                                                 Toxicology Data Management System                                     Page: 1
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                    Date of
 Species: RATS                                           Vehicle: CORN OIL                                Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302306  07/11/97   729       50(3)      37  (693)    510.6     2,4-HEXADIENAL                             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302306  07/11/97   732       50(5)      37  (699)    314.6     2,4-HEXADIENAL                             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                    Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                        Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  050516105  03/06/96   729       50(5)      33  (683)    322.1     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                    Date of
 Species: RATS                                           Vehicle: WATER                                   Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058812206  06/25/97   727       50(3)      26  (667)    483.6     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805005  10/30/95   729       50(3)      25  (665)    488.4     METHACRYLONITRILE                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058812206  06/25/97   728       50(5)      30  (672)    327.2     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805005  10/30/95   731       50(5)      38  (710)    315.4     METHACRYLONITRILE                          |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 4
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                Date of
 Species: RATS                                           Vehicle: AIR                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302607  08/14/97   733       50( )      28  (684)    506.2     DECALIN                                    |
|BATTELLE NORTHWEST 058812403  01/18/96   733       50( )      27  (667)    501.0     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   733       49( )      24  (681)    507.1     NAPHTHALENE                                |
|BATTELLE NORTHWEST 059000407  10/06/97   729       50( )      27  (675)    540.3     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600105  01/18/99   729       50( )      29  (701)    534.2     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142707  01/06/97   729       50( )      20  (668)    518.0     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302607  08/14/97   734       50( )      32  (700)    345.9     DECALIN                                    |
|BATTELLE NORTHWEST 058812403  01/18/96   735       50( )      34  (682)    337.2     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   734       49( )      28  (700)    325.2     NAPHTHALENE                                |
|BATTELLE NORTHWEST 059000407  10/06/97   730       50( )      33  (675)    366.9     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600105  01/18/99   730       50( )      36  (696)    362.8     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142707  01/06/97   731       50( )      33  (688)    351.1     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 5
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                           Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902905  09/26/94   736      100(5)      57  (692)    498.3     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902905  09/26/94   737      100(5)      59  (692)    338.0     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 6
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                      Date of
 Species: RATS                                           Vehicle: FEED                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055634803  06/06/96   726       50(3)      30  (687)    492.7     CITRAL                                     |
|BATTELLE COLUMBUS  058812003  12/18/95   729       50(3)      24  (659)    496.8     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  055611103  09/08/97   731       50(3)      29  (699)    492.1     TRANS-CINNAMALDEHYDE                       |
|SOUTHERN RESEARCH  059201205  07/15/98   729       50(3)      35  (704)    446.9     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  050520308  02/08/96   729       60(3)      39  (698)    447.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(3)      31  (697)    443.8     P-NITROTOLUENE                             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055634803  06/06/96   732       50(5)      35  (703)    335.2     CITRAL                                     |
|BATTELLE COLUMBUS  058812003  12/18/95   730       50(5)      36  (694)    330.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  055611103  09/08/97   735       50(5)      34  (702)    344.4     TRANS-CINNAMALDEHYDE                       |
|SOUTHERN RESEARCH  059201205  07/15/98   734       50(5)      40  (707)    320.6     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  050520308  02/08/96   730       60(5)      47  (713)    299.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(5)      39  (702)    295.2     P-NITROTOLUENE                             |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 7
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                      Date of
 Species: RATS                                           Vehicle: WATER                                   Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058803105  03/31/97   729       50(3)      23  (662)    519.6     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058800705  08/14/95   729       50(3)      29  (665)    502.2     SODIUM NITRITE                             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058803105  03/31/97   729       50(5)      30  (683)    350.8     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058800705  08/14/95   730       50(5)      33  (695)    350.1     SODIUM NITRITE                             |
|________________________________________________________________________________________________________________________________|

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 9
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       48/50 (96%)                                     45/50 (90%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    21/50 (42%)                                     18/50 (36%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         50/50 (100%)                                    47/50 (94%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   11/50 (22%)                                     10/50 (20%)                                |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)                                       0/50 (0%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/50 (8%)                                       1/50 (2%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/50 (8%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              7/50 (14%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            7/50 (14%)                                      2/50 (4%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       2/50 (4%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              1/49 (2%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            3/49 (6%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 4/49 (8%)                                       7/50 (14%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              4/50 (8%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 4/50 (8%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)                                       0/50 (0%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)                                       0/50 (0%)                                 |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)                                       0/50 (0%)                                 |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         1/50 (2%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    1/50 (2%)                                       3/50 (6%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            2/50 (4%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         3/50 (6%)                                      22/50 (44%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     3/50 (6%)                                      23/50 (46%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    5/50 (10%)                                     24/50 (48%)                                |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)                                       1/50 (2%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                             10/50 (20%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                10/50 (20%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      12/50 (24%)                                     19/50 (38%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      12/50 (24%)                                     19/50 (38%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              2/49 (4%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 2/49 (4%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         5/50 (10%)                                      1/50 (2%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      3/50 (6%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)                                       1/50 (2%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)                                       1/50 (2%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              4/50 (8%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      7/50 (14%)                                      2/50 (4%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               3/50 (6%)                                       0/50 (0%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             41/50 (82%)                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/50 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              4/50 (8%)                                      12/50 (24%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 5/50 (10%)                                     13/50 (26%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       14/50 (28%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    14/50 (28%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 27
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                                                                       45/50 (90%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                                                                    20/50 (40%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors                                                         47/50 (94%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma                                                        0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                                                                  0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,                                                   12/50 (24%)                                |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,                                                     0/50 (0%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,                                                     0/50 (0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex                                                             0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant                                                           1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,                                                            2/50 (4%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                                                                             0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant                                                        0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign                                                             0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or                                                        0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                                                                              7/49 (14%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                                                                            3/49 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                                                                10/49 (20%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                                                                 0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                                                                    0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                                                                    1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                                                                              2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                                                                 2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                                                                             0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                                                                             0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                                                                               0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma                                                               1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma                                                             0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or                                                          0/50 (0%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or                                                          1/50 (2%)                                 |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,                                                            1/50 (2%)                                 |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma                                                         2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or                                                    2/50 (4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                                                                            2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                                                                 3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                                                                        28/50 (56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma                                                    28/50 (56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,                                                   30/50 (60%)                                |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,                                                             0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                                                                 1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                                                                              0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                                                                      27/50 (54%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                                                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                                                                      27/50 (54%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                                                                                                                        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                                                                                                           |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                                                                               0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                                                                0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous                                                     0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                                                                 1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or                                                              1/50 (2%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell                                                     1/50 (2%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,                                                         1/50 (2%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                                                                               1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                                                                   0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal                                                       1/50 (2%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or                                                           0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,                                                             0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,                                                             0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                                                                    0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,                                                      3/50 (6%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                                                                         1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,                                                               2/50 (4%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                                                                          1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign                                                    0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma                                                      1/50 (2%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,                                                     1/50 (2%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                                                                    0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                                                                 1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                                                                               0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or                                                           0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                                                                               0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                                                                                                                        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                                                                                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                                                                       0/48 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                                                                    1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS                                                      1/48 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                                                                              2/49 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                                                                            1/49 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                                                                 3/49 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                                                                            0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                                                                 0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                                                                         0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or                                                           0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                                                                    0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma                                                               1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                                                                            1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: SODIUM PHOSPHATE                         Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       11/50 (22%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    11/50 (22%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

                                                This page intentionally left blank
                                                 Toxicology Data Management System                                     Page: 45
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       49/50 (98%)   47/50 (94%)                       37/50 (74%)   35/50 (70%)                  |
| Overall Incidence               Total 96/100 (96%)    Mean 96%     SD 2.83%     Total 72/100 (72%)     Mean 72%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)   29/50 (58%)                       12/50 (24%)   26/50 (52%)                  |
| Overall Incidence               Total 58/100 (58%)    Mean 58%     SD 0%        Total 38/100 (38%)     Mean 38%     SD 19.8%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         49/50 (98%)   49/50 (98%)                       42/50 (84%)   45/50 (90%)                  |
| Overall Incidence               Total 98/100 (98%)    Mean 98%     SD 0%        Total 87/100 (87%)     Mean 87%     SD 4.24%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   15/50 (30%)   20/50 (40%)                        7/50 (14%)   21/50 (42%)                  |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 35/100 (35%)    Mean 35%     SD 7.07%     Total 28/100 (28%)     Mean 28%     SD 19.8%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      NOS                                                                                                                         |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     1/50 (2%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              7/50 (14%)    3/50 (6%)                         2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 10/100 (10%)    Mean 10%     SD 5.66%     Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           1/50 (2%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            7/50 (14%)    4/50 (8%)                         3/50 (6%)     1/50 (2%)                   |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 11/100 (11%)    Mean 11%     SD 4.24%     Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              1/50 (2%)     2/50 (4%)                         3/50 (6%)     2/49 (4%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 5/99 (5.05%)     Mean 5.04%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            1/50 (2%)     1/50 (2%)                         0/50 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 2/50 (4%)     3/50 (6%)                         3/50 (6%)     3/49 (6%)                   |
| Overall Incidence               Total 5/100 (5%)      Mean 5%      SD 1.41%     Total 6/99 (6.06%)     Mean 6.06%   SD 0.09%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/49 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/99 (1.01%)     Mean 1.02%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    1/50 (2%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     1/50 (2%)                         1/50 (2%)     1/50 (2%)                   |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)     1/50 (2%)                         1/50 (2%)     1/50 (2%)                   |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         1/50 (2%)     3/50 (6%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)                         1/50 (2%)     3/50 (6%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         2/50 (4%)     2/50 (4%)                        15/50 (30%)   21/50 (42%)                  |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 0%        Total 36/100 (36%)     Mean 36%     SD 8.49%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     4/50 (8%)     2/50 (4%)                        15/50 (30%)   21/50 (42%)                  |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 2.83%     Total 36/100 (36%)     Mean 36%     SD 8.49%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    4/50 (8%)     2/50 (4%)                        16/50 (32%)   23/50 (46%)                  |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 2.83%     Total 39/100 (39%)     Mean 39%     SD 9.9%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     1/50 (2%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     1/50 (2%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     2/50 (4%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     2/50 (4%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/46 (0%)     0/46 (0%)                         1/46 (2%)     1/48 (2%)                   |
| Overall Incidence               Total 0/92 (0%)       Mean 0%      SD 0%        Total 2/94 (2.13%)     Mean 2.13%   SD 0.06%     |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      19/50 (38%)   17/50 (34%)                       21/50 (42%)   12/50 (24%)                  |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 36/100 (36%)    Mean 36%     SD 2.83%     Total 33/100 (33%)     Mean 33%     SD 12.73%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      20/50 (40%)   17/50 (34%)                       21/50 (42%)   13/50 (26%)                  |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 37/100 (37%)    Mean 37%     SD 4.24%     Total 34/100 (34%)     Mean 34%     SD 11.31%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 1/50 (2%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   1/50 (2%)     0/50 (0%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/50 (2%)     0/50 (0%)                         1/50 (2%)     1/50 (2%)                   |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)     0/50 (0%)                         1/50 (2%)     1/50 (2%)                   |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     0/50 (0%)                         1/50 (2%)     1/50 (2%)                   |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         4/50 (8%)     2/50 (4%)                         1/50 (2%)     2/50 (4%)                   |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 2.83%     Total 3/100 (3%)       Mean 3%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      2/50 (4%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/50 (2%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             3/50 (6%)     2/50 (4%)                         0/50 (0%)     1/50 (2%)                   |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 5/100 (5%)      Mean 5%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             3/50 (6%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              1/50 (2%)     3/50 (6%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      3/50 (6%)     3/50 (6%)                         1/50 (2%)     0/50 (0%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             44/50 (88%)   40/50 (80%)                                                                  |
| Overall Incidence               Total 84/100 (84%)    Mean 84%     SD 5.66%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/45 (0%)     0/49 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/94 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/45 (0%)     0/49 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/94 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/45 (0%)     0/49 (0%)                         0/45 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/94 (0%)       Mean 0%      SD 0%        Total 0/93 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              8/50 (16%)    9/50 (18%)                       11/50 (22%)    3/50 (6%)                   |
| Overall Incidence               Total 17/100 (17%)    Mean 17%     SD 1.41%     Total 14/100 (14%)     Mean 14%     SD 11.31%    |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            2/50 (4%)     1/50 (2%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                10/50 (20%)   10/50 (20%)                       11/50 (22%)    5/50 (10%)                  |
| Overall Incidence               Total 20/100 (20%)    Mean 20%     SD 0%        Total 16/100 (16%)     Mean 16%     SD 8.49%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            2/50 (4%)     0/50 (0%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     1/50 (2%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        7/50 (14%)    7/50 (14%)                  |
| Overall Incidence                                                               Total 14/100 (14%)     Mean 14%     SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     7/50 (14%)    7/50 (14%)                  |
| Overall Incidence                                                               Total 14/100 (14%)     Mean 14%     SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 63
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       47/50 (94%)   47/50 (94%)   46/49 (94%)         46/50 (92%)   44/50 (88%)   38/49 (78%)    |
|                                       50/50 (100%)  50/50 (100%)  48/50 (96%)         41/50 (82%)   37/50 (74%)   41/50 (82%)    |
| Overall Incidence               Total 288/299 (96.32%)Mean 96.31%  SD 2.96%     Total 247/299 (82.61%) Mean 82.59%  SD 6.6%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    27/50 (54%)   26/50 (52%)   34/49 (69%)         25/50 (50%)   25/50 (50%)   26/49 (53%)    |
|                                       35/50 (70%)   33/50 (66%)   28/50 (56%)         33/50 (66%)   30/50 (60%)   28/50 (56%)    |
| Overall Incidence               Total 183/299 (61.2%) Mean 61.23%  SD 8.14%     Total 167/299 (55.85%) Mean 55.84%  SD 6.27%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         49/50 (98%)   49/50 (98%)   48/49 (98%)         49/50 (98%)   49/50 (98%)   44/49 (90%)    |
|                                       50/50 (100%)  50/50 (100%)  50/50 (100%)        49/50 (98%)   44/50 (88%)   47/50 (94%)    |
| Overall Incidence               Total 296/299 (99%)   Mean 98.99%  SD 1.1%      Total 282/299 (94.31%) Mean 94.3%   SD 4.5%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 3/299 (1%)       Mean 1.01%   SD 1.7%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   19/50 (38%)   16/50 (32%)   26/49 (53%)         11/50 (22%)   14/50 (28%)   16/49 (33%)    |
|      Mononuclear, or Undifferentiated 33/50 (66%)   25/50 (50%)   22/50 (44%)         24/50 (48%)   26/50 (52%)   21/50 (42%)    |
| Overall Incidence               Total 141/299 (47.16%)Mean 47.18%  SD 12.01%    Total 112/299 (37.46%) Mean 37.44%  SD 11.79%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.68%   SD 1.67%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 64
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/50 (2%)     2/50 (4%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      NOS                               2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.68%   SD 1.65%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              1/50 (2%)     2/50 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/299 (2.01%)   Mean 2%      SD 1.79%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.67%   SD 2.06%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.67%   SD 2.06%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     1/49 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.68%   SD 1.67%     Total 4/296 (1.35%)    Mean 1.36%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/49 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/296 (0.68%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              7/49 (14%)   10/50 (20%)    4/49 (8%)           1/50 (2%)     2/50 (4%)     3/48 (6%)     |
|                                       12/50 (24%)    5/50 (10%)    4/50 (8%)           2/49 (4%)     2/50 (4%)     2/49 (4%)     |
| Overall Incidence               Total 42/298 (14.09%) Mean 14.07%  SD 6.67%     Total 12/296 (4.05%)   Mean 4.07%   SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 65
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/49 (4%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     1/50 (2%)           0/49 (0%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence               Total 7/298 (2.35%)   Mean 2.35%   SD 1.52%     Total 1/296 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            8/49 (16%)   10/50 (20%)    5/49 (10%)          1/50 (2%)     2/50 (4%)     3/48 (6%)     |
|      Complex, Malignant, NOS          14/50 (28%)    6/50 (12%)    5/50 (10%)          2/49 (4%)     3/50 (6%)     2/49 (4%)     |
| Overall Incidence               Total 48/298 (16.11%) Mean 16.09%  SD 7.01%     Total 13/296 (4.39%)   Mean 4.4%    SD 1.56%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.67%   SD 2.06%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.67%   SD 2.06%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 66
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/297 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|      Astrocytoma                       0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/297 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)     3/48 (6%)           8/48 (17%)    5/49 (10%)    4/49 (8%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     2/50 (4%)     |
| Overall Incidence               Total 5/298 (1.68%)   Mean 1.71%   SD 2.43%     Total 20/295 (6.78%)   Mean 6.84%   SD 6.13%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     2/50 (4%)     3/48 (6%)           1/48 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 6/298 (2.01%)   Mean 2.04%   SD 2.61%     Total 4/295 (1.36%)    Mean 1.35%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     3/50 (6%)     6/48 (13%)          9/48 (19%)    5/49 (10%)    4/49 (8%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/49 (2%)     2/50 (4%)     |
| Overall Incidence               Total 11/298 (3.69%)  Mean 3.75%   SD 4.98%     Total 24/295 (8.14%)   Mean 8.19%   SD 5.93%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 67
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 68
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/50 (6%)     1/50 (2%)     2/49 (4%)           1/50 (2%)     1/50 (2%)     1/49 (2%)     |
|                                        4/50 (8%)     3/50 (6%)     1/50 (2%)           0/49 (0%)     1/49 (2%)     1/49 (2%)     |
| Overall Incidence               Total 14/299 (4.68%)  Mean 4.68%   SD 2.42%     Total 5/296 (1.69%)    Mean 1.69%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            4/50 (8%)     2/50 (4%)     4/49 (8%)           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/49 (2%)     0/49 (0%)     1/49 (2%)     |
| Overall Incidence               Total 12/299 (4.01%)  Mean 4.03%   SD 3.39%     Total 4/296 (1.35%)    Mean 1.35%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 7/50 (14%)    3/50 (6%)     6/49 (12%)          2/50 (4%)     1/50 (2%)     2/49 (4%)     |
|                                        4/50 (8%)     4/50 (8%)     2/50 (4%)           1/49 (2%)     1/49 (2%)     2/49 (4%)     |
| Overall Incidence               Total 26/299 (8.7%)   Mean 8.71%   SD 3.77%     Total 9/296 (3.04%)    Mean 3.04%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/50 (2%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/50 (2%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/299 (1%)      Mean 1%      SD 1.1%      Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/296 (0.34%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.33%   SD 1.03%     Total 1/296 (0.34%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/296 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 69
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        3/50 (6%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.34%   SD 2.42%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.34%   SD 0.83%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.34%   SD 0.83%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Hepatocellular Adenoma            3/50 (6%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 5/299 (1.67%)   Mean 1.68%   SD 2.67%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Hepatocellular Adenoma, or        3/50 (6%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/49 (0%)     1/50 (2%)     |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 5/299 (1.67%)   Mean 1.68%   SD 2.67%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         1/50 (2%)     6/50 (12%)    2/49 (4%)           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     4/50 (8%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 14/299 (4.68%)  Mean 4.68%   SD 4.5%      Total 2/297 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 70
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/50 (2%)     1/50 (2%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.33%   SD 1.03%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    2/50 (4%)     7/50 (14%)    2/49 (4%)           2/50 (4%)     1/50 (2%)     1/49 (2%)     |
|      Alveolar/Bronchiolar Adenoma      1/50 (2%)     2/50 (4%)     4/50 (8%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 18/299 (6.02%)  Mean 6.01%   SD 4.37%     Total 4/297 (1.35%)    Mean 1.34%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     1/49 (2%)           5/50 (10%)    0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           5/50 (10%)    4/50 (8%)     2/50 (4%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 19/299 (6.35%)   Mean 6.35%   SD 3.88%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     1/49 (2%)           5/50 (10%)    0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           5/50 (10%)    4/50 (8%)     3/50 (6%)     |
| Overall Incidence               Total 3/299 (1%)      Mean 1.01%   SD 1.68%     Total 20/299 (6.69%)   Mean 6.69%   SD 3.72%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 71
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         2/50 (4%)     2/50 (4%)     0/49 (0%)          25/50 (50%)   20/50 (40%)   17/49 (35%)    |
|                                        2/50 (4%)     3/50 (6%)     2/50 (4%)          25/50 (50%)   19/50 (38%)   16/50 (32%)    |
| Overall Incidence               Total 11/299 (3.68%)  Mean 3.67%   SD 1.97%     Total 122/299 (40.8%)  Mean 40.78%  SD 7.65%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     3/50 (6%)     2/50 (4%)     0/49 (0%)          25/50 (50%)   20/50 (40%)   17/49 (35%)    |
|                                        2/50 (4%)     3/50 (6%)     2/50 (4%)          25/50 (50%)   19/50 (38%)   17/50 (34%)    |
| Overall Incidence               Total 12/299 (4.01%)  Mean 4%      SD 2.19%     Total 123/299 (41.14%) Mean 41.12%  SD 7.22%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    4/50 (8%)     2/50 (4%)     1/49 (2%)          29/50 (58%)   20/50 (40%)   18/49 (37%)    |
|      or Adenoma                        2/50 (4%)     3/50 (6%)     2/50 (4%)          27/50 (54%)   23/50 (46%)   19/50 (38%)    |
| Overall Incidence               Total 14/299 (4.68%)  Mean 4.67%   SD 2.06%     Total 136/299 (45.48%) Mean 45.46%  SD 8.86%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.34%   SD 0.83%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/297 (0.34%)   Mean 0.33%   SD 0.82%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/49 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/297 (0.34%)   Mean 0.33%   SD 0.82%     Total 1/297 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 72
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     1/50 (2%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     1/50 (2%)     0/49 (0%)           3/50 (6%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 3/299 (1%)       Mean 1%      SD 2.45%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)     2/49 (4%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/299 (0.67%)    Mean 0.68%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|      Malignant, NOS                                                                    0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 3/299 (1%)       Mean 1.01%   SD 1.7%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 3/299 (1%)       Mean 1.01%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 73
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/49 (0%)     1/44 (2%)     0/45 (0%)           0/49 (0%)     0/40 (0%)     0/42 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/45 (0%)     |
| Overall Incidence               Total 1/286 (0.35%)   Mean 0.38%   SD 0.93%     Total 0/274 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      27/50 (54%)   36/49 (73%)   31/49 (63%)         34/50 (68%)   30/50 (60%)   23/49 (47%)    |
|   Adenoma                             35/50 (70%)   38/50 (76%)   35/50 (70%)         30/49 (61%)   27/49 (55%)   31/49 (63%)    |
| Overall Incidence               Total 202/298 (67.79%)Mean 67.79%  SD 8%        Total 175/296 (59.12%) Mean 59.09%  SD 7.29%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 74
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     1/49 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma                            0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/298 (0.67%)   Mean 0.67%   SD 1.04%     Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      27/50 (54%)   37/49 (76%)   31/49 (63%)         34/50 (68%)   30/50 (60%)   23/49 (47%)    |
|   Carcinoma or Adenoma                35/50 (70%)   39/50 (78%)   35/50 (70%)         30/49 (61%)   27/49 (55%)   31/49 (63%)    |
| Overall Incidence               Total 204/298 (68.46%)Mean 68.46%  SD 8.74%     Total 175/296 (59.12%) Mean 59.09%  SD 7.29%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 75
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/299 (2.01%)   Mean 2.01%   SD 2.19%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/299 (2.01%)   Mean 2.01%   SD 2.19%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 76
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         3/50 (6%)     2/50 (4%)     4/49 (8%)           1/50 (2%)     1/50 (2%)     1/49 (2%)     |
|      Carcinoma, Basosq. Tumor (M or    2/50 (4%)     1/50 (2%)     5/50 (10%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 17/299 (5.69%)  Mean 5.69%   SD 2.97%     Total 4/299 (1.34%)    Mean 1.34%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/50 (2%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 12/299 (4.01%)  Mean 4.03%   SD 3.39%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/299 (2.34%)   Mean 2.34%   SD 1.5%      Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 77
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     0/49 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.33%   SD 1.03%     Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|      Papilloma                         1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.33%   SD 1.03%     Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|      Papilloma, Squamous Cell          2/50 (4%)     1/50 (2%)     5/50 (10%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 16/299 (5.35%)  Mean 5.36%   SD 3.04%     Total 3/299 (1%)       Mean 1.01%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|      Papilloma, or Keratoacanthoma     2/50 (4%)     1/50 (2%)     5/50 (10%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 16/299 (5.35%)  Mean 5.36%   SD 3.04%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              2/50 (4%)     1/50 (2%)     5/49 (10%)          0/50 (0%)     3/50 (6%)     0/49 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 14/299 (4.68%)  Mean 4.7%    SD 2.81%     Total 5/299 (1.67%)    Mean 1.67%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 78
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      4/50 (8%)     2/50 (4%)     7/49 (14%)          2/50 (4%)     3/50 (6%)     1/49 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   3/50 (6%)     3/50 (6%)     6/50 (12%)          3/50 (6%)     0/50 (0%)     1/50 (2%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 25/299 (8.36%)  Mean 8.38%   SD 3.97%     Total 10/299 (3.34%)   Mean 3.34%   SD 2.42%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         2/50 (4%)     1/50 (2%)     2/49 (4%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.68%   SD 1.05%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               2/50 (4%)     1/50 (2%)     2/49 (4%)           2/50 (4%)     0/50 (0%)     1/49 (2%)     |
|      Myxosarcoma, or Fibrous           1/50 (2%)     1/50 (2%)     4/50 (8%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 11/299 (3.68%)  Mean 3.68%   SD 2.34%     Total 5/299 (1.67%)    Mean 1.67%   SD 1.97%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.63%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 79
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/297 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             40/50 (80%)   40/50 (80%)   38/49 (78%)                                                    |
|                                       41/50 (82%)   41/50 (82%)   36/50 (72%)                                                    |
| Overall Incidence               Total 236/299 (78.93%)Mean 78.93%  SD 3.77%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 80
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/50 (0%)     0/47 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/49 (0%)           0/45 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/280 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/50 (0%)     0/47 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     1/49 (2%)     0/49 (0%)           0/45 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/289 (0.35%)   Mean 0.34%   SD 0.83%     Total 0/280 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/50 (0%)     0/47 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     1/49 (2%)     0/49 (0%)           0/45 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/289 (0.35%)   Mean 0.34%   SD 0.83%     Total 0/280 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              7/50 (14%)    5/49 (10%)    9/46 (20%)          5/50 (10%)    6/47 (13%)    4/47 (9%)     |
|                                        3/50 (6%)     7/50 (14%)    1/50 (2%)           8/49 (16%)    3/49 (6%)     2/50 (4%)     |
| Overall Incidence               Total 32/295 (10.85%) Mean 10.96%  SD 6.29%     Total 28/292 (9.59%)   Mean 9.62%   SD 4.47%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     1/49 (2%)     1/46 (2%)           3/50 (6%)     3/47 (6%)     3/47 (6%)     |
|                                        1/50 (2%)     2/50 (4%)     0/50 (0%)           2/49 (4%)     1/49 (2%)     1/50 (2%)     |
| Overall Incidence               Total 5/295 (1.69%)   Mean 1.7%    SD 1.52%     Total 13/292 (4.45%)   Mean 4.48%   SD 2.09%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 7/50 (14%)    6/49 (12%)   10/46 (22%)          8/50 (16%)    8/47 (17%)    7/47 (15%)    |
|                                        4/50 (8%)     9/50 (18%)    1/50 (2%)           9/49 (18%)    4/49 (8%)     3/50 (6%)     |
| Overall Incidence               Total 37/295 (12.54%) Mean 12.66%  SD 7.05%     Total 39/292 (13.36%)  Mean 13.41%  SD 5.08%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     0/47 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     1/47 (2%)     1/47 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     2/50 (4%)     |
| Overall Incidence               Total 2/295 (0.68%)   Mean 0.67%   SD 1.03%     Total 4/292 (1.37%)    Mean 1.38%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     1/47 (2%)     1/47 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     2/50 (4%)     |
| Overall Incidence               Total 2/295 (0.68%)   Mean 0.67%   SD 1.03%     Total 4/292 (1.37%)    Mean 1.38%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 81
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 1/295 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     0/49 (0%)     1/48 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     1/49 (2%)     1/50 (2%)     |
| Overall Incidence               Total 1/297 (0.34%)   Mean 0.35%   SD 0.85%     Total 3/295 (1.02%)    Mean 1.02%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 82
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 1/295 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     0/49 (0%)     1/48 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/297 (0.34%)   Mean 0.35%   SD 0.85%     Total 2/295 (0.68%)    Mean 0.69%   SD 1.06%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        7/50 (14%)   10/50 (20%)   15/49 (31%)    |
|                                                                                        5/50 (10%)   10/50 (20%)    6/50 (12%)    |
| Overall Incidence                                                               Total 53/299 (17.73%)  Mean 17.77%  SD 7.52%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 83
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: INHALATION                                 Date of
 Species: RATS                                           Vehicle: AIR                                      Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     7/50 (14%)   10/50 (20%)   15/49 (31%)    |
|                                                                                        5/50 (10%)   11/50 (22%)    6/50 (12%)    |
| Overall Incidence                                                               Total 54/299 (18.06%)  Mean 18.1%   SD 7.68%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 6/299 (2.01%)    Mean 2.01%   SD 1.81%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 6/299 (2.01%)    Mean 2.01%   SD 1.81%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 85
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       99/100(99%)                                     92/100(92%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    66/100(66%)                                     40/100(40%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors        100/100(100%)                                    98/100(98%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   50/100(50%)                                     20/100(20%)                                |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/100(0%)                                       0/100(0%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/100(4%)                                       0/100(0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/100(4%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 86
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/99 (0%)                                       6/100(6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/99 (0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/98 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             24/98 (24%)                                      7/96 (7%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/98 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/98 (2%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           26/98 (27%)                                      7/96 (7%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 87
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        2/100(2%)                                       2/100(2%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                             13/100(13%)                                     11/90 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                13/100(13%)                                     11/90 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 88
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/99 (3%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 89
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            1/99 (1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 4/99 (4%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 90
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/100(0%)                                       0/100(0%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          1/100(1%)                                       0/100(0%)                                 |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            1/100(1%)                                       0/100(0%)                                 |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         3/100(3%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    3/100(3%)                                       4/100(4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 91
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         6/100(6%)                                      56/100(56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     6/100(6%)                                      56/100(56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    6/100(6%)                                      58/100(58%)                                |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 92
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/100(0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 93
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              3/98 (3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 3/98 (3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/85 (0%)                                       1/88 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      34/98 (35%)                                     61/99 (62%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/98 (0%)                                       3/99 (3%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      34/98 (35%)                                     64/99 (65%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 94
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 95
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   3/100(3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                3/100(3%)                                       0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     3/100(3%)                                       0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)                                       0/100(0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     3/100(3%)                                       0/100(0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,        14/100(14%)                                      1/100(1%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 96
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                     10/100(10%)                                      1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)                                       0/100(0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/100(1%)                                       0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/100(11%)                                      1/100(1%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 97
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/100(11%)                                      1/100(1%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                             12/100(12%)                                      4/100(4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,     13/100(13%)                                      6/100(6%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/100(1%)                                       2/100(2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/100(0%)                                       0/100(0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/100(0%)                                       0/100(0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 98
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/100(1%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             93/100(93%)                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            1/100(1%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 99
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       2/97 (2%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/97 (0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      2/97 (2%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                             15/99 (15%)                                     15/100(15%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/99 (1%)                                       5/100(5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                16/99 (16%)                                     19/100(19%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/99 (1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/99 (1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 100
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               1/99 (1%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            1/99 (1%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 101
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: MAGNETIC FIELDS                            Date of
 Species: RATS                                           Vehicle: MAGNETIC FIELDS                          Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       13/100(13%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    13/100(13%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 103
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       50/50 (100%)  42/50 (84%)   50/50 (100%)        37/50 (74%)   37/50 (74%)   39/50 (78%)    |
|                                       49/50 (98%)   60/60 (100%)  49/50 (98%)         43/50 (86%)   47/60 (78%)   33/50 (66%)    |
| Overall Incidence               Total 300/310 (96.77%)Mean 96.67%  SD 6.28%     Total 236/310 (76.13%) Mean 76.06%  SD 6.59%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    35/50 (70%)   34/50 (68%)   30/50 (60%)         15/50 (30%)   16/50 (32%)   21/50 (42%)    |
|                                       22/50 (44%)   37/60 (62%)   33/50 (66%)         19/50 (38%)   24/60 (40%)   22/50 (44%)    |
| Overall Incidence               Total 191/310 (61.61%)Mean 61.61%  SD 9.41%     Total 117/310 (37.74%) Mean 37.67%  SD 5.57%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         50/50 (100%)  49/50 (98%)   50/50 (100%)        47/50 (94%)   43/50 (86%)   45/50 (90%)    |
|                                       50/50 (100%)  60/60 (100%)  50/50 (100%)        45/50 (90%)   54/60 (90%)   43/50 (86%)    |
| Overall Incidence               Total 309/310 (99.68%)Mean 99.67%  SD 0.82%     Total 277/310 (89.35%) Mean 89.33%  SD 3.01%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 1%      SD 1.67%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 0.94%   SD 1.04%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/60 (2%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 6/310 (1.94%)   Mean 1.94%   SD 1.27%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.28%   SD 0.68%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   33/50 (66%)   27/50 (54%)   22/50 (44%)         14/50 (28%)    8/50 (16%)    9/50 (18%)    |
|      Mononuclear, or Undifferentiated 15/50 (30%)   30/60 (50%)   24/50 (48%)          6/50 (12%)   21/60 (35%)   13/50 (26%)    |
| Overall Incidence               Total 151/310 (48.71%)Mean 48.67%  SD 11.84%    Total 71/310 (22.9%)   Mean 22.5%   SD 8.62%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.63%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 104
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     2/50 (4%)     2/50 (4%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               2/50 (4%)     2/60 (3%)     5/50 (10%)          0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 16/310 (5.16%)  Mean 5.22%   SD 2.51%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              2/50 (4%)     2/50 (4%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     2/60 (3%)     5/50 (10%)          0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 16/310 (5.16%)  Mean 5.22%   SD 2.51%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.63%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.28%   SD 0.68%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 0.94%   SD 1.64%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           5/50 (10%)    2/60 (3%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 11/310 (3.55%)   Mean 3.56%   SD 3.44%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/307 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              6/50 (12%)    4/50 (8%)     5/50 (10%)          2/49 (4%)     2/50 (4%)     0/50 (0%)     |
|                                        8/50 (16%)    2/60 (3%)     3/50 (6%)           0/49 (0%)     2/60 (3%)     2/49 (4%)     |
| Overall Incidence               Total 28/310 (9.03%)  Mean 9.22%   SD 4.49%     Total 8/307 (2.61%)    Mean 2.58%   SD 2.02%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/307 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 105
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     2/60 (3%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/49 (0%)     |
| Overall Incidence               Total 4/310 (1.29%)   Mean 1.22%   SD 1.91%     Total 1/307 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            7/50 (14%)    6/50 (12%)    5/50 (10%)          2/49 (4%)     2/50 (4%)     1/50 (2%)     |
|      Complex, Malignant, NOS           8/50 (16%)    4/60 (7%)     3/50 (6%)           0/49 (0%)     2/60 (3%)     2/49 (4%)     |
| Overall Incidence               Total 33/310 (10.65%) Mean 10.78%  SD 3.99%     Total 9/307 (2.93%)    Mean 2.92%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.63%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.28%   SD 0.68%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 0.94%   SD 1.64%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 3/310 (0.97%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 106
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|      Astrocytoma                       0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 3/310 (0.97%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              4/50 (8%)     3/50 (6%)     2/50 (4%)           9/49 (18%)    1/47 (2%)     4/49 (8%)     |
|                                        0/50 (0%)     2/60 (3%)     2/50 (4%)           5/50 (10%)   12/59 (20%)    7/50 (14%)    |
| Overall Incidence               Total 13/310 (4.19%)  Mean 4.22%   SD 2.69%     Total 38/304 (12.5%)   Mean 12.17%  SD 6.78%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     3/50 (6%)           0/49 (0%)     0/47 (0%)     3/49 (6%)     |
|                                        0/50 (0%)     2/60 (3%)     2/50 (4%)           3/50 (6%)     2/59 (3%)     2/50 (4%)     |
| Overall Incidence               Total 8/310 (2.58%)   Mean 2.56%   SD 2.36%     Total 10/304 (3.29%)   Mean 3.25%   SD 2.74%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 5/50 (10%)    3/50 (6%)     5/50 (10%)          9/49 (18%)    1/47 (2%)     7/49 (14%)    |
|                                        0/50 (0%)     4/60 (7%)     4/50 (8%)           8/50 (16%)   14/59 (24%)    8/50 (16%)    |
| Overall Incidence               Total 21/310 (6.77%)  Mean 6.78%   SD 3.71%     Total 47/304 (15.46%)  Mean 15.08%  SD 7.15%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/304 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/304 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/304 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/59 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/304 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 107
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.28%   SD 0.68%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 108
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/49 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/60 (3%)     3/50 (6%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
| Overall Incidence               Total 7/309 (2.27%)   Mean 2.23%   SD 2.26%     Total 1/310 (0.32%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/60 (0%)     2/50 (4%)           2/50 (4%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/309 (0.97%)   Mean 1%      SD 1.67%     Total 4/310 (1.29%)    Mean 1.33%   SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/49 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     2/60 (3%)     5/50 (10%)          2/50 (4%)     1/60 (2%)     0/50 (0%)     |
| Overall Incidence               Total 10/309 (3.24%)  Mean 3.23%   SD 3.48%     Total 5/310 (1.61%)    Mean 1.61%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 109
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.03%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/60 (3%)     0/50 (0%)           1/50 (2%)     1/60 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 0.89%   SD 1.44%     Total 2/310 (0.65%)    Mean 0.61%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/310 (1.29%)   Mean 1.28%   SD 1.61%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     1/60 (2%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/310 (1.29%)   Mean 1.28%   SD 1.61%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatocellular Adenoma            0/50 (0%)     3/60 (5%)     1/50 (2%)           1/50 (2%)     1/60 (2%)     0/50 (0%)     |
| Overall Incidence               Total 7/310 (2.26%)   Mean 2.17%   SD 2.04%     Total 2/310 (0.65%)    Mean 0.61%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatocellular Adenoma, or        0/50 (0%)     3/60 (5%)     1/50 (2%)           1/50 (2%)     1/60 (2%)     0/50 (0%)     |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 7/310 (2.26%)   Mean 2.17%   SD 2.04%     Total 2/310 (0.65%)    Mean 0.61%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         2/50 (4%)     2/50 (4%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        2/50 (4%)     1/60 (2%)     1/50 (2%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
| Overall Incidence               Total 10/310 (3.23%)  Mean 3.28%   SD 1.12%     Total 4/310 (1.29%)    Mean 1.28%   SD 1.61%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 110
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 0.94%   SD 1.64%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    2/50 (4%)     2/50 (4%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     3/50 (6%)     |
|      Alveolar/Bronchiolar Adenoma      4/50 (8%)     2/60 (3%)     1/50 (2%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
| Overall Incidence               Total 13/310 (4.19%)  Mean 4.22%   SD 2.01%     Total 5/310 (1.61%)    Mean 1.61%   SD 2.33%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           4/50 (8%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 7/310 (2.26%)    Mean 2.33%   SD 2.94%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           4/50 (8%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 8/310 (2.58%)    Mean 2.67%   SD 3.01%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 111
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         3/50 (6%)     3/50 (6%)     2/50 (4%)          26/50 (52%)   15/50 (30%)   25/50 (50%)    |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)          26/50 (52%)   23/60 (38%)   14/50 (28%)    |
| Overall Incidence               Total 8/310 (2.58%)   Mean 2.67%   SD 3.01%     Total 129/310 (41.61%) Mean 41.72%  SD 11.11%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     4/50 (8%)     3/50 (6%)     2/50 (4%)          26/50 (52%)   16/50 (32%)   25/50 (50%)    |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)          26/50 (52%)   23/60 (38%)   14/50 (28%)    |
| Overall Incidence               Total 9/310 (2.9%)    Mean 3%      SD 3.52%     Total 130/310 (41.94%) Mean 42.06%  SD 10.71%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    4/50 (8%)     3/50 (6%)     2/50 (4%)          26/50 (52%)   16/50 (32%)   26/50 (52%)    |
|      or Adenoma                        0/50 (0%)     0/60 (0%)     0/50 (0%)          28/50 (56%)   23/60 (38%)   14/50 (28%)    |
| Overall Incidence               Total 9/310 (2.9%)    Mean 3%      SD 3.52%     Total 133/310 (42.9%)  Mean 43.06%  SD 11.82%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 112
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.03%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     2/50 (4%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.03%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 113
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/309 (1.29%)   Mean 1.28%   SD 1%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/309 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/60 (2%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/309 (1.62%)   Mean 1.62%   SD 0.8%      Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/48 (0%)     0/46 (0%)     0/47 (0%)           2/43 (5%)     0/45 (0%)     0/47 (0%)     |
|                                        0/47 (0%)     0/58 (0%)     0/48 (0%)           0/49 (0%)     0/57 (0%)     0/46 (0%)     |
| Overall Incidence               Total 0/294 (0%)      Mean 0%      SD 0%        Total 2/287 (0.7%)     Mean 0.78%   SD 1.9%      |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       8/50 (16%)   11/50 (22%)   13/50 (26%)         12/50 (24%)   23/50 (46%)   19/50 (38%)    |
|   Adenoma                              9/50 (18%)   11/59 (19%)   15/48 (31%)         23/50 (46%)   19/59 (32%)   15/50 (30%)    |
| Overall Incidence               Total 67/307 (21.82%) Mean 21.98%  SD 5.74%     Total 111/309 (35.92%) Mean 36.03%  SD 8.93%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 114
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/50 (0%)     0/59 (0%)     1/48 (2%)           2/50 (4%)     0/59 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/307 (0.33%)   Mean 0.35%   SD 0.85%     Total 2/309 (0.65%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       8/50 (16%)   11/50 (22%)   13/50 (26%)         12/50 (24%)   23/50 (46%)   19/50 (38%)    |
|   Carcinoma or Adenoma                 9/50 (18%)   11/59 (19%)   16/48 (33%)         25/50 (50%)   19/59 (32%)   15/50 (30%)    |
| Overall Incidence               Total 68/307 (22.15%) Mean 22.33%  SD 6.44%     Total 113/309 (36.57%) Mean 36.7%   SD 9.91%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/59 (0%)     0/48 (0%)           0/50 (0%)     1/59 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/307 (0.65%)   Mean 0.67%   SD 1.03%     Total 2/309 (0.65%)    Mean 0.62%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/59 (0%)     0/48 (0%)           0/50 (0%)     1/59 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/307 (0.65%)   Mean 0.67%   SD 1.03%     Total 2/309 (0.65%)    Mean 0.62%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     2/60 (3%)     2/50 (4%)                                                     |
| Overall Incidence               Total 4/310 (1.29%)   Mean 1.22%   SD 1.91%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     2/60 (3%)     2/50 (4%)                                                     |
| Overall Incidence               Total 4/310 (1.29%)   Mean 1.22%   SD 1.91%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 1%      SD 1.67%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 115
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/60 (3%)     1/50 (2%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/310 (1.29%)   Mean 1.22%   SD 1.42%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     2/60 (3%)     1/50 (2%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/310 (1.29%)   Mean 1.22%   SD 1.42%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  1/50 (2%)     2/60 (3%)     1/50 (2%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 7/310 (2.26%)   Mean 2.22%   SD 1.38%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 116
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       1/50 (2%)     2/60 (3%)     1/50 (2%)           2/50 (4%)     0/60 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 8/310 (2.58%)   Mean 2.56%   SD 0.89%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         7/50 (14%)    6/50 (12%)    4/50 (8%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    2/50 (4%)     7/60 (12%)    4/50 (8%)           2/50 (4%)     0/60 (0%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 30/310 (9.68%)  Mean 9.61%   SD 3.63%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.63%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.61%   SD 0.95%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      5/50 (10%)    3/50 (6%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     5/60 (8%)     2/50 (4%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 19/310 (6.13%)  Mean 6.06%   SD 2.88%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 4/310 (1.29%)    Mean 1.33%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 117
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 1%      SD 1.1%      Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 1%      SD 1.1%      Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             6/50 (12%)    4/50 (8%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          1/50 (2%)     5/60 (8%)     3/50 (6%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 22/310 (7.1%)   Mean 7.06%   SD 3.31%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             6/50 (12%)    4/50 (8%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     1/50 (2%)     5/60 (8%)     3/50 (6%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 22/310 (7.1%)   Mean 7.06%   SD 3.31%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 1%      SD 1.1%      Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     5/60 (8%)     1/50 (2%)           1/50 (2%)     3/60 (5%)     0/50 (0%)     |
| Overall Incidence               Total 12/310 (3.87%)  Mean 3.72%   SD 2.46%     Total 4/310 (1.29%)    Mean 1.17%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 118
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      4/50 (8%)     4/50 (8%)     5/50 (10%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Myxoma, Myxosarcoma, or Fibrous   2/50 (4%)     5/60 (8%)     2/50 (4%)           1/50 (2%)     3/60 (5%)     2/50 (4%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 22/310 (7.1%)   Mean 7.06%   SD 2.48%     Total 7/310 (2.26%)    Mean 2.17%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         2/50 (4%)     0/50 (0%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 6/310 (1.94%)   Mean 2%      SD 3.35%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               3/50 (6%)     2/50 (4%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     2/50 (4%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 10/310 (3.23%)  Mean 3.33%   SD 3.27%     Total 3/310 (0.97%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 1%      SD 1.1%      Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 119
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             49/50 (98%)   41/50 (82%)   45/50 (90%)                                                    |
|                                       48/50 (96%)   55/60 (92%)   49/50 (98%)                                                    |
| Overall Incidence               Total 287/310 (92.58%)Mean 92.61%  SD 6.16%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 120
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/50 (0%)     0/46 (0%)     0/43 (0%)           0/49 (0%)     0/46 (0%)     0/43 (0%)     |
|                                        0/48 (0%)     0/56 (0%)     0/49 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/292 (0%)      Mean 0%      SD 0%        Total 0/291 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/50 (0%)     0/46 (0%)     0/43 (0%)           0/49 (0%)     0/46 (0%)     1/43 (2%)     |
|                                        0/48 (0%)     0/56 (0%)     0/49 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/292 (0%)      Mean 0%      SD 0%        Total 1/291 (0.34%)    Mean 0.39%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/50 (0%)     0/46 (0%)     0/43 (0%)           0/49 (0%)     0/46 (0%)     1/43 (2%)     |
|                                        0/48 (0%)     0/56 (0%)     0/49 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/292 (0%)      Mean 0%      SD 0%        Total 1/291 (0.34%)    Mean 0.39%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              7/50 (14%)    8/50 (16%)    4/50 (8%)           8/50 (16%)    5/50 (10%)    5/50 (10%)    |
|                                        9/48 (19%)   10/59 (17%)   11/50 (22%)          9/49 (18%)    9/60 (15%)    6/50 (12%)    |
| Overall Incidence               Total 49/307 (15.96%) Mean 15.95%  SD 4.74%     Total 42/309 (13.59%)  Mean 13.56%  SD 3.43%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     3/50 (6%)     |
|                                        1/48 (2%)     0/59 (0%)     0/50 (0%)           0/49 (0%)     1/60 (2%)     0/50 (0%)     |
| Overall Incidence               Total 4/307 (1.3%)    Mean 1.35%   SD 1.64%     Total 6/309 (1.94%)    Mean 1.94%   SD 2.53%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 9/50 (18%)    8/50 (16%)    5/50 (10%)          8/50 (16%)    7/50 (14%)    8/50 (16%)    |
|                                       10/48 (21%)   10/59 (17%)   11/50 (22%)          9/49 (18%)   10/60 (17%)    6/50 (12%)    |
| Overall Incidence               Total 53/307 (17.26%) Mean 17.3%   SD 4.25%     Total 48/309 (15.53%)  Mean 15.51%  SD 2.22%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              3/50 (6%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/48 (2%)     0/59 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/307 (1.63%)   Mean 1.68%   SD 2.34%     Total 1/309 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     1/59 (2%)     0/50 (0%)           1/49 (2%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/307 (0.98%)   Mean 0.95%   SD 1.05%     Total 2/309 (0.65%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 4/50 (8%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/48 (2%)     1/59 (2%)     0/50 (0%)           1/49 (2%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 8/307 (2.61%)   Mean 2.63%   SD 3.02%     Total 3/309 (0.97%)    Mean 1.01%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 121
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.03%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.03%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.28%   SD 0.68%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 122
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.28%   SD 0.68%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       14/50 (28%)   10/50 (20%)    7/50 (14%)    |
|                                                                                        8/50 (16%)   11/60 (18%)    6/50 (12%)    |
| Overall Incidence                                                               Total 56/310 (18.06%)  Mean 18.06%  SD 5.66%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 123
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: FEED                                     Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    14/50 (28%)   11/50 (22%)    7/50 (14%)    |
|                                                                                        8/50 (16%)   11/60 (18%)    6/50 (12%)    |
| Overall Incidence                                                               Total 57/310 (18.39%)  Mean 18.39%  SD 5.85%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/60 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 2/310 (0.65%)    Mean 0.61%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 1%      SD 1.67%     Total 1/310 (0.32%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     2/50 (4%)           0/50 (0%)     2/60 (3%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 1%      SD 1.67%     Total 3/310 (0.97%)    Mean 0.89%   SD 1.44%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 125
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       47/50 (94%)   47/50 (94%)                       44/50 (88%)   42/50 (84%)                  |
| Overall Incidence               Total 94/100 (94%)    Mean 94%     SD 0%        Total 86/100 (86%)     Mean 86%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    35/50 (70%)   30/50 (60%)                       25/50 (50%)   23/50 (46%)                  |
| Overall Incidence               Total 65/100 (65%)    Mean 65%     SD 7.07%     Total 48/100 (48%)     Mean 48%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         49/50 (98%)   49/50 (98%)                       50/50 (100%)  45/50 (90%)                  |
| Overall Incidence               Total 98/100 (98%)    Mean 98%     SD 0%        Total 95/100 (95%)     Mean 95%     SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   16/50 (32%)   17/50 (34%)                       10/50 (20%)   15/50 (30%)                  |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence               Total 33/100 (33%)    Mean 33%     SD 1.41%     Total 25/100 (25%)     Mean 25%     SD 7.07%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     6/50 (12%)    3/50 (6%)                         0/50 (0%)     0/50 (0%)                   |
|      NOS                                                                                                                         |
| Overall Incidence               Total 9/100 (9%)      Mean 9%      SD 4.24%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              6/50 (12%)    3/50 (6%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 9/100 (9%)      Mean 9%      SD 4.24%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 126
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/47 (0%)     0/50 (0%)                         1/49 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 2/99 (2.02%)     Mean 2.02%   SD 0.03%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/47 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       1/47 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/97 (1.03%)    Mean 1.06%   SD 1.5%      Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              4/47 (9%)     6/50 (12%)                        0/49 (0%)     4/50 (8%)                   |
| Overall Incidence               Total 10/97 (10.31%)  Mean 10.26%  SD 2.47%     Total 4/99 (4.04%)     Mean 4%      SD 5.66%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/47 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           5/47 (11%)    1/50 (2%)                         2/49 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 6/97 (6.19%)    Mean 6.32%   SD 6.11%     Total 2/99 (2.02%)     Mean 2.04%   SD 2.89%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            9/47 (19%)    7/50 (14%)                        2/49 (4%)     4/50 (8%)                   |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 16/97 (16.49%)  Mean 16.57%  SD 3.64%     Total 6/99 (6.06%)     Mean 6.04%   SD 2.77%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 127
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Astrocytoma                                                                                                                 |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              3/50 (6%)     0/50 (0%)                         6/48 (13%)    8/46 (17%)                  |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%     Total 14/94 (14.89%)   Mean 14.95%  SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            3/50 (6%)     5/50 (10%)                        5/48 (10%)    2/46 (4%)                   |
| Overall Incidence               Total 8/100 (8%)      Mean 8%      SD 2.83%     Total 7/94 (7.45%)     Mean 7.38%   SD 4.29%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 6/50 (12%)    5/50 (10%)                       10/48 (21%)   10/46 (22%)                  |
| Overall Incidence               Total 11/100 (11%)    Mean 11%     SD 1.41%     Total 20/94 (21.28%)   Mean 21.29%  SD 0.64%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              1/50 (2%)     0/50 (0%)                         0/48 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 128
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/48 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/94 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    2/50 (4%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/44 (5%)     4/50 (8%)                         0/47 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/94 (6.38%)    Mean 6.27%   SD 2.44%     Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 129
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/44 (0%)     1/50 (2%)                         0/47 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/94 (1.06%)    Mean 1%      SD 1.41%     Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/44 (5%)     5/50 (10%)                        0/47 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 7/94 (7.45%)    Mean 7.27%   SD 3.86%     Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/47 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/47 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/47 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/97 (1.03%)    Mean 1.06%   SD 1.5%      Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/47 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/47 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/97 (1.03%)    Mean 1.06%   SD 1.5%      Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/47 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/47 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/47 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     1/47 (2%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/97 (1.03%)    Mean 1.06%   SD 1.5%      Total 0/99 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 130
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         2/50 (4%)     2/50 (4%)                         0/50 (0%)     3/50 (6%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 0%        Total 3/100 (3%)       Mean 3%      SD 4.24%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/50 (2%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    3/50 (6%)     2/50 (4%)                         1/50 (2%)     3/50 (6%)                   |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 5/100 (5%)      Mean 5%      SD 1.41%     Total 4/100 (4%)       Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 131
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         4/50 (8%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 5/100 (5%)       Mean 5%      SD 4.24%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         4/50 (8%)     2/50 (4%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 6/100 (6%)       Mean 6%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         1/50 (2%)     3/50 (6%)                        36/50 (72%)   21/50 (42%)                  |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 57/100 (57%)     Mean 57%     SD 21.21%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     1/50 (2%)     3/50 (6%)                        36/50 (72%)   23/50 (46%)                  |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 59/100 (59%)     Mean 59%     SD 18.38%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    1/50 (2%)     3/50 (6%)                        37/50 (74%)   23/50 (46%)                  |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 60/100 (60%)     Mean 60%     SD 19.8%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 132
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/46 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/46 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/96 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)                         1/50 (2%)     1/50 (2%)                   |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/50 (0%)                   |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 133
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/44 (0%)     0/50 (0%)                         1/47 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/94 (0%)       Mean 0%      SD 0%        Total 1/97 (1.03%)     Mean 1.06%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            1/44 (2%)     0/50 (0%)                         0/47 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/94 (1.06%)    Mean 1.14%   SD 1.61%     Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 1/44 (2%)     0/50 (0%)                         1/47 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/94 (1.06%)    Mean 1.14%   SD 1.61%     Total 1/97 (1.03%)     Mean 1.06%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   2/44 (5%)     0/50 (0%)                         0/47 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/94 (2.13%)    Mean 2.27%   SD 3.21%     Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              1/45 (2%)     0/45 (0%)                         0/49 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 1/90 (1.11%)    Mean 1.11%   SD 1.57%     Total 0/95 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      15/47 (32%)   13/50 (26%)                       20/48 (42%)   24/50 (48%)                  |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 28/97 (28.87%)  Mean 28.96%  SD 4.18%     Total 44/98 (44.9%)    Mean 44.83%  SD 4.48%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/47 (0%)     0/50 (0%)                         1/48 (2%)     0/50 (0%)                   |
|   Carcinoma                                                                                                                      |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 1/98 (1.02%)     Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      15/47 (32%)   13/50 (26%)                       21/48 (44%)   24/50 (48%)                  |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 28/97 (28.87%)  Mean 28.96%  SD 4.18%     Total 45/98 (45.92%)   Mean 45.88%  SD 3.01%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 134
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/47 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/47 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/97 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              1/48 (2%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.04%   SD 1.47%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 1/48 (2%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/98 (1.02%)    Mean 1.04%   SD 1.47%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/99 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 135
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     1/50 (2%)                         0/50 (0%)     1/50 (2%)                   |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     1/50 (2%)                         0/50 (0%)     2/50 (4%)                   |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         1/50 (2%)     3/50 (6%)                         0/50 (0%)     3/50 (6%)                   |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 3/100 (3%)       Mean 3%      SD 4.24%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 136
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/50 (2%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/50 (2%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/100 (2%)      Mean 2%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     1/50 (2%)                         0/50 (0%)     2/50 (4%)                   |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma                                                                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             1/50 (2%)     2/50 (4%)                         0/50 (0%)     1/50 (2%)                   |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 137
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             1/50 (2%)     2/50 (4%)                         0/50 (0%)     0/50 (0%)                   |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              6/50 (12%)    0/50 (0%)                         1/50 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 6/100 (6%)      Mean 6%      SD 8.49%     Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      9/50 (18%)    1/50 (2%)                         1/50 (2%)     1/50 (2%)                   |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 10/100 (10%)    Mean 10%     SD 11.31%    Total 2/100 (2%)       Mean 2%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               3/50 (6%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 138
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              3/50 (6%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/100 (3%)      Mean 3%      SD 4.24%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/43 (0%)     0/50 (0%)                         0/48 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/93 (0%)       Mean 0%      SD 0%        Total 0/98 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     1/50 (2%)                         2/50 (4%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/100 (1%)      Mean 1%      SD 1.41%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             45/50 (90%)   47/50 (94%)                                                                  |
| Overall Incidence               Total 92/100 (92%)    Mean 92%     SD 2.83%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 139
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/39 (0%)     0/50 (0%)                         1/48 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 0/89 (0%)       Mean 0%      SD 0%        Total 1/97 (1.03%)     Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/39 (0%)     0/50 (0%)                         0/48 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/89 (0%)       Mean 0%      SD 0%        Total 0/97 (0%)        Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/39 (0%)     0/50 (0%)                         1/48 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 0/89 (0%)       Mean 0%      SD 0%        Total 1/97 (1.03%)     Mean 1.04%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              4/42 (10%)   12/50 (24%)                        6/45 (13%)    7/50 (14%)                  |
| Overall Incidence               Total 16/92 (17.39%)  Mean 16.76%  SD 10.24%    Total 13/95 (13.68%)   Mean 13.67%  SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            2/42 (5%)     2/50 (4%)                         1/45 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 4/92 (4.35%)    Mean 4.38%   SD 0.54%     Total 3/95 (3.16%)     Mean 3.11%   SD 1.26%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 6/42 (14%)   14/50 (28%)                        7/45 (16%)    9/50 (18%)                  |
| Overall Incidence               Total 20/92 (21.74%)  Mean 21.14%  SD 9.7%      Total 16/95 (16.84%)   Mean 16.78%  SD 1.73%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/42 (2%)     1/50 (2%)                         0/45 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/92 (2.17%)    Mean 2.19%   SD 0.27%     Total 1/95 (1.05%)     Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/42 (0%)     1/50 (2%)                         1/45 (2%)     1/50 (2%)                   |
| Overall Incidence               Total 1/92 (1.09%)    Mean 1%      SD 1.41%     Total 2/95 (2.11%)     Mean 2.11%   SD 0.16%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/42 (2%)     2/50 (4%)                         1/45 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 3/92 (3.26%)    Mean 3.19%   SD 1.14%     Total 3/95 (3.16%)     Mean 3.11%   SD 1.26%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 140
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/46 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/95 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/46 (0%)     1/49 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/95 (1.05%)    Mean 1.02%   SD 1.44%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/46 (0%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/95 (0%)       Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/46 (0%)     1/49 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/95 (1.05%)    Mean 1.02%   SD 1.44%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              1/46 (2%)     0/49 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/95 (1.05%)    Mean 1.09%   SD 1.54%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     2/50 (4%)                   |
| Overall Incidence                                                               Total 2/100 (2%)       Mean 2%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 141
 Version: 03/03/03                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: RATS                                           Vehicle: WATER                                    Input File: 3-MAR-2003 
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        8/50 (16%)    7/50 (14%)                  |
| Overall Incidence                                                               Total 15/100 (15%)     Mean 15%     SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/100 (1%)       Mean 1%      SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     9/50 (18%)    7/50 (14%)                  |
| Overall Incidence                                                               Total 16/100 (16%)     Mean 16%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/100 (0%)      Mean 0%      SD 0%        Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            3/50 (6%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 3/50 (6%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/100 (4%)      Mean 4%      SD 2.83%     Total 0/100 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
