                                                 Toxicology Data Management System                                     Page: 1
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                      Date of
 Species: MICE                                           Vehicle: WATER                                   Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058803106  03/19/97   729       50(1)      40  (703)     53.9     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058800706  08/02/95   727       50(1)      39  (708)     51.4     SODIUM NITRITE                             |
|SOUTHERN RESEARCH  059601004  09/30/98   729       50(1)      38  (694)     54.1     SODIUM DICHLORATE                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058803106  03/19/97   728       50(5)      37  (699)     61.4     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058800706  08/02/95   728       50(5)      40  (702)     58.8     SODIUM NITRITE                             |
|SOUTHERN RESEARCH  059601004  09/30/98   735       50(5)      36  (691)     66.5     SODIUM DICHLORATE                          |
|________________________________________________________________________________________________________________________________|

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 3
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       27/50 (54%)   28/50 (56%)   34/50 (68%)         22/50 (44%)   13/50 (26%)   38/50 (76%)    |
| Overall Incidence               Total 89/150 (59.33%) Mean 59.33%  SD 7.57%     Total 73/150 (48.67%)  Mean 48.67%  SD 25.32%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    19/50 (38%)   27/50 (54%)   29/50 (58%)         18/50 (36%)   12/50 (24%)   33/50 (66%)    |
| Overall Incidence               Total 75/150 (50%)    Mean 50%     SD 10.58%    Total 63/150 (42%)     Mean 42%     SD 21.63%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         39/50 (78%)   40/50 (80%)   45/50 (90%)         32/50 (64%)   21/50 (42%)   47/50 (94%)    |
| Overall Incidence               Total 124/150 (82.67%)Mean 82.67%  SD 6.43%     Total 100/150 (66.67%) Mean 66.67%  SD 26.1%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 2.31%     Total 4/150 (2.67%)    Mean 2.67%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     7/50 (14%)    1/50 (2%)           3/50 (6%)     1/50 (2%)     3/50 (6%)     |
| Overall Incidence               Total 8/150 (5.33%)   Mean 5.33%   SD 7.57%     Total 7/150 (4.67%)    Mean 4.67%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        2/50 (4%)     7/50 (14%)    1/50 (2%)           5/50 (10%)    1/50 (2%)     5/50 (10%)    |
| Overall Incidence               Total 10/150 (6.67%)  Mean 6.67%   SD 6.43%     Total 11/150 (7.33%)   Mean 7.33%   SD 4.62%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     1/50 (2%)     1/50 (2%)     3/50 (6%)           5/50 (10%)    7/50 (14%)   23/50 (46%)    |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 5/150 (3.33%)   Mean 3.33%   SD 2.31%     Total 35/150 (23.33%)  Mean 23.33%  SD 19.73%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                                                                                                                         |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/150 (2%)      Mean 2%      SD 3.46%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 4
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence               Total 0/149 (0%)      Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     2/50 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/149 (1.34%)   Mean 1.33%   SD 2.31%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              2/50 (4%)     4/50 (8%)     6/50 (12%)          1/50 (2%)     0/50 (0%)    11/50 (22%)    |
| Overall Incidence               Total 12/150 (8%)     Mean 8%      SD 4%        Total 12/150 (8%)      Mean 8%      SD 12.17%    |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 3/50 (6%)     4/50 (8%)     6/50 (12%)          1/50 (2%)     0/50 (0%)    12/50 (24%)    |
| Overall Incidence               Total 13/150 (8.67%)  Mean 8.67%   SD 3.06%     Total 13/150 (8.67%)   Mean 8.67%   SD 13.32%    |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/150 (2%)      Mean 2%      SD 2%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)     5/50 (10%)    2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/150 (5.33%)   Mean 5.33%   SD 4.16%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 5
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)     5/50 (10%)    2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/150 (5.33%)   Mean 5.33%   SD 4.16%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)     5/50 (10%)    3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 9/150 (6%)      Mean 6%      SD 4%        Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    2/50 (4%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/150 (2.67%)   Mean 2.67%   SD 2.31%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              0/50 (0%)     3/50 (6%)     1/48 (2%)           2/50 (4%)     0/50 (0%)     0/46 (0%)     |
| Overall Incidence               Total 4/148 (2.7%)    Mean 2.69%   SD 3.05%     Total 2/146 (1.37%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     3/50 (6%)     1/48 (2%)           2/50 (4%)     0/50 (0%)     0/46 (0%)     |
| Overall Incidence               Total 4/148 (2.7%)    Mean 2.69%   SD 3.05%     Total 2/146 (1.37%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/149 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/148 (0.68%)   Mean 0.69%   SD 1.2%      Total 0/149 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     2/49 (4%)     |
| Overall Incidence               Total 1/148 (0.68%)   Mean 0.67%   SD 1.15%     Total 3/149 (2.01%)    Mean 2.03%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     2/50 (4%)     1/48 (2%)           2/50 (4%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence               Total 3/148 (2.03%)   Mean 2.03%   SD 2%        Total 3/149 (2.01%)    Mean 2.01%   SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     5/50 (10%)    6/48 (13%)          0/50 (0%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence               Total 11/148 (7.43%)  Mean 7.5%    SD 6.61%     Total 1/149 (0.67%)    Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              17/50 (34%)   19/50 (38%)   30/48 (63%)         11/50 (22%)    9/50 (18%)   30/49 (61%)    |
| Overall Incidence               Total 66/148 (44.59%) Mean 44.83%  SD 15.43%    Total 50/149 (33.56%)  Mean 33.74%  SD 23.88%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            14/50 (28%)    9/50 (18%)   20/48 (42%)          7/50 (14%)    2/50 (4%)     3/49 (6%)     |
| Overall Incidence               Total 43/148 (29.05%) Mean 29.22%  SD 11.88%    Total 12/149 (8.05%)   Mean 8.04%   SD 5.27%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         14/50 (28%)   12/50 (24%)   23/48 (48%)          7/50 (14%)    2/50 (4%)     4/49 (8%)     |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 49/148 (33.11%) Mean 33.31%  SD 12.81%    Total 13/149 (8.72%)   Mean 8.72%   SD 5.02%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         29/50 (58%)   24/50 (48%)   41/48 (85%)         17/50 (34%)   10/50 (20%)   31/49 (63%)    |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence               Total 94/148 (63.51%) Mean 63.81%  SD 19.37%    Total 58/149 (38.93%)  Mean 39.09%  SD 22.08%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           29/50 (58%)   26/50 (52%)   41/48 (85%)         17/50 (34%)   10/50 (20%)   31/49 (63%)    |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 96/148 (64.86%) Mean 65.14%  SD 17.82%    Total 58/149 (38.93%)  Mean 39.09%  SD 22.08%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 1/149 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         3/50 (6%)    10/50 (20%)    6/50 (12%)          2/50 (4%)     1/50 (2%)     3/50 (6%)     |
| Overall Incidence               Total 19/150 (12.67%) Mean 12.67%  SD 7.02%     Total 6/150 (4%)       Mean 4%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       3/50 (6%)     4/50 (8%)     4/50 (8%)           2/50 (4%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 11/150 (7.33%)  Mean 7.33%   SD 1.15%     Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    6/50 (12%)   13/50 (26%)   10/50 (20%)          3/50 (6%)     1/50 (2%)     4/50 (8%)     |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence               Total 29/150 (19.33%) Mean 19.33%  SD 7.02%     Total 8/150 (5.33%)    Mean 5.33%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                                                                                                                  |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     0/47 (0%)     1/45 (2%)     |
| Overall Incidence                                                               Total 1/142 (0.7%)     Mean 0.74%   SD 1.28%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/50 (2%)     0/47 (0%)     1/45 (2%)     |
| Overall Incidence                                                               Total 2/142 (1.41%)    Mean 1.41%   SD 1.22%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/50 (2%)     0/47 (0%)     1/45 (2%)     |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                               Total 2/142 (1.41%)    Mean 1.41%   SD 1.22%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/47 (0%)     3/45 (7%)     |
| Overall Incidence                                                               Total 3/142 (2.11%)    Mean 2.22%   SD 3.85%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/49 (0%)     0/47 (0%)           1/49 (2%)     1/48 (2%)     3/46 (7%)     |
|   Adenoma                                                                                                                        |
| Overall Incidence               Total 0/145 (0%)      Mean 0%      SD 0%        Total 5/143 (3.5%)     Mean 3.55%   SD 2.57%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/49 (0%)     0/47 (0%)           1/49 (2%)     1/48 (2%)     3/46 (7%)     |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence               Total 0/145 (0%)      Mean 0%      SD 0%        Total 5/143 (3.5%)     Mean 3.55%   SD 2.57%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/49 (2%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/48 (0%)     0/46 (0%)     |
| Overall Incidence               Total 1/145 (0.69%)   Mean 0.68%   SD 1.18%     Total 0/143 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/49 (2%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/48 (0%)     0/46 (0%)     |
| Overall Incidence               Total 1/145 (0.69%)   Mean 0.68%   SD 1.18%     Total 0/143 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 2/150 (1.33%)    Mean 1.33%   SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 4/150 (2.67%)    Mean 2.67%   SD 3.06%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 3/150 (2%)       Mean 2%      SD 3.46%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     3/50 (6%)     0/48 (0%)           1/50 (2%)     0/49 (0%)     2/49 (4%)     |
| Overall Incidence               Total 3/148 (2.03%)   Mean 2%      SD 3.46%     Total 3/148 (2.03%)    Mean 2.03%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 0/150 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/50 (2%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 2/150 (1.33%)   Mean 1.33%   SD 1.15%     Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/150 (0.67%)   Mean 0.67%   SD 1.15%     Total 3/150 (2%)       Mean 2%      SD 2%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              3/50 (6%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 3/150 (2%)      Mean 2%      SD 3.46%                                                      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/46 (0%)     0/37 (0%)     0/43 (0%)           1/49 (2%)     0/46 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/126 (0%)      Mean 0%      SD 0%        Total 1/143 (0.7%)     Mean 0.68%   SD 1.18%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/46 (0%)     0/37 (0%)     0/43 (0%)           0/49 (0%)     1/46 (2%)     0/48 (0%)     |
| Overall Incidence               Total 0/126 (0%)      Mean 0%      SD 0%        Total 1/143 (0.7%)     Mean 0.72%   SD 1.26%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/46 (0%)     0/37 (0%)     0/43 (0%)           0/49 (0%)     1/46 (2%)     0/48 (0%)     |
| Overall Incidence               Total 0/126 (0%)      Mean 0%      SD 0%        Total 1/143 (0.7%)     Mean 0.72%   SD 1.26%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     1/48 (2%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 1/146 (0.68%)    Mean 0.69%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 11/09/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: All Laboratories                          Route: ORAL                                       Date of
 Species: MICE                                           Vehicle: WATER                                    Input File: 9-NOV-2004 
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/48 (0%)           0/49 (0%)     0/49 (0%)     1/48 (2%)     |
| Overall Incidence               Total 0/148 (0%)      Mean 0%      SD 0%        Total 1/146 (0.68%)    Mean 0.69%   SD 1.2%      |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence               Total 0/150 (0%)      Mean 0%      SD 0%        Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/150 (0.67%)    Mean 0.67%   SD 1.15%     |
 __________________________________________________________________________________________________________________________________
