                                                 Toxicology Data Management System                                     Page: 1
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   730       50(1)      38  (707)     53.4     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  058813804  09/14/99   730       50(1)      44  (717)     46.0     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   727      100(1)      91  (707)     49.6     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   729       50(1)      40  (703)     53.9     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   730       50(1)      39  (702)     52.5     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   729       49(1)      35  (704)     50.6     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   733       50(1)      40  (705)     46.9     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   727       50(1)      39  (708)     51.4     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   728      100(1)      91  (705)     46.5     TRANS-CINNAMALDEHYDE                       |
|BATTELLE COLUMBUS  050510914  09/24/98   726       50(1)      37  (710)     53.4     TRIETHANOLAMINE                            |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   729       50(5)      39  (709)     62.7     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  058813804  09/14/99   729       50(5)      40  (706)     46.2     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   733       99(5)      81  (695)     48.0     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   728       50(5)      37  (699)     61.4     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   729       50(5)      37  (692)     62.9     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   731       50(5)      35  (700)     58.1     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   734       50(5)      42  (717)     46.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   728       50(5)      40  (702)     58.8     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   733      100(5)      84  (711)     46.0     TRANS-CINNAMALDEHYDE                       |
|BATTELLE COLUMBUS  050510914  09/24/98   729       50(1)      35  (692)     62.7     TRIETHANOLAMINE                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302606  08/28/97   733       50( )      40  (701)     54.1     DECALIN                                    |
|BATTELLE NORTHWEST 058812404  01/25/96   733       50( )      37  (711)     51.6     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   729       50( )      35  (703)     54.3     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   729       50( )      34  (690)     53.0     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   729       50( )      39  (710)     55.4     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302606  08/28/97   735       49( )      37  (708)     61.5     DECALIN                                    |
|BATTELLE NORTHWEST 058812404  01/25/96   735       50( )      42  (713)     54.8     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   731       50( )      39  (718)     59.8     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   731       50( )      36  (702)     54.6     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   731       50( )      38  (692)     58.7     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902906  10/05/94   734      100(1)      76  (711)     53.4     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902906  10/05/94   735      100(5)      70  (702)     59.7     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 4
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302307  07/25/97   729       50(1)      44  (721)     57.3     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201206  07/29/98   729       50(1)      43  (706)     46.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601004  09/30/98   729       50(1)      38  (694)     54.1     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  050520309  02/20/96   729       60(1)      52  (712)     48.0     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   729       50(1)      46  (722)     47.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   729       50(1)      39  (696)     51.4     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302307  07/25/97   732       50(5)      42  (717)     64.2     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201206  07/29/98   732       50(5)      46  (720)     38.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601004  09/30/98   735       50(5)      36  (691)     66.5     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  050520309  02/20/96   731       60(5)      52  (708)     46.6     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   732       50(5)      46  (727)     41.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   735       50(5)      34  (674)     59.5     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 5
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       34/50 (68%)   27/50 (54%)   40/100(40%)         29/50 (58%)   15/50 (30%)   28/99 (28%)    |
|                                       27/50 (54%)   29/50 (58%)   29/49 (59%)         22/50 (44%)   17/50 (34%)   24/50 (48%)    |
|                                       16/50 (32%)   28/50 (56%)   37/100(37%)         15/50 (30%)   13/50 (26%)   32/100(32%)    |
|                                       30/50 (60%)                                     24/50 (48%)                                |
| Overall Incidence               Total 297/599 (49.58%)Mean 51.82%  SD 11.55%    Total 219/599 (36.56%) Mean 37.83%  SD 10.82%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)   17/50 (34%)   32/100(32%)         24/50 (48%)   16/50 (32%)   24/99 (24%)    |
|                                       19/50 (38%)   24/50 (48%)   24/49 (49%)         18/50 (36%)   17/50 (34%)   20/50 (40%)    |
|                                       21/50 (42%)   27/50 (54%)   28/100(28%)         12/50 (24%)   12/50 (24%)   46/100(46%)    |
|                                       28/50 (56%)                                     27/50 (54%)                                |
| Overall Incidence               Total 249/599 (41.57%)Mean 43.9%   SD 10.65%    Total 216/599 (36.06%) Mean 36.22%  SD 10.7%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)   38/50 (76%)   55/100(55%)         39/50 (78%)   25/50 (50%)   45/99 (45%)    |
|                                       39/50 (78%)   38/50 (76%)   40/49 (82%)         32/50 (64%)   29/50 (58%)   34/50 (68%)    |
|                                       32/50 (64%)   40/50 (80%)   57/100(57%)         23/50 (46%)   21/50 (42%)   62/100(62%)    |
|                                       45/50 (90%)                                     38/50 (76%)                                |
| Overall Incidence               Total 429/599 (71.62%)Mean 74.76%  SD 12.36%    Total 348/599 (58.1%)  Mean 58.95%  SD 12.86%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     2/100(2%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        2/50 (4%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     4/100(4%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 10/599 (1.67%)  Mean 1.5%    SD 1.72%     Total 10/599 (1.67%)   Mean 1.5%    SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)     3/50 (6%)     3/100(3%)           4/50 (8%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     6/50 (12%)    3/49 (6%)           3/50 (6%)     1/50 (2%)     2/50 (4%)     |
|                                        3/50 (6%)     7/50 (14%)    2/100(2%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        3/50 (6%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 33/599 (5.51%)  Mean 6.11%   SD 4.23%     Total 16/599 (2.67%)   Mean 3.1%    SD 2.77%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)    3/50 (6%)     5/100(5%)           4/50 (8%)     1/50 (2%)     1/99 (1%)     |
|                                        2/50 (4%)     6/50 (12%)    3/49 (6%)           5/50 (10%)    1/50 (2%)     4/50 (8%)     |
|                                        3/50 (6%)     7/50 (14%)    5/100(5%)           0/50 (0%)     1/50 (2%)     5/100(5%)     |
|                                        4/50 (8%)                                       4/50 (8%)                                 |
| Overall Incidence               Total 43/599 (7.18%)  Mean 7.61%   SD 3.33%     Total 26/599 (4.34%)   Mean 4.6%    SD 3.63%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)                                       4/50 (8%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.4%    SD 0.84%     Total 7/599 (1.17%)    Mean 1.2%    SD 2.53%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     2/50 (4%)     4/100(4%)           4/50 (8%)     8/50 (16%)    7/99 (7%)     |
|      Lymphocytic, Mixed, NOS, or       1/50 (2%)     3/50 (6%)     2/49 (4%)           5/50 (10%)    7/50 (14%)    9/50 (18%)    |
|      Undifferentiated Cell Type        3/50 (6%)     1/50 (2%)     8/100(8%)           6/50 (12%)    7/50 (14%)   23/100(23%)    |
|                                        0/50 (0%)                                       8/50 (16%)                                |
| Overall Incidence               Total 27/599 (4.51%)  Mean 4.21%   SD 2.39%     Total 84/599 (14.02%)  Mean 13.81%  SD 4.81%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      NOS                               1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/599 (0.83%)    Mean 0.9%    SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/599 (0.83%)    Mean 0.9%    SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/50 (6%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     5/49 (10%)          0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     2/99 (2%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 17/597 (2.85%)  Mean 3.02%   SD 3.48%     Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/597 (0%)      Mean 0%      SD 0%        Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/597 (0%)      Mean 0%      SD 0%        Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 1/596 (0.17%)   Mean 0.2%    SD 0.63%     Total 2/595 (0.34%)    Mean 0.4%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/596 (0%)      Mean 0%      SD 0%        Total 3/595 (0.5%)     Mean 0.4%    SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     1/99 (1%)     |
|      Complex, Malignant, NOS           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 1/596 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/595 (0.84%)    Mean 0.81%   SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      2/50 (4%)     0/49 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 6/598 (1%)      Mean 1.2%    SD 1.93%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/49 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/598 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/598 (0.33%)   Mean 0.3%    SD 0.67%     Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 3/599 (0.5%)     Mean 0.5%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 3/599 (0.5%)     Mean 0.5%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.2%    SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.2%    SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%                                                      |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/50 (0%)     0/45 (0%)     0/100(0%)           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/46 (0%)           0/50 (0%)     0/39 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/48 (0%)     0/100(0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/576 (0%)      Mean 0%      SD 0%        Total 0/582 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/45 (0%)     0/100(0%)           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/46 (0%)           0/50 (0%)     0/39 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/48 (0%)     0/100(0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/576 (0%)      Mean 0%      SD 0%        Total 0/582 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              5/50 (10%)    6/50 (12%)    4/100(4%)          10/50 (20%)    1/50 (2%)     3/99 (3%)     |
|                                        2/50 (4%)     6/50 (12%)    3/49 (6%)           1/50 (2%)     4/50 (8%)     2/50 (4%)     |
|                                        5/50 (10%)    4/50 (8%)     8/100(8%)           3/50 (6%)     0/50 (0%)     2/100(2%)     |
|                                        7/50 (14%)                                      5/50 (10%)                                |
| Overall Incidence               Total 50/599 (8.35%)  Mean 8.81%   SD 3.41%     Total 31/599 (5.18%)   Mean 5.7%    SD 5.89%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 3/599 (0.5%)    Mean 0.6%    SD 0.97%     Total 7/599 (1.17%)    Mean 1.2%    SD 1.62%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)    7/50 (14%)    4/100(4%)          11/50 (22%)    1/50 (2%)     4/99 (4%)     |
|                                        3/50 (6%)     6/50 (12%)    3/49 (6%)           1/50 (2%)     4/50 (8%)     4/50 (8%)     |
|                                        5/50 (10%)    4/50 (8%)     8/100(8%)           3/50 (6%)     0/50 (0%)     3/100(3%)     |
|                                        7/50 (14%)                                      7/50 (14%)                                |
| Overall Incidence               Total 53/599 (8.85%)  Mean 9.41%   SD 3.52%     Total 38/599 (6.34%)   Mean 6.9%    SD 6.67%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/598 (0.17%)   Mean 0.2%    SD 0.63%     Total 1/598 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/598 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 3/599 (0.5%)     Mean 0.6%    SD 1.9%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.41%   SD 1.29%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 7/599 (1.17%)   Mean 1.1%    SD 1.37%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 20/599 (3.34%)  Mean 3.6%    SD 3.4%      Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.41%   SD 1.29%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 20/599 (3.34%)  Mean 3.6%    SD 3.4%      Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     3/49 (6%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 22/599 (3.67%)  Mean 4.01%   SD 3.44%     Total 3/599 (0.5%)     Mean 0.5%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/599 (1.34%)   Mean 1.3%    SD 1.64%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           2/50 (4%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/599 (1.34%)   Mean 1.51%   SD 2.28%     Total 2/595 (0.34%)    Mean 0.4%    SD 1.26%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/595 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           2/50 (4%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/599 (1.34%)   Mean 1.51%   SD 2.28%     Total 3/595 (0.5%)     Mean 0.6%    SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/599 (0.5%)    Mean 0.6%    SD 0.97%     Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/599 (0.5%)    Mean 0.6%    SD 0.97%     Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 2/598 (0.33%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)     0/50 (0%)     2/100(2%)           2/50 (4%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/49 (2%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 12/599 (2%)     Mean 2.2%    SD 1.75%     Total 5/598 (0.84%)    Mean 1%      SD 1.7%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/599 (1.34%)   Mean 1.6%    SD 3.1%      Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              23/50 (46%)   11/50 (22%)   20/100(20%)         14/50 (28%)    5/50 (10%)    8/99 (8%)     |
|                                       17/50 (34%)   19/50 (38%)   17/49 (35%)         11/50 (22%)    7/50 (14%)    9/50 (18%)    |
|                                        6/50 (12%)   19/50 (38%)   14/100(14%)          4/50 (8%)     9/50 (18%)    7/99 (7%)     |
|                                       19/50 (38%)                                      9/50 (18%)                                |
| Overall Incidence               Total 165/599 (27.55%)Mean 29.67%  SD 11.69%    Total 83/598 (13.88%)  Mean 15.12%  SD 6.92%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            14/50 (28%)    8/50 (16%)   13/100(13%)          7/50 (14%)    0/50 (0%)     4/99 (4%)     |
|                                       14/50 (28%)   11/50 (22%)   13/49 (27%)          7/50 (14%)    3/50 (6%)     2/50 (4%)     |
|                                        9/50 (18%)    9/50 (18%)   13/100(13%)          3/50 (6%)     2/50 (4%)     3/99 (3%)     |
|                                       17/50 (34%)                                      6/50 (12%)                                |
| Overall Incidence               Total 121/599 (20.2%) Mean 21.65%  SD 7.19%     Total 37/598 (6.19%)   Mean 6.71%   SD 4.9%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         14/50 (28%)    8/50 (16%)   13/100(13%)          7/50 (14%)    0/50 (0%)     4/99 (4%)     |
|      Hepatoblastoma                   14/50 (28%)   12/50 (24%)   14/49 (29%)          7/50 (14%)    3/50 (6%)     2/50 (4%)     |
|                                        9/50 (18%)   12/50 (24%)   13/100(13%)          3/50 (6%)     2/50 (4%)     3/99 (3%)     |
|                                       18/50 (36%)                                      6/50 (12%)                                |
| Overall Incidence               Total 127/599 (21.2%) Mean 22.86%  SD 7.64%     Total 37/598 (6.19%)   Mean 6.71%   SD 4.9%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         32/50 (64%)   18/50 (36%)   28/100(28%)         20/50 (40%)    5/50 (10%)   12/99 (12%)    |
|      Hepatocellular Adenoma           29/50 (58%)   23/50 (46%)   24/49 (49%)         17/50 (34%)   10/50 (20%)   10/50 (20%)    |
|                                       15/50 (30%)   24/50 (48%)   26/100(26%)          6/50 (12%)   10/50 (20%)    9/99 (9%)     |
|                                       33/50 (66%)                                     12/50 (24%)                                |
| Overall Incidence               Total 252/599 (42.07%)Mean 45.1%   SD 14.73%    Total 111/598 (18.56%) Mean 20.12%  SD 10.31%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           32/50 (64%)   18/50 (36%)   28/100(28%)         20/50 (40%)    5/50 (10%)   12/99 (12%)    |
|      Hepatocellular Adenoma, or       29/50 (58%)   24/50 (48%)   24/49 (49%)         17/50 (34%)   10/50 (20%)   10/50 (20%)    |
|      Hepatoblastoma                   15/50 (30%)   26/50 (52%)   26/100(26%)          6/50 (12%)   10/50 (20%)    9/99 (9%)     |
|                                       33/50 (66%)                                     12/50 (24%)                                |
| Overall Incidence               Total 255/599 (42.57%)Mean 45.7%   SD 14.89%    Total 111/598 (18.56%) Mean 20.12%  SD 10.31%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.65%     Total 1/598 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        10/50 (20%)   14/50 (28%)   12/100(12%)          4/50 (8%)     0/50 (0%)     5/99 (5%)     |
|                                        3/50 (6%)    10/50 (20%)    2/49 (4%)           2/50 (4%)     2/50 (4%)     6/50 (12%)    |
|                                        6/50 (12%)   10/50 (20%)    9/100(9%)           0/50 (0%)     1/50 (2%)     3/100(3%)     |
|                                        6/50 (12%)                                      3/50 (6%)                                 |
| Overall Incidence               Total 82/599 (13.69%) Mean 14.31%  SD 7.47%     Total 26/599 (4.34%)   Mean 4.41%   SD 3.66%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)     2/50 (4%)     9/100(9%)           2/50 (4%)     1/50 (2%)     6/99 (6%)     |
|                                        3/50 (6%)     5/50 (10%)    4/49 (8%)           2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        7/50 (14%)    4/50 (8%)     7/100(7%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        7/50 (14%)                                      2/50 (4%)                                 |
| Overall Incidence               Total 52/599 (8.68%)  Mean 8.82%   SD 3.19%     Total 17/599 (2.84%)   Mean 2.61%   SD 1.91%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)   16/50 (32%)   20/100(20%)          6/50 (12%)    1/50 (2%)    11/99 (11%)    |
|      Alveolar/Bronchiolar Adenoma      6/50 (12%)   14/50 (28%)    6/49 (12%)          3/50 (6%)     3/50 (6%)     6/50 (12%)    |
|                                       13/50 (26%)   13/50 (26%)   14/100(14%)          0/50 (0%)     1/50 (2%)     5/100(5%)     |
|                                       12/50 (24%)                                      5/50 (10%)                                |
| Overall Incidence               Total 128/599 (21.37%)Mean 22.22%  SD 7.23%     Total 41/599 (6.84%)   Mean 6.61%   SD 4.46%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.4%    SD 1.26%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 3/599 (0.5%)     Mean 0.6%    SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 3/599 (0.5%)     Mean 0.6%    SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/595 (0%)      Mean 0%      SD 0%        Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/595 (0%)      Mean 0%      SD 0%        Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/595 (0%)      Mean 0%      SD 0%        Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.3%    SD 0.68%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 3/599 (0.5%)     Mean 0.5%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          8/50 (16%)    1/49 (2%)     3/99 (3%)     |
|                                                                                        0/50 (0%)     1/47 (2%)     2/50 (4%)     |
|                                                                                        2/50 (4%)     0/47 (0%)     2/100(2%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 20/592 (3.38%)   Mean 3.52%   SD 4.59%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 4/592 (0.68%)    Mean 0.6%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 4/592 (0.68%)    Mean 0.6%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     2/50 (4%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 3/592 (0.51%)    Mean 0.5%    SD 1.27%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/592 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     2/100(2%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 4/592 (0.68%)    Mean 0.5%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/592 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/592 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     1/49 (2%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/592 (0.17%)    Mean 0.2%    SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/598 (0.17%)   Mean 0.1%    SD 0.32%     Total 0/595 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/598 (0%)      Mean 0%      SD 0%        Total 0/595 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           2/48 (4%)     2/50 (4%)     8/97 (8%)     |
|   Adenoma                              0/49 (0%)     0/47 (0%)     0/48 (0%)           1/49 (2%)     2/48 (4%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           3/48 (6%)     1/48 (2%)    11/97 (11%)    |
|                                        0/50 (0%)                                       8/50 (16%)                                |
| Overall Incidence               Total 0/585 (0%)      Mean 0%      SD 0%        Total 40/584 (6.85%)   Mean 6.24%   SD 4.45%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     0/97 (0%)     |
|   Carcinoma                            0/49 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           0/48 (0%)     0/48 (0%)     0/97 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/585 (0%)      Mean 0%      SD 0%        Total 0/584 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           2/48 (4%)     2/50 (4%)     8/97 (8%)     |
|   Carcinoma or Adenoma                 0/49 (0%)     0/47 (0%)     0/48 (0%)           1/49 (2%)     2/48 (4%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           3/48 (6%)     1/48 (2%)    11/97 (11%)    |
|                                        0/50 (0%)                                       8/50 (16%)                                |
| Overall Incidence               Total 0/585 (0%)      Mean 0%      SD 0%        Total 40/584 (6.85%)   Mean 6.24%   SD 4.45%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/49 (2%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     2/97 (2%)     |
|                                        1/49 (2%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     1/98 (1%)           1/48 (2%)     0/48 (0%)     0/97 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/585 (0.68%)   Mean 0.71%   SD 0.96%     Total 5/584 (0.86%)    Mean 0.82%   SD 1.43%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/49 (2%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     2/97 (2%)     |
|                                        1/49 (2%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     1/98 (1%)           1/48 (2%)     0/48 (0%)     0/97 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/585 (0.68%)   Mean 0.71%   SD 0.96%     Total 5/584 (0.86%)    Mean 0.82%   SD 1.43%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.65%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/590 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/590 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%                                                      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 3/599 (0.5%)     Mean 0.5%    SD 1.27%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|      Trichoepithelioma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|      Papilloma, Sq Papilloma,          0/50 (0%)                                       0/50 (0%)                                 |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.3%    SD 0.69%     Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/100(2%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/599 (0.5%)    Mean 0.3%    SD 0.67%     Total 2/599 (0.33%)    Mean 0.2%    SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.4%    SD 0.84%     Total 3/599 (0.5%)     Mean 0.6%    SD 0.97%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.65%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.65%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|      Carcinoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.3%    SD 0.69%     Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.3%    SD 0.69%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     1/100(1%)           3/50 (6%)     1/50 (2%)     2/99 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     2/50 (4%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     1/50 (2%)     4/100(4%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 21/599 (3.51%)   Mean 3.6%    SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     1/100(1%)           2/50 (4%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     4/100(4%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 10/599 (1.67%)   Mean 1.6%    SD 1.84%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     1/100(1%)           3/50 (6%)     1/50 (2%)     2/99 (2%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     2/50 (4%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     1/50 (2%)     4/100(4%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 21/599 (3.51%)   Mean 3.6%    SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/599 (0.83%)    Mean 0.8%    SD 1.4%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      or NOS)                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/599 (0.83%)    Mean 0.8%    SD 1.4%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     2/99 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 10/599 (1.67%)   Mean 1.8%    SD 2.39%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/599 (0.83%)    Mean 0.8%    SD 1.4%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/597 (0.17%)   Mean 0.2%    SD 0.65%     Total 0/591 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/49 (2%)           1/50 (2%)     0/47 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     3/50 (6%)     1/100(1%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        2/49 (4%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 10/597 (1.68%)  Mean 1.91%   SD 1.92%     Total 3/591 (0.51%)    Mean 0.6%    SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/597 (0.17%)   Mean 0.1%    SD 0.32%     Total 0/591 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/597 (0%)      Mean 0%      SD 0%        Total 0/591 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           3/50 (6%)     1/50 (2%)     0/100(0%)           3/50 (6%)     2/50 (4%)     1/99 (1%)     |
|      Papilloma Squamous                1/50 (2%)     0/50 (0%)     1/49 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 8/599 (1.34%)   Mean 1.6%    SD 1.84%     Total 12/599 (2%)      Mean 2.2%    SD 2.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              3/50 (6%)     1/50 (2%)     0/100(0%)           3/50 (6%)     1/50 (2%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 7/599 (1.17%)   Mean 1.4%    SD 1.9%      Total 11/599 (1.84%)   Mean 2%      SD 2.05%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        3/50 (6%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 6/599 (1%)      Mean 1%      SD 1.89%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.3%    SD 0.67%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|      Malignant, NOS                    0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           1/49 (2%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     0/46 (0%)     0/93 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/535 (0%)      Mean 0%      SD 0%        Total 1/567 (0.18%)    Mean 0.2%    SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           0/49 (0%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     1/46 (2%)     0/93 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/535 (0%)      Mean 0%      SD 0%        Total 1/567 (0.18%)    Mean 0.22%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           0/49 (0%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     1/46 (2%)     0/93 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/535 (0%)      Mean 0%      SD 0%        Total 1/567 (0.18%)    Mean 0.22%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/596 (0%)      Mean 0%      SD 0%        Total 0/588 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/596 (0.17%)   Mean 0.2%    SD 0.65%     Total 0/588 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/596 (0.17%)   Mean 0.2%    SD 0.65%     Total 0/588 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/100(1%)           2/50 (4%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/99 (1%)           2/50 (4%)     0/49 (0%)     1/98 (1%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/596 (0.84%)   Mean 0.8%    SD 0.92%     Total 5/588 (0.85%)    Mean 0.9%    SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/596 (0.17%)   Mean 0.2%    SD 0.65%     Total 1/588 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/100(1%)           2/50 (4%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/99 (1%)           2/50 (4%)     0/49 (0%)     1/98 (1%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 6/596 (1.01%)   Mean 1.01%   SD 0.95%     Total 6/588 (1.02%)    Mean 1.1%    SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.3%    SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.3%    SD 0.68%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/599 (0.5%)    Mean 0.6%    SD 0.97%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/592 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/592 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/592 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/592 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     4/50 (8%)     2/99 (2%)     |
|                                                                                        0/50 (0%)     3/50 (6%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 12/599 (2%)      Mean 2.1%    SD 2.77%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     5/50 (10%)    2/99 (2%)     |
|                                                                                        0/50 (0%)     3/50 (6%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 13/599 (2.17%)   Mean 2.3%    SD 3.27%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 39
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       32/50 (64%)   29/50 (58%)   30/50 (60%)         28/49 (57%)   25/50 (50%)   25/50 (50%)    |
|                                       32/50 (64%)   31/50 (62%)                       27/50 (54%)   19/50 (38%)                  |
| Overall Incidence               Total 154/250 (61.6%) Mean 61.6%   SD 2.61%     Total 124/249 (49.8%)  Mean 49.83%  SD 7.26%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/50 (46%)   21/50 (42%)   22/50 (44%)         22/49 (45%)   20/50 (40%)   23/50 (46%)    |
|                                       23/50 (46%)   27/50 (54%)                       19/50 (38%)   17/50 (34%)                  |
| Overall Incidence               Total 116/250 (46.4%) Mean 46.4%   SD 4.56%     Total 101/249 (40.56%) Mean 40.58%  SD 4.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         43/50 (86%)   41/50 (82%)   41/50 (82%)         39/49 (80%)   35/50 (70%)   37/50 (74%)    |
|                                       42/50 (84%)   42/50 (84%)                       39/50 (78%)   32/50 (64%)                  |
| Overall Incidence               Total 209/250 (83.6%) Mean 83.6%   SD 1.67%     Total 182/249 (73.09%) Mean 73.12%  SD 6.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 2/250 (0.8%)    Mean 0.8%    SD 1.1%      Total 3/249 (1.2%)     Mean 1.21%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     3/50 (6%)     3/50 (6%)           1/49 (2%)     3/50 (6%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)                         1/50 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 9/250 (3.6%)    Mean 3.6%    SD 2.19%     Total 8/249 (3.21%)    Mean 3.21%   SD 1.78%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)     3/50 (6%)     4/50 (8%)           2/49 (4%)     4/50 (8%)     1/50 (2%)     |
|                                        2/50 (4%)     1/50 (2%)                         2/50 (4%)     2/50 (4%)                   |
| Overall Incidence               Total 11/250 (4.4%)   Mean 4.4%    SD 2.61%     Total 11/249 (4.42%)   Mean 4.42%   SD 2.19%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         2/50 (4%)     3/50 (6%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 7/249 (2.81%)    Mean 2.8%    SD 2.28%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     1/50 (2%)     3/50 (6%)          11/49 (22%)    8/50 (16%)   13/50 (26%)    |
|      Lymphocytic, Mixed, NOS, or       3/50 (6%)     2/50 (4%)                         5/50 (10%)    7/50 (14%)                  |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 12/250 (4.8%)   Mean 4.8%    SD 1.79%     Total 44/249 (17.67%)  Mean 17.69%  SD 6.47%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/49 (4%)     2/50 (4%)     1/48 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        4/49 (8%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 10/246 (4.07%)  Mean 4.07%   SD 2.5%      Total 2/248 (0.81%)    Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 1/248 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)     0/50 (0%)     0/47 (0%)           2/48 (4%)     2/49 (4%)     0/47 (0%)     |
|                                        0/48 (0%)     0/50 (0%)                         1/49 (2%)     2/49 (4%)                   |
| Overall Incidence               Total 0/244 (0%)      Mean 0%      SD 0%        Total 7/242 (2.89%)    Mean 2.87%   SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/50 (0%)     0/47 (0%)           0/48 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/48 (0%)     0/50 (0%)                         1/49 (2%)     0/49 (0%)                   |
| Overall Incidence               Total 0/244 (0%)      Mean 0%      SD 0%        Total 1/242 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)     0/50 (0%)     0/47 (0%)           2/48 (4%)     2/49 (4%)     0/47 (0%)     |
|      Complex, Malignant, NOS           0/48 (0%)     0/50 (0%)                         2/49 (4%)     2/49 (4%)                   |
| Overall Incidence               Total 0/244 (0%)      Mean 0%      SD 0%        Total 8/242 (3.31%)    Mean 3.28%   SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/49 (2%)     1/49 (2%)     0/49 (0%)           0/49 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 2/246 (0.81%)   Mean 0.82%   SD 1.12%     Total 2/247 (0.81%)    Mean 0.8%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/49 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/42 (0%)     0/43 (0%)     0/38 (0%)           0/41 (0%)     0/46 (0%)     0/40 (0%)     |
|                                        0/39 (0%)     0/42 (0%)                         0/40 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/204 (0%)      Mean 0%      SD 0%        Total 0/213 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/42 (0%)     0/43 (0%)     0/38 (0%)           0/41 (0%)     0/46 (0%)     0/40 (0%)     |
|                                        0/39 (0%)     0/42 (0%)                         0/40 (0%)     0/46 (0%)                   |
| Overall Incidence               Total 0/204 (0%)      Mean 0%      SD 0%        Total 0/213 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              6/50 (12%)    1/50 (2%)     6/50 (12%)          3/49 (6%)     3/50 (6%)     3/50 (6%)     |
|                                        7/50 (14%)    8/50 (16%)                        4/50 (8%)     2/50 (4%)                   |
| Overall Incidence               Total 28/250 (11.2%)  Mean 11.2%   SD 5.4%      Total 15/249 (6.02%)   Mean 6.02%   SD 1.42%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            3/50 (6%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 4/250 (1.6%)    Mean 1.6%    SD 2.61%     Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 9/50 (18%)    1/50 (2%)     7/50 (14%)          4/49 (8%)     3/50 (6%)     3/50 (6%)     |
|                                        7/50 (14%)    8/50 (16%)                        5/50 (10%)    2/50 (4%)                   |
| Overall Incidence               Total 32/250 (12.8%)  Mean 12.8%   SD 6.26%     Total 17/249 (6.83%)   Mean 6.83%   SD 2.3%      |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 2/249 (0.8%)     Mean 0.8%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/250 (0.8%)    Mean 0.8%    SD 1.79%     Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 3/250 (1.2%)    Mean 1.2%    SD 1.79%     Total 2/249 (0.8%)     Mean 0.8%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 4/250 (1.6%)    Mean 1.6%    SD 1.67%     Total 2/249 (0.8%)     Mean 0.8%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/49 (2%)     3/50 (6%)     2/48 (4%)           1/49 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/48 (0%)     1/50 (2%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 7/245 (2.86%)   Mean 2.84%   SD 2.3%      Total 3/247 (1.21%)    Mean 1.22%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/245 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/49 (2%)     3/50 (6%)     2/48 (4%)           1/49 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/48 (0%)     1/50 (2%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 7/245 (2.86%)   Mean 2.84%   SD 2.3%      Total 3/247 (1.21%)    Mean 1.22%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/249 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/249 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)     0/50 (0%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 2/249 (0.8%)    Mean 0.8%    SD 1.79%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/249 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     2/50 (4%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 6/250 (2.4%)    Mean 2.4%    SD 1.67%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              22/50 (44%)   17/50 (34%)   18/50 (36%)          7/49 (14%)   12/50 (24%)   14/49 (29%)    |
|                                       23/50 (46%)   15/50 (30%)                        9/50 (18%)    6/50 (12%)                  |
| Overall Incidence               Total 95/250 (38%)    Mean 38%     SD 6.78%     Total 48/248 (19.35%)  Mean 19.37%  SD 6.86%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            10/50 (20%)   11/50 (22%)    9/50 (18%)          4/49 (8%)     6/50 (12%)    4/49 (8%)     |
|                                       16/50 (32%)   14/50 (28%)                        6/50 (12%)    6/50 (12%)                  |
| Overall Incidence               Total 60/250 (24%)    Mean 24%     SD 5.83%     Total 26/248 (10.48%)  Mean 10.47%  SD 2.1%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)   11/50 (22%)    9/50 (18%)          4/49 (8%)     6/50 (12%)    4/49 (8%)     |
|      Hepatoblastoma                   16/50 (32%)   14/50 (28%)                        6/50 (12%)    6/50 (12%)                  |
| Overall Incidence               Total 60/250 (24%)    Mean 24%     SD 5.83%     Total 26/248 (10.48%)  Mean 10.47%  SD 2.1%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         28/50 (56%)   26/50 (52%)   25/50 (50%)         11/49 (22%)   18/50 (36%)   18/49 (37%)    |
|      Hepatocellular Adenoma           34/50 (68%)   26/50 (52%)                       13/50 (26%)   12/50 (24%)                  |
| Overall Incidence               Total 139/250 (55.6%) Mean 55.6%   SD 7.27%     Total 72/248 (29.03%)  Mean 29.04%  SD 6.81%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           28/50 (56%)   26/50 (52%)   25/50 (50%)         11/49 (22%)   18/50 (36%)   18/49 (37%)    |
|      Hepatocellular Adenoma, or       34/50 (68%)   26/50 (52%)                       13/50 (26%)   12/50 (24%)                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 139/250 (55.6%) Mean 55.6%   SD 7.27%     Total 72/248 (29.03%)  Mean 29.04%  SD 6.81%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         8/50 (16%)   13/50 (26%)   13/50 (26%)          1/49 (2%)     3/50 (6%)     2/50 (4%)     |
|                                        6/50 (12%)   13/50 (26%)                        2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 53/250 (21.2%)  Mean 21.2%   SD 6.72%     Total 9/249 (3.61%)    Mean 3.61%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       8/50 (16%)    6/50 (12%)    6/50 (12%)          6/49 (12%)    1/50 (2%)     1/50 (2%)     |
|                                        7/50 (14%)   12/50 (24%)                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 39/250 (15.6%)  Mean 15.6%   SD 4.98%     Total 8/249 (3.21%)    Mean 3.25%   SD 5.13%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   15/50 (30%)   18/50 (36%)   17/50 (34%)          7/49 (14%)    4/50 (8%)     3/50 (6%)     |
|      Alveolar/Bronchiolar Adenoma     13/50 (26%)   22/50 (44%)                        2/50 (4%)     1/50 (2%)                   |
| Overall Incidence               Total 85/250 (34%)    Mean 34%     SD 6.78%     Total 17/249 (6.83%)   Mean 6.86%   SD 4.72%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/249 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/249 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/49 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/249 (0%)      Mean 0%      SD 0%        Total 1/248 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     1/50 (2%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 2/249 (0.8%)     Mean 0.81%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)     0/47 (0%)     2/50 (4%)     |
|                                                                                        1/49 (2%)     1/48 (2%)                   |
| Overall Incidence                                                               Total 5/243 (2.06%)    Mean 2.03%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/49 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 1/243 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/49 (2%)     0/47 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 1/243 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           1/49 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 2/243 (0.82%)    Mean 0.82%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/49 (2%)     0/47 (0%)     2/50 (4%)     |
|                                                                                        0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 3/243 (1.23%)    Mean 1.21%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/49 (2%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 1/243 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/48 (0%)                   |
| Overall Incidence                                                               Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/48 (2%)     0/48 (0%)     0/43 (0%)          13/49 (27%)   10/50 (20%)    9/48 (19%)    |
|   Adenoma                              0/49 (0%)     1/50 (2%)                        10/47 (21%)    8/49 (16%)                  |
| Overall Incidence               Total 2/238 (0.84%)   Mean 0.82%   SD 1.12%     Total 50/243 (20.58%)  Mean 20.58%  SD 3.8%      |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/48 (0%)     0/43 (0%)           0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|   Carcinoma                            0/49 (0%)     1/50 (2%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 1/238 (0.42%)   Mean 0.4%    SD 0.89%     Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/48 (2%)     0/48 (0%)     0/43 (0%)          13/49 (27%)   10/50 (20%)    9/48 (19%)    |
|   Carcinoma or Adenoma                 0/49 (0%)     2/50 (4%)                        10/47 (21%)    8/49 (16%)                  |
| Overall Incidence               Total 3/238 (1.26%)   Mean 1.22%   SD 1.8%      Total 50/243 (20.58%)  Mean 20.58%  SD 3.8%      |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/48 (0%)     0/43 (0%)           1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 1/243 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/48 (0%)     0/43 (0%)           1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/47 (0%)     0/49 (0%)                   |
| Overall Incidence               Total 0/238 (0%)      Mean 0%      SD 0%        Total 1/243 (0.41%)    Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/48 (0%)     0/50 (0%)     1/49 (2%)                                                     |
|                                        0/46 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/243 (0.41%)   Mean 0.41%   SD 0.91%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/48 (0%)     0/50 (0%)     1/49 (2%)                                                     |
|                                        0/46 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/243 (0.41%)   Mean 0.41%   SD 0.91%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/48 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/46 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/243 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)                                                                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%                                                      |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     1/50 (2%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 3/249 (1.2%)     Mean 1.2%    SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   1/50 (2%)     0/50 (0%)                         1/50 (2%)     2/50 (4%)                   |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 6/249 (2.41%)    Mean 2.42%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     1/50 (2%)     |
|      Myxosarcoma, or Fibrous           1/50 (2%)     0/50 (0%)                         1/50 (2%)     2/50 (4%)                   |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 6/249 (2.41%)    Mean 2.42%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)                         1/50 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 6/249 (2.41%)    Mean 2.42%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/49 (0%)     2/50 (4%)     2/48 (4%)           1/49 (2%)     1/50 (2%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         1/49 (2%)     2/50 (4%)                   |
| Overall Incidence               Total 4/246 (1.63%)   Mean 1.63%   SD 2.24%     Total 5/247 (2.02%)    Mean 2.02%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/49 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/247 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     2/50 (4%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 4/250 (1.6%)    Mean 1.6%    SD 2.19%     Total 3/249 (1.2%)     Mean 1.2%    SD 1.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)                         0/50 (0%)     2/50 (4%)                   |
| Overall Incidence               Total 3/250 (1.2%)    Mean 1.2%    SD 1.79%     Total 2/249 (0.8%)     Mean 0.8%    SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         1/50 (2%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     2/50 (4%)     2/50 (4%)                                                     |
|                                        1/50 (2%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 5/250 (2%)      Mean 2%      SD 2%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|      Malignant, NOS                    0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)     0/35 (0%)     0/40 (0%)           0/48 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/41 (0%)     0/35 (0%)                         0/43 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/195 (0%)      Mean 0%      SD 0%        Total 0/227 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)     0/35 (0%)     0/40 (0%)           0/48 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/41 (0%)     0/35 (0%)                         0/43 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/195 (0%)      Mean 0%      SD 0%        Total 0/227 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)     0/35 (0%)     0/40 (0%)           0/48 (0%)     0/47 (0%)     0/45 (0%)     |
|                                        0/41 (0%)     0/35 (0%)                         0/43 (0%)     0/44 (0%)                   |
| Overall Incidence               Total 0/195 (0%)      Mean 0%      SD 0%        Total 0/227 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/48 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/240 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/48 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/240 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/48 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/240 (0%)      Mean 0%      SD 0%        Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/48 (0%)     0/47 (0%)     1/48 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/49 (2%)     0/48 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 2/240 (0.83%)   Mean 0.82%   SD 1.13%     Total 3/248 (1.21%)    Mean 1.21%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/48 (0%)     1/47 (2%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/240 (0.42%)   Mean 0.43%   SD 0.95%     Total 0/248 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/48 (0%)     1/47 (2%)     1/48 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/49 (2%)     0/48 (0%)                         2/50 (4%)     0/50 (0%)                   |
| Overall Incidence               Total 3/240 (1.25%)   Mean 1.25%   SD 1.14%     Total 3/248 (1.21%)    Mean 1.21%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 1/249 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 1/249 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 1/250 (0.4%)    Mean 0.4%    SD 0.89%     Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)     0/50 (0%)     1/48 (2%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)                         0/48 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 2/246 (0.81%)   Mean 0.82%   SD 1.12%     Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/48 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)     0/50 (0%)     1/48 (2%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)                         0/48 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 2/246 (0.81%)   Mean 0.82%   SD 1.12%     Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)                         0/48 (0%)     0/48 (0%)                   |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/243 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/249 (0.4%)     Mean 0.41%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 1/249 (0.4%)     Mean 0.4%    SD 0.89%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/50 (4%)     2/50 (4%)                   |
| Overall Incidence                                                               Total 4/249 (1.61%)    Mean 1.6%    SD 2.19%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)                   |
| Overall Incidence                                                               Total 2/249 (0.8%)     Mean 0.8%    SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        3/50 (6%)     2/50 (4%)                   |
| Overall Incidence                                                               Total 6/249 (2.41%)    Mean 2.4%    SD 2.61%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 62
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)                         0/50 (0%)     0/50 (0%)                   |
| Overall Incidence               Total 0/250 (0%)      Mean 0%      SD 0%        Total 0/249 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 63
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       54/100(54%)                                     52/100(52%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    40/100(40%)                                     55/100(55%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         71/100(71%)                                     78/100(78%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      6/100(6%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        6/100(6%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/100(1%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     8/100(8%)                                      32/100(32%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/100(0%)                                       0/100(0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 64
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/99 (3%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/99 (0%)                                       1/92 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/98 (1%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/98 (2%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            2/98 (2%)                                       0/90 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               1/99 (1%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 65
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/100(0%)                                       0/99 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 66
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/84 (0%)                                       0/70 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/84 (0%)                                       0/70 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                             12/100(12%)                                     10/100(10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                12/100(12%)                                     12/100(12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 67
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 68
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/99 (1%)                                       2/87 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            2/99 (2%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/99 (3%)                                       2/87 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/99 (1%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            1/99 (1%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 2/99 (2%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 69
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      4/100(4%)                                       1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       2/100(2%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              30/100(30%)                                     17/98 (17%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            19/100(19%)                                      6/98 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         21/100(21%)                                      6/98 (6%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         46/100(46%)                                     22/98 (22%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           47/100(47%)                                     22/98 (22%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/100(0%)                                       1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 70
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        26/100(26%)                                      9/95 (9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       8/100(8%)                                       2/95 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   30/100(30%)                                     11/95 (12%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 71
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/100(0%)                                       1/100(1%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 72
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/79 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          2/79 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        2/79 (3%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 73
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                      17/83 (20%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                       0/83 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                      17/83 (20%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/83 (0%)                                       1/83 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/83 (0%)                                       1/83 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 74
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/99 (0%)                                       1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 75
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/100(0%)                                       0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/100(0%)                                       0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)                                       1/100(1%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/100(0%)                                       1/100(1%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/100(0%)                                       1/100(1%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 76
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)                                       1/100(1%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 77
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/100(0%)                                       4/100(4%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/100(0%)                                       4/100(4%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/100(0%)                                       2/100(2%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/100(0%)                                       2/100(2%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       4/100(4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/99 (2%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 78
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/99 (0%)                                       1/91 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/100(0%)                                       1/100(1%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/99 (1%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/99 (0%)                                                                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 79
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/69 (0%)                                       1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/69 (0%)                                       1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              1/99 (1%)                                       2/92 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 80
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 81
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 83
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       37/50 (74%)   23/50 (46%)   34/50 (68%)         27/50 (54%)   13/50 (26%)   38/50 (76%)    |
|                                       30/60 (50%)   25/50 (50%)   32/50 (64%)         21/60 (35%)   17/50 (34%)   15/50 (30%)    |
| Overall Incidence               Total 181/310 (58.39%)Mean 58.67%  SD 11.5%     Total 131/310 (42.26%) Mean 42.5%   SD 19.03%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/50 (46%)   20/50 (40%)   29/50 (58%)         17/50 (34%)   12/50 (24%)   33/50 (66%)    |
|                                       26/60 (43%)   14/50 (28%)   29/50 (58%)         16/60 (27%)    9/50 (18%)   21/50 (42%)    |
| Overall Incidence               Total 141/310 (45.48%)Mean 45.56%  SD 11.44%    Total 108/310 (34.84%) Mean 35.11%  SD 17.26%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)   32/50 (64%)   45/50 (90%)         39/50 (78%)   23/50 (46%)   47/50 (94%)    |
|                                       45/60 (75%)   31/50 (62%)   44/50 (88%)         33/60 (55%)   21/50 (42%)   31/50 (62%)    |
| Overall Incidence               Total 242/310 (78.06%)Mean 78.17%  SD 13.03%    Total 194/310 (62.58%) Mean 62.83%  SD 19.9%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           3/60 (5%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.61%   SD 0.95%     Total 6/310 (1.94%)    Mean 1.83%   SD 2.23%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     3/50 (6%)     |
|                                        4/60 (7%)     1/50 (2%)     3/50 (6%)           0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 15/310 (4.84%)  Mean 4.78%   SD 2.51%     Total 7/310 (2.26%)    Mean 2.33%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)    2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     5/50 (10%)    |
|                                        5/60 (8%)     1/50 (2%)     3/50 (6%)           3/60 (5%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 17/310 (5.48%)  Mean 5.39%   SD 3.32%     Total 13/310 (4.19%)   Mean 4.17%   SD 3.37%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 4/310 (1.29%)   Mean 1.28%   SD 1%        Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     2/50 (4%)     3/50 (6%)           4/50 (8%)     6/50 (12%)   23/50 (46%)    |
|      Lymphocytic, Mixed, NOS, or       3/60 (5%)     3/50 (6%)     3/50 (6%)           8/60 (13%)    3/50 (6%)     7/50 (14%)    |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 16/310 (5.16%)  Mean 5.17%   SD 0.98%     Total 51/310 (16.45%)  Mean 16.56%  SD 14.76%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 84
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              4/50 (8%)     0/50 (0%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/60 (3%)     3/49 (6%)     3/49 (6%)           1/59 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 15/308 (4.87%)  Mean 4.93%   SD 2.84%     Total 2/309 (0.65%)    Mean 0.62%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/49 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/308 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/49 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/308 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/49 (0%)     0/49 (0%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/306 (0%)      Mean 0%      SD 0%        Total 2/308 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/60 (0%)     0/49 (0%)     1/49 (2%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/306 (0.33%)   Mean 0.34%   SD 0.83%     Total 2/308 (0.65%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     3/50 (6%)     |
|      Complex, Malignant, NOS           0/60 (0%)     0/49 (0%)     1/49 (2%)           0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/306 (0.33%)   Mean 0.34%   SD 0.83%     Total 4/308 (1.3%)     Mean 1.33%   SD 2.42%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     1/50 (2%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/309 (0.65%)   Mean 0.67%   SD 1.03%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 85
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/309 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/309 (0.32%)   Mean 0.28%   SD 0.68%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 86
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     1/50 (2%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     1/50 (2%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.28%   SD 0.68%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 87
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/48 (0%)     0/46 (0%)     0/44 (0%)           0/44 (0%)     0/49 (0%)     0/40 (0%)     |
|                                        0/54 (0%)     0/49 (0%)     0/44 (0%)           0/54 (0%)     0/49 (0%)     0/45 (0%)     |
| Overall Incidence               Total 0/285 (0%)      Mean 0%      SD 0%        Total 0/281 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/48 (0%)     0/46 (0%)     0/44 (0%)           0/44 (0%)     0/49 (0%)     0/40 (0%)     |
|                                        0/54 (0%)     0/49 (0%)     0/44 (0%)           0/54 (0%)     0/49 (0%)     1/45 (2%)     |
| Overall Incidence               Total 0/285 (0%)      Mean 0%      SD 0%        Total 1/281 (0.36%)    Mean 0.37%   SD 0.91%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              7/50 (14%)    9/50 (18%)    6/50 (12%)          7/50 (14%)    3/50 (6%)    11/50 (22%)    |
|                                        4/60 (7%)     3/50 (6%)     4/50 (8%)           4/60 (7%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 33/310 (10.65%) Mean 10.78%  SD 4.72%     Total 29/310 (9.35%)   Mean 9.44%   SD 7.17%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        1/60 (2%)     0/50 (0%)     2/50 (4%)           1/60 (2%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 6/310 (1.94%)   Mean 1.94%   SD 1.79%     Total 5/310 (1.61%)    Mean 1.61%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 9/50 (18%)   10/50 (20%)    6/50 (12%)          7/50 (14%)    4/50 (8%)    12/50 (24%)    |
|                                        5/60 (8%)     3/50 (6%)     6/50 (12%)          5/60 (8%)     2/50 (4%)     4/50 (8%)     |
| Overall Incidence               Total 39/310 (12.58%) Mean 12.72%  SD 5.41%     Total 34/310 (10.97%)  Mean 11.06%  SD 7.1%      |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/308 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/308 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 88
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.28%   SD 0.68%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 89
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/60 (3%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/310 (1.94%)   Mean 1.89%   SD 1.66%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/60 (3%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/310 (1.94%)   Mean 1.89%   SD 1.66%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/60 (3%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/310 (2.26%)   Mean 2.22%   SD 2.26%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.28%   SD 0.68%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 90
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)     0/50 (0%)     1/48 (2%)           1/47 (2%)     0/50 (0%)     0/46 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     3/49 (6%)           0/60 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 6/306 (1.96%)   Mean 2.03%   SD 2.57%     Total 1/301 (0.33%)    Mean 0.35%   SD 0.87%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/47 (0%)     0/50 (0%)     0/46 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/306 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     1/48 (2%)           1/47 (2%)     0/50 (0%)     0/46 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     3/49 (6%)           0/60 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 6/306 (1.96%)   Mean 2.03%   SD 2.57%     Total 1/301 (0.33%)    Mean 0.35%   SD 0.87%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/58 (0%)     0/50 (0%)     1/49 (2%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/306 (0.65%)   Mean 0.67%   SD 1.04%     Total 0/307 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/58 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/306 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/307 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/58 (0%)     0/50 (0%)     1/49 (2%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 3/306 (0.98%)   Mean 1.01%   SD 1.1%      Total 0/307 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/58 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/306 (0%)      Mean 0%      SD 0%        Total 0/307 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/308 (0.32%)   Mean 0.35%   SD 0.85%     Total 0/307 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     2/49 (4%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/308 (0%)      Mean 0%      SD 0%        Total 2/307 (0.65%)    Mean 0.68%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     1/48 (2%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/60 (2%)     1/50 (2%)     2/50 (4%)           0/60 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 7/308 (2.27%)   Mean 2.29%   SD 0.85%     Total 1/307 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 91
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       2/50 (4%)     0/50 (0%)     6/48 (13%)          0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/60 (2%)     0/50 (0%)     3/50 (6%)           0/60 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 12/308 (3.9%)   Mean 4.03%   SD 4.77%     Total 1/307 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              23/50 (46%)    7/50 (14%)   30/48 (63%)         11/50 (22%)    3/50 (6%)    30/49 (61%)    |
|                                       18/60 (30%)   14/50 (28%)   16/50 (32%)          7/60 (12%)    6/49 (12%)    9/49 (18%)    |
| Overall Incidence               Total 108/308 (35.06%)Mean 35.42%  SD 16.73%    Total 66/307 (21.5%)   Mean 21.92%  SD 20.05%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             8/50 (16%)    4/50 (8%)    20/48 (42%)          3/50 (6%)     2/50 (4%)     3/49 (6%)     |
|                                       12/60 (20%)    8/50 (16%)   23/50 (46%)          2/60 (3%)     3/49 (6%)     8/49 (16%)    |
| Overall Incidence               Total 75/308 (24.35%) Mean 24.61%  SD 15.45%    Total 21/307 (6.84%)   Mean 6.98%   SD 4.73%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)    4/50 (8%)    23/48 (48%)          3/50 (6%)     2/50 (4%)     4/49 (8%)     |
|      Hepatoblastoma                   13/60 (22%)    8/50 (16%)   24/50 (48%)          2/60 (3%)     3/49 (6%)     8/49 (16%)    |
| Overall Incidence               Total 82/308 (26.62%) Mean 26.93%  SD 16.96%    Total 22/307 (7.17%)   Mean 7.32%   SD 4.73%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         31/50 (62%)   10/50 (20%)   41/48 (85%)         13/50 (26%)    4/50 (8%)    31/49 (63%)    |
|      Hepatocellular Adenoma           27/60 (45%)   20/50 (40%)   36/50 (72%)          9/60 (15%)    8/49 (16%)   16/49 (33%)    |
| Overall Incidence               Total 165/308 (53.57%)Mean 54.07%  SD 23.7%     Total 81/307 (26.38%)  Mean 26.87%  SD 19.83%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           31/50 (62%)   10/50 (20%)   41/48 (85%)         13/50 (26%)    4/50 (8%)    31/49 (63%)    |
|      Hepatocellular Adenoma, or       28/60 (47%)   20/50 (40%)   36/50 (72%)          9/60 (15%)    8/49 (16%)   16/49 (33%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 166/308 (53.9%) Mean 54.35%  SD 23.58%    Total 81/307 (26.38%)  Mean 26.87%  SD 19.83%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     2/50 (4%)     0/50 (0%)           0/60 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/308 (0.65%)   Mean 0.67%   SD 1.63%     Total 0/307 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/49 (0%)     1/49 (2%)     |
| Overall Incidence               Total 0/308 (0%)      Mean 0%      SD 0%        Total 1/307 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        11/50 (22%)   11/50 (22%)    6/50 (12%)          2/49 (4%)     4/50 (8%)     3/50 (6%)     |
|                                        9/60 (15%)    6/50 (12%)   12/50 (24%)          2/60 (3%)     5/50 (10%)    1/50 (2%)     |
| Overall Incidence               Total 55/310 (17.74%) Mean 17.83%  SD 5.46%     Total 17/309 (5.5%)    Mean 5.57%   SD 3.02%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 92
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       9/50 (18%)    6/50 (12%)    4/50 (8%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        5/60 (8%)     2/50 (4%)     7/50 (14%)          3/60 (5%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 33/310 (10.65%) Mean 10.72%  SD 4.97%     Total 6/309 (1.94%)    Mean 1.83%   SD 1.83%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   19/50 (38%)   14/50 (28%)   10/50 (20%)          2/49 (4%)     4/50 (8%)     4/50 (8%)     |
|      Alveolar/Bronchiolar Adenoma     14/60 (23%)    8/50 (16%)   18/50 (36%)          5/60 (8%)     6/50 (12%)    2/50 (4%)     |
| Overall Incidence               Total 83/310 (26.77%) Mean 26.89%  SD 8.79%     Total 23/309 (7.44%)   Mean 7.4%    SD 3.01%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/309 (0.32%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 93
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 2/310 (0.65%)    Mean 0.61%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|      or Adenoma                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 94
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma Squamous, or Papilloma  0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 95
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)     0/50 (0%)     1/45 (2%)     |
|                                                                                        1/59 (2%)     3/48 (6%)     1/49 (2%)     |
| Overall Incidence                                                               Total 7/300 (2.33%)    Mean 2.37%   SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/49 (0%)     0/50 (0%)     1/45 (2%)     |
|                                                                                        0/59 (0%)     1/48 (2%)     0/49 (0%)     |
| Overall Incidence                                                               Total 2/300 (0.67%)    Mean 0.72%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/49 (0%)     0/50 (0%)     1/45 (2%)     |
|      Malignant, NOS                                                                    0/59 (0%)     1/48 (2%)     0/49 (0%)     |
| Overall Incidence                                                               Total 2/300 (0.67%)    Mean 0.72%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)     0/50 (0%)     0/45 (0%)     |
|                                                                                        0/59 (0%)     1/48 (2%)     0/49 (0%)     |
| Overall Incidence                                                               Total 1/300 (0.33%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/50 (0%)     0/45 (0%)     |
|                                                                                        0/59 (0%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/49 (2%)     0/50 (0%)     3/45 (7%)     |
|                                                                                        2/59 (3%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 6/300 (2%)       Mean 2.02%   SD 2.67%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/50 (0%)     0/45 (0%)     |
|                                                                                        0/59 (0%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)     0/50 (0%)     0/45 (0%)     |
|                                                                                        0/59 (0%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 96
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)     0/50 (0%)     0/45 (0%)     |
|                                                                                        0/59 (0%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence                                                               Total 0/300 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/48 (0%)           0/47 (0%)     0/50 (0%)     0/46 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/306 (0%)      Mean 0%      SD 0%        Total 0/301 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/47 (0%)     0/50 (0%)     0/46 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/49 (0%)     1/49 (2%)     |
| Overall Incidence               Total 0/306 (0%)      Mean 0%      SD 0%        Total 1/301 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/49 (0%)     0/47 (0%)           2/46 (4%)     1/50 (2%)     3/46 (7%)     |
|   Adenoma                              1/53 (2%)     0/46 (0%)     1/49 (2%)           3/58 (5%)     0/45 (0%)     5/48 (10%)    |
| Overall Incidence               Total 2/292 (0.68%)   Mean 0.65%   SD 1.02%     Total 14/293 (4.78%)   Mean 4.74%   SD 3.63%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/49 (0%)     0/47 (0%)           0/46 (0%)     0/50 (0%)     0/46 (0%)     |
|   Carcinoma                            0/53 (0%)     0/46 (0%)     0/49 (0%)           0/58 (0%)     0/45 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/292 (0%)      Mean 0%      SD 0%        Total 0/293 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/49 (0%)     0/47 (0%)           2/46 (4%)     1/50 (2%)     3/46 (7%)     |
|   Carcinoma or Adenoma                 1/53 (2%)     0/46 (0%)     1/49 (2%)           3/58 (5%)     0/45 (0%)     5/48 (10%)    |
| Overall Incidence               Total 2/292 (0.68%)   Mean 0.65%   SD 1.02%     Total 14/293 (4.78%)   Mean 4.74%   SD 3.63%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/49 (0%)     0/47 (0%)           2/46 (4%)     0/50 (0%)     0/46 (0%)     |
|                                        0/53 (0%)     0/46 (0%)     0/49 (0%)           0/58 (0%)     0/45 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/292 (0%)      Mean 0%      SD 0%        Total 2/293 (0.68%)    Mean 0.72%   SD 1.77%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/49 (0%)     0/47 (0%)           2/46 (4%)     0/50 (0%)     0/46 (0%)     |
|                                        0/53 (0%)     0/46 (0%)     0/49 (0%)           0/58 (0%)     0/45 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/292 (0%)      Mean 0%      SD 0%        Total 2/293 (0.68%)    Mean 0.72%   SD 1.77%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/308 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/308 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 97
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/308 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/306 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/306 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           5/50 (10%)    0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 6/310 (1.94%)    Mean 2%      SD 4%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 98
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 3/310 (0.97%)   Mean 1%      SD 1.67%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 99
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.03%     Total 3/310 (0.97%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 100
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.03%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.67%   SD 1.03%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 3/310 (0.97%)   Mean 1%      SD 1.67%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/60 (0%)     1/50 (2%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/310 (0.97%)   Mean 1%      SD 1.67%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/60 (0%)     0/50 (0%)     0/50 (0%)           1/60 (2%)     2/50 (4%)     3/50 (6%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 6/310 (1.94%)    Mean 1.94%   SD 2.53%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           0/60 (0%)     0/50 (0%)     0/50 (0%)           1/60 (2%)     2/50 (4%)     3/50 (6%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 6/310 (1.94%)    Mean 1.94%   SD 2.53%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     3/50 (6%)     |
|      (malignant or NOS)                0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 4/310 (1.29%)    Mean 1.33%   SD 2.42%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 101
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     3/50 (6%)     |
|      or Schwannoma (benign, malignant  0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 4/310 (1.29%)    Mean 1.33%   SD 2.42%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           1/60 (2%)     1/50 (2%)     3/50 (6%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 5/310 (1.61%)    Mean 1.61%   SD 2.33%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     3/50 (6%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 4/310 (1.29%)    Mean 1.33%   SD 2.42%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/60 (2%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/306 (0.33%)   Mean 0.28%   SD 0.68%     Total 0/304 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/49 (4%)     1/50 (2%)     0/48 (0%)           0/48 (0%)     0/50 (0%)     2/49 (4%)     |
|                                        2/60 (3%)     0/50 (0%)     1/49 (2%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 6/306 (1.96%)   Mean 1.91%   SD 1.68%     Total 2/304 (0.66%)    Mean 0.68%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/306 (0%)      Mean 0%      SD 0%        Total 0/304 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/49 (0%)           0/59 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/306 (0%)      Mean 0%      SD 0%        Total 0/304 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           2/50 (4%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     2/50 (4%)     0/50 (0%)     |
|      Papilloma Squamous                0/60 (0%)     1/50 (2%)     1/50 (2%)           1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/310 (1.29%)   Mean 1.33%   SD 1.63%     Total 5/310 (1.61%)    Mean 1.61%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 102
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              2/50 (4%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     2/50 (4%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)     1/50 (2%)           1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/310 (1.29%)   Mean 1.33%   SD 1.63%     Total 5/310 (1.61%)    Mean 1.61%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|      Malignant, NOS                    0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)     0/47 (0%)     0/43 (0%)           0/44 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/57 (0%)     0/47 (0%)     0/42 (0%)           0/57 (0%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/280 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)     0/47 (0%)     0/43 (0%)           0/44 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/57 (0%)     0/47 (0%)     0/42 (0%)           0/57 (0%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/280 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 103
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)     0/47 (0%)     0/43 (0%)           0/44 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/57 (0%)     0/47 (0%)     0/42 (0%)           0/57 (0%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/280 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/306 (0%)      Mean 0%      SD 0%        Total 0/305 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/306 (0%)      Mean 0%      SD 0%        Total 0/305 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/306 (0%)      Mean 0%      SD 0%        Total 0/305 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/48 (0%)           1/49 (2%)     1/49 (2%)     1/48 (2%)     |
|                                        1/59 (2%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/306 (0.65%)   Mean 0.62%   SD 0.96%     Total 3/305 (0.98%)    Mean 1.03%   SD 1.13%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/306 (0%)      Mean 0%      SD 0%        Total 0/305 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/48 (0%)           1/49 (2%)     1/49 (2%)     1/48 (2%)     |
|                                        1/59 (2%)     0/50 (0%)     0/49 (0%)           0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/306 (0.65%)   Mean 0.62%   SD 0.96%     Total 3/305 (0.98%)    Mean 1.03%   SD 1.13%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/60 (3%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/310 (0.65%)   Mean 0.56%   SD 1.36%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 104
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/308 (0%)      Mean 0%      SD 0%        Total 0/305 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/308 (0%)      Mean 0%      SD 0%        Total 0/305 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/308 (0%)      Mean 0%      SD 0%        Total 0/305 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/59 (0%)     0/50 (0%)     0/50 (0%)           0/59 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/308 (0%)      Mean 0%      SD 0%        Total 1/305 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 105
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        2/60 (3%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence                                                               Total 6/310 (1.94%)    Mean 1.89%   SD 2.44%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                                                                        2/60 (3%)     3/50 (6%)     0/50 (0%)     |
| Overall Incidence                                                               Total 7/310 (2.26%)    Mean 2.22%   SD 2.26%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/310 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 106
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)     0/50 (0%)           0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/310 (0.32%)   Mean 0.33%   SD 0.82%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
