                                                 Toxicology Data Management System                                     Page: 1
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   730       50(1)      38  (707)     53.4     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  055634804  06/19/96   727      100(1)      91  (707)     49.6     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   729       50(1)      40  (703)     53.9     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   730       50(1)      39  (702)     52.5     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   729       49(1)      35  (704)     50.6     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   733       50(1)      40  (705)     46.9     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   727       50(1)      39  (708)     51.4     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   728      100(1)      91  (705)     46.5     TRANS-CINNAMALDEHYDE                       |
|BATTELLE COLUMBUS  050510914  09/24/98   726       50(1)      37  (710)     53.4     TRIETHANOLAMINE                            |
|BATTELLE NORTHWEST 059302606  08/28/97   733       50( )      40  (701)     54.1     DECALIN                                    |
|BATTELLE NORTHWEST 058812404  01/25/96   733       50( )      37  (711)     51.6     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   729       50( )      35  (703)     54.3     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   729       50( )      34  (690)     53.0     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   729       50( )      39  (710)     55.4     VANADIUM PENTOXIDE                         |
|IITRI              058902906  10/05/94   734      100(1)      76  (711)     53.4     MAGNETIC FIELDS (EMF)                      |
|SOUTHERN RESEARCH  059302307  07/25/97   729       50(1)      44  (721)     57.3     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201206  07/29/98   729       50(1)      43  (706)     46.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  050520309  02/20/96   729       60(1)      52  (712)     48.0     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   729       50(1)      46  (722)     47.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   729       50(1)      39  (696)     51.4     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   729       50(5)      39  (709)     62.7     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  055634804  06/19/96   733       99(5)      81  (695)     48.0     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   728       50(5)      37  (699)     61.4     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   729       50(5)      37  (692)     62.9     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   731       50(5)      35  (700)     58.1     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   734       50(5)      42  (717)     46.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   728       50(5)      40  (702)     58.8     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   733      100(5)      84  (711)     46.0     TRANS-CINNAMALDEHYDE                       |
|BATTELLE COLUMBUS  050510914  09/24/98   729       50(1)      35  (692)     62.7     TRIETHANOLAMINE                            |
|BATTELLE NORTHWEST 059302606  08/28/97   735       49( )      37  (708)     61.5     DECALIN                                    |
|BATTELLE NORTHWEST 058812404  01/25/96   735       50( )      42  (713)     54.8     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   731       50( )      39  (718)     59.8     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   731       50( )      36  (702)     54.6     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   731       50( )      38  (692)     58.7     VANADIUM PENTOXIDE                         |
|IITRI              058902906  10/05/94   735      100(5)      70  (702)     59.7     MAGNETIC FIELDS (EMF)                      |
|SOUTHERN RESEARCH  059302307  07/25/97   732       50(5)      42  (717)     64.2     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201206  07/29/98   732       50(5)      46  (720)     38.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  050520309  02/20/96   731       60(5)      52  (708)     46.6     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   732       50(5)      46  (727)     41.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   735       50(5)      34  (674)     59.5     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       34/50 (68%)   40/100(40%)   27/50 (54%)         29/50 (58%)   28/99 (28%)   22/50 (44%)    |
|                                       29/50 (58%)   29/49 (59%)   16/50 (32%)         17/50 (34%)   24/50 (48%)   15/50 (30%)    |
|                                       28/50 (56%)   37/100(37%)   30/50 (60%)         13/50 (26%)   32/100(32%)   24/50 (48%)    |
|                                       32/50 (64%)   29/50 (58%)   30/50 (60%)         28/49 (57%)   25/50 (50%)   25/50 (50%)    |
|                                       32/50 (64%)   31/50 (62%)   54/100(54%)         27/50 (54%)   19/50 (38%)   52/100(52%)    |
|                                       37/50 (74%)   23/50 (46%)   30/60 (50%)         27/50 (54%)   13/50 (26%)   21/60 (35%)    |
|                                       25/50 (50%)   32/50 (64%)                       17/50 (34%)   15/50 (30%)                  |
| Overall Incidence               Total 625/1159 (53.93%Mean 55.51%  SD 10.55%    Total 473/1158 (40.85%)Mean 41.42%  SD 11.13%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)   32/100(32%)   19/50 (38%)         24/50 (48%)   24/99 (24%)   18/50 (36%)    |
|                                       24/50 (48%)   24/49 (49%)   21/50 (42%)         17/50 (34%)   20/50 (40%)   12/50 (24%)    |
|                                       27/50 (54%)   28/100(28%)   28/50 (56%)         12/50 (24%)   46/100(46%)   27/50 (54%)    |
|                                       23/50 (46%)   21/50 (42%)   22/50 (44%)         22/49 (45%)   20/50 (40%)   23/50 (46%)    |
|                                       23/50 (46%)   27/50 (54%)   40/100(40%)         19/50 (38%)   17/50 (34%)   55/100(55%)    |
|                                       23/50 (46%)   20/50 (40%)   26/60 (43%)         17/50 (34%)   12/50 (24%)   16/60 (27%)    |
|                                       14/50 (28%)   29/50 (58%)                        9/50 (18%)   21/50 (42%)                  |
| Overall Incidence               Total 500/1159 (43.14%Mean 44.62%  SD 8.93%     Total 431/1158 (37.22%)Mean 36.64%  SD 10.68%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)   55/100(55%)   39/50 (78%)         39/50 (78%)   45/99 (45%)   32/50 (64%)    |
|                                       38/50 (76%)   40/49 (82%)   32/50 (64%)         29/50 (58%)   34/50 (68%)   23/50 (46%)    |
|                                       40/50 (80%)   57/100(57%)   45/50 (90%)         21/50 (42%)   62/100(62%)   38/50 (76%)    |
|                                       43/50 (86%)   41/50 (82%)   41/50 (82%)         39/49 (80%)   35/50 (70%)   37/50 (74%)    |
|                                       42/50 (84%)   42/50 (84%)   71/100(71%)         39/50 (78%)   32/50 (64%)   78/100(78%)    |
|                                       45/50 (90%)   32/50 (64%)   45/60 (75%)         39/50 (78%)   23/50 (46%)   33/60 (55%)    |
|                                       31/50 (62%)   44/50 (88%)                       21/50 (42%)   31/50 (62%)                  |
| Overall Incidence               Total 868/1159 (74.89%Mean 76.98%  SD 11.18%    Total 730/1158 (63.04%)Mean 63.3%   SD 13.37%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     2/100(2%)     2/50 (4%)           0/50 (0%)     1/99 (1%)     2/50 (4%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     3/100(3%)     1/50 (2%)           0/50 (0%)     4/100(4%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     3/60 (5%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 14/1159 (1.21%) Mean 1.13%   SD 1.42%     Total 17/1158 (1.47%)  Mean 1.4%    SD 1.7%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)     3/100(3%)     0/50 (0%)           4/50 (8%)     0/99 (0%)     3/50 (6%)     |
|                                        6/50 (12%)    3/49 (6%)     3/50 (6%)           1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        7/50 (14%)    2/100(2%)     3/50 (6%)           1/50 (2%)     1/100(1%)     3/50 (6%)     |
|                                        1/50 (2%)     3/50 (6%)     3/50 (6%)           1/49 (2%)     3/50 (6%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     6/100(6%)           1/50 (2%)     2/50 (4%)     2/100(2%)     |
|                                        4/50 (8%)     2/50 (4%)     4/60 (7%)           1/50 (2%)     2/50 (4%)     0/60 (0%)     |
|                                        1/50 (2%)     3/50 (6%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 59/1159 (5.09%) Mean 5.29%   SD 3.43%     Total 29/1158 (2.5%)   Mean 2.75%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 4
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)    5/100(5%)     2/50 (4%)           4/50 (8%)     1/99 (1%)     5/50 (10%)    |
|                                        6/50 (12%)    3/49 (6%)     3/50 (6%)           1/50 (2%)     4/50 (8%)     0/50 (0%)     |
|                                        7/50 (14%)    5/100(5%)     4/50 (8%)           1/50 (2%)     5/100(5%)     4/50 (8%)     |
|                                        1/50 (2%)     3/50 (6%)     4/50 (8%)           2/49 (4%)     4/50 (8%)     1/50 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     6/100(6%)           2/50 (4%)     2/50 (4%)     2/100(2%)     |
|                                        5/50 (10%)    2/50 (4%)     5/60 (8%)           1/50 (2%)     2/50 (4%)     3/60 (5%)     |
|                                        1/50 (2%)     3/50 (6%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 73/1159 (6.3%)  Mean 6.42%   SD 3.28%     Total 46/1158 (3.97%)  Mean 4.15%   SD 2.92%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     2/100(2%)     4/50 (8%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           2/50 (4%)     3/50 (6%)     2/100(2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/60 (2%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 5/1159 (0.43%)  Mean 0.43%   SD 0.8%      Total 18/1158 (1.55%)  Mean 1.6%    SD 2.21%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     4/100(4%)     1/50 (2%)           4/50 (8%)     7/99 (7%)     5/50 (10%)    |
|      Lymphocytic, Mixed, NOS, or       3/50 (6%)     2/49 (4%)     3/50 (6%)           7/50 (14%)    9/50 (18%)    6/50 (12%)    |
|      Undifferentiated Cell Type        1/50 (2%)     8/100(8%)     0/50 (0%)           7/50 (14%)   23/100(23%)    8/50 (16%)    |
|                                        3/50 (6%)     1/50 (2%)     3/50 (6%)          11/49 (22%)    8/50 (16%)   13/50 (26%)    |
|                                        3/50 (6%)     2/50 (4%)     8/100(8%)           5/50 (10%)    7/50 (14%)   32/100(32%)    |
|                                        2/50 (4%)     2/50 (4%)     3/60 (5%)           4/50 (8%)     6/50 (12%)    8/60 (13%)    |
|                                        3/50 (6%)     3/50 (6%)                         3/50 (6%)     7/50 (14%)                  |
| Overall Incidence               Total 58/1159 (5%)    Mean 4.75%   SD 2.07%     Total 180/1158 (15.54%)Mean 14.79%  SD 6.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 5
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     1/100(1%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 7/1158 (0.6%)    Mean 0.6%    SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     1/100(1%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 8/1158 (0.69%)   Mean 0.7%    SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/50 (6%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     5/49 (10%)    0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/99 (2%)     3/50 (6%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        2/49 (4%)     2/50 (4%)     1/48 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        4/49 (8%)     1/50 (2%)     3/99 (3%)           1/50 (2%)     0/50 (0%)     0/92 (0%)     |
|                                        4/50 (8%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     1/59 (2%)     |
|                                        3/49 (6%)     3/49 (6%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 42/1150 (3.65%) Mean 3.86%   SD 2.99%     Total 3/1146 (0.26%)   Mean 0.29%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1150 (0%)     Mean 0%      SD 0%        Total 1/1146 (0.09%)   Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     1/92 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1150 (0%)     Mean 0%      SD 0%        Total 1/1146 (0.09%)   Mean 0.05%   SD 0.24%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/99 (0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     1/49 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/47 (0%)           2/48 (4%)     2/49 (4%)     0/47 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     1/98 (1%)           1/49 (2%)     2/49 (4%)     0/90 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 2/1145 (0.17%)  Mean 0.15%   SD 0.49%     Total 9/1135 (0.79%)   Mean 0.92%   SD 1.56%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/99 (0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/99 (0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/47 (0%)           0/48 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     2/98 (2%)           1/49 (2%)     0/49 (0%)     0/90 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     1/49 (2%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 3/1145 (0.26%)  Mean 0.2%    SD 0.63%     Total 4/1135 (0.35%)   Mean 0.3%    SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/99 (0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|      Complex, Malignant, NOS           0/50 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/99 (0%)     1/50 (2%)           0/50 (0%)     1/99 (1%)     1/49 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/47 (0%)           2/48 (4%)     2/49 (4%)     0/47 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     2/98 (2%)           2/49 (4%)     2/49 (4%)     0/90 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     1/49 (2%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 4/1145 (0.35%)  Mean 0.3%    SD 0.74%     Total 13/1135 (1.15%)  Mean 1.22%   SD 1.65%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      2/50 (4%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/49 (2%)     0/49 (0%)           0/49 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/49 (0%)     1/50 (2%)     0/96 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 10/1154 (0.87%) Mean 1%      SD 1.52%     Total 2/1152 (0.17%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/99 (1%)           0/49 (0%)     0/50 (0%)     0/96 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1154 (0.09%)  Mean 0.05%   SD 0.23%     Total 0/1152 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/49 (0%)     0/50 (0%)     0/96 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/1154 (0.26%)  Mean 0.23%   SD 0.59%     Total 1/1152 (0.09%)   Mean 0.05%   SD 0.22%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 1/1158 (0.09%)   Mean 0.05%   SD 0.23%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 6/1158 (0.52%)   Mean 0.5%    SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 7/1158 (0.6%)    Mean 0.6%    SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1155 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1155 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1155 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1155 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 1/1155 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1155 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 3/1158 (0.26%)   Mean 0.2%    SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 3/1158 (0.26%)   Mean 0.2%    SD 0.52%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.08%   SD 0.37%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/100(1%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/98 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/1157 (0.09%)  Mean 0.05%   SD 0.22%                                                      |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/48 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/40 (0%)     0/46 (0%)     0/49 (0%)           0/39 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/48 (0%)           0/48 (0%)     0/100(0%)     0/48 (0%)     |
|                                        0/42 (0%)     0/43 (0%)     0/38 (0%)           0/41 (0%)     0/46 (0%)     0/40 (0%)     |
|                                        0/39 (0%)     0/42 (0%)     0/84 (0%)           0/40 (0%)     0/46 (0%)     0/70 (0%)     |
|                                        0/48 (0%)     0/46 (0%)     0/54 (0%)           0/44 (0%)     0/49 (0%)     0/54 (0%)     |
|                                        0/49 (0%)     0/44 (0%)                         0/49 (0%)     1/45 (2%)                   |
| Overall Incidence               Total 0/1060 (0%)     Mean 0%      SD 0%        Total 1/1057 (0.09%)   Mean 0.11%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              5/50 (10%)    4/100(4%)     2/50 (4%)          10/50 (20%)    3/99 (3%)     1/50 (2%)     |
|                                        6/50 (12%)    3/49 (6%)     5/50 (10%)          4/50 (8%)     2/50 (4%)     3/50 (6%)     |
|                                        4/50 (8%)     8/100(8%)     7/50 (14%)          0/50 (0%)     2/100(2%)     5/50 (10%)    |
|                                        6/50 (12%)    1/50 (2%)     6/50 (12%)          3/49 (6%)     3/50 (6%)     3/50 (6%)     |
|                                        7/50 (14%)    8/50 (16%)   12/100(12%)          4/50 (8%)     2/50 (4%)    10/100(10%)    |
|                                        7/50 (14%)    9/50 (18%)    4/60 (7%)           7/50 (14%)    3/50 (6%)     4/60 (7%)     |
|                                        3/50 (6%)     4/50 (8%)                         2/50 (4%)     2/50 (4%)                   |
| Overall Incidence               Total 111/1159 (9.58%)Mean 9.84%   SD 4.31%     Total 73/1158 (6.3%)   Mean 6.49%   SD 4.52%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/100(0%)     1/50 (2%)           1/50 (2%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     2/50 (4%)     |
|                                        3/50 (6%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     2/100(2%)     |
|                                        2/50 (4%)     1/50 (2%)     1/60 (2%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)     2/50 (4%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 12/1159 (1.04%) Mean 1.18%   SD 1.76%     Total 15/1158 (1.3%)   Mean 1.29%   SD 1.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)    4/100(4%)     3/50 (6%)          11/50 (22%)    4/99 (4%)     1/50 (2%)     |
|                                        6/50 (12%)    3/49 (6%)     5/50 (10%)          4/50 (8%)     4/50 (8%)     3/50 (6%)     |
|                                        4/50 (8%)     8/100(8%)     7/50 (14%)          0/50 (0%)     3/100(3%)     7/50 (14%)    |
|                                        9/50 (18%)    1/50 (2%)     7/50 (14%)          4/49 (8%)     3/50 (6%)     3/50 (6%)     |
|                                        7/50 (14%)    8/50 (16%)   12/100(12%)          5/50 (10%)    2/50 (4%)    12/100(12%)    |
|                                        9/50 (18%)   10/50 (20%)    5/60 (8%)           7/50 (14%)    4/50 (8%)     5/60 (8%)     |
|                                        3/50 (6%)     6/50 (12%)                        2/50 (4%)     4/50 (8%)                   |
| Overall Incidence               Total 123/1159 (10.61%Mean 11.02%  SD 4.95%     Total 88/1158 (7.6%)   Mean 7.78%   SD 4.98%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1158 (0.09%)  Mean 0.1%    SD 0.45%     Total 1/1154 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1158 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1154 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     3/50 (6%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 4/1158 (0.35%)   Mean 0.4%    SD 1.39%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 2/1158 (0.17%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.91%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.08%   SD 0.37%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     2/100(2%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 8/1159 (0.69%)  Mean 0.65%   SD 1.14%     Total 3/1158 (0.26%)   Mean 0.25%   SD 0.64%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            2/50 (4%)     3/100(3%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     1/49 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    1/100(1%)     3/50 (6%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     1/50 (2%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 27/1159 (2.33%) Mean 2.42%   SD 2.84%     Total 3/1158 (0.26%)   Mean 0.25%   SD 0.64%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/1159 (0.26%)  Mean 0.3%    SD 0.99%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            2/50 (4%)     3/100(3%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     1/49 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    1/100(1%)     3/50 (6%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     1/50 (2%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 28/1159 (2.42%) Mean 2.52%   SD 2.79%     Total 4/1158 (0.35%)   Mean 0.35%   SD 0.75%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 2/50 (4%)     3/100(3%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     3/49 (6%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        5/50 (10%)    1/100(1%)     3/50 (6%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     1/50 (2%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 31/1159 (2.67%) Mean 2.82%   SD 2.83%     Total 5/1158 (0.43%)   Mean 0.45%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.08%   SD 0.37%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    1/50 (2%)     2/100(2%)     2/50 (4%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 10/1159 (0.86%) Mean 0.85%   SD 1.35%     Total 3/1158 (0.26%)   Mean 0.25%   SD 0.64%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/46 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/49 (2%)     3/50 (6%)     2/48 (4%)           1/49 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/48 (0%)     1/50 (2%)     1/99 (1%)           1/49 (2%)     0/50 (0%)     2/87 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/59 (0%)           1/47 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     3/49 (6%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 21/1151 (1.82%) Mean 2.02%   SD 2.34%     Total 8/1134 (0.71%)   Mean 0.73%   SD 1.21%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/46 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     2/99 (2%)           0/49 (0%)     0/50 (0%)     0/87 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/59 (0%)           0/47 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 2/1151 (0.17%)  Mean 0.1%    SD 0.45%     Total 1/1134 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     2/49 (4%)     0/50 (0%)           0/46 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        3/50 (6%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/49 (2%)     3/50 (6%)     2/48 (4%)           1/49 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/48 (0%)     1/50 (2%)     3/99 (3%)           1/49 (2%)     0/50 (0%)     2/87 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/59 (0%)           1/47 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     3/49 (6%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 23/1151 (2%)    Mean 2.12%   SD 2.34%     Total 9/1134 (0.79%)   Mean 0.83%   SD 1.23%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/99 (1%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/58 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     1/49 (2%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 7/1154 (0.61%)  Mean 0.65%   SD 0.94%     Total 0/1144 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/99 (1%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/58 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 3/1154 (0.26%)  Mean 0.25%   SD 0.64%     Total 0/1144 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/99 (2%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/58 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     1/49 (2%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 10/1154 (0.87%) Mean 0.9%    SD 1.21%     Total 0/1144 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/58 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/1154 (0%)     Mean 0%      SD 0%        Total 1/1144 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 2/1152 (0.17%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)     2/100(2%)     0/50 (0%)           2/50 (4%)     0/99 (0%)     2/50 (4%)     |
|                                        2/50 (4%)     1/49 (2%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     4/100(4%)           0/50 (0%)     0/50 (0%)     1/98 (1%)     |
|                                        1/50 (2%)     1/50 (2%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     2/50 (4%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 28/1159 (2.42%) Mean 2.49%   SD 1.44%     Total 6/1152 (0.52%)   Mean 0.55%   SD 1.28%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/100(2%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     3/50 (6%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 16/1159 (1.38%) Mean 1.49%   SD 2.58%     Total 0/1152 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              23/50 (46%)   20/100(20%)   17/50 (34%)         14/50 (28%)    8/99 (8%)    11/50 (22%)    |
|                                       19/50 (38%)   17/49 (35%)    6/50 (12%)          7/50 (14%)    9/50 (18%)    4/50 (8%)     |
|                                       19/50 (38%)   14/100(14%)   19/50 (38%)          9/50 (18%)    7/99 (7%)     9/50 (18%)    |
|                                       22/50 (44%)   17/50 (34%)   18/50 (36%)          7/49 (14%)   12/50 (24%)   14/49 (29%)    |
|                                       23/50 (46%)   15/50 (30%)   30/100(30%)          9/50 (18%)    6/50 (12%)   17/98 (17%)    |
|                                       23/50 (46%)    7/50 (14%)   18/60 (30%)         11/50 (22%)    3/50 (6%)     7/60 (12%)    |
|                                       14/50 (28%)   16/50 (32%)                        6/49 (12%)    9/49 (18%)                  |
| Overall Incidence               Total 357/1159 (30.8%)Mean 32.23%  SD 10.49%    Total 179/1152 (15.54%)Mean 16.28%  SD 6.58%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            14/50 (28%)   13/100(13%)   14/50 (28%)          7/50 (14%)    4/99 (4%)     7/50 (14%)    |
|                                       11/50 (22%)   13/49 (27%)    9/50 (18%)          3/50 (6%)     2/50 (4%)     3/50 (6%)     |
|                                        9/50 (18%)   13/100(13%)   17/50 (34%)          2/50 (4%)     3/99 (3%)     6/50 (12%)    |
|                                       10/50 (20%)   11/50 (22%)    9/50 (18%)          4/49 (8%)     6/50 (12%)    4/49 (8%)     |
|                                       16/50 (32%)   14/50 (28%)   19/100(19%)          6/50 (12%)    6/50 (12%)    6/98 (6%)     |
|                                        8/50 (16%)    4/50 (8%)    12/60 (20%)          3/50 (6%)     2/50 (4%)     2/60 (3%)     |
|                                        8/50 (16%)   23/50 (46%)                        3/49 (6%)     8/49 (16%)                  |
| Overall Incidence               Total 247/1159 (21.31%Mean 22.28%  SD 8.71%     Total 87/1152 (7.55%)  Mean 8.07%   SD 4.2%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         14/50 (28%)   13/100(13%)   14/50 (28%)          7/50 (14%)    4/99 (4%)     7/50 (14%)    |
|      Hepatoblastoma                   12/50 (24%)   14/49 (29%)    9/50 (18%)          3/50 (6%)     2/50 (4%)     3/50 (6%)     |
|                                       12/50 (24%)   13/100(13%)   18/50 (36%)          2/50 (4%)     3/99 (3%)     6/50 (12%)    |
|                                       10/50 (20%)   11/50 (22%)    9/50 (18%)          4/49 (8%)     6/50 (12%)    4/49 (8%)     |
|                                       16/50 (32%)   14/50 (28%)   21/100(21%)          6/50 (12%)    6/50 (12%)    6/98 (6%)     |
|                                       10/50 (20%)    4/50 (8%)    13/60 (22%)          3/50 (6%)     2/50 (4%)     2/60 (3%)     |
|                                        8/50 (16%)   24/50 (48%)                        3/49 (6%)     8/49 (16%)                  |
| Overall Incidence               Total 259/1159 (22.35%Mean 23.36%  SD 8.97%     Total 87/1152 (7.55%)  Mean 8.07%   SD 4.2%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         32/50 (64%)   28/100(28%)   29/50 (58%)         20/50 (40%)   12/99 (12%)   17/50 (34%)    |
|      Hepatocellular Adenoma           23/50 (46%)   24/49 (49%)   15/50 (30%)         10/50 (20%)   10/50 (20%)    6/50 (12%)    |
|                                       24/50 (48%)   26/100(26%)   33/50 (66%)         10/50 (20%)    9/99 (9%)    12/50 (24%)    |
|                                       28/50 (56%)   26/50 (52%)   25/50 (50%)         11/49 (22%)   18/50 (36%)   18/49 (37%)    |
|                                       34/50 (68%)   26/50 (52%)   46/100(46%)         13/50 (26%)   12/50 (24%)   22/98 (22%)    |
|                                       31/50 (62%)   10/50 (20%)   27/60 (45%)         13/50 (26%)    4/50 (8%)     9/60 (15%)    |
|                                       20/50 (40%)   36/50 (72%)                        8/49 (16%)   16/49 (33%)                  |
| Overall Incidence               Total 543/1159 (46.85%Mean 48.9%   SD 14.53%    Total 250/1152 (21.7%) Mean 22.84%  SD 9.39%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           32/50 (64%)   28/100(28%)   29/50 (58%)         20/50 (40%)   12/99 (12%)   17/50 (34%)    |
|      Hepatocellular Adenoma, or       24/50 (48%)   24/49 (49%)   15/50 (30%)         10/50 (20%)   10/50 (20%)    6/50 (12%)    |
|      Hepatoblastoma                   26/50 (52%)   26/100(26%)   33/50 (66%)         10/50 (20%)    9/99 (9%)    12/50 (24%)    |
|                                       28/50 (56%)   26/50 (52%)   25/50 (50%)         11/49 (22%)   18/50 (36%)   18/49 (37%)    |
|                                       34/50 (68%)   26/50 (52%)   47/100(47%)         13/50 (26%)   12/50 (24%)   22/98 (22%)    |
|                                       31/50 (62%)   10/50 (20%)   28/60 (47%)         13/50 (26%)    4/50 (8%)     9/60 (15%)    |
|                                       20/50 (40%)   36/50 (72%)                        8/49 (16%)   16/49 (33%)                  |
| Overall Incidence               Total 548/1159 (47.28%Mean 49.33%  SD 14.5%     Total 250/1152 (21.7%) Mean 22.84%  SD 9.39%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/98 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        2/50 (4%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 3/1159 (0.26%)  Mean 0.3%    SD 0.98%     Total 2/1152 (0.17%)   Mean 0.15%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1152 (0.09%)   Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/95 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1152 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        10/50 (20%)   12/100(12%)    3/50 (6%)           4/50 (8%)     5/99 (5%)     2/50 (4%)     |
|                                       10/50 (20%)    2/49 (4%)     6/50 (12%)          2/50 (4%)     6/50 (12%)    0/50 (0%)     |
|                                       10/50 (20%)    9/100(9%)     6/50 (12%)          1/50 (2%)     3/100(3%)     3/50 (6%)     |
|                                        8/50 (16%)   13/50 (26%)   13/50 (26%)          1/49 (2%)     3/50 (6%)     2/50 (4%)     |
|                                        6/50 (12%)   13/50 (26%)   26/100(26%)          2/50 (4%)     1/50 (2%)     9/95 (9%)     |
|                                       11/50 (22%)   11/50 (22%)    9/60 (15%)          2/49 (4%)     4/50 (8%)     2/60 (3%)     |
|                                        6/50 (12%)   12/50 (24%)                        5/50 (10%)    1/50 (2%)                   |
| Overall Incidence               Total 196/1159 (16.91%Mean 17.1%   SD 7%        Total 58/1152 (5.03%)  Mean 4.95%   SD 3.13%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)     9/100(9%)     3/50 (6%)           2/50 (4%)     6/99 (6%)     2/50 (4%)     |
|                                        5/50 (10%)    4/49 (8%)     7/50 (14%)          1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        4/50 (8%)     7/100(7%)     7/50 (14%)          0/50 (0%)     2/100(2%)     2/50 (4%)     |
|                                        8/50 (16%)    6/50 (12%)    6/50 (12%)          6/49 (12%)    1/50 (2%)     1/50 (2%)     |
|                                        7/50 (14%)   12/50 (24%)    8/100(8%)           0/50 (0%)     0/50 (0%)     2/95 (2%)     |
|                                        9/50 (18%)    6/50 (12%)    5/60 (8%)           0/49 (0%)     0/50 (0%)     3/60 (5%)     |
|                                        2/50 (4%)     7/50 (14%)                        1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 126/1159 (10.87%Mean 11.32%  SD 4.69%     Total 31/1152 (2.69%)  Mean 2.57%   SD 2.9%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)   20/100(20%)    6/50 (12%)          6/50 (12%)   11/99 (11%)    3/50 (6%)     |
|      Alveolar/Bronchiolar Adenoma     14/50 (28%)    6/49 (12%)   13/50 (26%)          3/50 (6%)     6/50 (12%)    0/50 (0%)     |
|                                       13/50 (26%)   14/100(14%)   12/50 (24%)          1/50 (2%)     5/100(5%)     5/50 (10%)    |
|                                       15/50 (30%)   18/50 (36%)   17/50 (34%)          7/49 (14%)    4/50 (8%)     3/50 (6%)     |
|                                       13/50 (26%)   22/50 (44%)   30/100(30%)          2/50 (4%)     1/50 (2%)    11/95 (12%)    |
|                                       19/50 (38%)   14/50 (28%)   14/60 (23%)          2/49 (4%)     4/50 (8%)     5/60 (8%)     |
|                                        8/50 (16%)   18/50 (36%)                        6/50 (12%)    2/50 (4%)                   |
| Overall Incidence               Total 300/1159 (25.88%Mean 26.58%  SD 8.72%     Total 87/1152 (7.55%)  Mean 7.32%   SD 4.03%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/95 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.05%   SD 0.22%     Total 1/1152 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/95 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/49 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1152 (0.09%)   Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.05%   SD 0.22%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           2/50 (4%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.89%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.05%   SD 0.22%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 2/1158 (0.17%)   Mean 0.18%   SD 0.57%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 6/1158 (0.52%)   Mean 0.55%   SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 7/1158 (0.6%)    Mean 0.65%   SD 1.14%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     2/50 (4%)     |
|      or Adenoma                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 7/1158 (0.6%)    Mean 0.65%   SD 1.14%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 1/1158 (0.09%)   Mean 0.05%   SD 0.22%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.05%   SD 0.22%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 2/1158 (0.17%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 4/1158 (0.35%)   Mean 0.35%   SD 0.75%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/96 (0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           1/49 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1153 (0%)     Mean 0%      SD 0%        Total 1/1155 (0.09%)   Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.15%   SD 0.49%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 4/1158 (0.35%)   Mean 0.35%   SD 0.75%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.15%   SD 0.49%     Total 5/1158 (0.43%)   Mean 0.45%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.05%   SD 0.22%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          8/50 (16%)    3/99 (3%)     0/50 (0%)     |
|                                                                                        1/47 (2%)     2/50 (4%)     2/50 (4%)     |
|                                                                                        0/47 (0%)     2/100(2%)     1/50 (2%)     |
|                                                                                        1/49 (2%)     0/47 (0%)     2/50 (4%)     |
|                                                                                        1/49 (2%)     1/48 (2%)     3/79 (4%)     |
|                                                                                        1/49 (2%)     0/50 (0%)     1/59 (2%)     |
|                                                                                        3/48 (6%)     1/49 (2%)                   |
| Overall Incidence                                                               Total 33/1120 (2.95%)  Mean 2.96%   SD 3.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/47 (0%)     1/100(1%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     2/79 (3%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        1/48 (2%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 8/1120 (0.71%)   Mean 0.63%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|      Malignant, NOS                                                                    0/47 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/47 (0%)     1/100(1%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     2/79 (3%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        1/48 (2%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 8/1120 (0.71%)   Mean 0.63%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     2/50 (4%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     1/100(1%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/48 (0%)     0/79 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        1/48 (2%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 6/1120 (0.54%)   Mean 0.56%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     1/100(1%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     1/79 (1%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 2/1120 (0.18%)   Mean 0.11%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     2/100(2%)     1/50 (2%)     |
|                                                                                        1/49 (2%)     0/47 (0%)     2/50 (4%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     1/79 (1%)     |
|                                                                                        1/49 (2%)     0/50 (0%)     2/59 (3%)     |
|                                                                                        0/48 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 11/1120 (0.98%)  Mean 0.89%   SD 1.27%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/48 (0%)     0/79 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 2/1120 (0.18%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/47 (0%)     1/100(1%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)     0/79 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)                   |
| Overall Incidence                                                               Total 1/1120 (0.09%)   Mean 0.05%   SD 0.22%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/46 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/49 (0%)     0/50 (0%)     0/87 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/59 (0%)           0/47 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/1151 (0.09%)  Mean 0.05%   SD 0.22%     Total 0/1134 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/46 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/49 (0%)     0/50 (0%)     0/87 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/59 (0%)           0/47 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 0/1151 (0%)     Mean 0%      SD 0%        Total 1/1134 (0.09%)   Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/98 (0%)     0/49 (0%)           2/48 (4%)     8/97 (8%)     1/49 (2%)     |
|   Adenoma                              0/47 (0%)     0/48 (0%)     0/49 (0%)           2/48 (4%)     2/49 (4%)     3/48 (6%)     |
|                                        0/49 (0%)     0/98 (0%)     0/50 (0%)           1/48 (2%)    11/97 (11%)    8/50 (16%)    |
|                                        1/48 (2%)     0/48 (0%)     0/43 (0%)          13/49 (27%)   10/50 (20%)    9/48 (19%)    |
|                                        0/49 (0%)     1/50 (2%)     0/83 (0%)          10/47 (21%)    8/49 (16%)   17/83 (20%)    |
|                                        0/48 (0%)     0/49 (0%)     1/53 (2%)           2/46 (4%)     1/50 (2%)     3/58 (5%)     |
|                                        0/46 (0%)     1/49 (2%)                         0/45 (0%)     5/48 (10%)                  |
| Overall Incidence               Total 4/1103 (0.36%)  Mean 0.4%    SD 0.82%     Total 116/1107 (10.48%)Mean 10.18%  SD 8.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/98 (0%)     0/49 (0%)           0/48 (0%)     0/97 (0%)     0/49 (0%)     |
|   Carcinoma                            0/47 (0%)     0/48 (0%)     0/49 (0%)           0/48 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/98 (0%)     0/50 (0%)           0/48 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/48 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/83 (0%)           0/47 (0%)     0/49 (0%)     0/83 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/53 (0%)           0/46 (0%)     0/50 (0%)     0/58 (0%)     |
|                                        0/46 (0%)     0/49 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 1/1103 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1107 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/98 (0%)     0/49 (0%)           2/48 (4%)     8/97 (8%)     1/49 (2%)     |
|   Carcinoma or Adenoma                 0/47 (0%)     0/48 (0%)     0/49 (0%)           2/48 (4%)     2/49 (4%)     3/48 (6%)     |
|                                        0/49 (0%)     0/98 (0%)     0/50 (0%)           1/48 (2%)    11/97 (11%)    8/50 (16%)    |
|                                        1/48 (2%)     0/48 (0%)     0/43 (0%)          13/49 (27%)   10/50 (20%)    9/48 (19%)    |
|                                        0/49 (0%)     2/50 (4%)     0/83 (0%)          10/47 (21%)    8/49 (16%)   17/83 (20%)    |
|                                        0/48 (0%)     0/49 (0%)     1/53 (2%)           2/46 (4%)     1/50 (2%)     3/58 (5%)     |
|                                        0/46 (0%)     1/49 (2%)                         0/45 (0%)     5/48 (10%)                  |
| Overall Incidence               Total 5/1103 (0.45%)  Mean 0.5%    SD 1.1%      Total 116/1107 (10.48%)Mean 10.18%  SD 8.04%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/49 (2%)     0/98 (0%)     1/49 (2%)           0/48 (0%)     2/97 (2%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/49 (0%)           0/48 (0%)     2/49 (4%)     1/48 (2%)     |
|                                        0/49 (0%)     1/98 (1%)     1/50 (2%)           0/48 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/48 (0%)     0/43 (0%)           1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/83 (0%)           0/47 (0%)     0/49 (0%)     1/83 (1%)     |
|                                        0/48 (0%)     0/49 (0%)     0/53 (0%)           2/46 (4%)     0/50 (0%)     0/58 (0%)     |
|                                        0/46 (0%)     0/49 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 4/1103 (0.36%)  Mean 0.36%   SD 0.76%     Total 9/1107 (0.81%)   Mean 0.79%   SD 1.4%      |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/49 (2%)     0/98 (0%)     1/49 (2%)           0/48 (0%)     2/97 (2%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/49 (0%)           0/48 (0%)     2/49 (4%)     1/48 (2%)     |
|                                        0/49 (0%)     1/98 (1%)     1/50 (2%)           0/48 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/48 (0%)     0/43 (0%)           1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/83 (0%)           0/47 (0%)     0/49 (0%)     1/83 (1%)     |
|                                        0/48 (0%)     0/49 (0%)     0/53 (0%)           2/46 (4%)     0/50 (0%)     0/58 (0%)     |
|                                        0/46 (0%)     0/49 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 4/1103 (0.36%)  Mean 0.36%   SD 0.76%     Total 9/1107 (0.81%)   Mean 0.79%   SD 1.4%      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/48 (0%)     0/50 (0%)     1/49 (2%)                                                     |
|                                        0/46 (0%)     0/50 (0%)     0/98 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/1148 (0.09%)  Mean 0.1%    SD 0.46%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/48 (0%)     0/50 (0%)     1/49 (2%)                                                     |
|                                        0/46 (0%)     0/50 (0%)     0/98 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/1148 (0.09%)  Mean 0.1%    SD 0.46%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/48 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/46 (0%)     0/50 (0%)     0/98 (0%)                                                     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/1148 (0.09%)  Mean 0.1%    SD 0.46%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/49 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     1/94 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1158 (0%)     Mean 0%      SD 0%        Total 1/1140 (0.09%)   Mean 0.05%   SD 0.24%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/49 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     1/94 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1158 (0%)     Mean 0%      SD 0%        Total 1/1140 (0.09%)   Mean 0.05%   SD 0.24%     |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%                                                      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.08%   SD 0.37%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     3/100(3%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 5/1158 (0.43%)   Mean 0.3%    SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     3/100(3%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 5/1158 (0.43%)   Mean 0.3%    SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     2/50 (4%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           5/50 (10%)    0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 9/1158 (0.78%)   Mean 0.85%   SD 2.37%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 3/1158 (0.26%)   Mean 0.3%    SD 0.73%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 3/1158 (0.26%)   Mean 0.3%    SD 0.73%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.05%   SD 0.22%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.05%   SD 0.22%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/49 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 2/1158 (0.17%)   Mean 0.15%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     1/49 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|      Papilloma, Sq Papilloma,          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Keratoacanthoma,                  0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|      Trichoepithelioma                 2/50 (4%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/1159 (0.43%)  Mean 0.45%   SD 1.05%     Total 4/1158 (0.35%)   Mean 0.3%    SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/1159 (0.35%)  Mean 0.25%   SD 0.64%     Total 3/1158 (0.26%)   Mean 0.2%    SD 0.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/100(0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/60 (0%)           1/50 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 4/1159 (0.35%)  Mean 0.4%    SD 0.82%     Total 9/1158 (0.78%)   Mean 0.9%    SD 1.21%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.05%   SD 0.22%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|      Carcinoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 2/1158 (0.17%)   Mean 0.1%    SD 0.31%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/1159 (0.26%)  Mean 0.25%   SD 0.64%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/1159 (0.26%)  Mean 0.25%   SD 0.64%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/1159 (0.43%)  Mean 0.45%   SD 1.05%     Total 2/1158 (0.17%)   Mean 0.15%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 5/1159 (0.43%)  Mean 0.45%   SD 1.05%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     1/100(1%)     0/50 (0%)           3/50 (6%)     2/99 (2%)     3/50 (6%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     0/49 (0%)     0/50 (0%)           3/50 (6%)     2/50 (4%)     1/50 (2%)     |
|      Histiocytoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     4/100(4%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           1/50 (2%)     2/50 (4%)     4/100(4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         2/50 (4%)     3/50 (6%)                   |
| Overall Incidence               Total 3/1159 (0.26%)  Mean 0.25%   SD 0.64%     Total 36/1158 (3.11%)  Mean 3.09%   SD 2.01%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     1/100(1%)     0/50 (0%)           2/50 (4%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     4/100(4%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.05%   SD 0.22%     Total 10/1158 (0.86%)  Mean 0.8%    SD 1.51%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     1/100(1%)     0/50 (0%)           3/50 (6%)     2/99 (2%)     3/50 (6%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/49 (0%)     0/50 (0%)           3/50 (6%)     2/50 (4%)     1/50 (2%)     |
|      Histiocytoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     4/100(4%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           1/50 (2%)     2/50 (4%)     4/100(4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         2/50 (4%)     3/50 (6%)                   |
| Overall Incidence               Total 3/1159 (0.26%)  Mean 0.25%   SD 0.64%     Total 36/1158 (3.11%)  Mean 3.09%   SD 2.01%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     2/100(2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 7/1158 (0.6%)    Mean 0.5%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|      or NOS)                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     2/100(2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 7/1158 (0.6%)    Mean 0.5%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     2/99 (2%)     3/50 (6%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           3/50 (6%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           1/50 (2%)     2/50 (4%)     4/100(4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     3/50 (6%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 25/1158 (2.16%)  Mean 2.19%   SD 2.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     2/100(2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 7/1158 (0.6%)    Mean 0.5%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     1/49 (2%)           0/49 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/49 (0%)     0/50 (0%)     0/91 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/60 (2%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 2/1150 (0.17%)  Mean 0.19%   SD 0.57%     Total 0/1134 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     1/49 (2%)     1/50 (2%)           0/47 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        3/50 (6%)     1/100(1%)     2/49 (4%)           0/49 (0%)     0/97 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     2/50 (4%)     2/48 (4%)           1/49 (2%)     1/50 (2%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     2/99 (2%)           1/49 (2%)     2/50 (4%)     0/91 (0%)     |
|                                        2/49 (4%)     1/50 (2%)     2/60 (3%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     1/49 (2%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 21/1150 (1.83%) Mean 1.94%   SD 1.84%     Total 8/1134 (0.71%)   Mean 0.8%    SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/49 (0%)           0/49 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/49 (0%)     0/50 (0%)     0/91 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/1150 (0.09%)  Mean 0.05%   SD 0.22%     Total 0/1134 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/49 (0%)           0/49 (0%)     0/97 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/49 (0%)     0/50 (0%)     1/91 (1%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/1150 (0%)     Mean 0%      SD 0%        Total 1/1134 (0.09%)   Mean 0.05%   SD 0.25%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.08%   SD 0.37%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           3/50 (6%)     0/100(0%)     1/50 (2%)           3/50 (6%)     1/99 (1%)     2/50 (4%)     |
|      Papilloma Squamous                0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)     1/50 (2%)           1/50 (2%)     1/100(1%)     2/50 (4%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/100(0%)           0/50 (0%)     2/50 (4%)     1/100(1%)     |
|                                        2/50 (4%)     0/50 (0%)     0/60 (0%)           2/50 (4%)     2/50 (4%)     1/60 (2%)     |
|                                        1/50 (2%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 15/1159 (1.29%) Mean 1.5%    SD 1.82%     Total 19/1158 (1.64%)  Mean 1.73%   SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              3/50 (6%)     0/100(0%)     0/50 (0%)           3/50 (6%)     1/99 (1%)     2/50 (4%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)     1/50 (2%)           1/50 (2%)     1/100(1%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/100(0%)           0/50 (0%)     2/50 (4%)     1/100(1%)     |
|                                        2/50 (4%)     0/50 (0%)     0/60 (0%)           2/50 (4%)     2/50 (4%)     1/60 (2%)     |
|                                        1/50 (2%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 13/1159 (1.12%) Mean 1.3%    SD 1.75%     Total 18/1158 (1.55%)  Mean 1.63%   SD 1.95%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     1/100(1%)     3/50 (6%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     1/100(1%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     2/50 (4%)     2/50 (4%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     1/99 (1%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 13/1158 (1.12%) Mean 1.15%   SD 1.73%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 2/1158 (0.17%)  Mean 0.15%   SD 0.49%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/100(1%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 2/1158 (0.17%)  Mean 0.15%   SD 0.49%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|      Malignant, NOS                    0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/1158 (0.09%)  Mean 0.1%    SD 0.45%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/1158 (0.09%)  Mean 0.1%    SD 0.45%                                                      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/99 (0%)     0/46 (0%)           0/50 (0%)     0/95 (0%)     1/49 (2%)     |
|                                        0/40 (0%)     0/40 (0%)     0/45 (0%)           0/43 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/37 (0%)     0/87 (0%)     0/48 (0%)           0/46 (0%)     0/93 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/35 (0%)     0/40 (0%)           0/48 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/41 (0%)     0/35 (0%)     0/69 (0%)           0/43 (0%)     0/44 (0%)     0/78 (0%)     |
|                                        0/44 (0%)     0/47 (0%)     0/57 (0%)           0/44 (0%)     0/50 (0%)     0/57 (0%)     |
|                                        0/47 (0%)     0/42 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/990 (0%)      Mean 0%      SD 0%        Total 1/1074 (0.09%)   Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/99 (0%)     0/46 (0%)           0/50 (0%)     0/95 (0%)     0/49 (0%)     |
|                                        0/40 (0%)     0/40 (0%)     0/45 (0%)           0/43 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/37 (0%)     0/87 (0%)     0/48 (0%)           1/46 (2%)     0/93 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/35 (0%)     0/40 (0%)           0/48 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/41 (0%)     0/35 (0%)     0/69 (0%)           0/43 (0%)     0/44 (0%)     1/78 (1%)     |
|                                        0/44 (0%)     0/47 (0%)     0/57 (0%)           0/44 (0%)     0/50 (0%)     0/57 (0%)     |
|                                        0/47 (0%)     0/42 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/990 (0%)      Mean 0%      SD 0%        Total 2/1074 (0.19%)   Mean 0.17%   SD 0.55%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/99 (0%)     0/46 (0%)           0/50 (0%)     0/95 (0%)     0/49 (0%)     |
|                                        0/40 (0%)     0/40 (0%)     0/45 (0%)           0/43 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/37 (0%)     0/87 (0%)     0/48 (0%)           1/46 (2%)     0/93 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/35 (0%)     0/40 (0%)           0/48 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/41 (0%)     0/35 (0%)     0/69 (0%)           0/43 (0%)     0/44 (0%)     1/78 (1%)     |
|                                        0/44 (0%)     0/47 (0%)     0/57 (0%)           0/44 (0%)     0/50 (0%)     0/57 (0%)     |
|                                        0/47 (0%)     0/42 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/990 (0%)      Mean 0%      SD 0%        Total 2/1074 (0.19%)   Mean 0.17%   SD 0.55%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)     0/50 (0%)           0/49 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     1/99 (1%)           0/50 (0%)     0/50 (0%)     2/92 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/1143 (0.09%)  Mean 0.05%   SD 0.23%     Total 2/1135 (0.18%)   Mean 0.11%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     1/49 (2%)     0/50 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)     0/50 (0%)           0/49 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/1143 (0.09%)  Mean 0.1%    SD 0.46%     Total 0/1135 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     1/49 (2%)     0/50 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)     0/50 (0%)           0/49 (0%)     0/98 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/1143 (0.09%)  Mean 0.1%    SD 0.46%     Total 0/1135 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/100(1%)     0/50 (0%)           2/50 (4%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     1/50 (2%)           0/46 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     1/99 (1%)     1/50 (2%)           0/49 (0%)     1/98 (1%)     0/50 (0%)     |
|                                        0/48 (0%)     0/47 (0%)     1/48 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/49 (2%)     0/48 (0%)     0/99 (0%)           2/50 (4%)     0/50 (0%)     0/92 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/59 (2%)           1/49 (2%)     1/49 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 8/1143 (0.7%)   Mean 0.69%   SD 0.91%     Total 10/1135 (0.88%)  Mean 0.96%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     1/49 (2%)     0/50 (0%)           0/46 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/99 (0%)     0/50 (0%)           0/49 (0%)     0/98 (0%)     1/50 (2%)     |
|                                        0/48 (0%)     1/47 (2%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/92 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 2/1143 (0.17%)  Mean 0.21%   SD 0.64%     Total 1/1135 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     1/100(1%)     0/50 (0%)           2/50 (4%)     0/97 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     1/49 (2%)     1/50 (2%)           0/46 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     1/99 (1%)     1/50 (2%)           0/49 (0%)     1/98 (1%)     1/50 (2%)     |
|                                        0/48 (0%)     1/47 (2%)     1/48 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/49 (2%)     0/48 (0%)     0/99 (0%)           2/50 (4%)     0/50 (0%)     0/92 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/59 (2%)           1/49 (2%)     1/49 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 10/1143 (0.87%) Mean 0.9%    SD 0.97%     Total 11/1135 (0.97%)  Mean 1.06%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.05%   SD 0.22%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/60 (3%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.17%   SD 0.75%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 3/1158 (0.26%)   Mean 0.25%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/99 (1%)     1/50 (2%)     |
|      Papilloma Squamous                0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 3/1158 (0.26%)   Mean 0.25%   SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/49 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1159 (0.17%)  Mean 0.2%    SD 0.62%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/43 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/48 (2%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/98 (0%)           0/48 (0%)     0/48 (0%)     0/79 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1152 (0.17%)  Mean 0.2%    SD 0.63%     Total 0/1120 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/43 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/98 (0%)           0/48 (0%)     0/48 (0%)     0/79 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1152 (0%)     Mean 0%      SD 0%        Total 1/1120 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/43 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/48 (2%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/98 (0%)           0/48 (0%)     0/48 (0%)     0/79 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/1152 (0.17%)  Mean 0.2%    SD 0.63%     Total 0/1120 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/43 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/98 (0%)           0/48 (0%)     0/48 (0%)     0/79 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/1152 (0%)     Mean 0%      SD 0%        Total 1/1120 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 2/1158 (0.17%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/1158 (0.09%)   Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/1158 (0.17%)   Mean 0.13%   SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/1158 (0.17%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/1158 (0.17%)   Mean 0.15%   SD 0.49%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     2/99 (2%)     0/50 (0%)     |
|                                                                                        3/50 (6%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     1/100(1%)     1/50 (2%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/50 (4%)     2/50 (4%)     1/100(1%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     2/60 (3%)     |
|                                                                                        3/50 (6%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 18/1158 (1.55%)  Mean 1.57%   SD 2.05%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/1158 (0.17%)   Mean 0.2%    SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 3/1158 (0.26%)   Mean 0.3%    SD 0.73%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 02/27/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 27-FEB-2003
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     2/99 (2%)     0/50 (0%)     |
|                                                                                        3/50 (6%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     1/100(1%)     1/50 (2%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        3/50 (6%)     2/50 (4%)     1/100(1%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     2/60 (3%)     |
|                                                                                        3/50 (6%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 21/1158 (1.81%)  Mean 1.87%   SD 2.15%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 0/1158 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/1159 (0%)     Mean 0%      SD 0%        Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/99 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/1159 (0.09%)  Mean 0.1%    SD 0.45%     Total 1/1158 (0.09%)   Mean 0.1%    SD 0.45%     |
 __________________________________________________________________________________________________________________________________
