   SD 1.46%     Total 9/208 (4.33%)    Mean 4.38%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 4/49 (8%)     4/60 (7%)     4/50 (8%)           7/50 (14%)   14/59 (24%)    8/50 (16%)    |
|                                                                                       10/49 (20%)                                |
| Overall Incidence               Total 12/159 (7.55%)  Mean 7.61%   SD 0.82%     Total 39/208 (18.75%)  Mean 18.53%  SD 4.38%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 0/159 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 0/159 (0%)      Mean 0%      SD 0%        Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/49 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 1/159 (0.63%)   Mean 0.67%   SD 1.15%     Total 0/208 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 75
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.56%   SD 0.96%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 76
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              4/50 (8%)     2/60 (3%)     3/50 (6%)           1/50 (2%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        2/50 (4%)                                 |
| Overall Incidence               Total 9/160 (5.63%)   Mean 5.78%   SD 2.34%     Total 4/210 (1.9%)     Mean 1.92%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.33%   SD 2.31%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 4/50 (8%)     2/60 (3%)     5/50 (10%)          1/50 (2%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        2/50 (4%)                                 |
| Overall Incidence               Total 11/160 (6.88%)  Mean 7.11%   SD 3.42%     Total 4/210 (1.9%)     Mean 1.92%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                                                                 0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 77
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)     2/60 (3%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.11%   SD 1.92%     Total 2/210 (0.95%)    Mean 0.92%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     1/60 (2%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.22%   SD 1.07%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     1/60 (2%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Hepatoblastoma                                                                    0/50 (0%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.22%   SD 1.07%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     3/60 (5%)     1/50 (2%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|      Hepatocellular Adenoma                                                            1/50 (2%)                                 |
| Overall Incidence               Total 4/160 (2.5%)    Mean 2.33%   SD 2.52%     Total 2/210 (0.95%)    Mean 0.92%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 78
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)     3/60 (5%)     1/50 (2%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|      Hepatocellular Adenoma, or                                                        1/50 (2%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 4/160 (2.5%)    Mean 2.33%   SD 2.52%     Total 2/210 (0.95%)    Mean 0.92%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         1/50 (2%)     1/60 (2%)     1/50 (2%)           3/50 (6%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        2/50 (4%)                                 |
| Overall Incidence               Total 3/160 (1.88%)   Mean 1.89%   SD 0.19%     Total 6/210 (2.86%)    Mean 2.92%   SD 2.63%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.56%   SD 0.96%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    1/50 (2%)     2/60 (3%)     1/50 (2%)           3/50 (6%)     1/60 (2%)     0/50 (0%)     |
|      Alveolar/Bronchiolar Adenoma                                                      2/50 (4%)                                 |
| Overall Incidence               Total 4/160 (2.5%)    Mean 2.44%   SD 0.77%     Total 6/210 (2.86%)    Mean 2.92%   SD 2.63%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 79
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           2/50 (4%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 3/210 (1.43%)    Mean 1.5%    SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            2/50 (4%)     0/60 (0%)     0/50 (0%)           2/50 (4%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        2/50 (4%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.33%   SD 2.31%     Total 5/210 (2.38%)    Mean 2.5%    SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     0/60 (0%)     0/50 (0%)           3/50 (6%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        3/50 (6%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.33%   SD 2.31%     Total 7/210 (3.33%)    Mean 3.5%    SD 3%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         3/50 (6%)     0/60 (0%)     0/50 (0%)          22/50 (44%)   23/60 (38%)   14/50 (28%)    |
|                                                                                       28/50 (56%)                                |
| Overall Incidence               Total 3/160 (1.88%)   Mean 2%      SD 3.46%     Total 87/210 (41.43%)  Mean 41.58%  SD 11.67%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     3/50 (6%)     0/60 (0%)     0/50 (0%)          23/50 (46%)   23/60 (38%)   14/50 (28%)    |
|                                                                                       28/50 (56%)                                |
| Overall Incidence               Total 3/160 (1.88%)   Mean 2%      SD 3.46%     Total 88/210 (41.9%)   Mean 42.08%  SD 11.85%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    5/50 (10%)    0/60 (0%)     0/50 (0%)          24/50 (48%)   23/60 (38%)   14/50 (28%)    |
|      or Adenoma                                                                       30/50 (60%)                                |
| Overall Incidence               Total 5/160 (3.13%)   Mean 3.33%   SD 5.77%     Total 91/210 (43.33%)  Mean 43.58%  SD 13.66%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 80
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     2/50 (4%)     |
|      Papilloma Squamous, or Papilloma                                                  0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 3/210 (1.43%)    Mean 1.5%    SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 81
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                             10/50 (20%)    1/60 (2%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 11/160 (6.88%)  Mean 7.22%   SD 11.1%     Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 82
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                10/50 (20%)    1/60 (2%)     1/50 (2%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 12/160 (7.5%)   Mean 7.89%   SD 10.49%    Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/58 (0%)     0/48 (0%)           0/49 (0%)     0/57 (0%)     0/46 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence               Total 0/156 (0%)      Mean 0%      SD 0%        Total 0/200 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      12/50 (24%)   11/59 (19%)   15/48 (31%)         19/50 (38%)   19/59 (32%)   15/50 (30%)    |
|   Adenoma                                                                             27/50 (54%)                                |
| Overall Incidence               Total 38/157 (24.2%)  Mean 24.63%  SD 6.33%     Total 80/209 (38.28%)  Mean 38.55%  SD 10.84%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/59 (0%)     1/48 (2%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence               Total 1/157 (0.64%)   Mean 0.69%   SD 1.2%      Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      12/50 (24%)   11/59 (19%)   16/48 (33%)         19/50 (38%)   19/59 (32%)   15/50 (30%)    |
|   Carcinoma or Adenoma                                                                27/50 (54%)                                |
| Overall Incidence               Total 39/157 (24.84%) Mean 25.33%  SD 7.43%     Total 80/209 (38.28%)  Mean 38.55%  SD 10.84%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     0/59 (0%)     0/48 (0%)           1/50 (2%)     1/59 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/157 (0%)      Mean 0%      SD 0%        Total 2/209 (0.96%)    Mean 0.92%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/59 (0%)     0/48 (0%)           1/50 (2%)     1/59 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/157 (0%)      Mean 0%      SD 0%        Total 2/209 (0.96%)    Mean 0.92%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 83
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              2/49 (4%)     2/60 (3%)     2/50 (4%)                                                     |
|                                                                                                                                  |
| Overall Incidence               Total 6/159 (3.77%)   Mean 3.8%    SD 0.41%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 2/49 (4%)     2/60 (3%)     2/50 (4%)                                                     |
|                                                                                                                                  |
| Overall Incidence               Total 6/159 (3.77%)   Mean 3.8%    SD 0.41%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 1/50 (2%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.33%   SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.42%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 84
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     2/60 (3%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/160 (1.88%)   Mean 1.78%   SD 1.68%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     2/60 (3%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign                                                         0/50 (0%)                                 |
| Overall Incidence               Total 3/160 (1.88%)   Mean 1.78%   SD 1.68%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)     2/60 (3%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Tumor Benign, or                                                                  0/50 (0%)                                 |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 4/160 (2.5%)    Mean 2.44%   SD 0.77%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or                                                  1/50 (2%)                                 |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     2/60 (3%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor                                                       1/50 (2%)                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 4/160 (2.5%)    Mean 2.44%   SD 0.77%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         5/50 (10%)    7/60 (12%)    4/50 (8%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or                                                    1/50 (2%)                                 |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 16/160 (10%)    Mean 9.89%   SD 1.84%     Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.33%   SD 2.31%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 85
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.56%   SD 0.96%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      3/50 (6%)     5/60 (8%)     2/50 (4%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 10/160 (6.25%)  Mean 6.11%   SD 2.17%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous                                                      1/50 (2%)                                 |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.33%   SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Papilloma                                                                         0/50 (0%)                                 |
| Overall Incidence               Total 2/160 (1.25%)   Mean 1.33%   SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 86
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)     5/60 (8%)     3/50 (6%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell                                                          0/50 (0%)                                 |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 12/160 (7.5%)   Mean 7.44%   SD 1.26%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)     5/60 (8%)     3/50 (6%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma                                                     0/50 (0%)                                 |
| Overall Incidence               Total 12/160 (7.5%)   Mean 7.44%   SD 1.26%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              4/50 (8%)     5/60 (8%)     1/50 (2%)           2/50 (4%)     3/60 (5%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 10/160 (6.25%)  Mean 6.11%   SD 3.56%     Total 6/210 (2.86%)    Mean 2.75%   SD 2.22%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      7/50 (14%)    5/60 (8%)     2/50 (4%)           2/50 (4%)     3/60 (5%)     2/50 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous                                                   3/50 (6%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 14/160 (8.75%)  Mean 8.78%   SD 5.01%     Total 10/210 (4.76%)   Mean 4.75%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         3/50 (6%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 3/160 (1.88%)   Mean 2%      SD 3.46%     Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               3/50 (6%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     2/50 (4%)     |
|      Myxosarcoma, or Fibrous                                                           2/50 (4%)                                 |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 4/160 (2.5%)    Mean 2.67%   SD 3.06%     Total 4/210 (1.9%)     Mean 2%      SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 87
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      (malignant or NOS)                                                                1/50 (2%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant                                                  1/50 (2%)                                 |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Papilloma Squamous                                                                0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 88
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             41/50 (82%)   55/60 (92%)   49/50 (98%)                                                    |
|                                                                                                                                  |
| Overall Incidence               Total 145/160 (90.63%)Mean 90.56%  SD 8.06%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                                                                                                                  |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/50 (0%)     0/56 (0%)     0/49 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
|                                                                                        0/48 (0%)                                 |
| Overall Incidence               Total 0/155 (0%)      Mean 0%      SD 0%        Total 0/201 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/50 (0%)     0/56 (0%)     0/49 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
|                                                                                        1/48 (2%)                                 |
| Overall Incidence               Total 0/155 (0%)      Mean 0%      SD 0%        Total 1/201 (0.5%)     Mean 0.52%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/50 (0%)     0/56 (0%)     0/49 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
|                                                                                        1/48 (2%)                                 |
| Overall Incidence               Total 0/155 (0%)      Mean 0%      SD 0%        Total 1/201 (0.5%)     Mean 0.52%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              4/50 (8%)    10/59 (17%)   11/50 (22%)         12/50 (24%)    9/60 (15%)    6/50 (12%)    |
|                                                                                        2/49 (4%)                                 |
| Overall Incidence               Total 25/159 (15.72%) Mean 15.65%  SD 7.09%     Total 29/209 (13.88%)  Mean 13.77%  SD 8.23%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/50 (2%)     0/59 (0%)     0/50 (0%)           1/50 (2%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        1/49 (2%)                                 |
| Overall Incidence               Total 1/159 (0.63%)   Mean 0.67%   SD 1.15%     Total 3/209 (1.44%)    Mean 1.43%   SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 5/50 (10%)   10/59 (17%)   11/50 (22%)         13/50 (26%)   10/60 (17%)    6/50 (12%)    |
|                                                                                        3/49 (6%)                                 |
| Overall Incidence               Total 26/159 (16.35%) Mean 16.32%  SD 6.02%     Total 32/209 (15.31%)  Mean 15.2%   SD 8.4%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 89
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/59 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 0/159 (0%)      Mean 0%      SD 0%        Total 0/209 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/50 (2%)     1/59 (2%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 2/159 (1.26%)   Mean 1.23%   SD 1.08%     Total 2/209 (0.96%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     1/59 (2%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence               Total 2/159 (1.26%)   Mean 1.23%   SD 1.08%     Total 2/209 (0.96%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|      Papilloma Squamous                                                                0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 90
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.56%   SD 0.96%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.56%   SD 0.96%     Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 0/160 (0%)      Mean 0%      SD 0%        Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 2/210 (0.95%)    Mean 1%      SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       14/50 (28%)   11/60 (18%)    6/50 (12%)    |
|                                                                                       11/50 (22%)                                |
| Overall Incidence                                                               Total 42/210 (20%)     Mean 20.08%  SD 6.7%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 91
 Version: 04/01/02                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 31-JAN-2002
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    14/50 (28%)   11/60 (18%)    6/50 (12%)    |
|                                                                                       11/50 (22%)                                |
| Overall Incidence                                                               Total 42/210 (20%)     Mean 20.08%  SD 6.7%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.5%    SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/210 (0.48%)    Mean 0.42%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/210 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 1/160 (0.63%)   Mean 0.67%   SD 1.15%     Total 1/210 (0.48%)    Mean 0.42%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/50 (2%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 3/160 (1.88%)   Mean 2%      SD 2%        Total 1/210 (0.48%)    Mean 0.42%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 2/50 (4%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     2/60 (3%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence               Total 4/160 (2.5%)    Mean 2.67%   SD 2.31%     Total 2/210 (0.95%)    Mean 0.83%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
