                                                 Toxicology Data Management System                                     Page: 1
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   730       50(1)      38  (707)     53.4     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  058813804  09/14/99   730       50(1)      44  (717)     46.0     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   727      100(1)      91  (707)     49.6     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   729       50(1)      40  (703)     53.9     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   730       50(1)      39  (702)     52.5     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   729       49(1)      35  (704)     50.6     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   733       50(1)      40  (705)     46.9     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   727       50(1)      39  (708)     51.4     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   728      100(1)      91  (705)     46.5     TRANS-CINNAMALDEHYDE                       |
|BATTELLE COLUMBUS  050510914  09/24/98   726       50(1)      37  (710)     53.4     TRIETHANOLAMINE                            |
|BATTELLE NORTHWEST 059302606  08/28/97   733       50( )      40  (701)     54.1     DECALIN                                    |
|BATTELLE NORTHWEST 058812404  01/25/96   733       50( )      37  (711)     51.6     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   729       50( )      35  (703)     54.3     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   729       50( )      34  (690)     53.0     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   729       50( )      39  (710)     55.4     VANADIUM PENTOXIDE                         |
|IITRI              058902906  10/05/94   734      100(1)      76  (711)     53.4     MAGNETIC FIELDS (EMF)                      |
|SOUTHERN RESEARCH  059302307  07/25/97   729       50(1)      44  (721)     57.3     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201206  07/29/98   729       50(1)      43  (706)     46.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601004  09/30/98   729       50(1)      38  (694)     54.1     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  050520309  02/20/96   729       60(1)      52  (712)     48.0     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   729       50(1)      46  (722)     47.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   729       50(1)      39  (696)     51.4     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   729       50(5)      39  (709)     62.7     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  058813804  09/14/99   729       50(5)      40  (706)     46.2     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   733       99(5)      81  (695)     48.0     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   728       50(5)      37  (699)     61.4     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   729       50(5)      37  (692)     62.9     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   731       50(5)      35  (700)     58.1     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   734       50(5)      42  (717)     46.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   728       50(5)      40  (702)     58.8     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   733      100(5)      84  (711)     46.0     TRANS-CINNAMALDEHYDE                       |
|BATTELLE COLUMBUS  050510914  09/24/98   729       50(1)      35  (692)     62.7     TRIETHANOLAMINE                            |
|BATTELLE NORTHWEST 059302606  08/28/97   735       49( )      37  (708)     61.5     DECALIN                                    |
|BATTELLE NORTHWEST 058812404  01/25/96   735       50( )      42  (713)     54.8     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   731       50( )      39  (718)     59.8     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   731       50( )      36  (702)     54.6     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   731       50( )      38  (692)     58.7     VANADIUM PENTOXIDE                         |
|IITRI              058902906  10/05/94   735      100(5)      70  (702)     59.7     MAGNETIC FIELDS (EMF)                      |
|SOUTHERN RESEARCH  059302307  07/25/97   732       50(5)      42  (717)     64.2     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201206  07/29/98   732       50(5)      46  (720)     38.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601004  09/30/98   735       50(5)      36  (691)     66.5     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  050520309  02/20/96   731       60(5)      52  (708)     46.6     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   732       50(5)      46  (727)     41.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   735       50(5)      34  (674)     59.5     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       34/50 (68%)   27/50 (54%)   40/100(40%)         29/50 (58%)   15/50 (30%)   28/99 (28%)    |
|                                       27/50 (54%)   29/50 (58%)   29/49 (59%)         22/50 (44%)   17/50 (34%)   24/50 (48%)    |
|                                       16/50 (32%)   28/50 (56%)   37/100(37%)         15/50 (30%)   13/50 (26%)   32/100(32%)    |
|                                       30/50 (60%)   32/50 (64%)   29/50 (58%)         24/50 (48%)   28/49 (57%)   25/50 (50%)    |
|                                       30/50 (60%)   32/50 (64%)   31/50 (62%)         25/50 (50%)   27/50 (54%)   19/50 (38%)    |
|                                       54/100(54%)   37/50 (74%)   23/50 (46%)         52/100(52%)   27/50 (54%)   13/50 (26%)    |
|                                       34/50 (68%)   30/60 (50%)   25/50 (50%)         38/50 (76%)   21/60 (35%)   17/50 (34%)    |
|                                       32/50 (64%)                                     15/50 (30%)                                |
| Overall Incidence               Total 686/1259 (54.49%Mean 56.01%  SD 10.39%    Total 526/1258 (41.81%)Mean 42.47%  SD 13.19%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)   17/50 (34%)   32/100(32%)         24/50 (48%)   16/50 (32%)   24/99 (24%)    |
|                                       19/50 (38%)   24/50 (48%)   24/49 (49%)         18/50 (36%)   17/50 (34%)   20/50 (40%)    |
|                                       21/50 (42%)   27/50 (54%)   28/100(28%)         12/50 (24%)   12/50 (24%)   46/100(46%)    |
|                                       28/50 (56%)   23/50 (46%)   21/50 (42%)         27/50 (54%)   22/49 (45%)   20/50 (40%)    |
|                                       22/50 (44%)   23/50 (46%)   27/50 (54%)         23/50 (46%)   19/50 (38%)   17/50 (34%)    |
|                                       40/100(40%)   23/50 (46%)   20/50 (40%)         55/100(55%)   17/50 (34%)   12/50 (24%)    |
|                                       29/50 (58%)   26/60 (43%)   14/50 (28%)         33/50 (66%)   16/60 (27%)    9/50 (18%)    |
|                                       29/50 (58%)                                     21/50 (42%)                                |
| Overall Incidence               Total 546/1259 (43.37%Mean 44.74%  SD 9.27%     Total 480/1258 (38.16%)Mean 37.76%  SD 11.99%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)   38/50 (76%)   55/100(55%)         39/50 (78%)   25/50 (50%)   45/99 (45%)    |
|                                       39/50 (78%)   38/50 (76%)   40/49 (82%)         32/50 (64%)   29/50 (58%)   34/50 (68%)    |
|                                       32/50 (64%)   40/50 (80%)   57/100(57%)         23/50 (46%)   21/50 (42%)   62/100(62%)    |
|                                       45/50 (90%)   43/50 (86%)   41/50 (82%)         38/50 (76%)   39/49 (80%)   35/50 (70%)    |
|                                       41/50 (82%)   42/50 (84%)   42/50 (84%)         37/50 (74%)   39/50 (78%)   32/50 (64%)    |
|                                       71/100(71%)   45/50 (90%)   32/50 (64%)         78/100(78%)   39/50 (78%)   23/50 (46%)    |
|                                       45/50 (90%)   45/60 (75%)   31/50 (62%)         47/50 (94%)   33/60 (55%)   21/50 (42%)    |
|                                       44/50 (88%)                                     31/50 (62%)                                |
| Overall Incidence               Total 951/1259 (75.54%Mean 77.53%  SD 11%       Total 802/1258 (63.75%)Mean 64.09%  SD 14.64%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     2/100(2%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        2/50 (4%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     4/100(4%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/49 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           2/50 (4%)     3/60 (5%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 14/1259 (1.11%) Mean 1.03%   SD 1.39%     Total 19/1258 (1.51%)  Mean 1.46%   SD 1.74%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 4
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)     3/50 (6%)     3/100(3%)           4/50 (8%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     6/50 (12%)    3/49 (6%)           3/50 (6%)     1/50 (2%)     2/50 (4%)     |
|                                        3/50 (6%)     7/50 (14%)    2/100(2%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        3/50 (6%)     1/50 (2%)     3/50 (6%)           3/50 (6%)     1/49 (2%)     3/50 (6%)     |
|                                        3/50 (6%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        6/100(6%)     4/50 (8%)     2/50 (4%)           2/100(2%)     1/50 (2%)     2/50 (4%)     |
|                                        1/50 (2%)     4/60 (7%)     1/50 (2%)           3/50 (6%)     0/60 (0%)     1/50 (2%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 63/1259 (5%)    Mean 5.17%   SD 3.34%     Total 33/1258 (2.62%)  Mean 2.87%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)    3/50 (6%)     5/100(5%)           4/50 (8%)     1/50 (2%)     1/99 (1%)     |
|                                        2/50 (4%)     6/50 (12%)    3/49 (6%)           5/50 (10%)    1/50 (2%)     4/50 (8%)     |
|                                        3/50 (6%)     7/50 (14%)    5/100(5%)           0/50 (0%)     1/50 (2%)     5/100(5%)     |
|                                        4/50 (8%)     1/50 (2%)     3/50 (6%)           4/50 (8%)     2/49 (4%)     4/50 (8%)     |
|                                        4/50 (8%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     2/50 (4%)     |
|                                        6/100(6%)     5/50 (10%)    2/50 (4%)           2/100(2%)     1/50 (2%)     2/50 (4%)     |
|                                        1/50 (2%)     5/60 (8%)     1/50 (2%)           5/50 (10%)    3/60 (5%)     2/50 (4%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 77/1259 (6.12%) Mean 6.2%    SD 3.26%     Total 52/1258 (4.13%)  Mean 4.32%   SD 3.09%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           4/50 (8%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     3/50 (6%)     |
|                                        1/100(1%)     0/50 (0%)     1/50 (2%)           2/100(2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     1/60 (2%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 7/1259 (0.56%)  Mean 0.58%   SD 0.89%     Total 18/1258 (1.43%)  Mean 1.45%   SD 2.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     2/50 (4%)     4/100(4%)           4/50 (8%)     8/50 (16%)    7/99 (7%)     |
|      Lymphocytic, Mixed, NOS, or       1/50 (2%)     3/50 (6%)     2/49 (4%)           5/50 (10%)    7/50 (14%)    9/50 (18%)    |
|      Undifferentiated Cell Type        3/50 (6%)     1/50 (2%)     8/100(8%)           6/50 (12%)    7/50 (14%)   23/100(23%)    |
|                                        0/50 (0%)     3/50 (6%)     1/50 (2%)           8/50 (16%)   11/49 (22%)    8/50 (16%)    |
|                                        3/50 (6%)     3/50 (6%)     2/50 (4%)          13/50 (26%)    5/50 (10%)    7/50 (14%)    |
|                                        8/100(8%)     2/50 (4%)     2/50 (4%)          32/100(32%)    4/50 (8%)     6/50 (12%)    |
|                                        3/50 (6%)     3/60 (5%)     3/50 (6%)          23/50 (46%)    8/60 (13%)    3/50 (6%)     |
|                                        3/50 (6%)                                       7/50 (14%)                                |
| Overall Incidence               Total 63/1259 (5%)    Mean 4.78%   SD 2%        Total 211/1258 (16.77%)Mean 16.27%  SD 9.22%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 5
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      NOS                               1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           1/100(1%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.18%   SD 0.59%     Total 8/1258 (0.64%)   Mean 0.64%   SD 0.9%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           1/100(1%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.18%   SD 0.59%     Total 9/1258 (0.72%)   Mean 0.73%   SD 0.94%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/50 (6%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     5/49 (10%)          0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     2/99 (2%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        3/50 (6%)     2/49 (4%)     2/50 (4%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        1/48 (2%)     4/49 (8%)     1/50 (2%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        3/99 (3%)     4/50 (8%)     0/50 (0%)           0/92 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     2/60 (3%)     3/49 (6%)           1/50 (2%)     1/59 (2%)     0/50 (0%)     |
|                                        3/49 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 45/1250 (3.6%)  Mean 3.78%   SD 3%        Total 5/1246 (0.4%)    Mean 0.44%   SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           0/92 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/49 (0%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1250 (0%)     Mean 0%      SD 0%        Total 1/1246 (0.08%)   Mean 0.09%   SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           1/92 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/49 (0%)           0/50 (0%)     0/59 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1250 (0%)     Mean 0%      SD 0%        Total 1/1246 (0.08%)   Mean 0.05%   SD 0.23%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           1/49 (2%)     2/48 (4%)     2/49 (4%)     |
|                                        0/47 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     1/49 (2%)     2/49 (4%)     |
|                                        1/98 (1%)     0/49 (0%)     0/50 (0%)           0/90 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/49 (0%)           1/50 (2%)     0/59 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/1244 (0.16%)  Mean 0.14%   SD 0.47%     Total 11/1235 (0.89%)  Mean 1.02%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     1/49 (2%)     0/49 (0%)     |
|                                        2/98 (2%)     0/49 (0%)     0/50 (0%)           0/90 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/49 (0%)           2/50 (4%)     0/59 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 3/1244 (0.24%)  Mean 0.19%   SD 0.6%      Total 6/1235 (0.49%)   Mean 0.46%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     1/99 (1%)     |
|      Complex, Malignant, NOS           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           1/49 (2%)     2/48 (4%)     2/49 (4%)     |
|                                        0/47 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     2/49 (4%)     2/49 (4%)     |
|                                        2/98 (2%)     0/49 (0%)     0/50 (0%)           0/90 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/49 (0%)           3/50 (6%)     0/59 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 4/1244 (0.32%)  Mean 0.28%   SD 0.71%     Total 17/1235 (1.38%)  Mean 1.48%   SD 1.87%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      2/50 (4%)     0/49 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/49 (2%)     1/49 (2%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/99 (0%)     0/50 (0%)     1/50 (2%)           0/96 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 10/1252 (0.8%)  Mean 0.91%   SD 1.48%     Total 4/1252 (0.32%)   Mean 0.36%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/49 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/99 (1%)     0/50 (0%)     0/50 (0%)           0/96 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1252 (0.08%)  Mean 0.05%   SD 0.22%     Total 0/1252 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           0/96 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/1252 (0.24%)  Mean 0.21%   SD 0.57%     Total 1/1252 (0.08%)   Mean 0.05%   SD 0.21%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 1/1258 (0.08%)   Mean 0.05%   SD 0.22%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           1/100(1%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.18%   SD 0.59%     Total 6/1258 (0.48%)   Mean 0.45%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           1/100(1%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.18%   SD 0.59%     Total 7/1258 (0.56%)   Mean 0.55%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1255 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1255 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1255 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1255 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 1/1255 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1255 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 3/1258 (0.24%)   Mean 0.18%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 3/1258 (0.24%)   Mean 0.18%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.08%   SD 0.36%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/98 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/1257 (0.08%)  Mean 0.05%   SD 0.21%                                                      |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/98 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/1257 (0%)     Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/50 (0%)     0/45 (0%)     0/100(0%)           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/46 (0%)           0/50 (0%)     0/39 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/48 (0%)     0/100(0%)     |
|                                        0/48 (0%)     0/42 (0%)     0/43 (0%)           0/48 (0%)     0/41 (0%)     0/46 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/42 (0%)           0/40 (0%)     0/40 (0%)     0/46 (0%)     |
|                                        0/84 (0%)     0/48 (0%)     0/46 (0%)           0/70 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/54 (0%)     0/49 (0%)           0/40 (0%)     0/54 (0%)     0/49 (0%)     |
|                                        0/44 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 0/1149 (0%)     Mean 0%      SD 0%        Total 0/1146 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/45 (0%)     0/100(0%)           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/46 (0%)           0/50 (0%)     0/39 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/48 (0%)     0/100(0%)     |
|                                        0/48 (0%)     0/42 (0%)     0/43 (0%)           0/48 (0%)     0/41 (0%)     0/46 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/42 (0%)           0/40 (0%)     0/40 (0%)     0/46 (0%)     |
|                                        0/84 (0%)     0/48 (0%)     0/46 (0%)           0/70 (0%)     0/44 (0%)     0/49 (0%)     |
|                                        0/44 (0%)     0/54 (0%)     0/49 (0%)           0/40 (0%)     0/54 (0%)     0/49 (0%)     |
|                                        0/44 (0%)                                       1/45 (2%)                                 |
| Overall Incidence               Total 0/1149 (0%)     Mean 0%      SD 0%        Total 1/1146 (0.09%)   Mean 0.1%    SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              5/50 (10%)    6/50 (12%)    4/100(4%)          10/50 (20%)    1/50 (2%)     3/99 (3%)     |
|                                        2/50 (4%)     6/50 (12%)    3/49 (6%)           1/50 (2%)     4/50 (8%)     2/50 (4%)     |
|                                        5/50 (10%)    4/50 (8%)     8/100(8%)           3/50 (6%)     0/50 (0%)     2/100(2%)     |
|                                        7/50 (14%)    6/50 (12%)    1/50 (2%)           5/50 (10%)    3/49 (6%)     3/50 (6%)     |
|                                        6/50 (12%)    7/50 (14%)    8/50 (16%)          3/50 (6%)     4/50 (8%)     2/50 (4%)     |
|                                       12/100(12%)    7/50 (14%)    9/50 (18%)         10/100(10%)    7/50 (14%)    3/50 (6%)     |
|                                        6/50 (12%)    4/60 (7%)     3/50 (6%)          11/50 (22%)    4/60 (7%)     2/50 (4%)     |
|                                        4/50 (8%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 123/1259 (9.77%)Mean 10.04%  SD 4.15%     Total 85/1258 (6.76%)  Mean 6.99%   SD 5.54%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     3/50 (6%)     0/50 (0%)           2/50 (4%)     1/49 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     2/50 (4%)     1/50 (2%)           2/100(2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           1/50 (2%)     1/60 (2%)     0/50 (0%)     |
|                                        2/50 (4%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 13/1259 (1.03%) Mean 1.17%   SD 1.7%      Total 16/1258 (1.27%)  Mean 1.26%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)    7/50 (14%)    4/100(4%)          11/50 (22%)    1/50 (2%)     4/99 (4%)     |
|                                        3/50 (6%)     6/50 (12%)    3/49 (6%)           1/50 (2%)     4/50 (8%)     4/50 (8%)     |
|                                        5/50 (10%)    4/50 (8%)     8/100(8%)           3/50 (6%)     0/50 (0%)     3/100(3%)     |
|                                        7/50 (14%)    9/50 (18%)    1/50 (2%)           7/50 (14%)    4/49 (8%)     3/50 (6%)     |
|                                        7/50 (14%)    7/50 (14%)    8/50 (16%)          3/50 (6%)     5/50 (10%)    2/50 (4%)     |
|                                       12/100(12%)    9/50 (18%)   10/50 (20%)         12/100(12%)    7/50 (14%)    4/50 (8%)     |
|                                        6/50 (12%)    5/60 (8%)     3/50 (6%)          12/50 (24%)    5/60 (8%)     2/50 (4%)     |
|                                        6/50 (12%)                                      4/50 (8%)                                 |
| Overall Incidence               Total 136/1259 (10.8%)Mean 11.2%   SD 4.75%     Total 101/1258 (8.03%) Mean 8.25%   SD 6.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/98 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1258 (0.16%)  Mean 0.18%   SD 0.59%     Total 1/1253 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/98 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1258 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1253 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 4/1258 (0.32%)   Mean 0.37%   SD 1.33%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 2/1258 (0.16%)   Mean 0.18%   SD 0.59%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/1259 (0.24%)  Mean 0.28%   SD 0.95%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.08%   SD 0.36%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/1259 (0.64%)  Mean 0.59%   SD 1.1%      Total 4/1258 (0.32%)   Mean 0.32%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     1/50 (2%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     2/60 (3%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 29/1259 (2.3%)  Mean 2.38%   SD 2.77%     Total 3/1258 (0.24%)   Mean 0.23%   SD 0.61%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.18%   SD 0.59%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/1259 (0.32%)  Mean 0.37%   SD 1.02%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     1/50 (2%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     2/60 (3%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 30/1259 (2.38%) Mean 2.47%   SD 2.72%     Total 4/1258 (0.32%)   Mean 0.32%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     3/49 (6%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/100(1%)     1/50 (2%)     1/50 (2%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     2/60 (3%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 34/1259 (2.7%)  Mean 2.84%   SD 2.85%     Total 5/1258 (0.4%)    Mean 0.41%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/60 (2%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.08%   SD 0.36%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           1/100(1%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 10/1259 (0.79%) Mean 0.77%   SD 1.31%     Total 4/1258 (0.32%)   Mean 0.32%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           2/50 (4%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/49 (2%)     3/50 (6%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        2/48 (4%)     0/48 (0%)     1/50 (2%)           1/49 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        1/99 (1%)     2/50 (4%)     0/50 (0%)           2/87 (2%)     1/47 (2%)     0/50 (0%)     |
|                                        1/48 (2%)     0/59 (0%)     0/50 (0%)           0/46 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        3/49 (6%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 22/1249 (1.76%) Mean 1.93%   SD 2.27%     Total 8/1230 (0.65%)   Mean 0.66%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        2/99 (2%)     0/50 (0%)     0/50 (0%)           0/87 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/59 (0%)     0/50 (0%)           0/46 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/1249 (0.16%)  Mean 0.09%   SD 0.43%     Total 1/1230 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           2/50 (4%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     1/49 (2%)     3/50 (6%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        2/48 (4%)     0/48 (0%)     1/50 (2%)           1/49 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        3/99 (3%)     2/50 (4%)     0/50 (0%)           2/87 (2%)     1/47 (2%)     0/50 (0%)     |
|                                        1/48 (2%)     0/59 (0%)     0/50 (0%)           0/46 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        3/49 (6%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 24/1249 (1.92%) Mean 2.02%   SD 2.27%     Total 9/1230 (0.73%)   Mean 0.75%   SD 1.19%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/99 (1%)     1/50 (2%)     0/50 (0%)           0/92 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/58 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 7/1253 (0.56%)  Mean 0.59%   SD 0.91%     Total 0/1244 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/99 (1%)     0/50 (0%)     1/50 (2%)           0/92 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/58 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 3/1253 (0.24%)  Mean 0.23%   SD 0.61%     Total 0/1244 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/99 (2%)     1/50 (2%)     1/50 (2%)           0/92 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/58 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 10/1253 (0.8%)  Mean 0.82%   SD 1.18%     Total 0/1244 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           0/92 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/58 (0%)     0/50 (0%)           0/50 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/1253 (0%)     Mean 0%      SD 0%        Total 1/1244 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/98 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/1257 (0.08%)  Mean 0.09%   SD 0.44%     Total 0/1251 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/98 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/60 (0%)     0/50 (0%)           2/49 (4%)     0/60 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/1257 (0.16%)  Mean 0.18%   SD 0.59%     Total 4/1251 (0.32%)   Mean 0.37%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)     0/50 (0%)     2/100(2%)           2/50 (4%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/49 (2%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        4/100(4%)     1/50 (2%)     1/50 (2%)           1/98 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     1/60 (2%)     1/50 (2%)           1/49 (2%)     0/60 (0%)     0/49 (0%)     |
|                                        2/50 (4%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 29/1257 (2.31%) Mean 2.35%   SD 1.47%     Total 7/1251 (0.56%)   Mean 0.59%   SD 1.26%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/100(2%)     2/50 (4%)     0/50 (0%)           0/98 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        6/48 (13%)    1/60 (2%)     0/50 (0%)           1/49 (2%)     0/60 (0%)     0/49 (0%)     |
|                                        3/50 (6%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 22/1257 (1.75%) Mean 1.92%   SD 3.42%     Total 1/1251 (0.08%)   Mean 0.09%   SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              23/50 (46%)   11/50 (22%)   20/100(20%)         14/50 (28%)    5/50 (10%)    8/99 (8%)     |
|                                       17/50 (34%)   19/50 (38%)   17/49 (35%)         11/50 (22%)    7/50 (14%)    9/50 (18%)    |
|                                        6/50 (12%)   19/50 (38%)   14/100(14%)          4/50 (8%)     9/50 (18%)    7/99 (7%)     |
|                                       19/50 (38%)   22/50 (44%)   17/50 (34%)          9/50 (18%)    7/49 (14%)   12/50 (24%)    |
|                                       18/50 (36%)   23/50 (46%)   15/50 (30%)         14/49 (29%)    9/50 (18%)    6/50 (12%)    |
|                                       30/100(30%)   23/50 (46%)    7/50 (14%)         17/98 (17%)   11/50 (22%)    3/50 (6%)     |
|                                       30/48 (63%)   18/60 (30%)   14/50 (28%)         30/49 (61%)    7/60 (12%)    6/49 (12%)    |
|                                       16/50 (32%)                                      9/49 (18%)                                |
| Overall Incidence               Total 398/1257 (31.66%Mean 33.15%  SD 12.14%    Total 214/1251 (17.11%)Mean 18.04%  SD 11.57%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            14/50 (28%)    8/50 (16%)   13/100(13%)          7/50 (14%)    0/50 (0%)     4/99 (4%)     |
|                                       14/50 (28%)   11/50 (22%)   13/49 (27%)          7/50 (14%)    3/50 (6%)     2/50 (4%)     |
|                                        9/50 (18%)    9/50 (18%)   13/100(13%)          3/50 (6%)     2/50 (4%)     3/99 (3%)     |
|                                       17/50 (34%)   10/50 (20%)   11/50 (22%)          6/50 (12%)    4/49 (8%)     6/50 (12%)    |
|                                        9/50 (18%)   16/50 (32%)   14/50 (28%)          4/49 (8%)     6/50 (12%)    6/50 (12%)    |
|                                       19/100(19%)    8/50 (16%)    4/50 (8%)           6/98 (6%)     3/50 (6%)     2/50 (4%)     |
|                                       20/48 (42%)   12/60 (20%)    8/50 (16%)          3/49 (6%)     2/60 (3%)     3/49 (6%)     |
|                                       23/50 (46%)                                      8/49 (16%)                                |
| Overall Incidence               Total 275/1257 (21.88%Mean 22.87%  SD 9.38%     Total 90/1251 (7.19%)  Mean 7.61%   SD 4.36%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         14/50 (28%)    8/50 (16%)   13/100(13%)          7/50 (14%)    0/50 (0%)     4/99 (4%)     |
|      Hepatoblastoma                   14/50 (28%)   12/50 (24%)   14/49 (29%)          7/50 (14%)    3/50 (6%)     2/50 (4%)     |
|                                        9/50 (18%)   12/50 (24%)   13/100(13%)          3/50 (6%)     2/50 (4%)     3/99 (3%)     |
|                                       18/50 (36%)   10/50 (20%)   11/50 (22%)          6/50 (12%)    4/49 (8%)     6/50 (12%)    |
|                                        9/50 (18%)   16/50 (32%)   14/50 (28%)          4/49 (8%)     6/50 (12%)    6/50 (12%)    |
|                                       21/100(21%)   10/50 (20%)    4/50 (8%)           6/98 (6%)     3/50 (6%)     2/50 (4%)     |
|                                       23/48 (48%)   13/60 (22%)    8/50 (16%)          4/49 (8%)     2/60 (3%)     3/49 (6%)     |
|                                       24/50 (48%)                                      8/49 (16%)                                |
| Overall Incidence               Total 290/1257 (23.07%Mean 24.14%  SD 10.17%    Total 91/1251 (7.27%)  Mean 7.7%    SD 4.35%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         32/50 (64%)   18/50 (36%)   28/100(28%)         20/50 (40%)    5/50 (10%)   12/99 (12%)    |
|      Hepatocellular Adenoma           29/50 (58%)   23/50 (46%)   24/49 (49%)         17/50 (34%)   10/50 (20%)   10/50 (20%)    |
|                                       15/50 (30%)   24/50 (48%)   26/100(26%)          6/50 (12%)   10/50 (20%)    9/99 (9%)     |
|                                       33/50 (66%)   28/50 (56%)   26/50 (52%)         12/50 (24%)   11/49 (22%)   18/50 (36%)    |
|                                       25/50 (50%)   34/50 (68%)   26/50 (52%)         18/49 (37%)   13/50 (26%)   12/50 (24%)    |
|                                       46/100(46%)   31/50 (62%)   10/50 (20%)         22/98 (22%)   13/50 (26%)    4/50 (8%)     |
|                                       41/48 (85%)   27/60 (45%)   20/50 (40%)         31/49 (63%)    9/60 (15%)    8/49 (16%)    |
|                                       36/50 (72%)                                     16/49 (33%)                                |
| Overall Incidence               Total 602/1257 (47.89%Mean 49.97%  SD 16.16%    Total 286/1251 (22.86%)Mean 24.09%  SD 12.8%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           32/50 (64%)   18/50 (36%)   28/100(28%)         20/50 (40%)    5/50 (10%)   12/99 (12%)    |
|      Hepatocellular Adenoma, or       29/50 (58%)   24/50 (48%)   24/49 (49%)         17/50 (34%)   10/50 (20%)   10/50 (20%)    |
|      Hepatoblastoma                   15/50 (30%)   26/50 (52%)   26/100(26%)          6/50 (12%)   10/50 (20%)    9/99 (9%)     |
|                                       33/50 (66%)   28/50 (56%)   26/50 (52%)         12/50 (24%)   11/49 (22%)   18/50 (36%)    |
|                                       25/50 (50%)   34/50 (68%)   26/50 (52%)         18/49 (37%)   13/50 (26%)   12/50 (24%)    |
|                                       47/100(47%)   31/50 (62%)   10/50 (20%)         22/98 (22%)   13/50 (26%)    4/50 (8%)     |
|                                       41/48 (85%)   28/60 (47%)   20/50 (40%)         31/49 (63%)    9/60 (15%)    8/49 (16%)    |
|                                       36/50 (72%)                                     16/49 (33%)                                |
| Overall Incidence               Total 607/1257 (48.29%Mean 50.37%  SD 16.11%    Total 286/1251 (22.86%)Mean 24.09%  SD 12.8%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/98 (1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/60 (0%)     2/50 (4%)           0/49 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 3/1257 (0.24%)  Mean 0.27%   SD 0.94%     Total 2/1251 (0.16%)   Mean 0.14%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/98 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 0/1257 (0%)     Mean 0%      SD 0%        Total 1/1251 (0.08%)   Mean 0.09%   SD 0.44%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/95 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1252 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        10/50 (20%)   14/50 (28%)   12/100(12%)          4/50 (8%)     0/50 (0%)     5/99 (5%)     |
|                                        3/50 (6%)    10/50 (20%)    2/49 (4%)           2/50 (4%)     2/50 (4%)     6/50 (12%)    |
|                                        6/50 (12%)   10/50 (20%)    9/100(9%)           0/50 (0%)     1/50 (2%)     3/100(3%)     |
|                                        6/50 (12%)    8/50 (16%)   13/50 (26%)          3/50 (6%)     1/49 (2%)     3/50 (6%)     |
|                                       13/50 (26%)    6/50 (12%)   13/50 (26%)          2/50 (4%)     2/50 (4%)     1/50 (2%)     |
|                                       26/100(26%)   11/50 (22%)   11/50 (22%)          9/95 (9%)     2/49 (4%)     4/50 (8%)     |
|                                        6/50 (12%)    9/60 (15%)    6/50 (12%)          3/50 (6%)     2/60 (3%)     5/50 (10%)    |
|                                       12/50 (24%)                                      1/50 (2%)                                 |
| Overall Incidence               Total 216/1259 (17.16%Mean 17.37%  SD 7.15%     Total 61/1252 (4.87%)  Mean 4.77%   SD 3.17%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)     2/50 (4%)     9/100(9%)           2/50 (4%)     1/50 (2%)     6/99 (6%)     |
|                                        3/50 (6%)     5/50 (10%)    4/49 (8%)           2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        7/50 (14%)    4/50 (8%)     7/100(7%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        7/50 (14%)    8/50 (16%)    6/50 (12%)          2/50 (4%)     6/49 (12%)    1/50 (2%)     |
|                                        6/50 (12%)    7/50 (14%)   12/50 (24%)          1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        8/100(8%)     9/50 (18%)    6/50 (12%)          2/95 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     5/60 (8%)     2/50 (4%)           1/50 (2%)     3/60 (5%)     1/50 (2%)     |
|                                        7/50 (14%)                                      1/50 (2%)                                 |
| Overall Incidence               Total 132/1259 (10.48%Mean 10.84%  SD 4.76%     Total 33/1252 (2.64%)  Mean 2.52%   SD 2.76%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)   16/50 (32%)   20/100(20%)          6/50 (12%)    1/50 (2%)    11/99 (11%)    |
|      Alveolar/Bronchiolar Adenoma      6/50 (12%)   14/50 (28%)    6/49 (12%)          3/50 (6%)     3/50 (6%)     6/50 (12%)    |
|                                       13/50 (26%)   13/50 (26%)   14/100(14%)          0/50 (0%)     1/50 (2%)     5/100(5%)     |
|                                       12/50 (24%)   15/50 (30%)   18/50 (36%)          5/50 (10%)    7/49 (14%)    4/50 (8%)     |
|                                       17/50 (34%)   13/50 (26%)   22/50 (44%)          3/50 (6%)     2/50 (4%)     1/50 (2%)     |
|                                       30/100(30%)   19/50 (38%)   14/50 (28%)         11/95 (12%)    2/49 (4%)     4/50 (8%)     |
|                                       10/50 (20%)   14/60 (23%)    8/50 (16%)          4/50 (8%)     5/60 (8%)     6/50 (12%)    |
|                                       18/50 (36%)                                      2/50 (4%)                                 |
| Overall Incidence               Total 326/1259 (25.89%Mean 26.53%  SD 8.5%      Total 92/1252 (7.35%)  Mean 7.11%   SD 4.01%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/95 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.05%   SD 0.21%     Total 1/1252 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/95 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1252 (0.08%)   Mean 0.09%   SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.05%   SD 0.21%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.18%   SD 0.85%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.05%   SD 0.21%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 2/1258 (0.16%)   Mean 0.17%   SD 0.54%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 7/1258 (0.56%)   Mean 0.59%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 8/1258 (0.64%)   Mean 0.68%   SD 1.13%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 8/1258 (0.64%)   Mean 0.68%   SD 1.13%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 1/1258 (0.08%)   Mean 0.05%   SD 0.21%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.05%   SD 0.21%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 2/1258 (0.16%)   Mean 0.18%   SD 0.59%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 4/1258 (0.32%)   Mean 0.32%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1253 (0%)     Mean 0%      SD 0%        Total 1/1255 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1253 (0%)     Mean 0%      SD 0%        Total 0/1255 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           0/99 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1253 (0%)     Mean 0%      SD 0%        Total 1/1255 (0.08%)   Mean 0.09%   SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.14%   SD 0.47%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 5/1258 (0.4%)    Mean 0.41%   SD 0.8%      |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.14%   SD 0.47%     Total 6/1258 (0.48%)   Mean 0.5%    SD 0.86%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           1/50 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 2/1258 (0.16%)   Mean 0.18%   SD 0.59%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.05%   SD 0.21%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          8/50 (16%)    1/49 (2%)     3/99 (3%)     |
|                                                                                        0/50 (0%)     1/47 (2%)     2/50 (4%)     |
|                                                                                        2/50 (4%)     0/47 (0%)     2/100(2%)     |
|                                                                                        1/50 (2%)     1/49 (2%)     0/47 (0%)     |
|                                                                                        2/50 (4%)     1/49 (2%)     1/48 (2%)     |
|                                                                                        3/79 (4%)     1/49 (2%)     0/50 (0%)     |
|                                                                                        1/45 (2%)     1/59 (2%)     3/48 (6%)     |
|                                                                                        1/49 (2%)                                 |
| Overall Incidence                                                               Total 35/1214 (2.88%)  Mean 2.88%   SD 3.31%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        2/79 (3%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/45 (2%)     0/59 (0%)     1/48 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 9/1214 (0.74%)   Mean 0.68%   SD 0.97%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        2/79 (3%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/45 (2%)     0/59 (0%)     1/48 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 9/1214 (0.74%)   Mean 0.68%   SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     2/50 (4%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/48 (0%)     |
|                                                                                        0/79 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/45 (0%)     0/59 (0%)     1/48 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 6/1214 (0.49%)   Mean 0.51%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        1/79 (1%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/45 (0%)     0/59 (0%)     0/48 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 2/1214 (0.16%)   Mean 0.1%    SD 0.34%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     2/100(2%)     |
|                                                                                        1/50 (2%)     1/49 (2%)     0/47 (0%)     |
|                                                                                        2/50 (4%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        1/79 (1%)     1/49 (2%)     0/50 (0%)     |
|                                                                                        3/45 (7%)     2/59 (3%)     0/48 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 14/1214 (1.15%)  Mean 1.11%   SD 1.74%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/48 (0%)     |
|                                                                                        0/79 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/45 (0%)     0/59 (0%)     0/48 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 2/1214 (0.16%)   Mean 0.18%   SD 0.59%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/79 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/45 (0%)     0/59 (0%)     0/48 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 1/1214 (0.08%)   Mean 0.05%   SD 0.21%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     1/49 (2%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                                                                        0/79 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/45 (0%)     0/59 (0%)     0/48 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 1/1214 (0.08%)   Mean 0.09%   SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           0/87 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/59 (0%)     0/50 (0%)           0/46 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/1249 (0.08%)  Mean 0.05%   SD 0.21%     Total 0/1230 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           0/87 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/59 (0%)     0/50 (0%)           0/46 (0%)     0/60 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 0/1249 (0%)     Mean 0%      SD 0%        Total 1/1230 (0.08%)   Mean 0.09%   SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           2/48 (4%)     2/50 (4%)     8/97 (8%)     |
|   Adenoma                              0/49 (0%)     0/47 (0%)     0/48 (0%)           1/49 (2%)     2/48 (4%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           3/48 (6%)     1/48 (2%)    11/97 (11%)    |
|                                        0/50 (0%)     1/48 (2%)     0/48 (0%)           8/50 (16%)   13/49 (27%)   10/50 (20%)    |
|                                        0/43 (0%)     0/49 (0%)     1/50 (2%)           9/48 (19%)   10/47 (21%)    8/49 (16%)    |
|                                        0/83 (0%)     0/48 (0%)     0/49 (0%)          17/83 (20%)    2/46 (4%)     1/50 (2%)     |
|                                        0/47 (0%)     1/53 (2%)     0/46 (0%)           3/46 (7%)     3/58 (5%)     0/45 (0%)     |
|                                        1/49 (2%)                                       5/48 (10%)                                |
| Overall Incidence               Total 4/1198 (0.33%)  Mean 0.36%   SD 0.79%     Total 121/1203 (10.06%)Mean 9.74%   SD 7.8%      |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     0/97 (0%)     |
|   Carcinoma                            0/49 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           0/48 (0%)     0/48 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/43 (0%)     0/49 (0%)     1/50 (2%)           0/48 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/83 (0%)     0/48 (0%)     0/49 (0%)           0/83 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/47 (0%)     0/53 (0%)     0/46 (0%)           0/46 (0%)     0/58 (0%)     0/45 (0%)     |
|                                        0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 1/1198 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1203 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           2/48 (4%)     2/50 (4%)     8/97 (8%)     |
|   Carcinoma or Adenoma                 0/49 (0%)     0/47 (0%)     0/48 (0%)           1/49 (2%)     2/48 (4%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           3/48 (6%)     1/48 (2%)    11/97 (11%)    |
|                                        0/50 (0%)     1/48 (2%)     0/48 (0%)           8/50 (16%)   13/49 (27%)   10/50 (20%)    |
|                                        0/43 (0%)     0/49 (0%)     2/50 (4%)           9/48 (19%)   10/47 (21%)    8/49 (16%)    |
|                                        0/83 (0%)     0/48 (0%)     0/49 (0%)          17/83 (20%)    2/46 (4%)     1/50 (2%)     |
|                                        0/47 (0%)     1/53 (2%)     0/46 (0%)           3/46 (7%)     3/58 (5%)     0/45 (0%)     |
|                                        1/49 (2%)                                       5/48 (10%)                                |
| Overall Incidence               Total 5/1198 (0.42%)  Mean 0.46%   SD 1.06%     Total 121/1203 (10.06%)Mean 9.74%   SD 7.8%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/49 (2%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     2/97 (2%)     |
|                                        1/49 (2%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     1/98 (1%)           1/48 (2%)     0/48 (0%)     0/97 (0%)     |
|                                        1/50 (2%)     0/48 (0%)     0/48 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/43 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/83 (0%)     0/48 (0%)     0/49 (0%)           1/83 (1%)     2/46 (4%)     0/50 (0%)     |
|                                        0/47 (0%)     0/53 (0%)     0/46 (0%)           0/46 (0%)     0/58 (0%)     0/45 (0%)     |
|                                        0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 4/1198 (0.33%)  Mean 0.32%   SD 0.73%     Total 9/1203 (0.75%)   Mean 0.72%   SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/49 (2%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     2/97 (2%)     |
|                                        1/49 (2%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     1/98 (1%)           1/48 (2%)     0/48 (0%)     0/97 (0%)     |
|                                        1/50 (2%)     0/48 (0%)     0/48 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/43 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/47 (0%)     0/49 (0%)     |
|                                        0/83 (0%)     0/48 (0%)     0/49 (0%)           1/83 (1%)     2/46 (4%)     0/50 (0%)     |
|                                        0/47 (0%)     0/53 (0%)     0/46 (0%)           0/46 (0%)     0/58 (0%)     0/45 (0%)     |
|                                        0/49 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 4/1198 (0.33%)  Mean 0.32%   SD 0.73%     Total 9/1203 (0.75%)   Mean 0.72%   SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        1/49 (2%)     0/46 (0%)     0/50 (0%)                                                     |
|                                        0/98 (0%)     0/49 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/1248 (0.08%)  Mean 0.09%   SD 0.44%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        1/49 (2%)     0/46 (0%)     0/50 (0%)                                                     |
|                                        0/98 (0%)     0/49 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/1248 (0.08%)  Mean 0.09%   SD 0.44%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)                                                     |
|                                        0/98 (0%)     0/49 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/1248 (0.08%)  Mean 0.09%   SD 0.44%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           1/94 (1%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/48 (0%)     0/59 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1258 (0%)     Mean 0%      SD 0%        Total 1/1238 (0.08%)   Mean 0.05%   SD 0.23%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           1/94 (1%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/48 (0%)     0/59 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1258 (0%)     Mean 0%      SD 0%        Total 1/1238 (0.08%)   Mean 0.05%   SD 0.23%     |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%                                                      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.08%   SD 0.36%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           3/100(3%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 5/1258 (0.4%)    Mean 0.27%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           3/100(3%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 5/1258 (0.4%)    Mean 0.27%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     5/50 (10%)    0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 9/1258 (0.72%)   Mean 0.77%   SD 2.27%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 3/1258 (0.24%)   Mean 0.27%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 3/1258 (0.24%)   Mean 0.27%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.05%   SD 0.21%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.05%   SD 0.21%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 2/1258 (0.16%)   Mean 0.14%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|      Papilloma, Sq Papilloma,          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|      Keratoacanthoma,                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Trichoepithelioma                 0/100(0%)     2/50 (4%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/1259 (0.4%)   Mean 0.41%   SD 1.01%     Total 4/1258 (0.32%)   Mean 0.27%   SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/100(2%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/1259 (0.32%)  Mean 0.23%   SD 0.61%     Total 3/1258 (0.24%)   Mean 0.18%   SD 0.5%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/100(0%)     1/50 (2%)     1/50 (2%)           0/100(0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/1259 (0.32%)  Mean 0.36%   SD 0.79%     Total 9/1258 (0.72%)   Mean 0.82%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.18%   SD 0.59%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.18%   SD 0.59%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.18%   SD 0.59%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 2/1258 (0.16%)   Mean 0.18%   SD 0.59%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.05%   SD 0.21%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|      Carcinoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 2/1258 (0.16%)   Mean 0.09%   SD 0.29%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/1259 (0.24%)  Mean 0.23%   SD 0.61%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/1259 (0.24%)  Mean 0.23%   SD 0.61%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     2/50 (4%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/1259 (0.4%)   Mean 0.41%   SD 1.01%     Total 2/1258 (0.16%)   Mean 0.14%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     2/50 (4%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/1259 (0.4%)   Mean 0.41%   SD 1.01%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     1/100(1%)           3/50 (6%)     1/50 (2%)     2/99 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     2/50 (4%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     1/50 (2%)     4/100(4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/49 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           4/100(4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     2/50 (4%)     |
|                                        0/50 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 3/1259 (0.24%)  Mean 0.23%   SD 0.61%     Total 37/1258 (2.94%)  Mean 2.9%    SD 2.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     1/100(1%)           2/50 (4%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     4/100(4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.05%   SD 0.21%     Total 11/1258 (0.87%)  Mean 0.82%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     1/100(1%)           3/50 (6%)     1/50 (2%)     2/99 (2%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     2/50 (4%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     1/50 (2%)     4/100(4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/49 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           4/100(4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     2/50 (4%)     |
|                                        0/50 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 3/1259 (0.24%)  Mean 0.23%   SD 0.61%     Total 37/1258 (2.94%)  Mean 2.9%    SD 2.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           2/100(2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           3/50 (6%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 11/1258 (0.87%)  Mean 0.82%   SD 1.59%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      or NOS)                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           2/100(2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           3/50 (6%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 11/1258 (0.87%)  Mean 0.82%   SD 1.59%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     2/99 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/49 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/100(0%)     0/50 (0%)     1/50 (2%)           4/100(4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     1/50 (2%)     |
|                                        0/50 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.18%   SD 0.59%     Total 25/1258 (1.99%)  Mean 1.99%   SD 2.14%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           2/100(2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           3/50 (6%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 11/1258 (0.87%)  Mean 0.82%   SD 1.59%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        1/49 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/49 (0%)     0/50 (0%)           0/91 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     1/60 (2%)     0/50 (0%)           0/49 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/1248 (0.16%)  Mean 0.17%   SD 0.55%     Total 0/1233 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/49 (2%)           1/50 (2%)     0/47 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     3/50 (6%)     1/100(1%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        2/49 (4%)     0/49 (0%)     2/50 (4%)           1/50 (2%)     1/49 (2%)     1/50 (2%)     |
|                                        2/48 (4%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     1/49 (2%)     2/50 (4%)     |
|                                        2/99 (2%)     2/49 (4%)     1/50 (2%)           0/91 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     2/60 (3%)     0/50 (0%)           2/49 (4%)     0/59 (0%)     0/49 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 22/1248 (1.76%) Mean 1.85%   SD 1.8%      Total 10/1233 (0.81%)  Mean 0.92%   SD 1.35%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/49 (0%)     0/50 (0%)           0/91 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/1248 (0.08%)  Mean 0.05%   SD 0.21%     Total 0/1233 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/49 (0%)     0/50 (0%)           1/91 (1%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/60 (0%)     0/50 (0%)           0/49 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/1248 (0%)     Mean 0%      SD 0%        Total 1/1233 (0.08%)   Mean 0.05%   SD 0.23%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.08%   SD 0.36%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.18%   SD 0.59%     Total 2/1258 (0.16%)   Mean 0.18%   SD 0.59%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           3/50 (6%)     1/50 (2%)     0/100(0%)           3/50 (6%)     2/50 (4%)     1/99 (1%)     |
|      Papilloma Squamous                1/50 (2%)     0/50 (0%)     1/49 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           2/50 (4%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/100(0%)     2/50 (4%)     0/50 (0%)           1/100(1%)     2/50 (4%)     2/50 (4%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 16/1259 (1.27%) Mean 1.46%   SD 1.77%     Total 21/1258 (1.67%)  Mean 1.76%   SD 1.92%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              3/50 (6%)     1/50 (2%)     0/100(0%)           3/50 (6%)     1/50 (2%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/100(0%)     2/50 (4%)     0/50 (0%)           1/100(1%)     2/50 (4%)     2/50 (4%)     |
|                                        0/50 (0%)     0/60 (0%)     1/50 (2%)           0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 14/1259 (1.11%) Mean 1.27%   SD 1.7%      Total 19/1258 (1.51%)  Mean 1.58%   SD 1.89%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        3/50 (6%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)                                                     |
|                                        2/50 (4%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        1/99 (1%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 13/1258 (1.03%) Mean 1.05%   SD 1.68%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 2/1258 (0.16%)  Mean 0.14%   SD 0.47%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 2/1258 (0.16%)  Mean 0.14%   SD 0.47%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|      Malignant, NOS                    0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/99 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/1258 (0.08%)  Mean 0.09%   SD 0.43%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/99 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/1258 (0.08%)  Mean 0.09%   SD 0.43%                                                      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           1/49 (2%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     0/46 (0%)     0/93 (0%)     |
|                                        0/48 (0%)     0/44 (0%)     0/35 (0%)           0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/40 (0%)     0/41 (0%)     0/35 (0%)           0/45 (0%)     0/43 (0%)     0/44 (0%)     |
|                                        0/69 (0%)     0/44 (0%)     0/47 (0%)           0/78 (0%)     0/44 (0%)     0/50 (0%)     |
|                                        0/43 (0%)     0/57 (0%)     0/47 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
|                                        0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/1079 (0%)     Mean 0%      SD 0%        Total 1/1168 (0.09%)   Mean 0.09%   SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           0/49 (0%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     1/46 (2%)     0/93 (0%)     |
|                                        0/48 (0%)     0/44 (0%)     0/35 (0%)           0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/40 (0%)     0/41 (0%)     0/35 (0%)           0/45 (0%)     0/43 (0%)     0/44 (0%)     |
|                                        0/69 (0%)     0/44 (0%)     0/47 (0%)           1/78 (1%)     0/44 (0%)     0/50 (0%)     |
|                                        0/43 (0%)     0/57 (0%)     0/47 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
|                                        0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/1079 (0%)     Mean 0%      SD 0%        Total 2/1168 (0.17%)   Mean 0.16%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           0/49 (0%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     1/46 (2%)     0/93 (0%)     |
|                                        0/48 (0%)     0/44 (0%)     0/35 (0%)           0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/40 (0%)     0/41 (0%)     0/35 (0%)           0/45 (0%)     0/43 (0%)     0/44 (0%)     |
|                                        0/69 (0%)     0/44 (0%)     0/47 (0%)           1/78 (1%)     0/44 (0%)     0/50 (0%)     |
|                                        0/43 (0%)     0/57 (0%)     0/47 (0%)           0/48 (0%)     0/57 (0%)     0/48 (0%)     |
|                                        0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/1079 (0%)     Mean 0%      SD 0%        Total 2/1168 (0.17%)   Mean 0.16%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/99 (1%)     0/50 (0%)     0/50 (0%)           2/92 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/59 (0%)     0/50 (0%)           0/48 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/1241 (0.08%)  Mean 0.05%   SD 0.22%     Total 2/1233 (0.16%)   Mean 0.1%    SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           0/92 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/59 (0%)     0/50 (0%)           0/48 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/1241 (0.08%)  Mean 0.09%   SD 0.44%     Total 0/1233 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           0/92 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/59 (0%)     0/50 (0%)           0/48 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/1241 (0.08%)  Mean 0.09%   SD 0.44%     Total 0/1233 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/100(1%)           2/50 (4%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/99 (1%)           2/50 (4%)     0/49 (0%)     1/98 (1%)     |
|                                        1/50 (2%)     0/48 (0%)     0/47 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        1/48 (2%)     1/49 (2%)     0/48 (0%)           0/49 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/99 (0%)     1/50 (2%)     0/50 (0%)           0/92 (0%)     1/49 (2%)     1/49 (2%)     |
|                                        0/48 (0%)     1/59 (2%)     0/50 (0%)           1/48 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 9/1241 (0.73%)  Mean 0.72%   SD 0.93%     Total 11/1233 (0.89%)  Mean 0.96%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/47 (2%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/99 (0%)     0/50 (0%)     0/50 (0%)           0/92 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/59 (0%)     0/50 (0%)           0/48 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/1241 (0.16%)  Mean 0.19%   SD 0.61%     Total 1/1233 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/100(1%)           2/50 (4%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/99 (1%)           2/50 (4%)     0/49 (0%)     1/98 (1%)     |
|                                        1/50 (2%)     0/48 (0%)     1/47 (2%)           1/50 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        1/48 (2%)     1/49 (2%)     0/48 (0%)           0/49 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/99 (0%)     1/50 (2%)     0/50 (0%)           0/92 (0%)     1/49 (2%)     1/49 (2%)     |
|                                        0/48 (0%)     1/59 (2%)     0/50 (0%)           1/48 (2%)     0/60 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 11/1241 (0.89%) Mean 0.91%   SD 0.97%     Total 12/1233 (0.97%)  Mean 1.06%   SD 1.47%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.05%   SD 0.21%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     2/60 (3%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1259 (0.16%)  Mean 0.15%   SD 0.71%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 3/1258 (0.24%)   Mean 0.23%   SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 3/1258 (0.24%)   Mean 0.23%   SD 0.62%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/1259 (0.24%)  Mean 0.27%   SD 0.71%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        1/48 (2%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/98 (0%)     0/50 (0%)     0/50 (0%)           0/79 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/59 (0%)     0/50 (0%)           0/49 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1251 (0.16%)  Mean 0.19%   SD 0.6%      Total 0/1219 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/98 (0%)     0/50 (0%)     0/50 (0%)           0/79 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/59 (0%)     0/50 (0%)           0/49 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1251 (0%)     Mean 0%      SD 0%        Total 1/1219 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        1/48 (2%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/98 (0%)     0/50 (0%)     0/50 (0%)           0/79 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/59 (0%)     0/50 (0%)           0/49 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/1251 (0.16%)  Mean 0.19%   SD 0.6%      Total 0/1219 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
|                                        0/98 (0%)     0/50 (0%)     0/50 (0%)           0/79 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/59 (0%)     0/50 (0%)           0/49 (0%)     0/59 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/1251 (0%)     Mean 0%      SD 0%        Total 1/1219 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 2/1258 (0.16%)   Mean 0.18%   SD 0.59%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/1258 (0.08%)   Mean 0.09%   SD 0.44%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/60 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/1258 (0.16%)   Mean 0.12%   SD 0.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/1258 (0.16%)   Mean 0.18%   SD 0.59%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/1258 (0.16%)   Mean 0.14%   SD 0.47%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     4/50 (8%)     2/99 (2%)     |
|                                                                                        0/50 (0%)     3/50 (6%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                                                                        1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     2/50 (4%)     2/50 (4%)     |
|                                                                                        1/100(1%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     2/60 (3%)     3/50 (6%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 23/1258 (1.83%)  Mean 1.88%   SD 2.39%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/100(0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/1258 (0.16%)   Mean 0.18%   SD 0.59%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/100(0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 4/1258 (0.32%)   Mean 0.36%   SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     5/50 (10%)    2/99 (2%)     |
|                                                                                        0/50 (0%)     3/50 (6%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                                                                        1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     3/50 (6%)     2/50 (4%)     |
|                                                                                        1/100(1%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        1/50 (2%)     2/60 (3%)     3/50 (6%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 27/1258 (2.15%)  Mean 2.24%   SD 2.68%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 0/1258 (0%)      Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     0/50 (0%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/1259 (0%)     Mean 0%      SD 0%        Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/100(0%)     1/50 (2%)     0/50 (0%)           0/100(0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/60 (0%)     0/50 (0%)           0/50 (0%)     0/60 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/1259 (0.08%)  Mean 0.09%   SD 0.43%     Total 1/1258 (0.08%)   Mean 0.09%   SD 0.43%     |
 __________________________________________________________________________________________________________________________________
